DrLLPS - Data resource of LLPS

LLPS-Fec-2333
SNRPD2

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Small nuclear ribonucleoprotein Sm D2
Gene Name:	SNRPD2
Ensembl Gene:	ENSFCAG00000022530.3
Ensembl Protein:	ENSFCAP00000020290.3
Organism:	Felis catus
Taxa ID:	9685
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nuclear speckle, Nucleolus	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-2573	P62317	Client	Nuclear speckle, Nucleolus	100.00	2e-59	185
Bos taurus	LLPS-Bot-0171	Q3SZF8	Client	Nucleolus	100.00	2e-59	185
Homo sapiens	LLPS-Hos-4228	P62316	Client	Nucleolus	100.00	2e-59	185

▼ FUNCTION

Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSFCAT00000027742.3	ENSFCAP00000020290.3
Ensembl	ENSFCAT00000045709.2	ENSFCAP00000026940.2
UniProt		M3X0Z8, M3X0Z8_FELCA
GeneBank	AANG04000747
RefSeq	XM_003997635.4	XP_003997684.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSLLNKPKSE MTPEELQKRE EEEFNTGPLS VLTQSVKNNT QVLINCRNNK KLLGRVKAFD 60 61 RHCNMVLENV KEMWTEVPKS GKGKKKSKPV NKDRYISKMF LRGDSVIVVL RNPLIAGK 118
Nucleotide CDS Sequence (FASTA)
1 ATGAGCCTCC TCAACAAGCC CAAGAGTGAG ATGACCCCCG AGGAGCTGCA GAAGCGGGAG 60 61 GAGGAAGAGT TTAACACGGG TCCGCTCTCT GTGCTCACGC AGTCGGTCAA GAACAACACC 120 121 CAAGTGCTCA TCAACTGCCG CAACAACAAG AAGCTCCTGG GCCGCGTGAA GGCCTTCGAT 180 181 AGGCACTGCA ACATGGTGCT GGAGAATGTG AAGGAGATGT GGACCGAGGT CCCCAAGAGC 240 241 GGCAAGGGCA AGAAGAAGTC CAAGCCAGTC AACAAGGACC GCTACATCTC CAAGATGTTC 300 301 CTGCGCGGGG ACTCCGTCAT CGTGGTCCTG CGGAACCCGC TCATCGCCGG CAAGTAG 357

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0687	Ribonucleoprotein

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0071013	Cellular Component	Catalytic step 2 spliceosome
GO:0005829	Cellular Component	Cytosol
GO:0005685	Cellular Component	U1 snRNP
GO:0005686	Cellular Component	U2 snRNP
GO:0046540	Cellular Component	U4/U6 x U5 tri-snRNP complex
GO:0005682	Cellular Component	U5 snRNP
GO:0000387	Biological Process	Spliceosomal snRNP assembly

▼ KEGG

fca:101093907

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Gog-2449	Gorilla gorilla	100.0	2e-59	185
LLPS-Icp-3111	Ictalurus punctatus	100.0	2e-59	185
LLPS-Caj-3150	Callithrix jacchus	100.0	2e-59	185
LLPS-Fud-2609	Fukomys damarensis	100.0	2e-59	185
LLPS-Ora-0054	Ornithorhynchus anatinus	100.0	1e-58	183
LLPS-Chs-1663	Chlorocebus sabaeus	100.0	2e-59	185
LLPS-Mea-0226	Mesocricetus auratus	100.0	2e-59	185
LLPS-Mum-2573	Mus musculus	100.0	2e-59	185
LLPS-Maf-0088	Macaca fascicularis	100.0	2e-59	185
LLPS-Sus-3020	Sus scrofa	100.0	2e-59	185
LLPS-Ran-3029	Rattus norvegicus	100.0	2e-59	185
LLPS-Myl-1905	Myotis lucifugus	100.0	1e-58	183
LLPS-Ova-1336	Ovis aries	100.0	2e-58	183
LLPS-Aim-0895	Ailuropoda melanoleuca	100.0	1e-58	183
LLPS-Mup-1401	Mustela putorius furo	100.0	2e-58	182
LLPS-Paa-3422	Papio anubis	100.0	2e-59	185
LLPS-Tut-0803	Tursiops truncatus	100.0	2e-59	185
LLPS-Bot-0171	Bos taurus	100.0	2e-59	185
LLPS-Scf-1208	Scleropages formosus	100.0	2e-59	185
LLPS-Dio-0578	Dipodomys ordii	100.0	2e-59	185
LLPS-Pes-0511	Pelodiscus sinensis	100.0	4e-52	166
LLPS-Otg-1876	Otolemur garnettii	100.0	1e-58	183
LLPS-Rhb-1325	Rhinopithecus bieti	100.0	2e-59	185
LLPS-Orc-1501	Oryctolagus cuniculus	100.0	2e-59	185
LLPS-Mod-0029	Monodelphis domestica	100.0	2e-58	183
LLPS-Pap-1048	Pan paniscus	100.0	2e-59	185
LLPS-Urm-0522	Ursus maritimus	100.0	2e-59	185
LLPS-Pat-0229	Pan troglodytes	100.0	2e-59	185
LLPS-Hos-4228	Homo sapiens	100.0	2e-59	185
LLPS-Loa-2038	Loxodonta africana	100.0	2e-58	183
LLPS-Cas-2737	Carlito syrichta	100.0	1e-58	183
LLPS-Gaga-2131	Gallus gallus	100.0	6e-36	126
LLPS-Ict-0769	Ictidomys tridecemlineatus	100.0	2e-59	185
LLPS-Nol-1812	Nomascus leucogenys	100.0	2e-59	185
LLPS-Anc-0752	Anolis carolinensis	100.0	2e-58	183
LLPS-Eqc-2102	Equus caballus	100.0	1e-53	171
LLPS-Cap-1542	Cavia porcellus	100.0	2e-58	183
LLPS-Caf-2902	Canis familiaris	100.0	2e-59	185
LLPS-Poa-0748	Pongo abelii	100.0	2e-59	185
LLPS-Asm-1423	Astyanax mexicanus	99.15	1e-58	183
LLPS-Sah-0314	Sarcophilus harrisii	99.15	9e-58	181
LLPS-Cea-1518	Cercocebus atys	99.15	6e-58	181
LLPS-Leo-1282	Lepisosteus oculatus	99.15	1e-58	183
LLPS-Dar-0595	Danio rerio	99.15	1e-58	183
LLPS-Xet-0373	Xenopus tropicalis	99.15	5e-58	182
LLPS-Mam-3218	Macaca mulatta	99.15	5e-58	181
LLPS-Lac-1189	Latimeria chalumnae	99.07	2e-51	164
LLPS-Ten-1080	Tetraodon nigroviridis	99.0	4e-45	148
LLPS-Aon-2465	Aotus nancymaae	98.31	2e-66	203
LLPS-Orl-2545	Oryzias latipes	98.31	5e-58	182
LLPS-Xim-0198	Xiphophorus maculatus	98.31	6e-58	181
LLPS-Orn-2712	Oreochromis niloticus	98.31	6e-58	181
LLPS-Pof-0487	Poecilia formosa	98.31	6e-58	181
LLPS-Man-1747	Macaca nemestrina	98.31	3e-57	180
LLPS-Mal-1830	Mandrillus leucophaeus	97.46	1e-56	178
LLPS-Scm-2857	Scophthalmus maximus	97.46	2e-57	180
LLPS-Tar-2846	Takifugu rubripes	96.61	3e-57	179
LLPS-Gaa-2027	Gasterosteus aculeatus	96.58	2e-56	177
LLPS-Php-0382	Physcomitrella patens	93.33	2e-44	147
LLPS-Thc-0760	Theobroma cacao	90.0	1e-43	144
LLPS-Coc-0062	Corchorus capsularis	90.0	6e-41	147
LLPS-Met-0133	Medicago truncatula	89.58	9e-47	153
LLPS-Vir-0159	Vigna radiata	89.58	3e-47	154
LLPS-Via-0231	Vigna angularis	89.58	2e-47	154
LLPS-Orni-1961	Oryza nivara	88.54	3e-47	154
LLPS-Orb-0658	Oryza barthii	88.54	3e-47	154
LLPS-Orgl-1783	Oryza glumaepatula	88.54	3e-47	154
LLPS-Orbr-0166	Oryza brachyantha	88.54	3e-47	155
LLPS-Sob-0306	Sorghum bicolor	88.54	7e-47	153
LLPS-Nia-2256	Nicotiana attenuata	88.54	7e-47	153
LLPS-Orp-0224	Oryza punctata	88.54	7e-47	156
LLPS-Org-1427	Oryza glaberrima	88.54	3e-47	154
LLPS-Orr-0181	Oryza rufipogon	88.54	3e-47	154
LLPS-Orm-1163	Oryza meridionalis	88.54	3e-47	154
LLPS-Drm-1686	Drosophila melanogaster	88.03	3e-50	162
LLPS-Amt-1526	Amborella trichopoda	87.76	2e-47	154
LLPS-Mua-0508	Musa acuminata	87.5	8e-47	153
LLPS-Sot-0315	Solanum tuberosum	87.5	5e-47	153
LLPS-Brr-2791	Brassica rapa	87.5	3e-46	151
LLPS-Sem-0937	Selaginella moellendorffii	87.37	1e-41	152
LLPS-Cus-0818	Cucumis sativus	87.0	2e-47	157
LLPS-Gor-1672	Gossypium raimondii	87.0	7e-47	154
LLPS-Zem-0558	Zea mays	86.87	2e-47	154
LLPS-Viv-0457	Vitis vinifera	86.0	3e-47	153
LLPS-Prp-2084	Prunus persica	86.0	2e-47	154
LLPS-Glm-0774	Glycine max	85.44	3e-47	154
LLPS-Osl-0450	Ostreococcus lucimarinus	85.26	5e-44	145
LLPS-Brd-0693	Brachypodium distachyon	85.15	3e-47	154
LLPS-Ori-1271	Oryza indica	84.62	3e-47	154
LLPS-Lep-0323	Leersia perrieri	84.62	3e-47	154
LLPS-Ors-1224	Oryza sativa	84.62	3e-47	154
LLPS-Sei-1449	Setaria italica	84.47	2e-47	154
LLPS-Chr-0370	Chlamydomonas reinhardtii	83.33	3e-41	139
LLPS-Cis-0960	Ciona savignyi	82.14	2e-45	150
LLPS-Tra-2075	Triticum aestivum	81.9	3e-48	156
LLPS-Hov-0459	Hordeum vulgare	81.9	2e-48	157
LLPS-Cae-1545	Caenorhabditis elegans	81.58	1e-51	166
LLPS-Mae-0423	Manihot esculenta	81.55	8e-46	150
LLPS-Phv-1175	Phaseolus vulgaris	80.91	2e-47	154
LLPS-Hea-1453	Helianthus annuus	80.36	2e-47	155
LLPS-Brn-0173	Brassica napus	80.0	1e-46	153
LLPS-Arl-1212	Arabidopsis lyrata	80.0	6e-47	153
LLPS-Art-0412	Arabidopsis thaliana	80.0	1e-46	152
LLPS-Pot-1175	Populus trichocarpa	80.0	3e-47	154
LLPS-Dac-1018	Daucus carota	79.65	6e-48	157
LLPS-Sol-1730	Solanum lycopersicum	79.09	7e-48	155
LLPS-Bro-0956	Brassica oleracea	79.09	3e-46	151
LLPS-Cii-0403	Ciona intestinalis	78.81	3e-47	154
LLPS-Crn-0374	Cryptococcus neoformans	69.81	6e-41	138
LLPS-Scc-0495	Schizosaccharomyces cryophilus	69.37	1e-43	145
LLPS-Scj-0567	Schizosaccharomyces japonicus	69.37	3e-44	146
LLPS-Abg-0328	Absidia glauca	69.37	2e-44	149
LLPS-Yal-0413	Yarrowia lipolytica	68.52	2e-41	139
LLPS-Scp-0327	Schizosaccharomyces pombe	68.47	5e-44	145
LLPS-Mel-0042	Melampsora laricipopulina	67.92	1e-38	132
LLPS-Pug-1219	Puccinia graminis	67.92	1e-38	132
LLPS-Put-1159	Puccinia triticina	67.92	2e-38	132
LLPS-Tru-0440	Triticum urartu	67.72	2e-43	144
LLPS-Blg-0738	Blumeria graminis	67.59	2e-42	142
LLPS-Ast-0213	Aspergillus terreus	67.59	3e-41	139
LLPS-Coo-0683	Colletotrichum orbiculare	66.67	9e-40	135
LLPS-Mao-0315	Magnaporthe oryzae	66.67	5e-41	138
LLPS-Asc-0402	Aspergillus clavatus	66.67	5e-41	138
LLPS-Scs-0242	Sclerotinia sclerotiorum	66.67	1e-40	137
LLPS-Cog-1030	Colletotrichum gloeosporioides	66.67	1e-40	137
LLPS-Nef-0427	Neosartorya fischeri	66.67	5e-41	138
LLPS-Asfu-1344	Aspergillus fumigatus	66.67	8e-41	138
LLPS-Usm-0707	Ustilago maydis	66.06	1e-39	134
LLPS-Spr-1035	Sporisorium reilianum	66.06	1e-39	134
LLPS-Map-0554	Magnaporthe poae	65.74	5e-40	135
LLPS-Gag-0204	Gaeumannomyces graminis	65.74	4e-40	136
LLPS-Zyt-1368	Zymoseptoria tritici	65.74	3e-40	136
LLPS-Asf-0534	Aspergillus flavus	65.74	2e-40	137
LLPS-Aso-1108	Aspergillus oryzae	65.74	2e-40	137
LLPS-Trr-0118	Trichoderma reesei	65.74	9e-40	135
LLPS-Fus-0596	Fusarium solani	65.74	4e-40	136
LLPS-Beb-0670	Beauveria bassiana	65.74	7e-40	135
LLPS-Dos-0260	Dothistroma septosporum	65.74	3e-41	139
LLPS-Cogr-0806	Colletotrichum graminicola	65.74	2e-39	134
LLPS-Trv-0544	Trichoderma virens	65.74	9e-40	135
LLPS-Gas-0540	Galdieria sulphuraria	64.89	3e-32	115
LLPS-Fuv-0527	Fusarium verticillioides	64.81	9e-39	132
LLPS-Fuo-0534	Fusarium oxysporum	64.81	9e-39	132
LLPS-Nec-1205	Neurospora crassa	63.89	3e-37	129
LLPS-Ved-0707	Verticillium dahliae	63.72	3e-38	131
LLPS-Pyt-1070	Pyrenophora teres	62.96	4e-41	138
LLPS-Pytr-0439	Pyrenophora triticirepentis	62.96	4e-41	138
LLPS-Lem-0951	Leptosphaeria maculans	62.04	1e-40	137
LLPS-Asn-0572	Aspergillus nidulans	61.0	2e-30	111
LLPS-Miv-1330	Microbotryum violaceum	60.19	2e-35	125
LLPS-Tum-0052	Tuber melanosporum	57.41	2e-35	124
LLPS-Phn-1134	Phaeosphaeria nodorum	54.84	4e-37	129
LLPS-Asg-0950	Ashbya gossypii	54.46	3e-36	125
LLPS-Chc-0618	Chondrus crispus	53.85	2e-28	106
LLPS-Sac-0993	Saccharomyces cerevisiae	52.68	8e-29	107
LLPS-Kop-0159	Komagataella pastoris	50.45	3e-34	121
LLPS-Cym-0186	Cyanidioschyzon merolae	34.52	1e-15	75.5
LLPS-Fia-0978	Ficedula albicollis	32.22	5e-07	48.5
LLPS-Meg-0694	Meleagris gallopavo	32.22	5e-07	48.5
LLPS-Anp-0816	Anas platyrhynchos	32.22	6e-07	48.1
LLPS-Tag-0407	Taeniopygia guttata	32.22	5e-07	48.5

LLPS-Fec-2333SNRPD2

Protein Sequence

Nucleotide Sequence

LLPS-Fec-2333
SNRPD2