LLPS-Drm-1663
Eaf

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ell-associated factor Eaf
Gene Name: Eaf, CG11166
Ensembl Gene: FBgn0033166
Ensembl Protein: FBpp0088081
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Cajal bodyPredicted from orthologs(View)

▼ FUNCTION

Promotes transcriptional elongation by Su(Tpl)/ELL. Essential for development.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MMMTKQKNSL  AERLNIGEEV  RELKLGATFN  PKNTSTAFHT  IKYDFKPASV  DTSRMASVDV  60
61    GSNNQVTVTV  PNSESSGVPH  TVYKGNQREY  AKECLMIYDK  ETGAITIEKL  NHNIQVKKTR  120
121   NEVTNKSVQL  PGQNMGQPHN  QGANGAAPVA  VPVPGQGSGT  APKMENSTMR  ISTKTKVSTG  180
181   SRRNNIIDFK  PRNSPMQQNS  PSRPVPVHRS  PQSAPAWDAN  NAQQTLPSIP  LITDDDDFGL  240
241   RAALHNSGHG  NTSGTAAGQP  DFGSTSSSTH  IGKQRQAPPH  GHGKRQQMHQ  RLSPPMAQQQ  300
301   QPSNYGRGYN  GGHNHAQQQQ  HHQRNSPQQQ  RPSAYGHGNS  MPIDVDSSRE  HELTSQSVAQ  360
361   AAAALEQQIG  GALSASSSSS  ESDSSDSDSG  SDSDDSTEDD  RSTQGQQQDH  QQQQQQQHQV  420
421   YQNHKHTQQQ  VAQQHHNQLP  NLGLGSISPA  YGSSHQQQHQ  QQMLPHQQKQ  KQQSGIYASN  480
481   GGFPNDFLQN  DLQLSSNSSD  DDDD  504
Nucleotide CDS Sequence (FASTA)
1     ATGATGATGA  CCAAACAGAA  GAATTCGCTG  GCCGAGCGCC  TCAACATCGG  TGAGGAGGTG  60
61    CGGGAACTGA  AGCTGGGCGC  CACCTTCAAC  CCGAAGAACA  CCTCGACCGC  CTTTCACACT  120
121   ATCAAATATG  ACTTCAAGCC  AGCGAGCGTG  GACACCAGCC  GCATGGCATC  TGTGGACGTC  180
181   GGCTCCAACA  ATCAAGTTAC  TGTTACCGTG  CCAAATTCTG  AAAGTTCCGG  AGTGCCTCAT  240
241   ACAGTTTATA  AGGGAAATCA  GAGAGAGTAT  GCAAAGGAGT  GTTTGATGAT  CTACGACAAG  300
301   GAGACGGGCG  CCATCACCAT  AGAAAAGCTA  AACCACAATA  TTCAAGTGAA  GAAGACCAGG  360
361   AATGAAGTCA  CCAACAAGTC  AGTCCAGCTG  CCTGGTCAGA  ACATGGGTCA  GCCCCACAAT  420
421   CAGGGTGCGA  ACGGAGCGGC  ACCAGTCGCG  GTCCCGGTAC  CTGGTCAAGG  CTCGGGAACG  480
481   GCACCCAAAA  TGGAGAATAG  CACCATGCGA  ATCTCAACCA  AGACGAAGGT  TTCTACCGGC  540
541   AGCCGTAGAA  ACAATATTAT  TGACTTCAAG  CCGCGCAATT  CGCCAATGCA  ACAGAACTCA  600
601   CCATCGCGTC  CAGTGCCAGT  CCACCGCAGT  CCCCAATCTG  CGCCGGCTTG  GGATGCTAAC  660
661   AATGCACAGC  AGACGCTGCC  CAGCATTCCC  CTGATCACCG  ACGACGACGA  CTTTGGGTTG  720
721   AGAGCCGCCC  TGCACAACAG  CGGACATGGG  AATACGTCAG  GCACCGCGGC  AGGTCAACCG  780
781   GATTTCGGAT  CTACGTCCTC  GTCCACGCAC  ATTGGCAAGC  AGCGGCAGGC  TCCTCCGCAT  840
841   GGCCATGGAA  AGCGCCAGCA  GATGCACCAG  CGCCTCAGCC  CACCAATGGC  TCAGCAGCAG  900
901   CAGCCATCTA  ACTATGGGCG  TGGTTACAAT  GGCGGCCACA  ACCACGCACA  ACAGCAGCAG  960
961   CACCATCAAC  GCAACTCGCC  GCAGCAGCAG  CGTCCTTCTG  CCTATGGCCA  CGGCAATAGC  1020
1021  ATGCCCATAG  ACGTGGACTC  GAGCAGGGAG  CATGAACTGA  CCTCGCAGTC  CGTGGCGCAA  1080
1081  GCGGCTGCCG  CCTTGGAACA  GCAAATTGGC  GGTGCACTGA  GTGCATCGAG  CTCCAGTTCG  1140
1141  GAGTCGGATT  CCAGCGACAG  TGACAGCGGT  AGCGACTCGG  ATGACAGCAC  AGAGGACGAT  1200
1201  CGCTCCACGC  AGGGCCAACA  GCAGGATCAC  CAGCAGCAGC  AGCAGCAGCA  GCATCAGGTC  1260
1261  TATCAGAATC  ACAAACACAC  TCAACAGCAG  GTGGCGCAGC  AGCACCATAA  TCAGCTGCCC  1320
1321  AACCTGGGCC  TCGGCTCCAT  ATCACCAGCA  TATGGCAGCA  GTCATCAACA  GCAGCATCAG  1380
1381  CAGCAGATGC  TTCCACATCA  ACAGAAACAG  AAGCAACAGT  CCGGCATTTA  TGCGTCCAAT  1440
1441  GGTGGCTTTC  CAAACGATTT  CCTACAAAAC  GATCTGCAGT  TGTCGTCAAA  TTCGTCCGAC  1500
1501  GATGACGACG  AC  1512

▼ KEYWORD

ID
Family
Activator
Alternative splicing
Complete proteome
Developmental protein
Nucleus
Phosphoprotein
Reference proteome
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
ELL-EAF complex
Cellular Component
Nucleoplasm
Cellular Component
Transcription elongation factor complex
Biological Process
Multicellular organism development
Biological Process
Positive regulation of transcription, DNA-templated
Biological Process
Regulation of DNA-templated transcription in response to stress
Biological Process
Wound healing

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Leo-3902Lepisosteus oculatus54.03e-28 117
LLPS-Mum-2136Mus musculus53.921e-27 115
LLPS-Urm-1777Ursus maritimus53.922e-27 114
LLPS-Aim-1313Ailuropoda melanoleuca52.945e-27 113
LLPS-Orl-1409Oryzias latipes52.882e-28 118
LLPS-Icp-3959Ictalurus punctatus52.884e-28 117
LLPS-Asm-4027Astyanax mexicanus52.883e-28 117
LLPS-Scf-4146Scleropages formosus52.882e-28 117
LLPS-Tar-1303Takifugu rubripes52.881e-28 118
LLPS-Xim-4032Xiphophorus maculatus52.884e-28 117
LLPS-Scm-3910Scophthalmus maximus52.883e-28 117
LLPS-Pof-2306Poecilia formosa52.884e-28 117
LLPS-Dar-1497Danio rerio52.882e-28 117
LLPS-Ten-1954Tetraodon nigroviridis52.887e-29 119
LLPS-Mea-3767Mesocricetus auratus52.831e-27 115
LLPS-Myl-2818Myotis lucifugus52.832e-27 114
LLPS-Ran-0121Rattus norvegicus52.832e-27 115
LLPS-Orc-2891Oryctolagus cuniculus52.835e-28 116
LLPS-Anp-0997Anas platyrhynchos52.635e-1887.8
LLPS-Pes-3099Pelodiscus sinensis52.177e-0856.6
LLPS-Fia-2089Ficedula albicollis51.953e-1888.2
LLPS-Aon-2695Aotus nancymaae51.891e-26 112
LLPS-Caj-2306Callithrix jacchus51.898e-27 113
LLPS-Bot-2747Bos taurus51.892e-27 115
LLPS-Mup-2720Mustela putorius furo51.892e-27 114
LLPS-Otg-0661Otolemur garnettii51.895e-27 114
LLPS-Caf-2364Canis familiaris51.892e-27 115
LLPS-Dio-2470Dipodomys ordii51.354e-28 117
LLPS-Ict-1960Ictidomys tridecemlineatus51.358e-28 116
LLPS-Cas-2371Carlito syrichta50.886e-27 114
LLPS-Sah-1826Sarcophilus harrisii50.68e-1990.1
LLPS-Sus-0083Sus scrofa50.451e-27 115
LLPS-Fec-4231Felis catus50.452e-27 115
LLPS-Loa-0799Loxodonta africana50.424e-29 119
LLPS-Cis-0738Ciona savignyi50.01e-23 103
LLPS-Cii-1259Ciona intestinalis50.02e-24 105
LLPS-Ova-1789Ovis aries50.01e-27 115
LLPS-Lac-1784Latimeria chalumnae50.01e-26 112
LLPS-Mod-2669Monodelphis domestica50.05e-26 110
LLPS-Anc-2919Anolis carolinensis50.03e-26 112
LLPS-Gaga-2833Gallus gallus50.01e-26 112
LLPS-Maf-0771Macaca fascicularis49.581e-27 115
LLPS-Man-1190Macaca nemestrina49.581e-27 115
LLPS-Pat-1328Pan troglodytes49.586e-27 114
LLPS-Pap-0233Pan paniscus49.585e-27 114
LLPS-Mam-0768Macaca mulatta49.581e-27 115
LLPS-Chs-3902Chlorocebus sabaeus49.578e-27 113
LLPS-Fud-0678Fukomys damarensis49.572e-27 115
LLPS-Cap-1288Cavia porcellus49.562e-28 118
LLPS-Ere-1023Erinaceus europaeus49.043e-25 108
LLPS-Cea-0800Cercocebus atys48.749e-27 113
LLPS-Gog-2716Gorilla gorilla48.741e-26 113
LLPS-Paa-3249Papio anubis48.747e-27 113
LLPS-Mal-1141Mandrillus leucophaeus48.747e-27 113
LLPS-Hos-1183Homo sapiens48.747e-27 113
LLPS-Poa-0154Pongo abelii48.745e-27 114
LLPS-Nol-2144Nomascus leucogenys48.749e-27 113
LLPS-Xet-1063Xenopus tropicalis48.112e-22 100
LLPS-Rhb-0946Rhinopithecus bieti47.93e-26 111
LLPS-Gaa-1666Gasterosteus aculeatus47.752e-26 112
LLPS-Orn-2473Oreochromis niloticus47.753e-26 111
LLPS-Ora-0931Ornithorhynchus anatinus46.996e-1787.0
LLPS-Meg-2369Meleagris gallopavo46.851e-25 110
LLPS-Eqc-2630Equus caballus46.856e-25 109
LLPS-Tag-3561Taeniopygia guttata45.956e-25 108
LLPS-Cae-1443Caenorhabditis elegans39.839e-1681.3
LLPS-Lep-1813Leersia perrieri33.044e-0859.3
LLPS-Dac-1452Daucus carota32.321e-0757.8
LLPS-Ori-1732Oryza indica31.861e-0860.5
LLPS-Orb-2420Oryza barthii31.861e-0860.5
LLPS-Orni-2303Oryza nivara31.861e-0860.5
LLPS-Orgl-2408Oryza glumaepatula31.861e-0860.8
LLPS-Orp-1408Oryza punctata31.862e-0860.5
LLPS-Ors-2303Oryza sativa31.861e-0860.5
LLPS-Orr-1062Oryza rufipogon31.861e-0860.5
LLPS-Orm-0045Oryza meridionalis31.862e-0860.5
LLPS-Sob-1205Sorghum bicolor30.974e-0859.3
LLPS-Zem-2406Zea mays30.973e-0859.3
LLPS-Sol-2006Solanum lycopersicum28.574e-0652.8