LLPS-Drm-a019
Cdk12
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cyclin-dependent kinase 12 |
| Gene Name: | Cdk12, CG7597 |
| Ensembl Gene: | FBgn0037093 |
| Ensembl Protein: | FBpp0078014 |
| Organism: | Drosophila melanogaster |
| Taxa ID: | 7227 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus | Predicted from orthologs | (View) |
▼ FUNCTION
| Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | FBtr0078358 | FBpp0078014 |
| Ensembl | FBtr0078357 | FBpp0078013 |
| Ensembl | FBtr0332716 | FBpp0304962 |
| UniProt | Q9VP22, CDK12_DROME, Q8T9E1, Q95SE1 | |
| GeneBank | AY069806, BT058001, AE014296, AY060835 | AAN12171.1, AAL39951.1, AAF51738.1, AAL28383.1, ACM16711.1 |
| RefSeq | NM_001275238.1, NM_141068.4, NM_168912.2 | NP_001262167.1, NP_649325.2, NP_730643.1 |
| Entrez | 40385 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MHASSAAATA LVEYSDVSSE DFSDQEAGDL DADAGKGAGN IKKPKPAPDN QFSKGRLDAK 60 61 PDKEGYDNYR SRRAEDSSDP VAAGSRQTSS SEATNPREEP SQASNTSKDE LWGREIYMSS 120 121 DSIDTDELEA EMKRQKRKKQ KKEKHKHKSK KKSKKRKKKR AKSYSSIDSM SDNDINALLD 180 181 RRYTPPTAPS KSNERTVSAA PSSFTPHNLK ESSSPATPPP VRRPNTNSNY YGESSLETAN 240 241 SALGSNLQVT VTNKQSISNR LRSPPPSSRS SGNGPRFGNS PRTPPPSHYS SSGGGGVGSG 300 301 SVVRDSRSSR YVNSPHKEDV SAHHRSSHDH GYQGRYSGAG SSSHDTRKVK RLSPELDRYN 360 361 HQPSTPPHKR RKFSDGREVG LGNFEHSRHH SGKYERYSRD RYSRRSSRSP SVQHSRSRQS 420 421 PSGGLSSGSN AFRHGGSHKH KYGTTVSSTP SHTTRTSKRA SGTGTSGDRY SRSPRTSSRY 480 481 MESSPPSPVG ASGSHHYHHR RSPRMRQRTR GDSRRRSPSS ASSESSASRS RSPTSRDLKH 540 541 KREEYIKKIS ETSLFAELVK DRHKRQKALK EIIERQEENS NSNSNGALTI NDNSSSVDGN 600 601 TPNAADGRSA PGSGTPAAAS TTSNGLQALG SKPDLDLNNI PMPNKQNDSV VSNPASNADV 660 661 PDSVAQLKQP LLVPPFSASK NNIKPKSLTS LPLPPGMNVL DLAGARSPSP GQKKESDEKN 720 721 VTSSGSANKS VLNLPMPPVI PGSEELSGDD DVIDSPEDFD APAVGTVHGH GGGPGTTRQR 780 781 PVILNRRDSR NNVRDWGERC VDVFEMIAQI GEGTYGQVYK ARDHHTNDMV ALKKVRLEHE 840 841 KEGFPITAVR EIKILRQLNH RNIVNLHEIV TDKQDAVEFR KDKGSFYLVF EYMDHDLMGL 900 901 LESGMVDFNE ENNASIMKQL LDGLNYCHKK NFLHRDIKCS NILMNNRGKV KLADFGLARL 960 961 YNADDRERPY TNKVITLWYR PPELLLGEER YGPSIDVWSC GCILGELFVK RPLFQANAEM 1020 1021 AQLETISKIC GSPVPAVWPN VIKLPLFHTL KQKKTHRRRL REDFEFMPAP ALDLLDKMLD 1080 1081 LDPDKRITAE DALRSPWLRK INPDEMPTPQ LPTWQDCHEL WSKKRRRQMR EQQESLPPTV 1140 1141 IASTKYQQHG ATMVGDA 1157 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCATGCAT CCTCCGCGGC GGCCACTGCA CTTGTGGAGT ACTCGGACGT CAGCTCAGAG 60 61 GACTTCTCGG ATCAGGAGGC AGGGGACTTG GATGCGGACG CCGGCAAGGG TGCCGGAAAC 120 121 ATCAAAAAAC CGAAGCCAGC TCCGGATAAT CAGTTCTCCA AAGGTCGTCT TGATGCCAAG 180 181 CCCGATAAAG AGGGTTATGA TAACTACAGA AGTAGAAGGG CGGAAGACTC AAGCGACCCA 240 241 GTGGCGGCCG GATCGAGGCA AACGTCTAGC AGCGAGGCCA CGAATCCGCG GGAGGAACCT 300 301 TCGCAGGCAT CCAACACCTC GAAGGACGAG CTGTGGGGCA GAGAGATATA CATGTCCAGC 360 361 GATTCTATCG ACACCGATGA GCTGGAGGCG GAAATGAAGC GGCAGAAGCG CAAAAAGCAG 420 421 AAAAAGGAAA AACACAAACA CAAGTCGAAG AAAAAGTCCA AGAAGCGCAA GAAGAAGCGG 480 481 GCCAAGTCAT ACTCCAGCAT CGATTCGATG TCAGACAATG ACATCAATGC CTTACTGGAC 540 541 CGGCGCTATA CTCCGCCGAC GGCTCCTAGC AAGAGCAACG AACGGACGGT TAGCGCTGCG 600 601 CCGTCCTCCT TCACCCCACA CAACCTCAAG GAGAGCAGTT CGCCAGCCAC TCCACCGCCA 660 661 GTGCGTCGCC CGAATACGAA CAGCAACTAC TACGGCGAGT CGTCCCTGGA GACGGCCAAC 720 721 TCTGCACTGG GAAGCAACCT GCAGGTCACA GTTACGAATA AGCAGTCGAT CAGCAACCGG 780 781 CTTCGTTCTC CTCCTCCGTC CTCCCGCTCC AGCGGCAACG GGCCGAGGTT TGGAAACTCC 840 841 CCGCGAACTC CACCGCCCTC TCACTACAGC TCCAGTGGCG GAGGAGGGGT TGGCAGTGGG 900 901 TCAGTGGTCC GCGATTCACG CAGCTCCCGC TATGTAAATA GTCCCCACAA AGAGGATGTA 960 961 AGTGCGCATC ACCGCTCTAG CCACGATCAC GGATATCAGG GACGTTACTC TGGTGCTGGG 1020 1021 TCGAGCAGTC ACGATACCAG GAAGGTGAAA CGACTGTCGC CGGAGCTGGA CCGCTACAAC 1080 1081 CATCAGCCAA GCACGCCACC CCACAAGCGT CGGAAGTTTA GCGATGGCAG GGAAGTGGGC 1140 1141 CTCGGAAACT TTGAGCACAG TAGACACCAC TCTGGAAAGT ACGAACGATA CAGCAGAGAT 1200 1201 CGATATTCTA GGCGGTCATC AAGGAGCCCC AGTGTGCAGC ACTCACGAAG TCGGCAATCT 1260 1261 CCCAGCGGCG GCCTGTCAAG TGGTTCGAAC GCGTTTCGCC ATGGTGGCAG TCACAAACAC 1320 1321 AAGTATGGGA CCACTGTTAG CTCGACGCCG TCGCATACGA CGAGGACCTC AAAACGCGCT 1380 1381 TCGGGAACTG GTACCTCTGG CGATCGCTAC TCGAGGTCGC CCAGAACAAG TTCGCGGTAC 1440 1441 ATGGAGTCAT CACCGCCATC GCCAGTCGGA GCTTCCGGTT CGCATCACTA TCATCATCGC 1500 1501 CGTTCGCCAA GGATGCGCCA GAGGACCAGA GGCGACAGTC GTCGCCGGTC GCCCAGTTCG 1560 1561 GCCAGCAGCG AAAGTTCTGC CTCTCGCAGC CGATCACCAA CGTCAAGAGA TCTAAAGCAC 1620 1621 AAGCGCGAAG AGTACATTAA GAAGATCAGT GAGACTAGCC TATTTGCCGA GCTGGTAAAG 1680 1681 GATCGTCACA AAAGGCAGAA GGCGCTGAAG GAAATCATTG AGCGGCAAGA GGAGAACAGC 1740 1741 AATAGCAACA GCAACGGTGC ACTGACTATT AACGACAACA GTTCCTCCGT GGATGGCAAT 1800 1801 ACACCCAACG CGGCTGATGG CCGATCTGCC CCTGGAAGTG GAACACCAGC AGCGGCGTCA 1860 1861 ACAACTTCCA ATGGGCTTCA AGCTTTGGGT AGCAAGCCGG ATCTGGACCT CAACAACATT 1920 1921 CCCATGCCAA ACAAGCAGAA CGATTCTGTG GTTTCGAATC CGGCTTCAAA CGCCGATGTT 1980 1981 CCGGACAGTG TCGCGCAGTT GAAGCAACCT TTGCTGGTGC CACCGTTCTC GGCTAGTAAG 2040 2041 AACAACATAA AACCGAAGAG CCTGACTTCT TTGCCGCTGC CGCCGGGTAT GAATGTGCTC 2100 2101 GACTTGGCCG GTGCAAGGTC TCCCTCTCCG GGGCAAAAGA AGGAATCGGA CGAAAAGAAC 2160 2161 GTTACTTCAA GCGGCAGCGC CAACAAGAGC GTGCTCAATC TTCCTATGCC GCCAGTAATT 2220 2221 CCCGGCAGCG AAGAGCTTAG TGGCGATGAT GATGTTATCG ACAGTCCTGA AGACTTTGAT 2280 2281 GCACCCGCGG TTGGCACTGT GCACGGTCAC GGTGGTGGGC CAGGGACAAC TCGTCAGCGC 2340 2341 CCAGTGATAC TCAACCGTCG TGACTCGCGA AACAACGTAC GCGACTGGGG CGAGCGCTGT 2400 2401 GTGGATGTTT TTGAGATGAT TGCGCAAATA GGGGAAGGAA CTTACGGACA GGTTTACAAG 2460 2461 GCGCGGGATC ATCATACCAA TGACATGGTA GCACTGAAGA AGGTTCGGCT GGAGCACGAG 2520 2521 AAGGAGGGCT TTCCCATTAC AGCTGTTCGT GAAATCAAAA TTCTGAGACA ACTTAACCAT 2580 2581 CGCAATATAG TCAACCTGCA TGAAATTGTG ACGGACAAGC AGGATGCTGT GGAGTTCCGT 2640 2641 AAAGACAAGG GATCCTTCTA CTTGGTGTTT GAGTACATGG ATCACGACTT GATGGGTCTG 2700 2701 CTGGAGTCTG GCATGGTCGA CTTCAACGAG GAAAACAACG CAAGCATTAT GAAGCAGCTC 2760 2761 TTGGACGGCC TCAACTACTG CCACAAAAAG AATTTTCTGC ATCGAGACAT CAAGTGCTCG 2820 2821 AACATTTTAA TGAACAACAG GGGTAAAGTA AAACTAGCTG ACTTTGGGCT GGCACGACTA 2880 2881 TACAATGCGG ACGATCGGGA ACGCCCCTAC ACGAACAAAG TAATTACCTT GTGGTATCGT 2940 2941 CCTCCTGAGC TTTTGCTGGG TGAGGAGCGT TACGGCCCGT CGATAGACGT GTGGTCCTGC 3000 3001 GGGTGCATCC TCGGCGAACT CTTTGTGAAG CGGCCCCTGT TCCAGGCTAA TGCGGAAATG 3060 3061 GCGCAGCTTG AAACGATATC AAAGATCTGT GGATCCCCGG TTCCTGCCGT GTGGCCGAAT 3120 3121 GTAATTAAGC TGCCTCTGTT CCACACTCTC AAACAAAAGA AGACGCACCG CCGCCGTCTA 3180 3181 CGAGAAGACT TTGAATTCAT GCCAGCCCCT GCACTTGATC TGCTGGACAA AATGCTTGAT 3240 3241 TTAGATCCGG ACAAGCGCAT CACAGCAGAA GACGCGCTCC GGTCACCGTG GCTAAGGAAA 3300 3301 ATCAACCCCG ACGAAATGCC AACGCCACAA TTGCCCACAT GGCAGGACTG CCATGAGCTT 3360 3361 TGGAGTAAGA AGCGCCGTCG GCAGATGCGG GAGCAACAGG AGTCGCTTCC TCCTACGGTG 3420 3421 ATAGCCTCGA CCAAATACCA ACAGCATGGA GCAACCATGG TGGGGGATGC TTAG 3474 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nuclear chromosome | |
Cellular Component | Nuclear cyclin-dependent protein kinase holoenzyme complex | |
Cellular Component | Polytene chromosome | |
Cellular Component | Polytene chromosome puff | |
Molecular Function | ATP binding | |
Molecular Function | Cyclin binding | |
Molecular Function | Cyclin-dependent protein serine/threonine kinase activity | |
Molecular Function | RNA polymerase II CTD heptapeptide repeat kinase activity | |
Biological Process | Phosphorylation of RNA polymerase II C-terminal domain | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Protein phosphorylation |