LLPS-Drm-2145
spartin

▼ OVERVIEW

Status: Unreviewed
Protein Name: Protein spartin
Gene Name: spartin, CG12001
Ensembl Gene: FBgn0037265
Ensembl Protein: FBpp0078501
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

During postembryonic development, functions with endocytic adapter Eps-15 in neurons to restrain synaptic growth, by inhibiting BMP signaling, and to control synaptic endocytosis. Required presynaptically for neuromuscular junction (NMJ) neurotransmission. Inhibits neuronal BMP signaling by promoting endocytic internalization and subsequent endosomal trafficking of the BMP receptor wit. In this way, regulates the Fmr1 translational regulator controlling Futsch expression to modulate neuronal microtubule stability, which controls both synaptogenesis and neuronal survival.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAEEESEFLE  AYAGIRTAYK  AAMTQVDLAV  SHEEQESPGQ  AIVAYELALR  MIEDTFGIPV  60
61    GLPNKIDTVQ  AEWNDACALI  QKLKSAETEL  RYRLKVLRSQ  KQSIDDSAVE  ATEESRAEMD  120
121   TKRPPLLAEN  PSTQYGIANA  SGAPKTYREL  AAGLRELLAV  RDAKVLLDEL  FRAQVKMYRI  180
181   EASGSVTTIS  GSSTMSLVMC  TVGGKWKYLS  GIYFIQCSMP  NEGTAGIWLY  PLVPSITNCY  240
241   QTEYGAFIFP  DMECQQPGNA  FGLMLTKEGQ  TSRTEDELED  LQQFFLDLLE  AVLAGTVVQL  300
301   KSPTSQRAGL  ASDTVSGSEQ  VSRHIVSAAD  FIASNLVRGA  EKTGGFMLRS  TPYIISKMTP  360
361   ASMDAQVPSS  VQTSVEVAQK  VTHAAAGMTG  WIAGKVGTAS  MAVGRYLAPH  IQEQGSKLLQ  420
421   KGFGYDTSEA  NSTMEGAMTI  AAGAVEGVST  VFDGLETSAK  ILGSSLSENS  VKIIEHKYGQ  480
481   QTGNLASGTF  DTVGNVFVVS  QNVNYITPKG  IAKKMVKRTG  EAVVSDYKRD  LRKSESHYIN  540
541   AGSLYPDLRA  LKE  553
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGAGG  AGGAAAGCGA  ATTCCTGGAG  GCCTATGCTG  GCATCAGAAC  AGCCTACAAA  60
61    GCGGCCATGA  CTCAGGTGGA  CCTGGCCGTA  AGTCACGAGG  AGCAGGAATC  CCCCGGCCAG  120
121   GCCATTGTGG  CCTATGAGCT  GGCCCTGCGT  ATGATAGAGG  ACACCTTCGG  CATTCCAGTA  180
181   GGTCTTCCCA  ACAAGATCGA  CACCGTGCAG  GCGGAGTGGA  ACGACGCCTG  TGCGCTGATC  240
241   CAAAAGCTCA  AGAGCGCCGA  AACGGAATTG  AGATACCGCC  TCAAAGTTCT  GCGATCCCAG  300
301   AAACAATCCA  TTGATGATTC  AGCCGTGGAG  GCCACGGAGG  AAAGTCGAGC  AGAGATGGAT  360
361   ACAAAAAGGC  CGCCGTTGCT  GGCGGAAAAC  CCCTCCACGC  AATATGGCAT  AGCCAATGCT  420
421   AGCGGAGCAC  CAAAAACCTA  CAGAGAGCTC  GCTGCCGGCT  TGCGGGAGCT  CTTGGCTGTT  480
481   CGGGACGCCA  AAGTCTTGCT  CGATGAGCTC  TTCCGTGCAC  AGGTCAAAAT  GTACCGAATC  540
541   GAAGCCAGTG  GATCAGTAAC  CACCATAAGC  GGCTCGTCAA  CTATGTCATT  GGTAATGTGC  600
601   ACCGTGGGTG  GCAAATGGAA  GTACCTCAGT  GGCATCTACT  TCATTCAGTG  CTCCATGCCA  660
661   AATGAGGGGA  CTGCAGGGAT  TTGGCTTTAC  CCCCTGGTTC  CCTCGATCAC  AAACTGCTAC  720
721   CAAACAGAGT  ACGGAGCCTT  TATTTTTCCT  GATATGGAGT  GCCAGCAGCC  GGGCAATGCA  780
781   TTTGGTTTGA  TGCTAACGAA  GGAGGGCCAG  ACATCGCGCA  CGGAGGACGA  ACTGGAGGAT  840
841   CTTCAGCAGT  TCTTTCTTGA  CCTGTTGGAG  GCCGTACTCG  CTGGCACGGT  AGTGCAGCTG  900
901   AAATCGCCGA  CCTCCCAACG  TGCTGGCCTA  GCTTCAGATA  CCGTTTCCGG  GTCGGAGCAG  960
961   GTGTCCAGAC  ACATTGTAAG  TGCGGCTGAT  TTCATTGCTA  GTAACCTGGT  ACGGGGCGCC  1020
1021  GAGAAGACAG  GAGGCTTTAT  GCTTAGGAGT  ACTCCGTATA  TCATTTCCAA  GATGACGCCA  1080
1081  GCCTCGATGG  ATGCTCAGGT  GCCCAGCTCC  GTCCAAACTT  CAGTTGAGGT  GGCCCAAAAA  1140
1141  GTGACGCACG  CCGCAGCCGG  AATGACAGGA  TGGATAGCTG  GAAAGGTGGG  CACTGCTTCA  1200
1201  ATGGCAGTCG  GCCGCTACCT  GGCTCCCCAC  ATTCAGGAGC  AAGGCTCTAA  ACTGCTGCAG  1260
1261  AAGGGATTTG  GCTACGACAC  CAGCGAGGCT  AATAGCACCA  TGGAGGGCGC  CATGACCATC  1320
1321  GCGGCAGGAG  CCGTGGAAGG  AGTGAGCACC  GTATTCGATG  GCCTCGAGAC  TTCCGCCAAG  1380
1381  ATCCTAGGCT  CCAGCCTCAG  TGAAAACTCC  GTCAAGATAA  TCGAACACAA  ATATGGCCAG  1440
1441  CAGACGGGGA  ATCTGGCTAG  TGGCACCTTT  GACACGGTGG  GCAACGTTTT  CGTGGTCAGT  1500
1501  CAGAACGTGA  ACTACATAAC  CCCGAAGGGC  ATTGCCAAGA  AAATGGTCAA  ACGAACAGGA  1560
1561  GAAGCTGTGG  TCAGTGACTA  CAAGCGAGAC  TTACGCAAAT  CGGAATCTCA  TTATATTAAT  1620
1621  GCCGGATCTC  TTTATCCGGA  TCTTCGAGCT  TTGAAGGAA  1659

▼ KEYWORD

ID
Family
Cell junction
Cell membrane
Complete proteome
Developmental protein
Endosome
Lipid droplet
Membrane
Neurodegeneration
Neurogenesis
Reference proteome
RNA editing
Synapse

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cell junction
Cellular Component
Early endosome
Cellular Component
Lipid droplet
Cellular Component
Plasma membrane
Cellular Component
Presynaptic membrane
Cellular Component
Terminal bouton
Molecular Function
Rab GTPase binding
Biological Process
Cell division
Biological Process
Negative regulation of BMP signaling pathway
Biological Process
Negative regulation of synaptic growth at neuromuscular junction
Biological Process
Nervous system development
Biological Process
Neuromuscular synaptic transmission

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Physicochemical
AAindex
Function
CGDB
Localization
COMPARTMENTS
Expression
ArrayExpress

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scf-1234Scleropages formosus34.342e-1995.5
LLPS-Gaga-2160Gallus gallus34.122e-31 132
LLPS-Pes-1880Pelodiscus sinensis34.125e-30 128
LLPS-Meg-3251Meleagris gallopavo34.125e-31 131
LLPS-Mup-1107Mustela putorius furo33.655e-31 132
LLPS-Bot-2343Bos taurus33.651e-30 130
LLPS-Myl-3742Myotis lucifugus33.491e-29 127
LLPS-Ova-4305Ovis aries33.494e-29 125
LLPS-Caf-4467Canis familiaris33.335e-29 125
LLPS-Anp-0146Anas platyrhynchos33.334e-28 123
LLPS-Cas-2630Carlito syrichta33.187e-31 131
LLPS-Eqc-1765Equus caballus33.181e-30 130
LLPS-Urm-0279Ursus maritimus33.184e-30 129
LLPS-Fec-2726Felis catus33.183e-30 129
LLPS-Tut-1465Tursiops truncatus33.181e-30 130
LLPS-Fud-2264Fukomys damarensis33.188e-31 131
LLPS-Caj-2140Callithrix jacchus33.184e-31 132
LLPS-Mea-3719Mesocricetus auratus33.187e-31 131
LLPS-Aon-4669Aotus nancymaae33.182e-30 130
LLPS-Ora-0006Ornithorhynchus anatinus32.925e-2098.2
LLPS-Aim-3606Ailuropoda melanoleuca32.862e-28 124
LLPS-Nol-3157Nomascus leucogenys32.71e-29 127
LLPS-Poa-2864Pongo abelii32.72e-29 127
LLPS-Cap-4639Cavia porcellus32.72e-30 129
LLPS-Pat-4441Pan troglodytes32.71e-29 127
LLPS-Pap-1820Pan paniscus32.71e-29 127
LLPS-Hos-0288Homo sapiens32.71e-29 127
LLPS-Ere-0747Erinaceus europaeus32.78e-2097.1
LLPS-Gog-4765Gorilla gorilla32.72e-29 127
LLPS-Fia-2916Ficedula albicollis32.484e-1892.0
LLPS-Orc-1656Oryctolagus cuniculus32.386e-30 128
LLPS-Lac-0595Latimeria chalumnae32.381e-28 124
LLPS-Ran-1087Rattus norvegicus32.315e-31 132
LLPS-Ict-3108Ictidomys tridecemlineatus32.232e-30 130
LLPS-Mam-4558Macaca mulatta32.231e-29 127
LLPS-Otg-0142Otolemur garnettii32.232e-29 127
LLPS-Rhb-4089Rhinopithecus bieti32.232e-29 127
LLPS-Man-1615Macaca nemestrina32.231e-29 127
LLPS-Paa-2627Papio anubis32.231e-29 127
LLPS-Mal-2496Mandrillus leucophaeus32.231e-29 127
LLPS-Dio-2213Dipodomys ordii32.232e-30 130
LLPS-Maf-4054Macaca fascicularis32.231e-29 127
LLPS-Chs-4414Chlorocebus sabaeus32.231e-29 127
LLPS-Cea-2855Cercocebus atys32.231e-29 127
LLPS-Mum-4796Mus musculus32.132e-29 127
LLPS-Ten-0299Tetraodon nigroviridis31.921e-25 115
LLPS-Pof-4085Poecilia formosa31.751e-26 118
LLPS-Loa-3767Loxodonta africana31.68e-29 125
LLPS-Anc-1311Anolis carolinensis31.432e-29 126
LLPS-Gaa-2487Gasterosteus aculeatus31.163e-26 117
LLPS-Mod-4295Monodelphis domestica31.064e-2098.2
LLPS-Tar-1975Takifugu rubripes31.036e-24 110
LLPS-Tag-2003Taeniopygia guttata30.979e-29 124
LLPS-Sus-3382Sus scrofa30.864e-1892.0
LLPS-Xet-3669Xenopus tropicalis30.81e-26 118
LLPS-Orn-1235Oreochromis niloticus30.665e-25 113
LLPS-Xim-2060Xiphophorus maculatus29.631e-25 114
LLPS-Leo-3016Lepisosteus oculatus28.759e-34 139
LLPS-Orl-0081Oryzias latipes28.717e-33 136
LLPS-Dar-0649Danio rerio28.572e-33 137
LLPS-Scm-2321Scophthalmus maximus28.571e-31 132
LLPS-Sah-3254Sarcophilus harrisii28.341e-34 141
LLPS-Asm-1744Astyanax mexicanus28.032e-32 135
LLPS-Cii-1751Ciona intestinalis27.721e-0652.0
LLPS-Icp-4218Ictalurus punctatus27.652e-31 132
LLPS-Put-0474Puccinia triticina26.292e-0654.3
LLPS-Cae-1764Caenorhabditis elegans19.694e-0963.2