• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Eqc-4538
HNRNPL

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Heterogeneous nuclear ribonucleoprotein L
Gene Name: HNRNPL
Ensembl Gene: ENSECAG00000012677.2
Ensembl Protein: ENSECAP00000010593.2
Organism: Equus caballus
Taxa ID: 9796
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Sam68 nuclear body, Stress granulePredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSRRLLPRAE  KRRRRLEQRQ  QPDEQRRRSG  AMVKMAAAGG  GGGGGRYYGG  GSEGGRAPKR  60
61    LKTDNAGDQH  GGGGGGGGGA  GAAGGGGGEN  YDDPHKTPAS  PVVHIRGLID  GVVEADLVEA  120
121   LQEFGPISYV  VVMPKKRQAL  VEFEDVLGAC  NAVNYAADNQ  IYIAGHPAFV  NYSTSQKISR  180
181   PGDSDDSRSV  NSVLLFTILN  PIYSITTDVL  YTICNPCGPV  QRIVIFRKNG  VQAMVEFDSV  240
241   QSAQRAKASL  NGADIYSGCC  TLKIEYAKPT  RLNVFRNDQD  TWDYTNPNLS  GQGDPGSNPN  300
301   KRQRQPPLLG  DHPAEYGGPH  GGYHSHYHDE  GYGPPPPHYE  GRRMGPPVGG  HRRGPSRYGP  360
361   QYGHPPPPPP  PPEYGPHADS  PVLMVYGLDQ  SKMNCDRVFN  VFCLYGNVEK  VKFMKSKPGA  420
421   AMVEMADGYA  VDRAITHLNN  NFMFGQKLKV  CVSKQPAIMP  GQSYGLEDGS  CSYKDFSESR  480
481   NNRFSTPEQA  AKNRIQHPSN  VLHFFNAPLE  VTEENFFEIC  DELGVKRPSS  VKVFSGKSER  540
541   SSSGLLEWES  KSDALETLGF  LNHYQMKNPN  GPYPYTLKLC  FSTAQHAS  588
Nucleotide CDS Sequence (FASTA)
1     ATGTCGCGGA  GGCTGCTGCC  CCGGGCGGAG  AAGCGGCGTC  GGCGGCTGGA  GCAGAGGCAG  60
61    CAGCCGGACG  AGCAGCGGAG  GCGGTCGGGA  GCGATGGTGA  AGATGGCGGC  GGCGGGCGGC  120
121   GGAGGCGGCG  GTGGCCGCTA  CTACGGTGGC  GGCAGTGAGG  GCGGCCGGGC  CCCTAAGCGG  180
181   CTCAAGACTG  ACAACGCCGG  TGACCAGCAC  GGAGGCGGCG  GCGGCGGCGG  TGGAGGAGCC  240
241   GGGGCGGCGG  GCGGCGGTGG  CGGGGAGAAC  TACGATGACC  CGCACAAAAC  CCCTGCCTCC  300
301   CCAGTTGTCC  ACATCAGGGG  CCTGATTGAC  GGTGTGGTGG  AAGCTGACCT  TGTGGAGGCC  360
361   TTGCAGGAGT  TTGGACCCAT  CAGCTATGTG  GTGGTAATGC  CTAAAAAGAG  ACAAGCATTG  420
421   GTGGAGTTTG  AAGACGTGTT  GGGGGCTTGC  AACGCCGTGA  ACTACGCAGC  GGACAACCAG  480
481   ATCTACATTG  CTGGTCACCC  AGCTTTTGTC  AATTACTCTA  CCAGCCAGAA  GATCTCCCGC  540
541   CCCGGGGACT  CGGATGACTC  CCGGAGCGTC  AACAGCGTGC  TGCTCTTTAC  CATCCTGAAC  600
601   CCCATCTATT  CCATCACCAC  GGATGTTCTG  TACACTATCT  GTAACCCTTG  TGGCCCTGTT  660
661   CAGAGAATTG  TCATTTTCCG  GAAGAATGGA  GTGCAGGCCA  TGGTGGAATT  TGACTCAGTG  720
721   CAGAGTGCTC  AGCGGGCCAA  GGCCTCGCTC  AATGGGGCTG  ACATCTACTC  AGGCTGCTGC  780
781   ACTCTGAAGA  TCGAGTACGC  CAAGCCCACA  CGCTTGAACG  TGTTCAGGAA  CGACCAGGAT  840
841   ACTTGGGACT  ACACCAACCC  CAATCTCAGT  GGACAAGGTG  ACCCTGGCAG  CAACCCTAAC  900
901   AAACGCCAGA  GGCAGCCCCC  TCTCCTGGGA  GATCACCCCG  CAGAATATGG  AGGGCCCCAC  960
961   GGTGGGTACC  ACAGCCATTA  CCATGATGAG  GGCTACGGCC  CCCCCCCACC  TCACTACGAA  1020
1021  GGGAGAAGGA  TGGGCCCACC  AGTGGGGGGT  CACCGCCGGG  GCCCAAGTCG  TTATGGCCCC  1080
1081  CAGTATGGGC  ATCCCCCACC  CCCTCCCCCA  CCACCCGAGT  ATGGCCCCCA  CGCCGACAGC  1140
1141  CCCGTGCTCA  TGGTCTATGG  CTTGGATCAA  TCTAAGATGA  ACTGTGATCG  AGTCTTCAAT  1200
1201  GTCTTCTGCT  TGTATGGCAA  TGTGGAGAAG  GTGAAATTCA  TGAAAAGCAA  GCCGGGGGCC  1260
1261  GCCATGGTGG  AGATGGCTGA  CGGCTATGCC  GTGGACCGGG  CCATCACCCA  CCTCAACAAC  1320
1321  AACTTCATGT  TCGGGCAGAA  GCTGAAAGTC  TGTGTCTCCA  AGCAGCCGGC  CATCATGCCT  1380
1381  GGTCAGTCCT  ACGGCCTGGA  GGACGGGTCC  TGCAGTTACA  AAGACTTCAG  CGAGTCCCGG  1440
1441  AACAATCGGT  TCTCCACTCC  GGAGCAGGCC  GCCAAGAACC  GCATCCAGCA  CCCTAGCAAC  1500
1501  GTGCTGCACT  TCTTCAACGC  CCCTCTGGAG  GTGACCGAGG  AGAACTTCTT  CGAGATCTGC  1560
1561  GATGAGCTGG  GAGTGAAGCG  GCCATCTTCT  GTGAAAGTGT  TCTCAGGCAA  AAGTGAGCGC  1620
1621  AGCTCCTCTG  GGCTGCTGGA  GTGGGAATCC  AAGAGCGACG  CCCTGGAGAC  TTTGGGCTTC  1680
1681  CTGAACCATT  ACCAGATGAA  GAACCCGAAT  GGTCCGTACC  CTTACACCCT  GAAGTTGTGT  1740
1741  TTCTCCACTG  CTCAGCATGC  CTCCTAA  1767

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Bot-1088Bos taurus99.640.0 951
LLPS-Fec-1740Felis catus99.640.0 951
LLPS-Caf-1925Canis familiaris99.640.0 951
LLPS-Caj-4686Callithrix jacchus99.64e-156 469
LLPS-Mal-0600Mandrillus leucophaeus99.560.0 835
LLPS-Pap-3208Pan paniscus99.560.0 835
LLPS-Chs-2941Chlorocebus sabaeus99.470.0 947
LLPS-Cea-3377Cercocebus atys99.470.0 947
LLPS-Hos-2742Homo sapiens99.470.0 947
LLPS-Pat-0446Pan troglodytes99.470.0 947
LLPS-Mam-0499Macaca mulatta99.470.0 947
LLPS-Ict-1113Ictidomys tridecemlineatus99.290.0 950
LLPS-Fud-4110Fukomys damarensis99.20.0 922
LLPS-Ova-1880Ovis aries99.190.0 904
LLPS-Myl-1850Myotis lucifugus99.110.0 944
LLPS-Poa-0783Pongo abelii98.930.0 940
LLPS-Otg-2709Otolemur garnettii98.470.0 825
LLPS-Mup-3590Mustela putorius furo98.40.0 911
LLPS-Cap-0736Cavia porcellus98.210.0 946
LLPS-Orc-1725Oryctolagus cuniculus98.040.0 943
LLPS-Sah-3652Sarcophilus harrisii97.410.0 903
LLPS-Mea-1387Mesocricetus auratus97.140.0 941
LLPS-Ora-0800Ornithorhynchus anatinus96.911e-130 397
LLPS-Mod-3936Monodelphis domestica96.050.0 920
LLPS-Pes-1016Pelodiscus sinensis95.60.0 889
LLPS-Gog-3516Gorilla gorilla95.492e-160 479
LLPS-Aon-1452Aotus nancymaae95.493e-160 479
LLPS-Nol-1959Nomascus leucogenys95.492e-160 479
LLPS-Meg-2456Meleagris gallopavo94.010.0 880
LLPS-Loa-4432Loxodonta africana93.846e-134 407
LLPS-Aim-3900Ailuropoda melanoleuca93.410.0 903
LLPS-Anc-3248Anolis carolinensis93.030.0 892
LLPS-Maf-3295Macaca fascicularis88.750.0 820
LLPS-Man-1460Macaca nemestrina88.750.0 820
LLPS-Paa-1954Papio anubis87.810.0 850
LLPS-Ran-2550Rattus norvegicus87.650.0 863
LLPS-Gaga-2530Gallus gallus87.370.0 840
LLPS-Dio-2865Dipodomys ordii87.230.0 854
LLPS-Rhb-2755Rhinopithecus bieti83.860.0 803
LLPS-Xet-3395Xenopus tropicalis83.360.0 831
LLPS-Orn-3005Oreochromis niloticus82.354e-134 409
LLPS-Leo-2045Lepisosteus oculatus80.940.0 774
LLPS-Scm-3244Scophthalmus maximus79.41e-123 382
LLPS-Cii-2075Ciona intestinalis77.891e-47 169
LLPS-Xim-1341Xiphophorus maculatus77.515e-114 357
LLPS-Pof-1468Poecilia formosa77.511e-113 356
LLPS-Scf-3914Scleropages formosus77.470.0 681
LLPS-Dar-0432Danio rerio75.150.0 736
LLPS-Orl-1121Oryzias latipes73.980.0 735
LLPS-Ten-0312Tetraodon nigroviridis73.620.0 717
LLPS-Gaa-3738Gasterosteus aculeatus73.110.0 716
LLPS-Asm-2716Astyanax mexicanus71.320.0 739
LLPS-Icp-3852Ictalurus punctatus70.460.0 740
LLPS-Lac-2748Latimeria chalumnae70.440.0 668
LLPS-Drm-1828Drosophila melanogaster68.751e-36 147
LLPS-Tar-1589Takifugu rubripes67.810.0 645
LLPS-Mum-0816Mus musculus56.630.0 533
LLPS-Fia-1555Ficedula albicollis56.630.0 533
LLPS-Urm-3720Ursus maritimus56.021e-180 528
LLPS-Anp-1228Anas platyrhynchos55.712e-178 521
LLPS-Tag-3496Taeniopygia guttata55.671e-178 524
LLPS-Sus-4147Sus scrofa55.61e-171 506
LLPS-Cis-0761Ciona savignyi50.841e-124 381
LLPS-Via-2262Vigna angularis38.763e-31 130
LLPS-Cae-1128Caenorhabditis elegans38.262e-97 316
LLPS-Glm-0434Glycine max38.071e-30 128
LLPS-Met-2381Medicago truncatula37.53e-0756.6
LLPS-Php-0485Physcomitrella patens37.381e-35 144
LLPS-Sob-0076Sorghum bicolor37.132e-34 139
LLPS-Sol-0241Solanum lycopersicum36.792e-31 130
LLPS-Phv-1946Phaseolus vulgaris36.795e-33 135
LLPS-Pot-0010Populus trichocarpa36.71e-34 140
LLPS-Sem-0161Selaginella moellendorffii36.622e-36 145
LLPS-Ori-1707Oryza indica36.411e-33 137
LLPS-Org-1253Oryza glaberrima36.411e-33 137
LLPS-Dac-0925Daucus carota36.273e-32 133
LLPS-Mae-0678Manihot esculenta36.273e-32 133
LLPS-Viv-0013Vitis vinifera36.153e-33 135
LLPS-Sei-0667Setaria italica36.146e-33 136
LLPS-Gor-0805Gossypium raimondii36.083e-33 136
LLPS-Art-1167Arabidopsis thaliana36.081e-31 131
LLPS-Brd-0228Brachypodium distachyon35.93e-33 135
LLPS-Hov-0599Hordeum vulgare35.786e-34 138
LLPS-Tra-0214Triticum aestivum35.783e-34 139
LLPS-Tru-0479Triticum urartu35.781e-33 138
LLPS-Hea-0266Helianthus annuus35.712e-28 122
LLPS-Prp-0878Prunus persica35.714e-31 130
LLPS-Mua-0557Musa acuminata35.647e-33 135
LLPS-Cus-1061Cucumis sativus35.577e-29 123
LLPS-Arl-1028Arabidopsis lyrata35.572e-31 130
LLPS-Orbr-1537Oryza brachyantha35.297e-33 135
LLPS-Ors-1001Oryza sativa35.153e-33 135
LLPS-Zem-1803Zea mays35.081e-28 124
LLPS-Brn-0316Brassica napus35.055e-31 129
LLPS-Bro-2161Brassica oleracea35.054e-31 129
LLPS-Thc-0684Theobroma cacao34.882e-32 136
LLPS-Brr-0547Brassica rapa34.541e-29 125
LLPS-Nia-0287Nicotiana attenuata34.434e-32 132
LLPS-Orni-0459Oryza nivara34.35e-31 129
LLPS-Lep-1507Leersia perrieri34.163e-29 124
LLPS-Sot-0609Solanum tuberosum34.113e-33 136
LLPS-Orp-1732Oryza punctata33.669e-29 122
LLPS-Orr-1169Oryza rufipogon33.669e-29 122
LLPS-Orm-1241Oryza meridionalis33.669e-29 122
LLPS-Tut-0856Tursiops truncatus31.744e-23 107
LLPS-Cas-3151Carlito syrichta30.652e-1789.4
LLPS-Amt-1008Amborella trichopoda28.878e-55 198