• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Fud-2105
H920_06774

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin beta chain
Gene Name: H920_06774
Ensembl Gene: ENSFDAG00000017964.1
Ensembl Protein: ENSFDAP00000010128.1
Organism: Fukomys damarensis
Taxa ID: 885580
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Chromatoid body, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     KSVWDLVQVG  ECRQAFWEVI  SDEHGIDPSG  NYVGDSDLQL  ERISVYYNEA  SSHKYVPRAI  60
61    LVDLEPGTMD  SVRSGAFGHL  FRPDNFIFGQ  SGAGNNWAKG  HYTEGAELVD  SVLDVVRKEC  120
121   ENCDCLQGFQ  LTHSLGGGTG  SGMGTLLISK  VREEYPDRIM  NTFSVVPSPK  VSDTVVEPYN  180
181   ATLSIHQLVE  NTDETYCIDN  EALYDICFRT  LKLATPTYGD  LNHLVSATMS  GVTTSLRFPG  240
241   QLNADLRKLA  VNMVPFPRLH  FFMPGFAPLT  ARGSQQYRAL  TVPELTQQMF  DAKNMMAACD  300
301   PRHGRYLTVA  TVFRGRMSMK  EVDEQMLAIQ  SKNSSYFVEW  IPNNVKVAVC  DIPPRGLKMS  360
361   STFIGNSTAI  QELFKRISEQ  FTAMFRRKAF  LHWYTGEGMD  EMEFTEAESN  MNDLVSEYQQ  420
421   YQDATAEEEG  EMYEDDDEES  EAQGPK  446
Nucleotide CDS Sequence (FASTA)
1     AAAAGTGTCT  GGGATCTGGT  ACAAGTGGGT  GAATGCCGGC  AAGCTTTCTG  GGAGGTCATC  60
61    AGCGATGAGC  ATGGCATTGA  CCCCAGCGGC  AACTACGTGG  GGGACTCGGA  CCTGCAGCTG  120
121   GAGCGTATCA  GTGTCTACTA  CAATGAGGCT  TCCTCTCACA  AGTATGTGCC  TCGGGCCATC  180
181   CTGGTGGACC  TGGAGCCGGG  GACCATGGAC  AGCGTTCGGT  CGGGTGCTTT  TGGGCACCTC  240
241   TTCCGGCCTG  ACAACTTCAT  CTTTGGTCAG  AGTGGGGCTG  GCAACAACTG  GGCGAAGGGT  300
301   CATTACACAG  AGGGCGCCGA  GCTGGTGGAC  TCGGTCCTGG  ATGTTGTGAG  GAAGGAGTGT  360
361   GAGAACTGCG  ACTGCCTGCA  GGGCTTCCAG  CTGACCCACT  CGCTGGGTGG  CGGCACGGGC  420
421   TCGGGCATGG  GCACCCTGCT  CATCAGCAAG  GTGCGCGAGG  AGTACCCCGA  CCGCATCATG  480
481   AACACCTTCA  GCGTGGTGCC  CTCGCCCAAG  GTGTCCGACA  CGGTGGTGGA  GCCCTACAAC  540
541   GCCACGCTGT  CCATCCACCA  GCTGGTGGAG  AACACGGACG  AGACCTACTG  CATCGACAAC  600
601   GAGGCCCTGT  ACGACATCTG  CTTCCGCACC  CTCAAGTTGG  CCACGCCCAC  CTACGGGGAC  660
661   CTCAACCACC  TGGTGTCGGC  CACCATGAGC  GGGGTGACCA  CCTCCCTCCG  CTTCCCGGGC  720
721   CAGCTCAATG  CTGACCTGCG  CAAGCTGGCT  GTGAACATGG  TGCCCTTCCC  GCGCCTGCAC  780
781   TTCTTCATGC  CCGGCTTTGC  TCCTCTCACT  GCCCGGGGCA  GCCAGCAGTA  CCGGGCCCTC  840
841   ACCGTGCCGG  AACTCACCCA  ACAGATGTTT  GATGCCAAGA  ACATGATGGC  TGCCTGTGAC  900
901   CCGCGCCACG  GCCGCTACCT  GACAGTGGCC  ACAGTCTTCC  GTGGCCGCAT  GTCCATGAAG  960
961   GAGGTGGACG  AGCAGATGCT  GGCCATCCAA  AGCAAGAACA  GCAGCTACTT  TGTGGAGTGG  1020
1021  ATCCCCAACA  ACGTCAAGGT  GGCCGTGTGC  GACATCCCAC  CTCGTGGGCT  CAAGATGTCC  1080
1081  TCCACCTTCA  TTGGCAACAG  CACAGCCATC  CAGGAGCTGT  TCAAGCGCAT  CTCGGAGCAG  1140
1141  TTCACGGCCA  TGTTCCGGCG  CAAGGCCTTC  CTGCACTGGT  ACACGGGCGA  GGGCATGGAC  1200
1201  GAGATGGAGT  TCACTGAGGC  CGAGAGCAAC  ATGAACGACC  TGGTGTCCGA  GTACCAGCAG  1260
1261  TACCAGGACG  CCACGGCCGA  GGAGGAGGGC  GAGATGTACG  AAGATGACGA  TGAGGAGTCC  1320
1321  GAGGCCCAGG  GCCCCAAGTG  A  1341

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
GTP-binding
Microtubule
Nucleotide-binding
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-1162Dipodomys ordii100.00.0 815
LLPS-Mod-0840Monodelphis domestica100.00.0 816
LLPS-Lac-3209Latimeria chalumnae100.00.0 820
LLPS-Mup-4320Mustela putorius furo99.770.0 815
LLPS-Mam-4161Macaca mulatta99.770.0 818
LLPS-Orc-2452Oryctolagus cuniculus99.770.0 816
LLPS-Meg-0062Meleagris gallopavo99.750.0 782
LLPS-Fia-1729Ficedula albicollis99.510.0 809
LLPS-Mal-4229Mandrillus leucophaeus99.080.0 818
LLPS-Paa-4512Papio anubis99.080.0 819
LLPS-Gog-1708Gorilla gorilla99.080.0 817
LLPS-Cea-4093Cercocebus atys99.080.0 818
LLPS-Cap-4069Cavia porcellus99.080.0 816
LLPS-Rhb-4458Rhinopithecus bieti99.080.0 819
LLPS-Pat-4436Pan troglodytes99.080.0 820
LLPS-Pap-4426Pan paniscus99.080.0 819
LLPS-Sah-3153Sarcophilus harrisii99.020.0 803
LLPS-Tut-2268Tursiops truncatus98.860.0 818
LLPS-Ran-0031Rattus norvegicus97.750.0 818
LLPS-Caj-0453Callithrix jacchus97.750.0 818
LLPS-Aon-0135Aotus nancymaae97.750.0 818
LLPS-Mum-3351Mus musculus97.750.0 818
LLPS-Mea-1825Mesocricetus auratus97.750.0 818
LLPS-Cas-0477Carlito syrichta97.740.0 815
LLPS-Nol-4529Nomascus leucogenys97.70.0 808
LLPS-Leo-3378Lepisosteus oculatus97.620.0 817
LLPS-Bot-2128Bos taurus97.520.0 818
LLPS-Chs-1192Chlorocebus sabaeus97.520.0 818
LLPS-Ict-2403Ictidomys tridecemlineatus97.520.0 818
LLPS-Poa-0704Pongo abelii97.520.0 818
LLPS-Caf-0253Canis familiaris97.520.0 818
LLPS-Eqc-2933Equus caballus97.520.0 818
LLPS-Man-1127Macaca nemestrina97.520.0 818
LLPS-Loa-1077Loxodonta africana97.520.0 818
LLPS-Hos-2655Homo sapiens97.520.0 818
LLPS-Fec-3006Felis catus97.520.0 818
LLPS-Sus-3257Sus scrofa97.30.0 818
LLPS-Otg-0512Otolemur garnettii97.30.0 817
LLPS-Scf-1907Scleropages formosus97.140.0 813
LLPS-Icp-0411Ictalurus punctatus97.140.0 813
LLPS-Ova-3450Ovis aries96.430.0 805
LLPS-Anp-3174Anas platyrhynchos95.490.0 763
LLPS-Pes-0353Pelodiscus sinensis94.710.0 776
LLPS-Anc-0793Anolis carolinensis93.610.0 768
LLPS-Drm-0325Drosophila melanogaster93.120.0 762
LLPS-Gaga-3156Gallus gallus92.860.0 782
LLPS-Dar-3915Danio rerio92.620.0 781
LLPS-Maf-4790Macaca fascicularis92.380.0 778
LLPS-Orn-0043Oreochromis niloticus92.380.0 783
LLPS-Xet-1072Xenopus tropicalis92.140.0 781
LLPS-Gaa-1416Gasterosteus aculeatus91.430.0 769
LLPS-Asm-3759Astyanax mexicanus91.430.0 771
LLPS-Orl-3812Oryzias latipes91.430.0 769
LLPS-Cis-0796Ciona savignyi91.430.0 772
LLPS-Cii-1237Ciona intestinalis91.430.0 773
LLPS-Ten-2857Tetraodon nigroviridis91.430.0 769
LLPS-Pof-2149Poecilia formosa91.430.0 769
LLPS-Urm-3705Ursus maritimus91.430.0 770
LLPS-Scm-0346Scophthalmus maximus91.430.0 769
LLPS-Aim-3912Ailuropoda melanoleuca91.190.0 772
LLPS-Xim-3736Xiphophorus maculatus91.190.0 768
LLPS-Tar-2601Takifugu rubripes91.190.0 770
LLPS-Myl-2541Myotis lucifugus90.950.0 769
LLPS-Ere-0293Erinaceus europaeus90.950.0 765
LLPS-Ora-3257Ornithorhynchus anatinus90.950.0 769
LLPS-Tag-2634Taeniopygia guttata90.950.0 771
LLPS-Cae-2098Caenorhabditis elegans90.00.0 759