LLPS-Eqc-a728
JPH3
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Junctophilin |
| Gene Name: | JPH3 |
| Ensembl Gene: | ENSECAG00000018366.2 |
| Ensembl Protein: | ENSECAP00000023751.1 |
| Organism: | Equus caballus |
| Taxa ID: | 9796 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSECAT00000060571.1 | ENSECAP00000023751.1 |
| Ensembl | ENSECAT00000019502.2 | ENSECAP00000015964.2 |
| UniProt | F7DL46, F7DL46_HORSE | |
| Entrez | 100056257 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSGGRFNFD DGGSYCGGWE DGKAHGHGVC TGPKGQGEYT GSWSHGFEVL GVYTWPSGNT 60 61 YQGTWAQGKR HGIGLESKGK WVYKGEWTHG FKGRYGVREC TGNGAKYEGT WSNGLQDGYG 120 121 TETYSDGGTY QGQWVGGMRQ GYGVRQSVPY GMAAVIRSPL RTSINSLRSE HTNGAALHPD 180 181 ASPAVAGSPA VSRGGFVLVA HSDSEILKSK KKGLFRRSLL SGLKLRKSES KSSLASQRSK 240 241 QSSFRSEAGM STVSSTASDI HSTISLGEGE AELSVIEDDI DATTTETYVG EWKNDKRSGF 300 301 GVSQRSDGLR YEGEWAGNRR HGYGCMTFPD GTKEEGKYKQ NVLVSGKRKN LIPLRASKIR 360 361 EKVDRAVEAA ERAATIAKQK AEIAASRTSH SRAKAEAALT AAQKAQEEAR IARITAKEFS 420 421 PSFQHRENGL EYQRPKHQLS SDDIEVISTG TPLQQESPEL YRKGTTPSDL TPDDSPLQSF 480 481 PASPSATPPP APATRNKVAH FSRQVSVDEE RGGDIQMLLE GRGGDYARNS WGEEKAGGSR 540 541 GIRSGALRSS QPADDFRARG SGHKQPSNPK PRERRTESPP TFSWTSHHRA GNPSSGGAKL 600 601 LELDEEKLSN YEMEMKPLLR MDAYMQDVHP QKRRYSKGGA CRGLGEDHRS EDRGFGAQRL 660 661 RSKSQNKENV RPASCAEPAV QRLESLRLGD RAEPRLLRWD LTFSPPQKSS PVALESDEEN 720 721 GDELKSSTVS GHWLVLGAEL GVVRAQARPP FASAELGHDP STHETSWGGG GSPSL 775 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCAGTG GGGGTAGGTT TAATTTTGAC GATGGTGGGT CCTACTGTGG AGGCTGGGAG 60 61 GACGGCAAGG CGCACGGCCA TGGCGTCTGC ACCGGCCCCA AGGGCCAAGG CGAATACACC 120 121 GGCTCGTGGA GCCACGGCTT CGAGGTGCTG GGCGTCTACA CCTGGCCCAG CGGCAACACG 180 181 TACCAGGGCA CCTGGGCGCA GGGCAAGCGC CACGGCATCG GCCTGGAGAG CAAGGGGAAG 240 241 TGGGTGTACA AGGGCGAGTG GACGCACGGA AAGGGGCGCT ACGGGGTGCG GGAGTGCACG 300 301 AGCAACGAGA CCAAGTACGA AGGGTCCTGG AGCAACGGGC TGCAGGACGG CTACGGCACC 360 361 GAGACCTACT CGGATGGAGG GACCTACCAG GGCCAGTGGG TCGGCGGCAT GCGCCAAGGC 420 421 TACGGCGTGC GGCAGAGTGT CCCCTACGGC ATGGCGGCGG TCATCCGCTC GCCCCTGAGG 480 481 ACGTCCATCA ACTCTCTGCG CAGTGAGCAC ACCAACGGCG CTGCGCTGCA CCCCGACGCG 540 541 TCCCCGGCGG TGGCGGGCAG CCCGGCCGTG TCCCGGGGGG GCTTCGTGCT GGTGGCGCAC 600 601 AGCGACTCCG AGATCCTCAA GAGCAAGAAG AAGGGGCTGT TCCGGCGCTC GCTGCTGAGC 660 661 GGGCTGAAGC TGCGCAAGTC GGAGTCCAAG AGCAGCCTGG CCAGCCAGCG CAGCAAGCAG 720 721 AGCTCCTTCC GCAGCGAGGC GGGCATGAGC ACGGTCAGCT CCACGGCCAG CGACATCCAC 780 781 TCCACCATCA GCCTGGGCGA GGGCGAGGCC GAGCTGTCGG TCATCGAGGA CGACATCGAC 840 841 GCCACCACCA CCGAGACCTA CGTGGGCGAG TGGAAGAACG ACAAGCGCTC GGGCTTCGGC 900 901 GTGAGCCAGC GCTCGGACGG GCTGCGCTAC GAGGGCGAGT GGGCGGGCAA CCGGCGGCAC 960 961 GGCTACGGCT GCATGACCTT CCCCGACGGC ACCAAGGAGG AGGGCAAGTA CAAGCAGAAC 1020 1021 GTGCTCGTGA GCGGCAAGCG CAAGAACCTG ATCTCGCTGC GCGCCAGCAA GATCCGCGAG 1080 1081 AAGGTGGACC GCGCCGTGGA GGCGGCAGAG CGCGCGGCCA CCATCGCCAA GCAGAAGGCG 1140 1141 GAGATCGCGG CCTCCAGGAC CTCCCACTCG AGGGCCAAGG CCGAGGCGGC CCTCACGGCA 1200 1201 GCCCAGAAGG CCCAGGAGGA AGCGCGGATC GCCAGGATCA CTGCCAAAGA GTTCTCACCT 1260 1261 TCCTTCCAGC ACAGGGAAAA CGGGCTCGAG TACCAGCGGC CGAAGCATCA GCTCTCCAGT 1320 1321 GACGACATCG AGGTGATCTC CACGGGGACG CCCCTGCAGC AGGAGAGCCC CGAGCTGTAC 1380 1381 CGCAAAGGCA CTACCCCTTC AGACCTGACC CCCGACGACA GCCCCCTGCA GAGCTTCCCT 1440 1441 GCCAGCCCCT CGGCCACCCC GCCCCCAGCC CCCGCCACAA GGAACAAGGT CGCCCACTTC 1500 1501 TCCCGGCAGG TCTCGGTGGA TGAAGAGCGA GGTGGGGACA TCCAGATGCT CCTGGAGGGC 1560 1561 CGGGGAGGGG ACTACGCCCG CAACAGCTGG GGCGAGGAGA AGGCCGGGGG CTCCAGGGGC 1620 1621 ATCCGCAGTG GCGCCCTCCG CAGCAGCCAG CCCGCAGATG ACTTCCGCGC CCGGGGCTCG 1680 1681 GGCCACAAGC AGCCCAGTAA CCCCAAGCCC CGGGAGCGGC GGACGGAGTC GCCCCCGACG 1740 1741 TTCTCCTGGA CTTCCCACCA CCGAGCCGGC AACCCCAGCT CTGGGGGCGC CAAGCTGCTG 1800 1801 GAGCTGGACG AGGAGAAGCT GAGCAACTAC GAGATGGAGA TGAAGCCGCT GCTGAGGATG 1860 1861 GACGCGTACA TGCAGGACGT GCACCCCCAG AAAAGACGCT ACAGCAAGGG GGGGGCCTGC 1920 1921 CGGGGCCTGG GGGAGGACCA CCGCTCCGAG GACCGGGGCT TTGGGGCGCA GAGACTGAGG 1980 1981 TCCAAGTCCC AGAACAAGGA GAACGTCAGG CCGGCCTCAT GCGCAGAGCC GGCCGTGCAG 2040 2041 AGACTGGAGA GCCTGCGGCT GGGGGACAGG GCTGAGCCCC GGCTGCTGCG CTGGGACTTG 2100 2101 ACCTTCTCCC CACCCCAGAA GTCCTCGCCT GTGGCACTGG AGTCAGACGA GGAGAACGGG 2160 2161 GACGAGCTCA AGTCCAGCAC GGGCTCGGCT CCCATCCTGG TGGCCATGGT GATCTTGCTC 2220 2221 AACATCGGAG TCGCCATTTT GTTTATTAAC TTTTTCATCT GA 2262 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Cellular Component | Junctional membrane complex | |
Cellular Component | Plasma membrane | |
Molecular Function | Calcium-release channel activity | |
Biological Process | Regulation of synaptic plasticity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a740 | Homo sapiens | 0.0 | 1302 | undefined |
| LLPS-Mum-a730 | Mus musculus | 0.0 | 1307 | undefined |