LLPS-Gag-0604
20349877
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mediator of RNA polymerase II transcription subunit 10; Mediator complex subunit 10 |
| Gene Name: | 20349877, MED10, GGTG_09419 |
| Ensembl Gene: | GGTG_09419 |
| Ensembl Protein: | EJT72557 |
| Organism: | Gaeumannomyces graminis |
| Taxa ID: | 644352 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EJT72557 | EJT72557 |
| UniProt | J3P7C6, J3P7C6_GAGT3 | |
| GeneBank | GL385399 | EJT72557.1 |
| RefSeq | XM_009227267.1 | XP_009225531.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MVQVTQYDNV GGQSSKEVVA NELKSLSNTL KQIHTVSTAS STRLPHVPTE LIQYVENGRN 60 61 PDIYTREFVE VVRRGNQLMR GKLHAYESFR DILAGEMRTA LPELRDDVDQ VIAATTPAPA 120 121 PAPAPARGVS NNTTPAAAAA QHPAAAARHS GRLDGDKTES DSYGGLPTPP SFGIDSTPPT 180 181 PTTPTSQATP SRRGAGRGRG RGRGAKGAGR GTRGAGRSGR GGRRGGAAND ENVARSGGNN 240 241 SGAATRRSSR IESARNAAQQ IQNSGLAGVA EELLVRHGAQ RQLVGAGAYH KTRMATILGA 300 301 RFAHSAAGLL IDFGLTAAFA AASLFVLGIH GVFHAIAYAF VTPWLALMRV LGTIKLSFIV 360 361 AGRIMRICGR LLIILLRWAT TYRGHRLFFL DPLTMEAMMP SSPVPHVEDE DEAEVEFESD 420 421 EDEGLFVDEA DLETREDEFT EEAPLPVFC 449 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGTCCAGG TGACGCAGTA CGACAATGTC GGAGGGCAGT CCAGCAAGGA AGTCGTCGCC 60 61 AACGAGCTGA AATCCCTCTC GAACACCCTG AAGCAGATCC ACACTGTCTC GACGGCCAGC 120 121 TCGACGCGGC TGCCGCACGT TCCGACAGAG CTGATCCAGT ACGTCGAGAA CGGCCGCAAC 180 181 CCCGACATCT ACACGCGCGA GTTCGTCGAG GTCGTCCGCC GCGGCAACCA GCTCATGCGA 240 241 GGCAAGCTGC ACGCCTATGA GTCGTTCCGC GACATCCTGG CTGGCGAGAT GCGCACGGCG 300 301 CTGCCCGAGC TGCGCGACGA CGTCGATCAA GTCATCGCCG CCACCACTCC TGCACCCGCT 360 361 CCGGCTCCTG CTCCCGCCAG AGGCGTCTCC AACAACACTA CACCTGCTGC TGCTGCTGCC 420 421 CAACACCCAG CCGCGGCCGC CCGGCACTCC GGACGGCTCG ACGGCGACAA GACTGAATCC 480 481 GACAGTTATG GGGGCCTGCC CACCCCACCA TCGTTTGGCA TCGATAGCAC CCCGCCGACT 540 541 CCCACCACGC CCACGTCACA GGCGACCCCT TCCCGGAGGG GAGCAGGCCG AGGCCGTGGA 600 601 CGCGGCCGTG GAGCAAAGGG AGCAGGCCGT GGCACTCGGG GTGCCGGTCG CAGTGGACGT 660 661 GGCGGCCGTC GTGGTGGTGC CGCGAATGAT GAGAATGTGG CTCGTAGCGG TGGCAACAAC 720 721 AGCGGCGCTG CCACGCGACG TTCCTCCCGC ATCGAGAGCG CGCGCAACGC GGCTCAGCAG 780 781 ATACAGAACT CGGGCCTGGC TGGAGTCGCC GAGGAGCTGC TCGTCCGCCA CGGCGCGCAG 840 841 CGCCAGCTCG TGGGCGCCGG CGCCTACCAC AAGACTCGCA TGGCCACGAT TCTGGGCGCC 900 901 CGCTTCGCCC ATTCGGCTGC TGGCCTTCTC ATCGACTTTG GACTCACCGC CGCTTTTGCT 960 961 GCTGCGAGCC TGTTTGTTTT GGGCATTCAC GGCGTCTTCC ACGCCATTGC CTACGCCTTT 1020 1021 GTCACGCCCT GGTTGGCCCT CATGCGCGTC CTGGGCACCA TTAAGCTCAG CTTCATCGTG 1080 1081 GCCGGTAGAA TCATGCGTAT CTGCGGTCGC CTCCTGATCA TTCTCCTCCG TTGGGCCACG 1140 1141 ACATATCGGG GACACCGGCT CTTCTTCCTC GACCCGCTCA CAATGGAGGC CATGATGCCC 1200 1201 TCGTCGCCAG TCCCGCATGT GGAGGATGAG GATGAGGCGG AGGTGGAGTT CGAGTCGGAC 1260 1261 GAGGATGAGG GTCTATTCGT CGATGAGGCC GACCTTGAGA CTCGGGAGGA TGAGTTTACG 1320 1321 GAGGAGGCTC CTCTGCCTGT CTTTTGCTAA 1350 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Mediator complex | |
Molecular Function | Transcription coregulator activity | |
Biological Process | Regulation of transcription by RNA polymerase II |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Map-0708 | Magnaporthe poae | 95.54 | 5e-70 | 226 |
| LLPS-Mao-0431 | Magnaporthe oryzae | 75.0 | 2e-53 | 183 |
| LLPS-Fuo-1078 | Fusarium oxysporum | 64.29 | 7e-41 | 149 |
| LLPS-Asn-0501 | Aspergillus nidulans | 63.64 | 2e-22 | 97.1 |
| LLPS-Fuv-0713 | Fusarium verticillioides | 63.39 | 2e-40 | 148 |
| LLPS-Trv-1164 | Trichoderma virens | 63.39 | 2e-41 | 151 |
| LLPS-Zyt-1314 | Zymoseptoria tritici | 62.12 | 1e-20 | 90.5 |
| LLPS-Beb-0937 | Beauveria bassiana | 61.61 | 1e-38 | 144 |
| LLPS-Trr-0016 | Trichoderma reesei | 61.61 | 6e-40 | 145 |
| LLPS-Asc-1447 | Aspergillus clavatus | 59.7 | 1e-20 | 93.2 |
| LLPS-Ast-0454 | Aspergillus terreus | 59.7 | 6e-21 | 93.6 |
| LLPS-Nef-0468 | Neosartorya fischeri | 59.7 | 1e-20 | 93.2 |
| LLPS-Asfu-1097 | Aspergillus fumigatus | 59.7 | 9e-21 | 93.2 |
| LLPS-Cogr-1218 | Colletotrichum graminicola | 51.26 | 2e-33 | 128 |
| LLPS-Dos-1596 | Dothistroma septosporum | 49.11 | 1e-25 | 106 |
| LLPS-Tum-1104 | Tuber melanosporum | 48.51 | 6e-26 | 107 |
| LLPS-Coo-1261 | Colletotrichum orbiculare | 47.06 | 9e-29 | 123 |
| LLPS-Blg-1458 | Blumeria graminis | 46.67 | 2e-27 | 112 |
| LLPS-Scs-1109 | Sclerotinia sclerotiorum | 45.31 | 8e-27 | 110 |
| LLPS-Asg-0312 | Ashbya gossypii | 40.54 | 1e-17 | 84.3 |
| LLPS-Pyt-0397 | Pyrenophora teres | 40.37 | 2e-18 | 87.0 |
| LLPS-Pytr-1627 | Pyrenophora triticirepentis | 40.37 | 2e-18 | 86.7 |
| LLPS-Sac-1366 | Saccharomyces cerevisiae | 39.64 | 3e-18 | 86.3 |
| LLPS-Spr-0801 | Sporisorium reilianum | 37.93 | 2e-06 | 52.4 |
| LLPS-Lep-1323 | Leersia perrieri | 36.92 | 4e-07 | 54.3 |
| LLPS-Abg-1686 | Absidia glauca | 36.36 | 4e-11 | 65.9 |
| LLPS-Asm-0837 | Astyanax mexicanus | 36.21 | 5e-07 | 53.1 |
| LLPS-Icp-3644 | Ictalurus punctatus | 36.21 | 4e-07 | 53.5 |
| LLPS-Miv-1523 | Microbotryum violaceum | 34.88 | 3e-09 | 60.5 |
| LLPS-Kop-1305 | Komagataella pastoris | 34.26 | 6e-15 | 77.0 |
| LLPS-Scp-1456 | Schizosaccharomyces pombe | 32.69 | 2e-14 | 75.1 |
| LLPS-Yal-0476 | Yarrowia lipolytica | 32.5 | 4e-10 | 62.8 |
| LLPS-Coc-0038 | Corchorus capsularis | 32.1 | 1e-07 | 55.5 |
| LLPS-Scj-1016 | Schizosaccharomyces japonicus | 31.58 | 1e-11 | 67.4 |
| LLPS-Meg-2231 | Meleagris gallopavo | 29.63 | 2e-07 | 54.3 |
| LLPS-Mod-3103 | Monodelphis domestica | 29.63 | 2e-07 | 54.7 |
| LLPS-Anp-0126 | Anas platyrhynchos | 29.63 | 2e-07 | 54.3 |
| LLPS-Pes-1007 | Pelodiscus sinensis | 29.63 | 1e-07 | 54.3 |
| LLPS-Fia-3640 | Ficedula albicollis | 29.63 | 2e-07 | 54.3 |
| LLPS-Gaga-0538 | Gallus gallus | 29.63 | 3e-07 | 53.9 |
| LLPS-Anc-2106 | Anolis carolinensis | 29.63 | 2e-07 | 54.3 |
| LLPS-Tag-1863 | Taeniopygia guttata | 29.63 | 2e-07 | 54.3 |
| LLPS-Leo-1125 | Lepisosteus oculatus | 28.4 | 9e-07 | 52.4 |
| LLPS-Gaa-0361 | Gasterosteus aculeatus | 28.4 | 1e-06 | 52.4 |
| LLPS-Dar-3568 | Danio rerio | 28.4 | 9e-07 | 52.4 |
| LLPS-Scm-0834 | Scophthalmus maximus | 28.4 | 6e-07 | 52.8 |
| LLPS-Lac-2661 | Latimeria chalumnae | 28.4 | 5e-07 | 53.1 |
| LLPS-Orn-3047 | Oreochromis niloticus | 28.4 | 5e-07 | 53.1 |
| LLPS-Xet-1602 | Xenopus tropicalis | 28.4 | 9e-07 | 52.4 |
| LLPS-Xim-2392 | Xiphophorus maculatus | 28.28 | 1e-07 | 55.1 |
| LLPS-Pof-0590 | Poecilia formosa | 28.28 | 1e-07 | 55.1 |
| LLPS-Sah-1048 | Sarcophilus harrisii | 28.24 | 1e-07 | 54.7 |
| LLPS-Mea-3212 | Mesocricetus auratus | 27.27 | 4e-07 | 53.5 |
| LLPS-Orl-2768 | Oryzias latipes | 27.27 | 9e-07 | 52.4 |
| LLPS-Tar-2340 | Takifugu rubripes | 27.27 | 4e-07 | 53.5 |
| LLPS-Ran-1007 | Rattus norvegicus | 27.27 | 4e-07 | 53.5 |
| LLPS-Ten-0850 | Tetraodon nigroviridis | 27.27 | 3e-07 | 53.9 |
| LLPS-Maf-2202 | Macaca fascicularis | 27.06 | 4e-07 | 53.5 |
| LLPS-Chs-1409 | Chlorocebus sabaeus | 27.06 | 4e-07 | 53.5 |
| LLPS-Sus-1871 | Sus scrofa | 27.06 | 4e-07 | 53.5 |
| LLPS-Aon-1884 | Aotus nancymaae | 27.06 | 4e-07 | 53.5 |
| LLPS-Cea-0863 | Cercocebus atys | 27.06 | 4e-07 | 53.5 |
| LLPS-Gog-0720 | Gorilla gorilla | 27.06 | 4e-07 | 53.5 |
| LLPS-Fud-1983 | Fukomys damarensis | 27.06 | 3e-07 | 53.5 |
| LLPS-Caj-3252 | Callithrix jacchus | 27.06 | 4e-07 | 53.5 |
| LLPS-Bot-2440 | Bos taurus | 27.06 | 4e-07 | 53.5 |
| LLPS-Paa-3030 | Papio anubis | 27.06 | 4e-07 | 53.5 |
| LLPS-Mal-1246 | Mandrillus leucophaeus | 27.06 | 4e-07 | 53.5 |
| LLPS-Aim-2678 | Ailuropoda melanoleuca | 27.06 | 3e-07 | 53.5 |
| LLPS-Mup-0354 | Mustela putorius furo | 27.06 | 4e-07 | 53.5 |
| LLPS-Myl-0735 | Myotis lucifugus | 27.06 | 4e-07 | 53.5 |
| LLPS-Ova-2666 | Ovis aries | 27.06 | 4e-07 | 53.5 |
| LLPS-Hos-1073 | Homo sapiens | 27.06 | 4e-07 | 53.5 |
| LLPS-Pat-2785 | Pan troglodytes | 27.06 | 4e-07 | 53.5 |
| LLPS-Pap-1761 | Pan paniscus | 27.06 | 4e-07 | 53.5 |
| LLPS-Fec-1436 | Felis catus | 27.06 | 5e-07 | 53.1 |
| LLPS-Man-3442 | Macaca nemestrina | 27.06 | 4e-07 | 53.5 |
| LLPS-Otg-1471 | Otolemur garnettii | 27.06 | 3e-07 | 53.9 |
| LLPS-Rhb-2306 | Rhinopithecus bieti | 27.06 | 4e-07 | 53.5 |
| LLPS-Poa-0259 | Pongo abelii | 27.06 | 4e-07 | 53.5 |
| LLPS-Caf-1904 | Canis familiaris | 27.06 | 3e-07 | 53.5 |
| LLPS-Cap-2640 | Cavia porcellus | 27.06 | 4e-07 | 53.5 |
| LLPS-Eqc-3001 | Equus caballus | 27.06 | 4e-07 | 53.5 |
| LLPS-Mam-0863 | Macaca mulatta | 27.06 | 4e-07 | 53.5 |
| LLPS-Cas-2052 | Carlito syrichta | 27.06 | 2e-07 | 54.3 |
| LLPS-Nol-3971 | Nomascus leucogenys | 27.06 | 4e-07 | 53.5 |
| LLPS-Dio-0589 | Dipodomys ordii | 25.88 | 2e-06 | 51.2 |