LLPS-Drm-0228
Sas-6

▼ OVERVIEW

Status: Reviewed
Protein Name: Spindle assembly abnormal protein 6 homolog
Gene Name: Sas-6, SAS6, CG15524
Ensembl Gene: FBgn0039731
Ensembl Protein: FBpp0084912
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Client
PDB: 5AL7 (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A17689959

▼ FUNCTION

Central scaffolding component of the centrioles ensuring their 9-fold symmetry (PubMed:17412918, PubMed:17463247, PubMed:30013109). Required for centrosome biogenesis and duplication (PubMed:17412918, PubMed:17463247, PubMed:30013109). In ciliated neurons, required for centriole assembly but not necessary for cilium basal body and cilia function (PubMed:30013109). Required for sperm cilium basal body elongation together with Cep135 and Ana2 (PubMed:30013109).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MWPPGSEDSY  SAKMDYGKSV  VNILPSVEML  VNFNGEMTRS  SKRSCLLYAE  RVDFKELLQL  60
61    RLTEKSDQRR  MYITTVDSAS  FQDLKQDQSL  NVSFSGFIDN  VVRMLKDCQS  GKLELHLTTR  120
121   DQNLSSGREV  HDYYLQFVEI  RSFKNLVHLS  LPCRSAPLNT  VLFYINSMLE  ASHKKQYILE  180
181   QSMQQMQAEI  NAQRAHAERL  TTENTNIREA  LAENTRILEE  KHAAEVHQYQ  EKLSKINEQR  240
241   SNELERNRRA  ISGFQAQLDK  ASLEKAELKS  AQEQAEKRCQ  TLSEELSCCK  ARVCTLKEQN  300
301   DKLHGDVANI  RKHERKLEYK  IEDLKQHTVE  LQEHIQKGNK  EKANIAAELE  AEKKILHTKR  360
361   QALEMASEEI  SKANQIIVKQ  SQELLNLKKT  IAWRTEVALQ  QEKAVQAKES  LLSLRENELR  420
421   EARITIEKLR  EEIPQQLQSM  RNFAQGLEQK  YSKQILILKE  RLAIPTGKEN  RR  472
Nucleotide CDS Sequence (FASTA)
1     ATGTGGCCTC  CAGGGAGCGA  GGATAGCTAC  TCCGCCAAAA  TGGACTATGG  CAAGAGCGTG  60
61    GTGAACATCC  TGCCCAGCGT  AGAGATGCTG  GTGAACTTTA  ATGGCGAAAT  GACGCGGTCT  120
121   AGCAAACGGT  CATGTCTACT  GTACGCGGAG  AGAGTGGACT  TCAAGGAGCT  GCTGCAACTC  180
181   CGATTAACGG  AGAAGTCCGA  TCAACGGCGC  ATGTACATCA  CCACAGTGGA  CAGCGCCTCC  240
241   TTTCAGGATC  TTAAACAGGA  TCAGTCGCTG  AATGTGTCAT  TCTCTGGGTT  CATTGACAAT  300
301   GTAGTGCGCA  TGCTGAAGGA  CTGCCAGTCG  GGTAAACTGG  AGCTGCACCT  GACCACACGG  360
361   GATCAGAACC  TTTCATCCGG  CAGGGAGGTC  CACGACTATT  ATCTTCAGTT  TGTTGAAATT  420
421   CGGTCCTTTA  AGAACCTAGT  TCACCTTAGC  CTGCCTTGTC  GTTCTGCTCC  CTTGAACACC  480
481   GTACTCTTCT  ACATAAACAG  CATGCTGGAA  GCCTCCCACA  AAAAGCAATA  TATTCTCGAG  540
541   CAAAGTATGC  AGCAAATGCA  GGCTGAAATC  AACGCACAAC  GCGCGCATGC  GGAAAGGTTG  600
601   ACCACGGAAA  ACACAAATAT  CAGGGAAGCT  TTGGCCGAAA  ATACTCGCAT  CTTAGAGGAA  660
661   AAGCATGCTG  CCGAGGTCCA  TCAATACCAG  GAAAAACTGT  CCAAAATAAA  CGAGCAGCGC  720
721   AGCAATGAGC  TGGAGAGAAA  TCGTAGAGCG  ATCTCCGGCT  TTCAGGCCCA  ATTGGACAAG  780
781   GCTTCGTTGG  AGAAAGCAGA  ACTAAAGTCG  GCCCAAGAGC  AGGCCGAGAA  ACGATGTCAA  840
841   ACCCTGTCCG  AGGAGTTGTC  CTGTTGCAAA  GCCAGAGTGT  GCACCCTAAA  AGAGCAAAAT  900
901   GACAAACTGC  ACGGGGATGT  GGCCAATATC  AGGAAGCATG  AACGCAAGTT  GGAGTACAAA  960
961   ATCGAGGACC  TCAAGCAGCA  CACTGTCGAG  CTGCAGGAAC  ATATTCAAAA  GGGAAACAAA  1020
1021  GAGAAGGCCA  ACATAGCCGC  TGAACTGGAG  GCCGAGAAGA  AGATCCTGCA  CACCAAGCGC  1080
1081  CAGGCTTTGG  AAATGGCCTC  CGAGGAGATC  TCCAAGGCCA  ACCAGATAAT  CGTTAAACAA  1140
1141  AGCCAGGAGC  TGCTCAACCT  CAAAAAGACC  ATTGCCTGGC  GCACAGAGGT  GGCTCTGCAG  1200
1201  CAAGAGAAGG  CGGTTCAGGC  CAAGGAGAGC  CTACTATCCC  TGCGGGAGAA  TGAGCTGCGC  1260
1261  GAGGCTCGAA  TAACTATTGA  AAAACTGAGG  GAGGAAATCC  CCCAGCAACT  GCAATCCATG  1320
1321  CGTAACTTTG  CCCAGGGACT  GGAGCAGAAG  TATTCCAAAC  AAATCCTCAT  TCTAAAAGAA  1380
1381  CGGCTTGCAA  TACCCACGGG  CAAAGAAAAT  CGGCGA  1416

▼ KEYWORD

ID
Family
3D-structure
Cell cycle
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centriole
Cellular Component
Centrosome
Cellular Component
Ciliary basal body
Biological Process
Centriole assembly
Biological Process
Centriole replication
Biological Process
Centriole-centriole cohesion
Biological Process
Centrosome cycle
Biological Process
Centrosome duplication
Biological Process
Ciliary basal body organization

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Physicochemical
AAindex
Structure
PDB
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mum-4023Mus musculus26.462e-0860.5
LLPS-Loa-0080Loxodonta africana26.182e-1067.0
LLPS-Chs-1939Chlorocebus sabaeus26.022e-1067.4
LLPS-Ran-3949Rattus norvegicus25.881e-0964.7
LLPS-Rhb-0729Rhinopithecus bieti25.776e-1168.9
LLPS-Man-1558Macaca nemestrina25.777e-1065.5
LLPS-Mam-2578Macaca mulatta25.777e-1065.5
LLPS-Cea-3681Cercocebus atys25.779e-1065.1
LLPS-Maf-4227Macaca fascicularis25.774e-1066.2
LLPS-Paa-3036Papio anubis25.771e-0965.1
LLPS-Mal-2904Mandrillus leucophaeus25.771e-0965.1
LLPS-Ova-1486Ovis aries25.651e-0965.1
LLPS-Pes-1718Pelodiscus sinensis25.637e-1065.1
LLPS-Lac-1895Latimeria chalumnae25.521e-1171.2
LLPS-Orc-0662Oryctolagus cuniculus25.395e-1065.9
LLPS-Urm-1909Ursus maritimus25.392e-0963.9
LLPS-Eqc-2410Equus caballus25.392e-1067.0
LLPS-Aim-1445Ailuropoda melanoleuca25.392e-0963.9
LLPS-Nol-0184Nomascus leucogenys25.321e-0861.2
LLPS-Poa-2358Pongo abelii25.322e-0860.5
LLPS-Mup-1300Mustela putorius furo25.261e-1067.8
LLPS-Fec-2641Felis catus25.131e-0861.2
LLPS-Orl-1775Oryzias latipes25.131e-0964.7
LLPS-Hos-1732Homo sapiens24.871e-0861.2
LLPS-Pat-1083Pan troglodytes24.871e-0861.2
LLPS-Pap-0731Pan paniscus24.871e-0861.2
LLPS-Caf-3314Canis familiaris24.871e-0861.6
LLPS-Gog-0644Gorilla gorilla24.871e-0861.2
LLPS-Cas-0557Carlito syrichta24.677e-0755.8
LLPS-Mea-0714Mesocricetus auratus24.672e-0860.5
LLPS-Xet-0169Xenopus tropicalis24.623e-1066.6
LLPS-Cii-0416Ciona intestinalis24.621e-0861.2
LLPS-Scm-1933Scophthalmus maximus24.616e-0652.8
LLPS-Ict-3428Ictidomys tridecemlineatus24.615e-0756.6
LLPS-Mod-3814Monodelphis domestica24.476e-0962.4
LLPS-Myl-3081Myotis lucifugus24.472e-0963.9
LLPS-Anc-2420Anolis carolinensis24.352e-1067.0
LLPS-Cap-0837Cavia porcellus24.327e-0755.8
LLPS-Sus-3633Sus scrofa24.213e-0963.5
LLPS-Otg-0911Otolemur garnettii24.164e-0859.7
LLPS-Meg-1906Meleagris gallopavo24.162e-0758.2
LLPS-Gaga-2520Gallus gallus24.166e-0756.2
LLPS-Dio-0150Dipodomys ordii24.163e-0963.5
LLPS-Fud-0905Fukomys damarensis24.013e-0963.5
LLPS-Anp-1372Anas platyrhynchos23.771e-0758.5
LLPS-Bot-1048Bos taurus23.776e-0859.3
LLPS-Tar-0235Takifugu rubripes23.668e-1271.6
LLPS-Sah-1206Sarcophilus harrisii23.597e-0755.8
LLPS-Icp-0787Ictalurus punctatus23.453e-1272.8
LLPS-Aon-2011Aotus nancymaae23.321e-0758.2
LLPS-Asm-1216Astyanax mexicanus22.983e-0860.5
LLPS-Leo-0176Lepisosteus oculatus22.741e-0758.2
LLPS-Fia-2844Ficedula albicollis22.722e-0860.8
LLPS-Xim-0698Xiphophorus maculatus22.621e-0655.5
LLPS-Dar-3959Danio rerio22.543e-0963.5
LLPS-Tag-1707Taeniopygia guttata22.452e-0757.8
LLPS-Scf-1889Scleropages formosus22.455e-0962.8