• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Eqc-0179
U2AF2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: U2 snRNP auxiliary factor large subunit
Gene Name: U2AF2
Ensembl Gene: ENSECAG00000010110.2
Ensembl Protein: ENSECAP00000008276.2
Organism: Equus caballus
Taxa ID: 9796
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Necessary for the splicing of pre-mRNA.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSDFDEFERQ  LNENKQERDK  ENRHRKRSHS  RSRSRDRKRR  SRSRDRRNRD  QRSASRDRRR  60
61    RSRSPRHEKK  KKVRKYWDVP  PPGFEHITPM  QYKAMQAAGQ  IPATALLPTM  TPDGLAVTPT  120
121   PVPVVGSQMT  RQARRLYVGN  IPFGITEEAM  MDFFNAQMRL  GGLTQAPGNP  VLAVQINQDK  180
181   NFAFLEFRSV  DETTQAMAFD  GIIFQGQSLK  IRRPHDYQPL  PGMSENPSVY  VPGVVSTVVP  240
241   DSAHKLFIGG  LPNYLNDDQV  KELLTSFGPL  KAFNLVKDSA  TGLSKGYAFC  EYVDINVTDQ  300
301   AIAGLNGMQL  GDKKLLVQRA  SVGAKNATLS  TINQTPVTLQ  VPGLMSSQVQ  MGGHPTEVLC  360
361   LMNMVLPEEL  LDDEEYEEIV  EDVRDECSKY  GLVKSIEIPR  PVDGVEVPGC  GKVCVCSLPP  420
421   PLSCSLAVFL  VCVYVCLPCP  PPFSLSLAVF  FSLSLTYSHT  PYYSSPEKRV  ALRWPRACGE  480
481   GWGVQCCFG  489
Nucleotide CDS Sequence (FASTA)
1     ATGTCGGACT  TCGACGAGTT  CGAGCGGCAG  CTCAACGAGA  ATAAGCAAGA  GCGGGACAAG  60
61    GAGAACCGGC  ACCGAAAGCG  CAGCCACAGC  CGCTCTCGAA  GCCGAGACCG  CAAGCGTCGG  120
121   AGCCGGAGCC  GGGACCGGCG  AAACCGGGAC  CAGAGGAGCG  CCTCTCGAGA  TAGGCGGCGA  180
181   AGAAGTCGTT  CCCCTCGCCA  TGAGAAGAAG  AAGAAGGTCC  GCAAATACTG  GGATGTGCCC  240
241   CCGCCCGGCT  TCGAGCACAT  CACGCCCATG  CAGTATAAGG  CCATGCAAGC  TGCGGGTCAG  300
301   ATTCCAGCCA  CCGCCCTTCT  CCCCACCATG  ACCCCTGACG  GTCTGGCTGT  GACCCCGACA  360
361   CCGGTACCTG  TGGTCGGGAG  CCAGATGACC  AGACAGGCCC  GGCGCCTCTA  CGTGGGCAAC  420
421   ATCCCCTTTG  GCATAACTGA  GGAGGCCATG  ATGGACTTCT  TCAACGCCCA  GATGCGCCTG  480
481   GGGGGCCTGA  CTCAGGCCCC  TGGCAATCCC  GTCTTGGCTG  TGCAGATTAA  CCAGGACAAG  540
541   AACTTTGCCT  TCTTGGAGTT  CCGCTCAGTG  GACGAGACCA  CCCAGGCCAT  GGCCTTTGAT  600
601   GGCATCATCT  TCCAGGGCCA  GTCGCTGAAG  ATCCGCAGGC  CTCATGACTA  CCAGCCCCTG  660
661   CCTGGCATGT  CGGAGAACCC  CTCCGTCTAT  GTGCCCGGAG  TTGTGTCCAC  TGTGGTCCCA  720
721   GACTCTGCCC  ACAAGCTGTT  CATCGGGGGC  TTACCCAACT  ACCTAAATGA  TGACCAGGTA  780
781   AAAGAGCTGC  TGACATCGTT  CGGGCCTCTC  AAGGCCTTCA  ACCTGGTCAA  GGACAGTGCC  840
841   ACGGGGCTCT  CCAAGGGCTA  CGCCTTCTGT  GAGTACGTGG  ACATCAACGT  CACAGATCAG  900
901   GCCATTGCGG  GGCTGAATGG  GATGCAGCTG  GGGGATAAGA  AACTGCTCGT  GCAGAGGGCG  960
961   AGTGTGGGAG  CCAAGAATGC  TACGCTGAGC  ACCATCAACC  AGACCCCTGT  GACCCTGCAA  1020
1021  GTGCCGGGCC  TGATGAGCTC  CCAGGTGCAG  ATGGGCGGCC  ACCCGACCGA  GGTCTTGTGC  1080
1081  CTCATGAACA  TGGTGCTGCC  TGAGGAGCTG  CTGGATGACG  AGGAGTACGA  GGAGATTGTG  1140
1141  GAGGACGTGC  GTGACGAGTG  CAGCAAGTAT  GGGCTCGTGA  AGTCCATCGA  GATCCCCCGG  1200
1201  CCCGTGGACG  GCGTCGAGGT  GCCTGGCTGT  GGAAAGATCT  TCGTGGAGTT  CACCTCTGTG  1260
1261  TTTGACTGCC  AGAAAGCCAT  GCAGGGCCTG  ACGGGTCGCA  AGTTCGCCAA  CAGAGTGGTT  1320
1321  GTCACAAAAT  ACTGTGACCC  CGACTCTTAC  CACCGCCGGG  ACTTCTGGTA  G  1371

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
mRNA processing
mRNA splicing
Nucleus
Reference proteome
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Commitment complex
Cellular Component
Nuclear speck
Cellular Component
U2-type prespliceosome
Cellular Component
U2AF
Molecular Function
Poly-pyrimidine tract binding
Molecular Function
Pre-mRNA 3'-splice site binding
Biological Process
MRNA processing
Biological Process
RNA splicing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caf-2277Canis familiaris99.420.0 609
LLPS-Man-3014Macaca nemestrina99.420.0 609
LLPS-Ran-1652Rattus norvegicus99.420.0 609
LLPS-Paa-0142Papio anubis99.420.0 609
LLPS-Mal-1110Mandrillus leucophaeus99.420.0 607
LLPS-Mup-1734Mustela putorius furo99.420.0 609
LLPS-Chs-1776Chlorocebus sabaeus99.420.0 609
LLPS-Cea-0176Cercocebus atys99.420.0 609
LLPS-Sus-0014Sus scrofa99.420.0 609
LLPS-Gog-0665Gorilla gorilla98.843e-95 296
LLPS-Gaga-0068Gallus gallus98.830.0 604
LLPS-Lac-0643Latimeria chalumnae98.770.0 564
LLPS-Aon-1109Aotus nancymaae98.534e-176 508
LLPS-Cas-1853Carlito syrichta98.270.0 603
LLPS-Ict-3598Ictidomys tridecemlineatus98.270.0 603
LLPS-Anc-0223Anolis carolinensis98.270.0 602
LLPS-Cap-0650Cavia porcellus98.270.0 603
LLPS-Mam-1110Macaca mulatta98.270.0 602
LLPS-Otg-1051Otolemur garnettii98.270.0 603
LLPS-Pap-1580Pan paniscus98.270.0 603
LLPS-Urm-0477Ursus maritimus98.270.0 600
LLPS-Pat-2936Pan troglodytes98.270.0 603
LLPS-Hos-0481Homo sapiens98.270.0 603
LLPS-Fec-1038Felis catus98.270.0 603
LLPS-Loa-0466Loxodonta africana98.270.0 603
LLPS-Tut-0167Tursiops truncatus98.270.0 603
LLPS-Dio-0633Dipodomys ordii98.270.0 603
LLPS-Fud-0757Fukomys damarensis98.270.0 603
LLPS-Caj-0298Callithrix jacchus98.270.0 603
LLPS-Mea-2278Mesocricetus auratus98.270.0 604
LLPS-Mum-0076Mus musculus98.270.0 603
LLPS-Maf-1630Macaca fascicularis98.270.0 603
LLPS-Aim-0003Ailuropoda melanoleuca98.240.0 593
LLPS-Poa-0993Pongo abelii98.167e-153 447
LLPS-Rhb-0086Rhinopithecus bieti97.980.0 601
LLPS-Bot-1527Bos taurus97.980.0 601
LLPS-Myl-0647Myotis lucifugus96.612e-92 288
LLPS-Xet-0745Xenopus tropicalis95.750.0 624
LLPS-Orn-2477Oreochromis niloticus95.290.0 581
LLPS-Ten-2160Tetraodon nigroviridis95.00.0 577
LLPS-Pof-0142Poecilia formosa95.00.0 580
LLPS-Xim-3552Xiphophorus maculatus95.00.0 579
LLPS-Orl-1166Oryzias latipes94.410.0 576
LLPS-Asm-2455Astyanax mexicanus92.670.0 568
LLPS-Tar-0310Takifugu rubripes92.350.0 549
LLPS-Scm-2515Scophthalmus maximus92.20.0 570
LLPS-Ova-0640Ovis aries89.80.0 541
LLPS-Dar-0831Danio rerio88.440.0 563
LLPS-Icp-1746Ictalurus punctatus86.380.0 554
LLPS-Gaa-0792Gasterosteus aculeatus86.360.0 583
LLPS-Leo-1703Lepisosteus oculatus83.386e-178 516
LLPS-Sah-0361Sarcophilus harrisii81.029e-136 406
LLPS-Nol-1097Nomascus leucogenys76.010.0 522
LLPS-Scf-1675Scleropages formosus74.530.0 532
LLPS-Cii-0019Ciona intestinalis72.221e-138 416
LLPS-Pes-0321Pelodiscus sinensis72.088e-132 397
LLPS-Drm-0039Drosophila melanogaster71.592e-153 451
LLPS-Cis-1490Ciona savignyi70.473e-138 414
LLPS-Cae-0501Caenorhabditis elegans60.532e-109 340
LLPS-Put-0105Puccinia triticina54.551e-35 144
LLPS-Usm-0779Ustilago maydis53.581e-67 236
LLPS-Spr-0828Sporisorium reilianum53.429e-68 236
LLPS-Mel-0350Melampsora laricipopulina52.881e-66 226
LLPS-Pug-0574Puccinia graminis48.82e-60 216
LLPS-Chr-1318Chlamydomonas reinhardtii47.812e-48 186
LLPS-Abg-0411Absidia glauca46.515e-73 247
LLPS-Hov-1118Hordeum vulgare46.462e-59 210
LLPS-Tra-0601Triticum aestivum46.21e-58 209
LLPS-Tru-0170Triticum urartu45.912e-58 209
LLPS-Brd-0615Brachypodium distachyon45.83e-60 213
LLPS-Sot-0230Solanum tuberosum45.514e-64 224
LLPS-Mua-0118Musa acuminata44.847e-61 213
LLPS-Org-0115Oryza glaberrima44.644e-57 205
LLPS-Orr-0299Oryza rufipogon44.642e-57 206
LLPS-Ors-0574Oryza sativa44.642e-57 206
LLPS-Orgl-0629Oryza glumaepatula44.643e-57 205
LLPS-Orb-0095Oryza barthii44.644e-57 205
LLPS-Orni-0365Oryza nivara44.352e-57 205
LLPS-Ori-0483Oryza indica44.352e-57 205
LLPS-Orm-0347Oryza meridionalis44.313e-59 209
LLPS-Orp-0470Oryza punctata44.281e-56 204
LLPS-Cus-0415Cucumis sativus44.252e-60 214
LLPS-Sol-0644Solanum lycopersicum44.083e-63 223
LLPS-Gor-1854Gossypium raimondii43.972e-56 203
LLPS-Osl-0088Ostreococcus lucimarinus43.663e-48 174
LLPS-Orbr-0656Oryza brachyantha43.445e-59 209
LLPS-Mae-1414Manihot esculenta43.273e-58 208
LLPS-Coc-1625Corchorus capsularis43.246e-57 210
LLPS-Brr-1753Brassica rapa43.243e-59 211
LLPS-Brn-2744Brassica napus43.243e-59 211
LLPS-Lep-0543Leersia perrieri43.22e-56 203
LLPS-Sem-2204Selaginella moellendorffii43.039e-60 206
LLPS-Via-0250Vigna angularis42.822e-58 209
LLPS-Viv-0048Vitis vinifera42.731e-57 206
LLPS-Pot-1553Populus trichocarpa42.734e-55 199
LLPS-Art-0339Arabidopsis thaliana42.647e-57 204
LLPS-Sei-1702Setaria italica42.54e-54 197
LLPS-Sob-0322Sorghum bicolor42.465e-60 212
LLPS-Crn-0573Cryptococcus neoformans42.392e-57 207
LLPS-Arl-0835Arabidopsis lyrata42.341e-57 206
LLPS-Gas-0692Galdieria sulphuraria42.316e-57 204
LLPS-Zem-0457Zea mays42.185e-59 209
LLPS-Map-0174Magnaporthe poae42.03e-44 166
LLPS-Gag-1338Gaeumannomyces graminis42.03e-43 166
LLPS-Bro-0065Brassica oleracea41.671e-61 216
LLPS-Phv-0507Phaseolus vulgaris41.646e-59 210
LLPS-Glm-0514Glycine max41.641e-59 212
LLPS-Met-1468Medicago truncatula41.445e-57 206
LLPS-Scs-0375Sclerotinia sclerotiorum41.399e-53 192
LLPS-Vir-1310Vigna radiata41.379e-59 210
LLPS-Thc-0027Theobroma cacao41.359e-57 204
LLPS-Amt-0436Amborella trichopoda41.194e-58 207
LLPS-Nia-0016Nicotiana attenuata41.112e-60 214
LLPS-Hea-1175Helianthus annuus41.065e-54 197
LLPS-Dac-0507Daucus carota41.013e-58 208
LLPS-Mao-0895Magnaporthe oryzae41.02e-46 176
LLPS-Miv-0639Microbotryum violaceum40.813e-59 212
LLPS-Php-1423Physcomitrella patens40.571e-53 195
LLPS-Cog-0199Colletotrichum gloeosporioides40.065e-51 187
LLPS-Tum-0798Tuber melanosporum39.837e-48 179
LLPS-Chc-0034Chondrus crispus39.772e-50 185
LLPS-Ved-0784Verticillium dahliae39.721e-50 187
LLPS-Cogr-0999Colletotrichum graminicola39.613e-52 191
LLPS-Coo-0760Colletotrichum orbiculare39.54e-49 183
LLPS-Blg-0727Blumeria graminis39.392e-51 189
LLPS-Fus-0652Fusarium solani39.111e-41 160
LLPS-Fuv-0615Fusarium verticillioides38.726e-42 162
LLPS-Asf-0279Aspergillus flavus38.675e-46 174
LLPS-Aso-0337Aspergillus oryzae38.677e-46 173
LLPS-Beb-0216Beauveria bassiana38.461e-40 158
LLPS-Fuo-0328Fusarium oxysporum38.446e-42 162
LLPS-Trv-0673Trichoderma virens38.362e-43 166
LLPS-Nec-0521Neurospora crassa38.191e-46 176
LLPS-Asni-1249Aspergillus niger37.918e-48 179
LLPS-Trr-0274Trichoderma reesei37.642e-43 166
LLPS-Asn-1143Aspergillus nidulans37.571e-45 172
LLPS-Pytr-0664Pyrenophora triticirepentis37.392e-44 169
LLPS-Zyt-0276Zymoseptoria tritici37.335e-45 171
LLPS-Prp-0232Prunus persica37.275e-50 184
LLPS-Nef-0312Neosartorya fischeri37.221e-45 172
LLPS-Pyt-0569Pyrenophora teres37.111e-44 170
LLPS-Asc-0205Aspergillus clavatus36.863e-46 174
LLPS-Lem-0857Leptosphaeria maculans36.832e-45 172
LLPS-Dos-0680Dothistroma septosporum36.392e-46 172
LLPS-Asfu-0005Aspergillus fumigatus36.119e-44 167
LLPS-Ast-0449Aspergillus terreus35.933e-47 174
LLPS-Phn-1027Phaeosphaeria nodorum35.591e-41 161
LLPS-Yal-0644Yarrowia lipolytica33.571e-1480.5
LLPS-Scp-0596Schizosaccharomyces pombe31.272e-27 119
LLPS-Scj-0646Schizosaccharomyces japonicus31.014e-31 129
LLPS-Scc-0963Schizosaccharomyces cryophilus28.573e-1788.6
LLPS-Tag-0366Taeniopygia guttata24.232e-1170.5
LLPS-Meg-0135Meleagris gallopavo24.232e-1170.5
LLPS-Mod-3209Monodelphis domestica24.232e-1170.5
LLPS-Anp-1811Anas platyrhynchos24.232e-1170.1