DrLLPS - Data resource of LLPS

LLPS-Drm-0966
SmB

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Small nuclear ribonucleoprotein-associated protein B
Gene Name:	SmB, CG5352
Ensembl Gene:	FBgn0262601
Ensembl Protein:	FBpp0293061
Organism:	Drosophila melanogaster
Taxa ID:	7227
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, Others	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Caenorhabditis elegans	LLPS-Cae-0057	P91918	Regulator	P granule	67.07	2e-32	120
Homo sapiens	LLPS-Hos-0591	P14678	Client	Nucleolus	63.76	6e-48	163

▼ FUNCTION

May have a functional role in pre-mRNA splicing or in snRNP structure. Involved in germline establishment and development.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	FBtr0304118	FBpp0293061
UniProt		Q05856, RSMB_DROME, M9MRL9
GeneBank	AY061171, AE014134, L02919	AAA28858.1, ADV37030.1, AAL28719.1
RefSeq	NM_001201851.2	NP_001188780.1
Entrez	34426

▼ SEQUENCE

Protein Sequence (FASTA)
1 MTIGKNNKMI QHLNYRVRIV LQDSRTFIGT FKAFDKHMNL ILGDCEEFRK IRSKNSKVPE 60 61 REEKRVLGFV LLRGENIVSL TVEGPPPPEE GLPRVPIPGA APGPGIGRVA GRGMPINLSA 120 121 VPAGLQGPVR GVGGPAQQHM APMGRGVPRA PMMGAPPPGM IPGGMPSMPG NMGRGAPPPM 180 181 RGPPPSMIRG APPPGRGGY 199
Nucleotide CDS Sequence (FASTA)
1 ATGACGATCG GCAAGAACAA CAAAATGATT CAGCACCTGA ATTATCGGGT GCGAATCGTG 60 61 CTGCAGGACT CGCGTACCTT CATCGGTACC TTCAAAGCCT TCGACAAACA CATGAACTTG 120 121 ATCCTCGGCG ACTGCGAGGA GTTCCGGAAG ATTCGCTCGA AGAATTCCAA GGTGCCCGAG 180 181 CGCGAGGAGA AGCGCGTGCT GGGCTTTGTA TTGCTGCGCG GCGAGAACAT AGTTTCACTG 240 241 ACGGTGGAGG GACCACCGCC GCCAGAGGAG GGCCTGCCCC GAGTTCCCAT TCCGGGAGCA 300 301 GCTCCTGGTC CGGGAATCGG TCGCGTGGCC GGACGCGGAA TGCCTATCAA CTTGTCCGCC 360 361 GTGCCAGCGG GTCTCCAGGG TCCCGTGAGA GGTGTGGGCG GACCCGCCCA ACAGCACATG 420 421 GCTCCGATGG GACGAGGAGT GCCACGAGCA CCGATGATGG GTGCACCGCC ACCGGGCATG 480 481 ATTCCCGGCG GCATGCCCTC GATGCCAGGA AACATGGGAC GCGGTGCTCC GCCACCGATG 540 541 CGCGGACCGC CGCCCAGCAT GATCCGTGGA GCACCACCAC CGGGCAGGGG TGGCTAT 597

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0488	Methylation
KW-0507	mRNA processing
KW-0508	mRNA splicing
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0677	Repeat
KW-0687	Ribonucleoprotein
KW-0694	RNA-binding
KW-0747	Spliceosome

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0015030	Cellular Component	Cajal body
GO:0071013	Cellular Component	Catalytic step 2 spliceosome
GO:0005737	Cellular Component	Cytoplasm
GO:0005634	Cellular Component	Nucleus
GO:0045495	Cellular Component	Pole plasm
GO:0071011	Cellular Component	Precatalytic spliceosome
GO:0030532	Cellular Component	Small nuclear ribonucleoprotein complex
GO:0005681	Cellular Component	Spliceosomal complex
GO:0005685	Cellular Component	U1 snRNP
GO:0005686	Cellular Component	U2 snRNP
GO:0071004	Cellular Component	U2-type prespliceosome
GO:0005687	Cellular Component	U4 snRNP
GO:0046540	Cellular Component	U4/U6 x U5 tri-snRNP complex
GO:0005682	Cellular Component	U5 snRNP
GO:0003723	Molecular Function	RNA binding
GO:0007281	Biological Process	Germ cell development
GO:0008406	Biological Process	Gonad development
GO:0000398	Biological Process	MRNA splicing, via spliceosome
GO:0007283	Biological Process	Spermatogenesis

▼ KEGG

dme:Dmel_CG5352

▼ ANNOTATION

Disorder
IUPred2A

Domain
PLAAC	SMART	Pfam	InterPro	LCR-eXXXplorer
CDD	Gene3D

Interaction
HINT	RAIN	Mentha	PINA	IID
iRefIndex	MIST

Drug
CTD

Physicochemical
AAindex

Localization
COMPARTMENTS

Expression
ArrayExpress

Element
RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Mea-3717	Mesocricetus auratus	73.08	4e-23	93.6
LLPS-Pat-4533	Pan troglodytes	71.97	1e-37	138
LLPS-Maf-0287	Macaca fascicularis	71.22	5e-40	145
LLPS-Cea-1182	Cercocebus atys	71.22	9e-40	145
LLPS-Man-0150	Macaca nemestrina	71.22	1e-39	144
LLPS-Fia-2462	Ficedula albicollis	71.22	3e-42	148
LLPS-Mam-0493	Macaca mulatta	71.22	8e-40	145
LLPS-Cas-1567	Carlito syrichta	71.22	3e-40	145
LLPS-Tag-1659	Taeniopygia guttata	71.22	1e-42	149
LLPS-Dio-0520	Dipodomys ordii	70.92	5e-42	147
LLPS-Chs-1177	Chlorocebus sabaeus	70.75	1e-45	157
LLPS-Mum-1506	Mus musculus	70.75	1e-45	157
LLPS-Aon-3481	Aotus nancymaae	70.75	2e-45	157
LLPS-Sah-0262	Sarcophilus harrisii	70.75	2e-45	157
LLPS-Gog-2005	Gorilla gorilla	70.75	1e-45	157
LLPS-Caj-2084	Callithrix jacchus	70.75	1e-45	157
LLPS-Bot-2106	Bos taurus	70.75	4e-46	158
LLPS-Ere-0035	Erinaceus europaeus	70.75	3e-45	157
LLPS-Ran-2397	Rattus norvegicus	70.75	1e-45	157
LLPS-Mup-1253	Mustela putorius furo	70.75	1e-45	157
LLPS-Ova-2837	Ovis aries	70.75	1e-45	157
LLPS-Mal-1438	Mandrillus leucophaeus	70.75	2e-45	157
LLPS-Mod-2790	Monodelphis domestica	70.75	3e-46	159
LLPS-Fec-2238	Felis catus	70.75	1e-45	157
LLPS-Pap-0279	Pan paniscus	70.75	1e-45	157
LLPS-Hos-0591	Homo sapiens	70.75	2e-45	157
LLPS-Otg-0215	Otolemur garnettii	70.75	2e-45	157
LLPS-Rhb-1063	Rhinopithecus bieti	70.75	2e-45	157
LLPS-Orc-0945	Oryctolagus cuniculus	70.75	1e-45	157
LLPS-Eqc-2161	Equus caballus	70.75	1e-45	157
LLPS-Cap-1206	Cavia porcellus	70.75	1e-45	157
LLPS-Poa-1139	Pongo abelii	70.75	1e-45	157
LLPS-Caf-1009	Canis familiaris	70.75	1e-45	157
LLPS-Xet-3594	Xenopus tropicalis	70.75	4e-46	159
LLPS-Gaga-0212	Gallus gallus	70.75	1e-46	160
LLPS-Nol-0242	Nomascus leucogenys	70.75	2e-45	157
LLPS-Urm-2541	Ursus maritimus	70.59	1e-39	141
LLPS-Sus-2610	Sus scrofa	70.55	1e-44	155
LLPS-Fud-0976	Fukomys damarensis	70.55	1e-44	155
LLPS-Aim-0086	Ailuropoda melanoleuca	70.55	2e-44	155
LLPS-Paa-1914	Papio anubis	70.55	1e-44	155
LLPS-Pes-0460	Pelodiscus sinensis	70.55	9e-46	157
LLPS-Anc-3082	Anolis carolinensis	70.5	3e-41	145
LLPS-Xim-3008	Xiphophorus maculatus	70.15	3e-39	140
LLPS-Leo-2780	Lepisosteus oculatus	70.07	1e-46	160
LLPS-Icp-1816	Ictalurus punctatus	70.07	5e-47	160
LLPS-Tut-0382	Tursiops truncatus	70.07	4e-46	159
LLPS-Dar-3146	Danio rerio	70.07	5e-47	160
LLPS-Ict-0350	Ictidomys tridecemlineatus	70.07	2e-46	159
LLPS-Myl-2954	Myotis lucifugus	69.86	9e-46	157
LLPS-Loa-4311	Loxodonta africana	69.86	1e-45	157
LLPS-Orl-3456	Oryzias latipes	69.5	3e-42	149
LLPS-Asm-3214	Astyanax mexicanus	69.39	3e-46	159
LLPS-Tar-3642	Takifugu rubripes	69.39	3e-46	158
LLPS-Scf-1187	Scleropages formosus	69.39	3e-46	159
LLPS-Gaa-2792	Gasterosteus aculeatus	69.39	4e-46	158
LLPS-Lac-1988	Latimeria chalumnae	69.39	9e-46	157
LLPS-Scm-1355	Scophthalmus maximus	69.39	3e-46	159
LLPS-Orn-0609	Oreochromis niloticus	69.39	4e-46	158
LLPS-Ten-0739	Tetraodon nigroviridis	69.39	3e-46	159
LLPS-Pof-2441	Poecilia formosa	69.18	3e-45	155
LLPS-Anp-2816	Anas platyrhynchos	69.07	1e-14	73.6
LLPS-Cae-0057	Caenorhabditis elegans	66.67	1e-31	118
LLPS-Cis-0442	Ciona savignyi	65.33	2e-26	104
LLPS-Meg-1329	Meleagris gallopavo	65.07	5e-37	134
LLPS-Cii-1188	Ciona intestinalis	64.0	8e-27	106
LLPS-Viv-0922	Vitis vinifera	57.93	8e-31	119
LLPS-Orp-0453	Oryza punctata	57.81	1e-15	75.9
LLPS-Chr-1029	Chlamydomonas reinhardtii	57.32	4e-20	89.7
LLPS-Amt-0058	Amborella trichopoda	57.32	3e-28	112
LLPS-Zem-1063	Zea mays	57.14	2e-18	85.1
LLPS-Chc-0679	Chondrus crispus	56.79	2e-25	102
LLPS-Gor-1328	Gossypium raimondii	56.76	1e-29	116
LLPS-Arl-0969	Arabidopsis lyrata	56.55	1e-28	113
LLPS-Art-0478	Arabidopsis thaliana	56.55	1e-28	113
LLPS-Orni-1525	Oryza nivara	56.46	6e-18	84.0
LLPS-Orr-1514	Oryza rufipogon	56.46	2e-18	84.7
LLPS-Orm-1001	Oryza meridionalis	56.46	2e-18	84.7
LLPS-Org-1443	Oryza glaberrima	56.46	2e-18	84.7
LLPS-Lep-1231	Leersia perrieri	56.25	2e-15	74.7
LLPS-Thc-0469	Theobroma cacao	56.08	3e-29	115
LLPS-Mae-1800	Manihot esculenta	56.08	1e-29	116
LLPS-Brn-0785	Brassica napus	55.86	2e-29	115
LLPS-Brr-1540	Brassica rapa	55.86	1e-28	112
LLPS-Bro-1724	Brassica oleracea	55.86	2e-29	114
LLPS-Sei-0175	Setaria italica	55.78	5e-18	84.0
LLPS-Sob-1607	Sorghum bicolor	55.78	3e-18	84.3
LLPS-Prp-0043	Prunus persica	55.56	1e-29	116
LLPS-Sol-0045	Solanum lycopersicum	55.47	9e-25	100
LLPS-Glm-0111	Glycine max	55.41	1e-29	116
LLPS-Via-0776	Vigna angularis	55.41	1e-29	115
LLPS-Vir-1366	Vigna radiata	55.41	1e-29	116
LLPS-Pot-2028	Populus trichocarpa	55.41	3e-28	112
LLPS-Phv-0240	Phaseolus vulgaris	55.41	7e-30	117
LLPS-Cus-0304	Cucumis sativus	55.17	3e-29	115
LLPS-Hea-0791	Helianthus annuus	55.1	4e-29	114
LLPS-Met-2143	Medicago truncatula	55.1	2e-21	93.6
LLPS-Coc-1130	Corchorus capsularis	54.73	2e-29	115
LLPS-Nia-0545	Nicotiana attenuata	54.17	4e-29	114
LLPS-Sot-1985	Solanum tuberosum	54.11	9e-21	91.7
LLPS-Pug-0878	Puccinia graminis	53.41	4e-21	91.7
LLPS-Dac-2308	Daucus carota	53.06	5e-28	111
LLPS-Put-0471	Puccinia triticina	52.87	2e-20	90.1
LLPS-Brd-0652	Brachypodium distachyon	52.03	1e-18	85.5
LLPS-Tra-0163	Triticum aestivum	52.03	8e-19	86.3
LLPS-Orgl-0348	Oryza glumaepatula	51.39	1e-17	83.2
LLPS-Osl-0817	Ostreococcus lucimarinus	51.22	6e-22	92.8
LLPS-Mel-0097	Melampsora laricipopulina	50.6	5e-19	84.0
LLPS-Gas-1307	Galdieria sulphuraria	49.38	6e-24	99.8
LLPS-Miv-0838	Microbotryum violaceum	48.94	9e-20	87.0
LLPS-Mua-0478	Musa acuminata	48.78	6e-22	94.7
LLPS-Trr-1201	Trichoderma reesei	47.78	7e-20	88.6
LLPS-Sem-0019	Selaginella moellendorffii	47.67	4e-23	94.4
LLPS-Mao-0660	Magnaporthe oryzae	47.19	2e-19	87.4
LLPS-Asfu-1019	Aspergillus fumigatus	46.75	5e-15	76.3
LLPS-Scj-1531	Schizosaccharomyces japonicus	46.48	3e-21	90.9
LLPS-Nef-0571	Neosartorya fischeri	46.07	7e-17	80.1
LLPS-Ved-0830	Verticillium dahliae	45.68	9e-17	79.7
LLPS-Trv-1203	Trichoderma virens	45.65	2e-19	87.0
LLPS-Php-2345	Physcomitrella patens	45.45	3e-18	84.7
LLPS-Cog-0121	Colletotrichum gloeosporioides	45.45	1e-18	85.1
LLPS-Abg-1118	Absidia glauca	45.14	7e-23	96.3
LLPS-Asn-0254	Aspergillus nidulans	45.07	6e-14	71.2
LLPS-Zyt-0188	Zymoseptoria tritici	45.05	2e-18	84.3
LLPS-Asc-0387	Aspergillus clavatus	44.94	9e-18	82.4
LLPS-Ast-0882	Aspergillus terreus	44.94	9e-17	79.7
LLPS-Beb-1438	Beauveria bassiana	44.71	5e-18	83.2
LLPS-Scc-0760	Schizosaccharomyces cryophilus	44.68	1e-19	86.3
LLPS-Aso-1469	Aspergillus oryzae	44.58	6e-17	80.1
LLPS-Dos-1598	Dothistroma septosporum	44.57	4e-17	80.5
LLPS-Coo-0874	Colletotrichum orbiculare	44.32	3e-18	83.6
LLPS-Scp-0881	Schizosaccharomyces pombe	44.06	6e-19	84.3
LLPS-Crn-1316	Cryptococcus neoformans	44.05	2e-20	90.1
LLPS-Asf-0787	Aspergillus flavus	43.84	3e-13	69.3
LLPS-Asni-0205	Aspergillus niger	43.82	1e-17	82.4
LLPS-Cogr-0443	Colletotrichum graminicola	43.82	5e-18	83.6
LLPS-Nec-0516	Neurospora crassa	43.48	2e-18	84.3
LLPS-Blg-0644	Blumeria graminis	43.33	2e-19	86.7
LLPS-Gag-0179	Gaeumannomyces graminis	43.01	4e-18	83.2
LLPS-Map-0008	Magnaporthe poae	43.01	4e-18	83.2
LLPS-Pytr-1309	Pyrenophora triticirepentis	42.86	5e-15	74.7
LLPS-Fus-0345	Fusarium solani	42.7	6e-18	82.8
LLPS-Pyt-0720	Pyrenophora teres	41.67	1e-15	76.6
LLPS-Phn-1440	Phaeosphaeria nodorum	41.18	4e-15	74.7
LLPS-Lem-0207	Leptosphaeria maculans	39.29	2e-15	75.5
LLPS-Yal-0740	Yarrowia lipolytica	38.95	9e-16	76.3
LLPS-Spr-0218	Sporisorium reilianum	37.84	1e-15	76.6
LLPS-Usm-0228	Ustilago maydis	37.04	5e-14	72.0
LLPS-Sac-1066	Saccharomyces cerevisiae	36.26	2e-12	66.6
LLPS-Asg-1280	Ashbya gossypii	35.29	8e-13	67.4
LLPS-Kop-0522	Komagataella pastoris	32.63	5e-12	65.1

LLPS-Drm-0966SmB

Protein Sequence

Nucleotide Sequence

LLPS-Drm-0966
SmB