LLPS-Eqc-a1065
MAOA
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A |
| Gene Name: | MAOA |
| Ensembl Gene: | ENSECAG00000022277.2 |
| Ensembl Protein: | ENSECAP00000043359.1 |
| Organism: | Equus caballus |
| Taxa ID: | 9796 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSECAT00000049590.1 | ENSECAP00000043359.1 |
| Ensembl | ENSECAT00000024641.2 | ENSECAP00000020478.2 |
| Ensembl | ENSECAT00000054261.1 | ENSECAP00000033746.1 |
| UniProt | Q5NU32, AOFA_HORSE | |
| GeneBank | AB178282 | BAD80721.1 |
| RefSeq | NM_001081832.1 | NP_001075301.1 |
| Entrez | 100033867 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSAQSPDASR GRGGNGRKGR EAQCAPGARG TAAQIQDPAS PLGSASSSTS RWSVHSEWRT 60 61 ISRLFSSNLS IAPTSDAAYS GSSSTPSQTG PGPSPRTHTD SQIGLYGSGA HGLSDWILMS 120 121 AARTSTPEGA APASNPDARN PRVSVRGSVP PSGSPRLLVL ESAPPSLPSS PQLSGLSTPP 180 181 GPPTPNNSPR VSLQESIQFS IPRSTEVSVE GAFPFSGAPA SVRGSVPPAM PRSPWSLEQA 240 241 SFPFFGSSRV SVLGSLPPSA LSSPWSSVQG SFPFLGSSES SVLESGPPSV LSSPWSSEQS 300 301 SFPFSGSSQP SVLESTPLLA LSSSLDSVLG PPTPNNSPRV SLQESAPPSL TRSSWVSVEE 360 361 LAPPPFSPRE SLEGPAPPLA GPTPIPTPGE SLSPIMASQE KASMAGHMFD VVVIGGGISG 420 421 LSAAKLLAEH ETNVLVLEAR DRVGGRTYTV RNKHVNYVDV GGAYVGPTQN RILRLSKELG 480 481 LETYKVNVNE RLVQYVKGKS YPFRGAFPPV WNPIAYLDYN NLWRTMDNMG KEIPADAPWE 540 541 APHAEEWDKM TMKDLIDKIC WTKTARQFAS LFVNINVTSE PHQVSALWFL WYVKQCGGTT 600 601 RIFSITNGGQ ERKFVGGSGQ VSERIMELLG DRVKLEHPVT YVDQSGDNII VETLNHEHFE 660 661 CKYVISAIPP ALTAKIHFKP ELPSERNQLI QRLPMGAIIK CMMYYKEAFW KKKDYCGSMI 720 721 IEDEEAPISI TLDDSKPDGS LPAIMGFILA RKADRLAKLH KEMRKKKICE LYAKVLGSQE 780 781 ALQPVHYEEK NWCEEQYSGG CYTAYFPPGI MTQYGRVIRQ PVGRIYFAGT ETATRWSGYM 840 841 EGAVEAGERA AREILNALGK VAEKDIWLQE PESKDVPAVE ITHSFWERNL PSVGGLLKII 900 901 GFSTSITALW IVVYKFKLLT RS 922 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGAGTC AGGAGAAGGC GAGTATGGCA GGCCACATGT TCGACGTAGT CGTGATAGGA 60 61 GGCGGCATCT CAGGATTGTC TGCTGCCAAA CTCTTAGCCG AACATGAAAC TAATGTTTTG 120 121 GTTTTGGAAG CCCGGGACAG AGTTGGAGGA AGAACATACA CTGTGAGGAA CAAACATGTG 180 181 AATTACGTAG ATGTTGGCGG GGCTTATGTA GGACCAACCC AGAACAGGAT CTTACGGTTA 240 241 TCTAAGGAGC TGGGTTTAGA GACCTACAAA GTGAACGTAA ATGAGCGTCT TGTTCAGTAT 300 301 GTCAAGGGGA AAAGTTATCC ATTTCGGGGA GCCTTTCCTC CAGTATGGAA TCCCATTGCG 360 361 TATCTGGATT ACAACAATCT GTGGCGGACA ATGGATAACA TGGGAAAGGA GATTCCAGCT 420 421 GATGCACCGT GGGAGGCCCC ACATGCTGAG GAATGGGACA AGATGACCAT GAAAGATCTC 480 481 ATCGATAAAA TCTGCTGGAC AAAGACTGCT AGACAGTTTG CATCTCTCTT TGTGAATATC 540 541 AATGTGACAT CAGAACCCCA CCAGGTGTCT GCCCTGTGGT TCTTGTGGTA TGTGAAGCAG 600 601 TGCGGAGGCA CCACTCGGAT ATTCTCGATT ACTAACGGGG GTCAGGAACG GAAGTTTGTA 660 661 GGTGGATCTG GTCAAGTGAG TGAACGGATA ATGGAACTGC TTGGGGACAG AGTGAAGCTA 720 721 GAGCATCCTG TCACCTATGT TGACCAGTCA GGTGACAACA TCATCGTAGA GACGTTGAAT 780 781 CATGAACATT TTGAGTGCAA ATACGTAATT AGCGCCATCC CTCCGGCTTT GACTGCCAAG 840 841 ATCCACTTCA AACCAGAGCT TCCATCAGAG AGAAATCAGT TGATTCAGCG TCTTCCAATG 900 901 GGGGCTATCA TTAAGTGCAT GATGTATTAC AAGGAGGCCT TTTGGAAGAA GAAGGATTAC 960 961 TGTGGCTCTA TGATCATTGA AGATGAGGAA GCTCCAATTT CAATAACCCT GGATGACAGC 1020 1021 AAGCCAGATG GGTCGCTGCC TGCCATCATG GGCTTCATCC TTGCCAGAAA GGCTGATCGA 1080 1081 CTTGCTAAGC TGCATAAAGA AATGAGGAAG AAGAAAATCT GTGAGCTCTA CGCCAAGGTA 1140 1141 CTGGGATCCC AAGAAGCTTT ACAACCGGTG CACTATGAAG AGAAGAACTG GTGTGAGGAG 1200 1201 CAGTACTCAG GGGGCTGCTA TACTGCCTAC TTCCCCCCAG GGATCATGAC TCAGTATGGA 1260 1261 AGGGTGATTC GTCAGCCAGT GGGCAGGATT TACTTTGCTG GCACGGAGAC TGCCACACGC 1320 1321 TGGAGCGGTT ACATGGAGGG AGCAGTAGAG GCGGGAGAGA GGGCAGCTAG AGAGATCTTG 1380 1381 AATGCTTTGG GGAAGGTGGC AGAGAAAGAC ATATGGCTTC AAGAACCTGA GTCAAAGGAT 1440 1441 GTTCCAGCTG TGGAAATCAC CCATTCCTTC TGGGAGAGGA ACCTGCCTTC CGTGGGAGGC 1500 1501 CTCCTGAAGA TCATTGGATT TTCCACATCA ATCACCGCCC TGTGGATCGT GGTATACAAA 1560 1561 TTCAAGCTGC TGACACGATC CTAA 1584 |
▼ KEYWORD
ID | Family |
Acetylation | |
Catecholamine metabolism | |
Complete proteome | |
FAD | |
Flavoprotein | |
Membrane | |
Mitochondrion | |
Mitochondrion outer membrane | |
Neurotransmitter degradation | |
Oxidoreductase | |
Phosphoprotein | |
Reference proteome | |
Transmembrane | |
Transmembrane helix
|
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Mitochondrial outer membrane | |
Molecular Function | Oxidoreductase activity | |
Biological Process | Catecholamine metabolic process | |
Biological Process | Neurotransmitter catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a1085 | Homo sapiens | 0.0 | 1020 | undefined |
| LLPS-Mum-a1069 | Mus musculus | 0.0 | 984 | undefined |