LLPS-Drm-2363
Sfmbt
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| Polycomb group (PcG) protein that binds to the Polycomb response elements (PREs) found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | FBtr0080491 | FBpp0080069 |
| Ensembl | FBtr0080492 | FBpp0080070 |
| Ensembl | FBtr0289981 | FBpp0288419 |
| Ensembl | FBtr0333236 | FBpp0305438 |
| UniProt | Q9VK33, SMBT_DROME, Q7KTB5, Q9VK32 | |
| GeneBank | BT006011, AE014134 | AAF53249.2, AAF53250.2, AAO74694.1 |
| RefSeq | NM_001273503.1, NM_135762.3, NM_165026.2 | NP_001260432.1, NP_609606.2, NP_723786.1 |
| Entrez | 34709 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNPSELRMMW MSSQYNSERI TLEDAATLLG HPTVGLSVME DLSAHQPTLD MNPMMSLMGG 60 61 DFTGQAAATA AALGVQPGTL IATNSNNLYG FAHMGGLQQQ LLQQSAAAAV FQNYAEAMDN 120 121 DVENGMVGMA MEAVVDDDDQ VYGQRDNNFD DNGSELEPKQ EIINIDDFVM MNEDNNSYDG 180 181 TDFMTSSDKD ISQSSSSCMA QMPGSLGVPG VEHDLLVPLP DGLLHHKLLG TTLVPAMGTL 240 241 NGNAFGNIMV STENTSSKQM QRTYSTAKGA NSTATTATCS ASTSSALRSQ RKTRKIEPVN 300 301 RPGLVLKTPI AYRGNIDPSV IPIQKDGMAV CKRCGAIGVK HTFYTKSRRF CSMACARGEL 360 361 YSLVLNTKME GDQATTSSPD PGAGSESADL PGDQQQSQSD IELDLHAAHI KNANYRFRIT 420 421 DQSKITQLNS FGEPMSMGGD AAANNVQMAA DETIAALNGG AVGDATAPGS TEEGASTPNS 480 481 YLSAAPTPKA LRLFKDIYPQ DDLPQIPKYE RLPVPCPQME KIISIRRRMY DPTHSYDWLP 540 541 RLSKENFNAA PVTCFPHAPG CEVWDNLGVG MKVEVENTDC DSIEVIQPGQ TPTSFWVATI 600 601 LEIKGYKALM SYEGFDTDSH DFWVNLCNAE VHSVGWCATR GKPLIPPRTI EHKYKDWKDF 660 661 LVGRLSGART LPSNFYNKIN DSLQSRFRLG LNLECVDKDR ISQVRLATVT KIVGKRLFLR 720 721 YFDSDDGFWC HEDSPIIHPV GWATTVGHNL AAPQDYLERM LAGREAMIEV HEDDATIELF 780 781 KMNFTFDEYY SDGKTNSFVE GMKLEAVDPL NLSSICPATV MAVLKFGYMM IRIDSYQPDA 840 841 SGSDWFCYHE KSPCIFPAGF CSVNNISVTP PNGYDSRTFT WEGYLRDTGA VAAGQHLFHR 900 901 IIPDHGFEVG MSLECADLMD PRLVCVATVA RVVGRLLKVH FDGWTDEYDQ WLDCESADIY 960 961 PVGWCVLVNH KLEGPPRVAH QQAPKPAPKP KIQRKRKPKK GAAGGKTPTD NNTQSVKSRT 1020 1021 IALKTTPHLP KLSIKLELKP EHHNAAFYEN NQPEEEGDEE DPDADGDGDG STSHISEQST 1080 1081 TQSSSDLIAG SGSGSGSASL VTLATGSNKT VKKSTTKSPA PPTVGRKATS YIANSSATNN 1140 1141 KYIPRLADID SSEPHLELVP DTWNVYDVSQ FLRVNDCTAH CDTFSRNKID GKRLLQLTKD 1200 1201 DIMPLLGMKV GPALKISDLI AQLKCKVNPG RARSHKTNKS PFL 1243 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAACCCAT CCGAGCTGCG CATGATGTGG ATGAGTAGTC AGTACAACTC GGAGCGCATT 60 61 ACACTGGAGG ATGCGGCCAC TCTGCTGGGT CATCCCACTG TTGGACTCTC TGTCATGGAG 120 121 GACCTCTCCG CCCATCAGCC AACTTTGGAC ATGAATCCGA TGATGAGCCT AATGGGGGGA 180 181 GATTTCACTG GTCAAGCGGC GGCGACTGCT GCGGCACTGG GTGTACAGCC GGGCACCCTG 240 241 ATTGCCACCA ACTCGAACAA CCTGTACGGA TTTGCCCACA TGGGCGGCCT GCAGCAGCAA 300 301 CTGCTCCAGC AGTCGGCGGC GGCGGCAGTC TTCCAGAACT ATGCGGAGGC AATGGATAAC 360 361 GATGTGGAGA ACGGCATGGT TGGCATGGCC ATGGAGGCGG TCGTGGACGA TGACGACCAA 420 421 GTGTACGGTC AGAGGGACAA TAACTTTGAT GATAATGGAT CCGAGTTGGA GCCCAAGCAA 480 481 GAGATTATCA ACATCGACGA CTTTGTGATG ATGAACGAGG ACAATAATTC GTACGATGGC 540 541 ACCGACTTTA TGACCTCCTC CGATAAGGAC ATTTCGCAGT CCTCCTCCTC CTGCATGGCA 600 601 CAGATGCCCG GAAGCTTGGG CGTCCCTGGA GTCGAGCACG ATCTTTTGGT TCCACTGCCC 660 661 GATGGCCTGC TGCACCACAA GCTGCTGGGC ACAACTCTGG TCCCTGCGAT GGGTACGCTA 720 721 AATGGCAATG CCTTTGGCAA CATAATGGTC AGCACTGAAA ACACATCCAG CAAGCAAATG 780 781 CAGCGCACCT ATAGTACGGC CAAGGGAGCC AATTCCACCG CAACCACCGC CACCTGCAGT 840 841 GCCTCCACGT CCTCCGCATT GCGATCACAG CGCAAGACGC GCAAGATCGA GCCCGTTAAC 900 901 AGGCCAGGAC TGGTGCTGAA GACACCCATC GCCTACAGGG GCAACATTGA CCCTTCGGTG 960 961 ATCCCCATAC AGAAAGATGG CATGGCTGTC TGTAAACGTT GTGGCGCCAT TGGAGTGAAG 1020 1021 CACACATTCT ACACAAAATC GCGACGTTTT TGCAGCATGG CCTGTGCCCG AGGCGAACTA 1080 1081 TATTCGTTGG TACTTAACAC TAAGATGGAG GGAGACCAGG CAACCACTAG TTCCCCGGAT 1140 1141 CCTGGAGCGG GTTCGGAGTC AGCCGATTTG CCTGGCGATC AGCAACAGTC GCAGTCGGAT 1200 1201 ATTGAGCTCG ATCTGCATGC GGCGCACATT AAGAATGCGA ATTATCGTTT TCGCATTACG 1260 1261 GATCAATCAA AGATTACCCA GTTGAATAGC TTCGGCGAAC CCATGTCAAT GGGCGGCGAC 1320 1321 GCAGCTGCCA ATAATGTACA AATGGCAGCA GATGAAACAA TTGCTGCGTT AAACGGCGGA 1380 1381 GCAGTGGGCG ATGCCACTGC TCCGGGCAGC ACCGAGGAGG GTGCATCCAC ACCCAATTCT 1440 1441 TATCTGAGCG CAGCACCCAC GCCCAAGGCC TTGCGACTTT TTAAGGACAT CTACCCACAG 1500 1501 GATGACCTGC CGCAAATACC CAAATACGAG CGCCTTCCCG TACCGTGTCC GCAAATGGAG 1560 1561 AAGATAATCA GCATTCGGCG GCGCATGTAT GATCCCACAC ACTCCTACGA CTGGTTGCCC 1620 1621 CGCCTTAGCA AGGAGAACTT CAATGCGGCA CCCGTCACTT GTTTTCCTCA TGCACCCGGT 1680 1681 TGCGAGGTAT GGGACAATTT GGGCGTGGGC ATGAAGGTTG AAGTGGAAAA TACGGATTGC 1740 1741 GATAGCATCG AAGTGATCCA ACCGGGTCAG ACTCCTACCT CGTTTTGGGT GGCCACCATC 1800 1801 CTGGAAATCA AAGGCTATAA GGCCTTAATG AGCTACGAGG GTTTCGATAC GGACTCGCAC 1860 1861 GACTTCTGGG TGAACCTCTG CAATGCCGAG GTGCATTCGG TGGGTTGGTG CGCCACTCGG 1920 1921 GGCAAGCCAT TAATTCCGCC CCGCACCATC GAGCACAAGT ACAAGGACTG GAAGGACTTT 1980 1981 CTGGTGGGAC GTTTATCCGG AGCCCGCACC CTTCCCTCCA ACTTTTACAA CAAAATCAAC 2040 2041 GACAGCCTCC AGTCGCGCTT CCGCCTTGGC CTGAATCTCG AGTGCGTGGA CAAGGATCGC 2100 2101 ATTTCGCAGG TGCGCCTGGC CACCGTCACC AAAATCGTGG GAAAGCGCCT CTTCCTGCGC 2160 2161 TACTTCGATT CCGACGACGG CTTTTGGTGT CACGAGGACT CGCCCATCAT CCATCCAGTT 2220 2221 GGCTGGGCAA CCACAGTAGG CCATAATCTG GCTGCACCGC AGGACTATCT GGAGCGCATG 2280 2281 TTAGCTGGTC GCGAAGCCAT GATTGAGGTT CATGAGGACG ATGCCACAAT CGAGTTGTTT 2340 2341 AAGATGAACT TCACCTTCGA CGAATACTAC AGTGACGGCA AAACCAATAG CTTTGTGGAG 2400 2401 GGCATGAAGC TGGAAGCGGT GGATCCACTC AACCTTTCAT CCATATGCCC GGCTACAGTA 2460 2461 ATGGCGGTTC TTAAGTTCGG ATACATGATG ATACGCATTG ATTCCTACCA ACCGGATGCC 2520 2521 TCAGGGTCGG ATTGGTTCTG TTACCATGAA AAGAGTCCGT GTATCTTTCC GGCTGGATTC 2580 2581 TGTTCCGTCA ACAACATTTC GGTTACCCCA CCGAACGGCT ACGACTCTCG TACATTCACC 2640 2641 TGGGAGGGTT ACCTCCGCGA CACGGGAGCC GTAGCCGCTG GCCAGCATCT ATTTCATCGG 2700 2701 ATTATTCCCG ATCATGGATT TGAGGTGGGT ATGAGTCTGG AGTGTGCAGA TCTCATGGAT 2760 2761 CCCCGACTCG TTTGCGTGGC CACGGTGGCG CGAGTGGTTG GTCGACTACT CAAGGTTCAC 2820 2821 TTTGACGGAT GGACGGATGA GTACGACCAG TGGTTGGATT GCGAATCAGC CGATATATAT 2880 2881 CCAGTCGGAT GGTGTGTACT GGTCAACCAT AAGCTAGAGG GCCCACCGAG AGTAGCACAT 2940 2941 CAGCAGGCCC CGAAACCGGC ACCAAAGCCC AAAATACAGC GAAAGCGAAA GCCCAAAAAG 3000 3001 GGAGCAGCGG GAGGCAAAAC TCCAACCGAT AATAATACTC AGTCGGTCAA ATCGCGTACA 3060 3061 ATTGCGCTCA AGACCACGCC GCACTTACCC AAGCTGAGCA TCAAGCTGGA GCTAAAGCCG 3120 3121 GAGCATCACA ATGCTGCCTT TTACGAGAAC AATCAGCCCG AGGAGGAAGG CGACGAGGAG 3180 3181 GATCCCGATG CGGATGGCGA TGGAGACGGA AGCACCAGCC ACATCTCCGA GCAGTCAACG 3240 3241 ACACAGTCGT CCAGTGATCT GATCGCTGGA TCGGGCAGTG GAAGTGGGTC CGCCTCGCTG 3300 3301 GTAACTCTCG CCACGGGCAG TAACAAAACG AACTCCTCTG CGACGAATAA TAAGTACATT 3360 3361 CCGCGTCTGG CCGACATCGA TTCGAGTGAA CCTCACTTGG AGCTGGTGCC GGATACATGG 3420 3421 AACGTGTACG ACGTATCCCA GTTCTTGCGG GTGAACGATT GCACAGCCCA CTGTGACACG 3480 3481 TTCAGCCGGA ACAAGATCGA CGGAAAGCGA CTCCTGCAGC TGACCAAGGA CGATATCATG 3540 3541 CCACTGTTGG GCATGAAGGT GGGCCCAGCA CTGAAAATTT CCGACCTTAT TGCACAGCTT 3600 3601 AAGTGCAAGG TTAATCCGGG CAGAGCCAGA TCCCACAAGA CCAACAAATC ACCGTTTTTA 3660 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Cellular Component | PcG protein complex | |
Molecular Function | Chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | Methylated histone binding | |
Molecular Function | Zinc ion binding | |
Biological Process | Chromatin silencing | |
Biological Process | Imaginal disc growth | |
Biological Process | Negative regulation of gene expression | |
Biological Process | Oogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Cii-2295 | Ciona intestinalis | 59.34 | 1e-64 | 231 |
| LLPS-Lac-3581 | Latimeria chalumnae | 51.46 | 6e-149 | 473 |
| LLPS-Bot-1244 | Bos taurus | 50.9 | 9e-99 | 341 |
| LLPS-Cis-2053 | Ciona savignyi | 50.22 | 1e-138 | 437 |
| LLPS-Cap-0015 | Cavia porcellus | 49.89 | 1e-139 | 448 |
| LLPS-Man-4061 | Macaca nemestrina | 49.66 | 1e-138 | 445 |
| LLPS-Pat-0675 | Pan troglodytes | 49.66 | 9e-139 | 446 |
| LLPS-Mam-2337 | Macaca mulatta | 49.66 | 1e-138 | 445 |
| LLPS-Poa-2761 | Pongo abelii | 49.66 | 1e-138 | 446 |
| LLPS-Aon-1384 | Aotus nancymaae | 49.66 | 5e-139 | 446 |
| LLPS-Cea-3567 | Cercocebus atys | 49.66 | 1e-138 | 445 |
| LLPS-Chs-2721 | Chlorocebus sabaeus | 49.66 | 1e-138 | 445 |
| LLPS-Mum-0464 | Mus musculus | 49.66 | 8e-138 | 444 |
| LLPS-Maf-3639 | Macaca fascicularis | 49.66 | 2e-138 | 445 |
| LLPS-Mal-0395 | Mandrillus leucophaeus | 49.66 | 2e-139 | 445 |
| LLPS-Leo-1129 | Lepisosteus oculatus | 49.55 | 6e-144 | 460 |
| LLPS-Rhb-1895 | Rhinopithecus bieti | 49.44 | 3e-139 | 447 |
| LLPS-Fia-2862 | Ficedula albicollis | 49.44 | 2e-140 | 451 |
| LLPS-Hos-3052 | Homo sapiens | 49.44 | 6e-138 | 444 |
| LLPS-Pap-2485 | Pan paniscus | 49.44 | 1e-137 | 443 |
| LLPS-Myl-2141 | Myotis lucifugus | 49.44 | 7e-138 | 443 |
| LLPS-Ran-1718 | Rattus norvegicus | 49.44 | 5e-138 | 444 |
| LLPS-Tag-1154 | Taeniopygia guttata | 49.34 | 1e-146 | 464 |
| LLPS-Gaga-4027 | Gallus gallus | 49.34 | 4e-147 | 468 |
| LLPS-Orn-1142 | Oreochromis niloticus | 49.33 | 4e-146 | 466 |
| LLPS-Gog-2120 | Gorilla gorilla | 49.32 | 2e-137 | 442 |
| LLPS-Ova-3309 | Ovis aries | 49.3 | 5e-130 | 422 |
| LLPS-Anp-1580 | Anas platyrhynchos | 49.23 | 7e-147 | 464 |
| LLPS-Orc-3333 | Oryctolagus cuniculus | 49.21 | 5e-138 | 444 |
| LLPS-Ict-2884 | Ictidomys tridecemlineatus | 49.21 | 4e-138 | 444 |
| LLPS-Cas-2475 | Carlito syrichta | 49.21 | 5e-138 | 444 |
| LLPS-Caj-1491 | Callithrix jacchus | 49.21 | 8e-138 | 443 |
| LLPS-Fud-0417 | Fukomys damarensis | 49.21 | 6e-138 | 444 |
| LLPS-Mea-2140 | Mesocricetus auratus | 49.21 | 5e-137 | 441 |
| LLPS-Paa-1346 | Papio anubis | 49.21 | 9e-138 | 443 |
| LLPS-Meg-2258 | Meleagris gallopavo | 49.12 | 2e-146 | 463 |
| LLPS-Dio-2615 | Dipodomys ordii | 49.11 | 9e-138 | 441 |
| LLPS-Sus-2414 | Sus scrofa | 49.1 | 4e-139 | 447 |
| LLPS-Anc-2354 | Anolis carolinensis | 49.01 | 3e-148 | 468 |
| LLPS-Xet-2506 | Xenopus tropicalis | 48.99 | 8e-145 | 460 |
| LLPS-Loa-2541 | Loxodonta africana | 48.98 | 3e-136 | 439 |
| LLPS-Ora-2356 | Ornithorhynchus anatinus | 48.98 | 3e-136 | 440 |
| LLPS-Caf-3271 | Canis familiaris | 48.88 | 3e-138 | 444 |
| LLPS-Mod-4172 | Monodelphis domestica | 48.8 | 4e-89 | 311 |
| LLPS-Scf-3126 | Scleropages formosus | 48.78 | 4e-143 | 457 |
| LLPS-Orl-0975 | Oryzias latipes | 48.77 | 6e-141 | 451 |
| LLPS-Xim-1036 | Xiphophorus maculatus | 48.77 | 2e-142 | 454 |
| LLPS-Otg-2930 | Otolemur garnettii | 48.76 | 8e-138 | 443 |
| LLPS-Pes-2906 | Pelodiscus sinensis | 48.68 | 1e-143 | 457 |
| LLPS-Fec-3949 | Felis catus | 48.65 | 9e-137 | 441 |
| LLPS-Urm-0963 | Ursus maritimus | 48.65 | 2e-137 | 442 |
| LLPS-Eqc-0462 | Equus caballus | 48.65 | 7e-137 | 441 |
| LLPS-Aim-3869 | Ailuropoda melanoleuca | 48.65 | 1e-137 | 443 |
| LLPS-Mup-2226 | Mustela putorius furo | 48.65 | 5e-138 | 444 |
| LLPS-Scm-0344 | Scophthalmus maximus | 48.55 | 9e-143 | 456 |
| LLPS-Tut-2330 | Tursiops truncatus | 48.44 | 6e-142 | 452 |
| LLPS-Sah-0990 | Sarcophilus harrisii | 48.21 | 4e-142 | 452 |
| LLPS-Dar-0374 | Danio rerio | 48.11 | 1e-141 | 453 |
| LLPS-Tar-3275 | Takifugu rubripes | 48.11 | 2e-141 | 453 |
| LLPS-Nol-3218 | Nomascus leucogenys | 48.0 | 4e-141 | 449 |
| LLPS-Pof-3828 | Poecilia formosa | 47.99 | 3e-137 | 435 |
| LLPS-Ten-2746 | Tetraodon nigroviridis | 47.87 | 3e-142 | 452 |
| LLPS-Asm-0725 | Astyanax mexicanus | 47.58 | 7e-140 | 449 |
| LLPS-Gaa-3578 | Gasterosteus aculeatus | 47.34 | 2e-120 | 387 |
| LLPS-Icp-3009 | Ictalurus punctatus | 47.12 | 4e-139 | 446 |
| LLPS-Ere-0072 | Erinaceus europaeus | 46.27 | 2e-07 | 59.3 |
| LLPS-Cae-0331 | Caenorhabditis elegans | 27.63 | 3e-38 | 157 |