DrLLPS - Data resource of LLPS

LLPS-Drm-1355
Dmel\CG2540

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Gamma-glutamylcyclotransferase
Gene Name:	Dmel\CG2540, CG2540, Dmel_CG2540
Ensembl Gene:	FBgn0030411
Ensembl Protein:	FBpp0073508
Organism:	Drosophila melanogaster
Taxa ID:	7227
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0324	P32656	Client	Stress granule	30.57	2e-22	97.4

▼ FUNCTION

Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	FBtr0073675	FBpp0073508
UniProt		Q9VYK7, Q9VYK7_DROME
GeneBank	AE014298, AY119542	AAF48185.1, AAM50196.1
RefSeq	NM_132590.3	NP_572818.1
Entrez	32216

▼ SEQUENCE

Protein Sequence (FASTA)
1 MLDFLTELRS SGSRADQLPG NIYTEFFANV IEEPREHGCK SADQDFTQGF SMLRTFDTEN 60 61 SNQLEPPAAT DADVWIFGYG SLVWKTDFPY IDRRRGFVWG FKRRFYQHSI DHRGIPERPG 120 121 RVVTLLPGDP AQDRVYGVAY RIAASQKGAV LDHLDYREKN GYERCSLEFH EYPTDGAEPI 180 181 QVIMYVATQA NDSYAGDVWQ VPCIARQIFS SAGPSGPNRE YLFNLAAAMD QLFPGAVDEH 240 241 LEELVACVKR YIVEDEPQLI RHALLHEISG ILEEEQLAEQ AHQLEKLLER CQKPGGREWL 300 301 IYAALQAKNK S 311
Nucleotide CDS Sequence (FASTA)
1 ATGTTGGACT TCCTGACGGA GCTGCGAAGC AGTGGTTCTA GGGCGGATCA GCTGCCCGGC 60 61 AACATATACA CCGAGTTCTT CGCGAACGTT ATCGAGGAGC CCAGGGAACA TGGATGCAAG 120 121 TCAGCGGATC AGGATTTTAC ACAAGGATTC TCCATGCTAC GCACTTTCGA TACCGAAAAT 180 181 AGCAATCAAT TGGAGCCGCC GGCGGCCACG GATGCGGATG TCTGGATCTT TGGCTATGGG 240 241 TCGTTGGTAT GGAAGACGGA CTTCCCGTAC ATAGACCGAC GACGCGGCTT CGTTTGGGGA 300 301 TTCAAGCGTC GCTTCTACCA GCACAGCATC GATCACCGGG GTATTCCCGA ACGTCCTGGT 360 361 CGCGTGGTCA CCCTGCTGCC AGGCGATCCC GCCCAGGATC GTGTCTATGG CGTCGCCTAT 420 421 CGCATAGCTG CTAGTCAAAA GGGTGCTGTG TTGGACCATC TGGATTACCG GGAGAAGAAC 480 481 GGGTATGAGC GCTGCAGCTT GGAGTTCCAC GAGTATCCGA CTGACGGTGC AGAACCCATC 540 541 CAAGTGATCA TGTACGTGGC CACGCAGGCG AACGATTCCT ATGCTGGTGA TGTGTGGCAA 600 601 GTTCCCTGTA TTGCGAGGCA AATCTTCAGC TCGGCCGGTC CCAGTGGCCC CAATCGCGAA 660 661 TACCTATTCA ACCTGGCCGC CGCCATGGAT CAGCTCTTTC CGGGAGCTGT AGACGAGCAT 720 721 CTCGAAGAAC TGGTTGCTTG CGTTAAGCGT TACATTGTCG AGGATGAGCC CCAGTTAATA 780 781 CGCCATGCGC TGTTGCATGA GATTTCCGGT ATTCTGGAGG AGGAACAGCT AGCGGAGCAG 840 841 GCACACCAGC TGGAGAAGCT TTTGGAGCGA TGTCAGAAAC CTGGCGGCCG CGAGTGGTTG 900 901 ATCTACGCTG CACTGCAAGC TAAAAACAAG TCG 933

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0456	Lyase
KW-1185	Reference proteome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0003839	Molecular Function	Gamma-glutamylcyclotransferase activity
GO:0061928	Molecular Function	Glutathione specific gamma-glutamylcyclotransferase activity
GO:0006751	Biological Process	Glutathione catabolic process

▼ KEGG

dme:Dmel_CG2540

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	Gene3D

Interaction
HINT	RAIN	Mentha	PINA	IID
iRefIndex	MIST

Physicochemical
AAindex

Localization
COMPARTMENTS

Element
microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Eqc-4316	Equus caballus	50.28	2e-48	166
LLPS-Cii-1386	Ciona intestinalis	50.28	4e-47	163
LLPS-Ova-4244	Ovis aries	50.28	1e-47	164
LLPS-Dar-4182	Danio rerio	49.72	5e-48	165
LLPS-Mod-1434	Monodelphis domestica	49.7	2e-44	156
LLPS-Urm-3930	Ursus maritimus	49.15	5e-47	162
LLPS-Tag-1026	Taeniopygia guttata	48.89	2e-48	166
LLPS-Caj-3340	Callithrix jacchus	48.89	1e-46	162
LLPS-Myl-1138	Myotis lucifugus	48.6	1e-44	157
LLPS-Pat-2696	Pan troglodytes	48.59	2e-45	159
LLPS-Pap-0470	Pan paniscus	48.59	2e-45	159
LLPS-Hos-4779	Homo sapiens	48.59	2e-45	159
LLPS-Man-3659	Macaca nemestrina	48.59	1e-45	159
LLPS-Nol-0629	Nomascus leucogenys	48.59	7e-46	160
LLPS-Poa-3538	Pongo abelii	48.59	1e-45	159
LLPS-Mam-2059	Macaca mulatta	48.59	1e-45	159
LLPS-Gog-4288	Gorilla gorilla	48.59	2e-45	159
LLPS-Maf-3874	Macaca fascicularis	48.59	1e-45	159
LLPS-Chs-4581	Chlorocebus sabaeus	48.59	2e-45	159
LLPS-Aon-0511	Aotus nancymaae	48.59	6e-46	160
LLPS-Cea-4217	Cercocebus atys	48.59	2e-45	159
LLPS-Cis-0175	Ciona savignyi	48.59	1e-45	159
LLPS-Mal-2486	Mandrillus leucophaeus	48.59	2e-45	159
LLPS-Mup-3589	Mustela putorius furo	48.59	4e-46	160
LLPS-Asm-0566	Astyanax mexicanus	48.35	4e-49	168
LLPS-Pes-0492	Pelodiscus sinensis	48.33	7e-47	162
LLPS-Icp-0121	Ictalurus punctatus	48.33	2e-47	164
LLPS-Scm-0522	Scophthalmus maximus	48.31	5e-49	169
LLPS-Gaga-2072	Gallus gallus	48.13	1e-46	162
LLPS-Fec-0584	Felis catus	48.02	5e-46	160
LLPS-Sah-3721	Sarcophilus harrisii	48.02	3e-44	155
LLPS-Ere-0251	Erinaceus europaeus	48.02	9e-45	157
LLPS-Fud-2425	Fukomys damarensis	47.8	4e-46	160
LLPS-Otg-0545	Otolemur garnettii	47.46	5e-45	157
LLPS-Loa-3664	Loxodonta africana	47.46	1e-44	156
LLPS-Mea-1715	Mesocricetus auratus	47.46	2e-45	158
LLPS-Mum-3508	Mus musculus	47.46	1e-45	159
LLPS-Ran-2792	Rattus norvegicus	47.46	8e-46	159
LLPS-Rhb-2009	Rhinopithecus bieti	47.28	6e-46	160
LLPS-Sus-3902	Sus scrofa	47.28	2e-46	161
LLPS-Cas-2903	Carlito syrichta	47.22	5e-46	160
LLPS-Aim-3048	Ailuropoda melanoleuca	47.22	3e-45	158
LLPS-Caf-2942	Canis familiaris	47.03	1e-45	159
LLPS-Anp-2061	Anas platyrhynchos	47.02	4e-31	120
LLPS-Cap-3697	Cavia porcellus	46.7	1e-44	156
LLPS-Dio-3476	Dipodomys ordii	46.7	7e-45	157
LLPS-Pof-3207	Poecilia formosa	46.59	2e-46	161
LLPS-Xim-2515	Xiphophorus maculatus	46.59	4e-46	160
LLPS-Ict-0354	Ictidomys tridecemlineatus	46.2	4e-45	157
LLPS-Ten-3112	Tetraodon nigroviridis	46.02	1e-42	151
LLPS-Scf-3225	Scleropages formosus	46.02	4e-43	152
LLPS-Anc-0424	Anolis carolinensis	45.6	5e-47	166
LLPS-Orn-4070	Oreochromis niloticus	45.45	3e-47	163
LLPS-Gaa-2843	Gasterosteus aculeatus	45.45	2e-43	154
LLPS-Xet-3827	Xenopus tropicalis	45.0	1e-42	151
LLPS-Mao-0817	Magnaporthe oryzae	44.9	5e-40	146
LLPS-Orc-2357	Oryctolagus cuniculus	44.85	9e-46	162
LLPS-Tar-0676	Takifugu rubripes	44.81	1e-45	159
LLPS-Cog-0723	Colletotrichum gloeosporioides	44.67	4e-27	110
LLPS-Trr-1387	Trichoderma reesei	44.26	1e-33	127
LLPS-Bot-0457	Bos taurus	44.07	2e-41	148
LLPS-Leo-2763	Lepisosteus oculatus	43.78	2e-44	156
LLPS-Gag-0501	Gaeumannomyces graminis	43.63	4e-40	147
LLPS-Thc-1736	Theobroma cacao	43.23	1e-36	135
LLPS-Brr-1014	Brassica rapa	43.09	5e-36	134
LLPS-Bro-1708	Brassica oleracea	43.09	2e-36	135
LLPS-Brn-1421	Brassica napus	43.09	1e-34	130
LLPS-Coc-0560	Corchorus capsularis	42.86	1e-36	135
LLPS-Prp-0706	Prunus persica	42.86	1e-36	137
LLPS-Lac-1047	Latimeria chalumnae	42.71	2e-42	151
LLPS-Osl-0717	Ostreococcus lucimarinus	42.49	4e-30	118
LLPS-Nec-0333	Neurospora crassa	42.44	2e-37	139
LLPS-Sot-2092	Solanum tuberosum	42.42	4e-31	121
LLPS-Hea-0658	Helianthus annuus	42.39	2e-34	130
LLPS-Viv-2493	Vitis vinifera	42.33	6e-37	136
LLPS-Cogr-0904	Colletotrichum graminicola	42.33	1e-26	109
LLPS-Coo-1626	Colletotrichum orbiculare	42.33	5e-28	113
LLPS-Ors-1462	Oryza sativa	42.16	1e-35	132
LLPS-Org-0939	Oryza glaberrima	42.16	8e-36	133
LLPS-Orni-2316	Oryza nivara	42.16	8e-36	133
LLPS-Orb-1117	Oryza barthii	42.16	8e-36	133
LLPS-Ori-1265	Oryza indica	42.16	8e-36	133
LLPS-Brd-1898	Brachypodium distachyon	42.16	2e-35	132
LLPS-Tra-0465	Triticum aestivum	42.16	1e-35	132
LLPS-Orgl-1373	Oryza glumaepatula	42.16	8e-36	133
LLPS-Art-2994	Arabidopsis thaliana	42.11	1e-35	133
LLPS-Paa-4191	Papio anubis	42.08	9e-33	127
LLPS-Via-1287	Vigna angularis	41.8	2e-34	129
LLPS-Sob-0025	Sorghum bicolor	41.71	1e-34	130
LLPS-Dac-1858	Daucus carota	41.71	1e-35	132
LLPS-Chr-0454	Chlamydomonas reinhardtii	41.71	2e-29	119
LLPS-Mae-2676	Manihot esculenta	41.67	2e-38	140
LLPS-Cym-1147	Cyanidioschyzon merolae	41.67	7e-40	145
LLPS-Amt-2246	Amborella trichopoda	41.49	8e-39	141
LLPS-Tut-1044	Tursiops truncatus	41.38	4e-31	121
LLPS-Phv-2237	Phaseolus vulgaris	41.27	3e-32	124
LLPS-Glm-1604	Glycine max	40.96	3e-34	129
LLPS-Sol-2429	Solanum lycopersicum	40.74	1e-34	130
LLPS-Met-2037	Medicago truncatula	40.53	2e-30	119
LLPS-Arl-2058	Arabidopsis lyrata	40.53	7e-33	126
LLPS-Fus-0802	Fusarium solani	40.51	7e-25	104
LLPS-Gor-1247	Gossypium raimondii	40.49	8e-35	132
LLPS-Fuv-0371	Fusarium verticillioides	40.48	3e-26	108
LLPS-Mel-0184	Melampsora laricipopulina	40.4	5e-36	134
LLPS-Gas-1263	Galdieria sulphuraria	40.31	5e-38	140
LLPS-Fuo-1580	Fusarium oxysporum	40.24	9e-27	109
LLPS-Cus-0763	Cucumis sativus	39.78	2e-34	129
LLPS-Blg-0051	Blumeria graminis	39.67	2e-16	79.0
LLPS-Pug-0256	Puccinia graminis	39.57	2e-27	111
LLPS-Nia-1411	Nicotiana attenuata	39.36	2e-33	127
LLPS-Map-0672	Magnaporthe poae	39.35	7e-29	117
LLPS-Miv-1435	Microbotryum violaceum	39.3	5e-31	121
LLPS-Sem-1534	Selaginella moellendorffii	39.26	2e-29	115
LLPS-Yal-1241	Yarrowia lipolytica	39.09	2e-35	134
LLPS-Orl-3074	Oryzias latipes	38.98	1e-24	103
LLPS-Tum-1545	Tuber melanosporum	38.95	6e-27	109
LLPS-Php-2123	Physcomitrella patens	38.8	1e-28	115
LLPS-Abg-1612	Absidia glauca	38.8	1e-32	125
LLPS-Mua-2468	Musa acuminata	38.59	8e-29	114
LLPS-Trv-1622	Trichoderma virens	38.34	5e-30	119
LLPS-Asni-1587	Aspergillus niger	37.43	1e-21	96.3
LLPS-Pot-0703	Populus trichocarpa	37.14	1e-30	122
LLPS-Ved-0195	Verticillium dahliae	37.1	1e-24	103
LLPS-Zyt-1372	Zymoseptoria tritici	36.95	3e-27	111
LLPS-Scj-1532	Schizosaccharomyces japonicus	36.5	9e-28	113
LLPS-Asn-0617	Aspergillus nidulans	36.36	7e-29	117
LLPS-Asg-0650	Ashbya gossypii	36.14	2e-24	103
LLPS-Phn-1520	Phaeosphaeria nodorum	35.95	4e-30	120
LLPS-Lep-0991	Leersia perrieri	35.54	2e-22	97.8
LLPS-Dos-1464	Dothistroma septosporum	35.41	5e-29	116
LLPS-Aso-0968	Aspergillus oryzae	34.97	1e-15	78.2
LLPS-Cae-1252	Caenorhabditis elegans	34.76	7e-24	102
LLPS-Scc-1598	Schizosaccharomyces cryophilus	34.67	2e-23	100
LLPS-Hov-0469	Hordeum vulgare	34.34	5e-22	96.7
LLPS-Vir-0820	Vigna radiata	34.24	1e-18	86.7
LLPS-Asf-1552	Aspergillus flavus	34.15	3e-09	59.7
LLPS-Tru-1001	Triticum urartu	33.73	2e-21	95.1
LLPS-Zem-2283	Zea mays	33.47	1e-28	115
LLPS-Orbr-2120	Oryza brachyantha	33.33	7e-24	102
LLPS-Scs-0847	Sclerotinia sclerotiorum	33.33	9e-23	98.6
LLPS-Orr-1295	Oryza rufipogon	33.17	1e-22	98.2
LLPS-Scp-0551	Schizosaccharomyces pombe	33.16	3e-22	97.1
LLPS-Asc-1645	Aspergillus clavatus	32.94	5e-12	68.2
LLPS-Sei-1929	Setaria italica	32.8	3e-21	94.4
LLPS-Orp-2095	Oryza punctata	32.04	4e-23	99.8
LLPS-Orm-0479	Oryza meridionalis	32.04	3e-22	97.1
LLPS-Crn-1412	Cryptococcus neoformans	31.75	5e-27	110
LLPS-Ast-1415	Aspergillus terreus	31.5	6e-15	76.6
LLPS-Nef-1463	Neosartorya fischeri	31.44	8e-19	88.2
LLPS-Lem-1045	Leptosphaeria maculans	31.33	4e-18	85.5
LLPS-Asfu-1613	Aspergillus fumigatus	31.3	3e-22	98.6
LLPS-Pytr-1506	Pyrenophora triticirepentis	31.02	1e-13	72.0
LLPS-Sac-0324	Saccharomyces cerevisiae	30.7	3e-22	97.4
LLPS-Kop-0599	Komagataella pastoris	30.34	8e-22	96.3

LLPS-Drm-1355Dmel\CG2540

Protein Sequence

Nucleotide Sequence

LLPS-Drm-1355
Dmel\CG2540