LLPS-Drm-2016
betaTub97EF
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tubulin beta chain |
| Gene Name: | betaTub97EF, 4t, B4t, BETA 98B, beta-Tub, beta-tub, beta-Tub97EF, beta4, beta4t, beta97F, betaTub4, betaTub98BC, betaTub98C, Dmbeta4, Dmel\CG4869, DTB1, T, Tub, Tub2C, CG4869, Dmel_CG4869 |
| Ensembl Gene: | FBgn0003890 |
| Ensembl Protein: | FBpp0289838 |
| Organism: | Drosophila melanogaster |
| Taxa ID: | 7227 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | FBtr0300611 | FBpp0289838 |
| Ensembl | FBtr0334906 | FBpp0306927 |
| UniProt | Q8MST5, Q8MST5_DROME | |
| GeneBank | AE014297, AY118611 | AAM49980.1, ACZ95047.1 |
| RefSeq | NM_001170282.2 | NP_001163753.1 |
| Entrez | 43359 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MREIVHLQAG QCGNQIGSKF WEIISDEHGI DPNGYYHGES ALQHERIDVY YNEASSGKYV 60 61 PRAVLIDLEP GTMDSVRQSP VGQLFRPDNF VYGQSGAGNN WAKGHYTEGA ELIDSVLEVL 120 121 RKESEGCDCL QGFQLAHSLG GGTGSGLGTL LISKIREEYP DRIMNSFSVV PSPKVSEVVV 180 181 EPYNATLSLH QLIVDTDETF CIDNEALYDI CYQSLRICSP TYQDLNHLVS VTMSGVTTCL 240 241 RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTAKGSQQ YRALTVAELT QQMFDAKNMM 300 301 TACDPRHGRY LTVACIFRGP MSMKEVDTQM YNVQSKNSSY FVEWIPNNVK VAVCDIPPRG 360 361 LKMSATFIGN STAIQEIFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLIS 420 421 EYQQYQEATA DDEVEFDDEQ AEQEGYESEV LQNGNGE 457 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGGAAA TTGTGCATCT GCAGGCGGGC CAGTGCGGCA ATCAGATCGG TTCGAAGTTC 60 61 TGGGAAATCA TCTCCGACGA GCACGGCATC GATCCCAATG GTTACTACCA CGGCGAGTCC 120 121 GCCCTGCAGC ACGAGCGGAT CGATGTTTAC TACAACGAGG CCAGCAGCGG GAAGTACGTG 180 181 CCGCGAGCGG TGCTCATCGA CCTGGAGCCG GGCACCATGG ACTCCGTCCG CCAGTCGCCG 240 241 GTGGGCCAGC TTTTCCGGCC AGATAACTTC GTTTACGGAC AGTCGGGAGC CGGCAACAAC 300 301 TGGGCCAAGG GCCATTACAC AGAGGGCGCC GAGCTGATCG ATTCCGTGCT GGAGGTGCTG 360 361 CGCAAGGAAT CCGAGGGCTG CGACTGCCTG CAGGGCTTCC AGCTGGCTCA CTCGCTTGGC 420 421 GGAGGCACTG GCTCCGGCCT GGGCACGCTG CTCATCTCGA AGATTCGCGA GGAGTACCCC 480 481 GACCGCATCA TGAACTCCTT CTCCGTGGTG CCATCGCCCA AGGTATCCGA CACTGTCGTG 540 541 GAGCCGTACA ATGCCACGCT GTCCATCCAC CAGCTGGTGG AGAACACCGA CGAGACATTC 600 601 TGCATTGACA ACGAGGCTCT CTACGACATC TGCTTCCGCA CGCTGAAGCT ATCGTCGCCC 660 661 ACCTACGGCG ATCTGAACCA TCTCGTCTCC GTCACAATGT CCGGAGTGAC CACCTGCCTG 720 721 CGCTTCCCTG GCCAGCTGAA CGCTGATCTT CGCAAGCTGG CGGTGAACAT GGTGCCCTTC 780 781 CCGCGTCTGC ACTTCTTCAT GCCCGGATTC GCTCCGCTGA CCGCCAAGGG ATCCCAGCAA 840 841 TATCGCGCCC TCACGGTGGC CGAGCTGACC CAGCAAATGT TCGATGCCAA AAACATGATG 900 901 ACCGCCTGTG ATCCCCGGCA CGGACGCTAC CTCACCGTGG CCTGCATCTT CCGGGGACCC 960 961 ATGTCCATGA AGGAGGTGGA CACGCAGATG TACAACGTGC AGAGCAAGAA CAGCAGCTAC 1020 1021 TTTGTCGAAT GGATTCCCAA CAACGTCAAG GTGGCCGTCT GCGACATCCC GCCCCGTGGG 1080 1081 CTCAAGATGT CCGCCACCTT CATTGGCAAC TCGACCGCCA TCCAGGAGAT CTTTAAGCGC 1140 1141 ATCTCCGAGC AGTTCACTGC CATGTTCCGG CGCAAGGCCT TCTTGCACTG GTACACCGGC 1200 1201 GAGGGCATGG ACGAGATGGA GTTCACCGAG GCCGAGAGCA ACATGAACGA TCTGATATCC 1260 1261 GAGTACCAAC AGTACCAGGA GGCTACCGCC GACGACGAAG TGGAGTTCGA TGACGAGCAG 1320 1321 GCCGAGCAGG AAGGCTACGA GTCGGAGGTC CTGCAGAACG GCAATGGCGA G 1371 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Microtubule | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | Structural constituent of cytoskeleton | |
Biological Process | Microtubule cytoskeleton organization | |
Biological Process | Microtubule-based process | |
Biological Process | Mitotic cell cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Leo-2361 | Lepisosteus oculatus | 87.67 | 0.0 | 758 |
| LLPS-Anc-1529 | Anolis carolinensis | 87.59 | 0.0 | 752 |
| LLPS-Orn-2508 | Oreochromis niloticus | 87.56 | 0.0 | 749 |
| LLPS-Cii-2095 | Ciona intestinalis | 87.44 | 0.0 | 756 |
| LLPS-Cis-0796 | Ciona savignyi | 87.44 | 0.0 | 756 |
| LLPS-Scm-0259 | Scophthalmus maximus | 87.44 | 0.0 | 755 |
| LLPS-Xet-1448 | Xenopus tropicalis | 87.44 | 0.0 | 757 |
| LLPS-Fud-3138 | Fukomys damarensis | 87.41 | 0.0 | 754 |
| LLPS-Gaga-0553 | Gallus gallus | 87.41 | 0.0 | 754 |
| LLPS-Chs-0448 | Chlorocebus sabaeus | 87.35 | 0.0 | 750 |
| LLPS-Mum-1755 | Mus musculus | 87.35 | 0.0 | 750 |
| LLPS-Maf-3352 | Macaca fascicularis | 87.35 | 0.0 | 750 |
| LLPS-Mea-3878 | Mesocricetus auratus | 87.35 | 0.0 | 750 |
| LLPS-Sah-3322 | Sarcophilus harrisii | 87.35 | 0.0 | 750 |
| LLPS-Caj-2185 | Callithrix jacchus | 87.35 | 0.0 | 750 |
| LLPS-Bot-4278 | Bos taurus | 87.35 | 0.0 | 750 |
| LLPS-Mod-3852 | Monodelphis domestica | 87.35 | 0.0 | 750 |
| LLPS-Fec-0114 | Felis catus | 87.35 | 0.0 | 750 |
| LLPS-Lac-4047 | Latimeria chalumnae | 87.35 | 0.0 | 750 |
| LLPS-Hos-2792 | Homo sapiens | 87.35 | 0.0 | 750 |
| LLPS-Man-4381 | Macaca nemestrina | 87.35 | 0.0 | 750 |
| LLPS-Cap-3489 | Cavia porcellus | 87.35 | 0.0 | 750 |
| LLPS-Caf-3592 | Canis familiaris | 87.35 | 0.0 | 750 |
| LLPS-Mam-0567 | Macaca mulatta | 87.35 | 0.0 | 750 |
| LLPS-Ict-2948 | Ictidomys tridecemlineatus | 87.35 | 0.0 | 750 |
| LLPS-Gaa-1346 | Gasterosteus aculeatus | 87.32 | 0.0 | 748 |
| LLPS-Pof-3559 | Poecilia formosa | 87.32 | 0.0 | 747 |
| LLPS-Icp-0893 | Ictalurus punctatus | 87.21 | 0.0 | 755 |
| LLPS-Asm-3759 | Astyanax mexicanus | 87.21 | 0.0 | 755 |
| LLPS-Dar-4256 | Danio rerio | 87.21 | 0.0 | 756 |
| LLPS-Scf-3711 | Scleropages formosus | 87.12 | 0.0 | 749 |
| LLPS-Xim-1769 | Xiphophorus maculatus | 86.98 | 0.0 | 753 |
| LLPS-Tut-2274 | Tursiops truncatus | 86.74 | 0.0 | 753 |
| LLPS-Dio-3707 | Dipodomys ordii | 86.74 | 0.0 | 753 |
| LLPS-Ran-2690 | Rattus norvegicus | 86.74 | 0.0 | 753 |
| LLPS-Aim-3912 | Ailuropoda melanoleuca | 86.74 | 0.0 | 753 |
| LLPS-Mup-4432 | Mustela putorius furo | 86.74 | 0.0 | 753 |
| LLPS-Paa-4095 | Papio anubis | 86.74 | 0.0 | 753 |
| LLPS-Pes-0306 | Pelodiscus sinensis | 86.74 | 0.0 | 753 |
| LLPS-Orc-0320 | Oryctolagus cuniculus | 86.74 | 0.0 | 753 |
| LLPS-Fia-0318 | Ficedula albicollis | 86.74 | 0.0 | 753 |
| LLPS-Cas-3644 | Carlito syrichta | 86.74 | 0.0 | 753 |
| LLPS-Tag-2634 | Taeniopygia guttata | 86.74 | 0.0 | 754 |
| LLPS-Nol-3061 | Nomascus leucogenys | 86.74 | 0.0 | 753 |
| LLPS-Rhb-2745 | Rhinopithecus bieti | 86.65 | 0.0 | 746 |
| LLPS-Ora-3257 | Ornithorhynchus anatinus | 86.51 | 0.0 | 750 |
| LLPS-Sus-2521 | Sus scrofa | 86.51 | 0.0 | 750 |
| LLPS-Cea-0167 | Cercocebus atys | 86.51 | 0.0 | 750 |
| LLPS-Orl-0208 | Oryzias latipes | 86.51 | 0.0 | 749 |
| LLPS-Gog-4560 | Gorilla gorilla | 86.51 | 0.0 | 750 |
| LLPS-Ere-0293 | Erinaceus europaeus | 86.51 | 0.0 | 746 |
| LLPS-Myl-4418 | Myotis lucifugus | 86.51 | 0.0 | 748 |
| LLPS-Mal-1974 | Mandrillus leucophaeus | 86.51 | 0.0 | 750 |
| LLPS-Eqc-3902 | Equus caballus | 86.48 | 0.0 | 744 |
| LLPS-Aon-3799 | Aotus nancymaae | 86.42 | 0.0 | 744 |
| LLPS-Pap-1145 | Pan paniscus | 86.42 | 0.0 | 744 |
| LLPS-Pat-0017 | Pan troglodytes | 86.42 | 0.0 | 744 |
| LLPS-Otg-1654 | Otolemur garnettii | 86.42 | 0.0 | 744 |
| LLPS-Tar-2601 | Takifugu rubripes | 86.28 | 0.0 | 751 |
| LLPS-Ten-2857 | Tetraodon nigroviridis | 86.18 | 0.0 | 744 |
| LLPS-Ova-2492 | Ovis aries | 86.01 | 0.0 | 746 |
| LLPS-Urm-3705 | Ursus maritimus | 86.01 | 0.0 | 746 |
| LLPS-Poa-2450 | Pongo abelii | 86.01 | 0.0 | 746 |
| LLPS-Cae-1854 | Caenorhabditis elegans | 85.59 | 0.0 | 759 |
| LLPS-Loa-1332 | Loxodonta africana | 84.92 | 0.0 | 736 |
| LLPS-Php-1447 | Physcomitrella patens | 80.7 | 0.0 | 704 |
| LLPS-Sem-0031 | Selaginella moellendorffii | 78.82 | 0.0 | 706 |