LLPS-Gaa-0215
MLKL
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Mixed lineage kinase domain like pseudokinase |
| Gene Name: | MLKL |
| Ensembl Gene: | ENSGACG00000008536.1 |
| Ensembl Protein: | ENSGACP00000011284.1 |
| Organism: | Gasterosteus aculeatus |
| Taxa ID: | 69293 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSGACT00000011307.1 | ENSGACP00000011284.1 |
| UniProt | G3P111, G3P111_GASAC |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEIVKEITSI AKKIYSLVEK VKANKKRSQR VGLRVKALDD LVRSIKKEQS GRCKEVKKCL 60 61 TELSCTLTTA KELIQSYTEA TWVKRLVKVG SHKDEFNCVN DRLTDAFQNL SGALQVEQSI 120 121 VQHRVFELVS RMKEDEEDRA EDEAELKTRQ TDKVGLLEYM QEQQRDMEIL KNNVEKILHG 180 181 MAQPSITDQQ IRNIKHHELK YDDVKKPFMV TANTEVYKGE FNGFPVAIKR YVDPLNISQS 240 241 ELQKIFDKEV ETMRRFESPN ILRMFGICVQ SGPGTSPRFL IIMEYCEKGS LRDVLDSDWA 300 301 ALSWPTRARM CRDAARGLYR LHQTEEKSKV HGCLNSNKFL VAEGYTVKLG GFELAKTETS 360 361 LRKTRRKESI SSLCYTSPEM LNDVNLNYSK ESEIYSIGIV MWEIASGRRP FDGWSNKEIN 420 421 NKVCNEKFKE ELPSDCPEEL ARLIDDCRDY DQFCRPSAGV LVDKLPSVVA 470 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAATCG TCAAGGAGAT CACGTCCATT GCCAAAAAGA TCTACTCCCT GGTAGAGAAA 60 61 GTGAAGGCCA ATAAAAAGCG CAGCCAGCGC GTTGGTTTGC GTGTCAAAGC CCTGGACGAC 120 121 CTGGTGAGGT CCATCAAAAA AGAACAAAGC GGAAGGTGCA AAGAGGTGAA AAAGTGCCTG 180 181 ACGGAGCTCT CCTGCACCCT GACAACGGCC AAGGAGCTCA TCCAGAGTTA CACTGAGGCC 240 241 ACCTGGGTGA AGCGCCTGGT GAAGGTCGGC AGCCACAAGG ACGAGTTCAA CTGTGTGAAC 300 301 GATCGCCTCA CCGACGCCTT CCAGAACCTG TCTGGAGCTC TGCAAGTGGA GCAGAGCATC 360 361 GTGCAGCACC GGGTGTTCGA GCTGGTCTCC AGAATGAAGG AGGACGAGGA GGACAGGGCG 420 421 GAGGACGAAG CTGAGCTGAA GACACGCCAA ACTGATAAGG TGGGGCTCCT GGAATACATG 480 481 CAGGAGCAGC AGAGAGACAT GGAAATCCTC AAAAACAACG TGGAAAAAAT ACTTCACGGA 540 541 ATGGCGCAGC CCAGCATCAC GGATCAACAG ATCCGAAACA TCAAACATCA CGAGTTGAAA 600 601 TACGACGATG TCAAAAAGCC CTTCATGGTC ACAGCGAACA CGGAGGTCTA CAAAGGAGAG 660 661 TTCAACGGGT TCCCGGTGGC CATCAAGAGA TACGTTGACC CGCTGAACAT CAGCCAGAGT 720 721 GAGCTGCAGA AAATCTTCGA CAAGGAGGTG GAAACCATGC GGCGGTTCGA GTCGCCCAAC 780 781 ATCCTGCGAA TGTTTGGCAT CTGTGTGCAG AGCGGGCCCG GAACCAGCCC CCGGTTCCTC 840 841 ATCATCATGG AGTACTGTGA GAAGGGAAGT CTCCGCGACG TCTTGGACTC GGATTGGGCC 900 901 GCTCTCTCCT GGCCCACCAG GGCTCGGATG TGTCGGGACG CAGCGCGAGG GCTCTACCGA 960 961 CTGCACCAGA CTGAAGAGAA ATCAAAGGTT CACGGATGCC TCAACAGCAA CAAGTTCCTG 1020 1021 GTGGCTGAAG GCTACACGGT CAAGCTGGGA GGCTTCGAGC TGGCAAAAAC CGAGACGTCC 1080 1081 CTGAGGAAGA CGAGGAGGAA GGAAAGCATC AGTTCGCTGT GCTACACGTC TCCAGAGATG 1140 1141 CTCAACGACG TCAACCTCAA TTACAGCAAA GAGTCTGAGA TCTACAGCAT TGGAATCGTC 1200 1201 ATGTGGGAAA TTGCTAGTGG CAGGAGACCC TTTGATGGTT GGTCAAACAA GGAGATCAAT 1260 1261 AACAAAGTGT GCAATGAGAA ATTCAAGGAG GAGCTCCCCT CCGATTGTCC CGAAGAACTG 1320 1321 GCTAGACTGA TCGACGACTG CCGGGACTAC GACCAGTTCT GCAGGCCGTC TGCTGGAGTG 1380 1381 CTGGTGGATA AACTGCCCAG CGTGGTGGCC 1410 |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Scm-3626 | Scophthalmus maximus | 59.71 | 0.0 | 525 |
| LLPS-Orn-3880 | Oreochromis niloticus | 57.78 | 9e-173 | 501 |
| LLPS-Xim-0516 | Xiphophorus maculatus | 55.97 | 3e-163 | 478 |
| LLPS-Pof-0224 | Poecilia formosa | 52.56 | 5e-149 | 441 |
| LLPS-Pes-0757 | Pelodiscus sinensis | 52.13 | 2e-57 | 194 |
| LLPS-Ten-0873 | Tetraodon nigroviridis | 51.78 | 1e-166 | 486 |
| LLPS-Lac-2346 | Latimeria chalumnae | 51.58 | 7e-90 | 290 |
| LLPS-Leo-0347 | Lepisosteus oculatus | 50.74 | 2e-146 | 434 |
| LLPS-Asm-1437 | Astyanax mexicanus | 50.42 | 2e-137 | 412 |
| LLPS-Icp-1953 | Ictalurus punctatus | 49.38 | 4e-133 | 400 |
| LLPS-Scf-0174 | Scleropages formosus | 48.64 | 9e-144 | 427 |
| LLPS-Orl-1922 | Oryzias latipes | 47.26 | 1e-143 | 427 |
| LLPS-Ora-1019 | Ornithorhynchus anatinus | 37.61 | 2e-89 | 288 |
| LLPS-Anp-0898 | Anas platyrhynchos | 37.58 | 4e-98 | 310 |
| LLPS-Gaga-1852 | Gallus gallus | 37.47 | 6e-98 | 310 |
| LLPS-Meg-0093 | Meleagris gallopavo | 37.32 | 2e-99 | 313 |
| LLPS-Fia-1164 | Ficedula albicollis | 37.14 | 2e-93 | 298 |
| LLPS-Tag-0187 | Taeniopygia guttata | 37.08 | 4e-93 | 297 |
| LLPS-Eqc-3593 | Equus caballus | 36.08 | 3e-80 | 263 |
| LLPS-Hos-1347 | Homo sapiens | 35.79 | 2e-76 | 253 |
| LLPS-Ova-1501 | Ovis aries | 35.65 | 6e-77 | 254 |
| LLPS-Cea-2618 | Cercocebus atys | 35.61 | 1e-75 | 251 |
| LLPS-Pap-2613 | Pan paniscus | 35.58 | 2e-75 | 251 |
| LLPS-Pat-2319 | Pan troglodytes | 35.58 | 2e-75 | 251 |
| LLPS-Paa-1303 | Papio anubis | 35.56 | 8e-77 | 254 |
| LLPS-Bot-1377 | Bos taurus | 35.5 | 2e-77 | 256 |
| LLPS-Sus-1043 | Sus scrofa | 35.38 | 1e-76 | 253 |
| LLPS-Mal-1687 | Mandrillus leucophaeus | 35.36 | 9e-77 | 254 |
| LLPS-Chs-4193 | Chlorocebus sabaeus | 35.36 | 5e-77 | 255 |
| LLPS-Rhb-2752 | Rhinopithecus bieti | 35.18 | 1e-73 | 246 |
| LLPS-Ran-3249 | Rattus norvegicus | 35.17 | 3e-75 | 250 |
| LLPS-Maf-0738 | Macaca fascicularis | 35.15 | 3e-76 | 253 |
| LLPS-Xet-3086 | Xenopus tropicalis | 35.1 | 3e-78 | 258 |
| LLPS-Aon-0077 | Aotus nancymaae | 35.1 | 1e-76 | 254 |
| LLPS-Anc-1433 | Anolis carolinensis | 34.89 | 9e-79 | 258 |
| LLPS-Ict-1049 | Ictidomys tridecemlineatus | 34.24 | 7e-79 | 260 |
| LLPS-Nol-0496 | Nomascus leucogenys | 33.4 | 2e-59 | 208 |
| LLPS-Mum-2566 | Mus musculus | 33.33 | 5e-67 | 229 |
| LLPS-Poa-1571 | Pongo abelii | 32.39 | 6e-39 | 149 |
| LLPS-Otg-1579 | Otolemur garnettii | 32.38 | 1e-60 | 211 |
| LLPS-Cas-0563 | Carlito syrichta | 32.26 | 2e-68 | 233 |
| LLPS-Man-1259 | Macaca nemestrina | 32.22 | 5e-60 | 209 |
| LLPS-Myl-4078 | Myotis lucifugus | 31.9 | 7e-70 | 236 |
| LLPS-Cap-4547 | Cavia porcellus | 31.6 | 5e-60 | 209 |
| LLPS-Dar-3325 | Danio rerio | 31.54 | 2e-18 | 92.4 |
| LLPS-Drm-2327 | Drosophila melanogaster | 30.5 | 6e-18 | 90.9 |
| LLPS-Coc-1219 | Corchorus capsularis | 30.43 | 3e-24 | 110 |
| LLPS-Art-2307 | Arabidopsis thaliana | 30.43 | 2e-24 | 110 |
| LLPS-Arl-1871 | Arabidopsis lyrata | 30.43 | 2e-24 | 110 |
| LLPS-Mam-3376 | Macaca mulatta | 29.74 | 2e-19 | 95.5 |
| LLPS-Fec-0711 | Felis catus | 29.74 | 1e-19 | 96.7 |
| LLPS-Mod-0666 | Monodelphis domestica | 29.69 | 2e-21 | 101 |
| LLPS-Mae-1655 | Manihot esculenta | 29.64 | 2e-22 | 105 |
| LLPS-Cii-1853 | Ciona intestinalis | 29.58 | 2e-38 | 149 |
| LLPS-Gas-1313 | Galdieria sulphuraria | 29.55 | 3e-24 | 110 |
| LLPS-Caf-0878 | Canis familiaris | 29.54 | 8e-20 | 97.1 |
| LLPS-Fud-1153 | Fukomys damarensis | 29.54 | 2e-19 | 95.5 |
| LLPS-Gog-2380 | Gorilla gorilla | 29.54 | 1e-19 | 96.3 |
| LLPS-Zem-0169 | Zea mays | 29.32 | 1e-18 | 92.8 |
| LLPS-Tut-2448 | Tursiops truncatus | 29.11 | 1e-18 | 93.2 |
| LLPS-Aim-4049 | Ailuropoda melanoleuca | 29.11 | 3e-18 | 91.7 |
| LLPS-Caj-2930 | Callithrix jacchus | 29.11 | 4e-19 | 94.7 |
| LLPS-Loa-2631 | Loxodonta africana | 29.06 | 1e-20 | 99.4 |
| LLPS-Dio-2004 | Dipodomys ordii | 29.01 | 1e-19 | 95.1 |
| LLPS-Mea-2543 | Mesocricetus auratus | 28.97 | 5e-18 | 90.5 |
| LLPS-Sei-1355 | Setaria italica | 28.95 | 1e-18 | 93.2 |
| LLPS-Hea-0396 | Helianthus annuus | 28.91 | 1e-21 | 102 |
| LLPS-Urm-1045 | Ursus maritimus | 28.69 | 2e-19 | 94.4 |
| LLPS-Mup-0019 | Mustela putorius furo | 28.69 | 2e-19 | 95.5 |
| LLPS-Viv-1388 | Vitis vinifera | 28.68 | 6e-18 | 91.3 |
| LLPS-Sot-0844 | Solanum tuberosum | 28.62 | 4e-21 | 98.2 |
| LLPS-Tar-2183 | Takifugu rubripes | 28.62 | 4e-21 | 100 |
| LLPS-Bro-1982 | Brassica oleracea | 28.47 | 2e-25 | 114 |
| LLPS-Brr-2708 | Brassica rapa | 28.47 | 3e-25 | 113 |
| LLPS-Brn-1860 | Brassica napus | 28.47 | 3e-25 | 113 |
| LLPS-Pot-1684 | Populus trichocarpa | 28.46 | 3e-20 | 98.2 |
| LLPS-Mua-2429 | Musa acuminata | 28.28 | 2e-19 | 93.2 |
| LLPS-Hov-0348 | Hordeum vulgare | 28.19 | 2e-19 | 93.6 |
| LLPS-Brd-1460 | Brachypodium distachyon | 28.11 | 7e-20 | 94.7 |
| LLPS-Gor-1018 | Gossypium raimondii | 27.96 | 6e-24 | 109 |
| LLPS-Cus-1543 | Cucumis sativus | 27.78 | 2e-23 | 107 |
| LLPS-Sem-0236 | Selaginella moellendorffii | 27.64 | 4e-23 | 103 |
| LLPS-Orm-2053 | Oryza meridionalis | 27.6 | 1e-22 | 105 |
| LLPS-Tra-0006 | Triticum aestivum | 27.44 | 6e-22 | 103 |
| LLPS-Orr-1337 | Oryza rufipogon | 27.24 | 6e-22 | 103 |
| LLPS-Org-0024 | Oryza glaberrima | 27.24 | 6e-22 | 103 |
| LLPS-Orp-1059 | Oryza punctata | 27.24 | 5e-22 | 103 |
| LLPS-Sob-2376 | Sorghum bicolor | 27.24 | 2e-20 | 96.3 |
| LLPS-Orb-0831 | Oryza barthii | 27.24 | 6e-22 | 103 |
| LLPS-Orni-0641 | Oryza nivara | 27.24 | 5e-22 | 103 |
| LLPS-Ors-2339 | Oryza sativa | 27.09 | 2e-19 | 95.1 |
| LLPS-Php-0748 | Physcomitrella patens | 26.94 | 3e-23 | 105 |
| LLPS-Lep-0654 | Leersia perrieri | 26.71 | 3e-21 | 101 |
| LLPS-Nia-0177 | Nicotiana attenuata | 26.52 | 1e-22 | 105 |
| LLPS-Thc-1708 | Theobroma cacao | 26.15 | 5e-23 | 106 |
| LLPS-Sol-1189 | Solanum lycopersicum | 25.97 | 4e-20 | 97.4 |
| LLPS-Dac-2338 | Daucus carota | 25.64 | 2e-19 | 95.5 |
| LLPS-Ori-1776 | Oryza indica | 25.44 | 1e-19 | 95.9 |
| LLPS-Phv-2181 | Phaseolus vulgaris | 24.38 | 1e-17 | 90.1 |
| LLPS-Orbr-1937 | Oryza brachyantha | 24.35 | 1e-19 | 96.3 |
| LLPS-Orgl-1886 | Oryza glumaepatula | 24.35 | 9e-19 | 94.0 |
| LLPS-Vir-0968 | Vigna radiata | 23.53 | 8e-18 | 90.1 |
| LLPS-Glm-0241 | Glycine max | 23.53 | 1e-17 | 90.1 |