LLPS-Drm-0080
Dmel\CG2852

▼ OVERVIEW

Status: Reviewed
Protein Name: Peptidyl-prolyl cis-trans isomerase
Gene Name: Dmel\CG2852, CG2852, Dmel_CG2852
Ensembl Gene: FBgn0034753
Ensembl Protein: FBpp0071844
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus, Postsynaptic densityPredicted from orthologsN/A(View)

▼ FUNCTION

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKLFLSVFVV  ALVAGVVVAD  DSKGPKVTEK  VFFDITIGGE  PAGRIEIGLF  GKTVPKTVEN  60
61    FKELALKPQG  EGYKGSKFHR  IIKDFMIQGG  DFTKGDGTGG  RSIYGERFED  ENFKLKHYGA  120
121   GWLSMANAGK  DTNGSQFFIT  TKQTSWLDGR  HVVFGKILSG  MNVVRQIENS  ATDARDRPVK  180
181   DVVIANSGTL  PVSEAFSVAK  ADATD  205
Nucleotide CDS Sequence (FASTA)
1     ATGAAGCTGT  TCTTATCCGT  TTTCGTGGTA  GCCCTGGTGG  CCGGCGTCGT  TGTTGCCGAC  60
61    GATAGCAAGG  GTCCCAAAGT  GACCGAGAAG  GTTTTCTTTG  ACATCACCAT  TGGCGGCGAG  120
121   CCCGCTGGTC  GCATCGAGAT  CGGTCTGTTC  GGCAAGACGG  TGCCCAAGAC  GGTGGAGAAC  180
181   TTCAAGGAGC  TGGCGCTGAA  GCCGCAGGGC  GAGGGCTACA  AGGGCAGCAA  GTTCCACCGC  240
241   ATCATCAAGG  ACTTCATGAT  CCAGGGCGGT  GACTTCACCA  AGGGCGACGG  CACCGGCGGT  300
301   CGCTCCATCT  ACGGCGAGCG  CTTCGAGGAT  GAGAACTTCA  AGCTGAAGCA  CTATGGCGCC  360
361   GGCTGGCTGA  GCATGGCCAA  CGCTGGCAAG  GACACCAACG  GATCGCAGTT  CTTCATCACC  420
421   ACCAAGCAGA  CCAGCTGGCT  GGATGGACGC  CACGTCGTCT  TCGGCAAGAT  CCTGTCGGGC  480
481   ATGAATGTGG  TGCGCCAGAT  CGAGAACTCG  GCCACTGATG  CCCGCGACCG  TCCCGTCAAG  540
541   GATGTGGTCA  TCGCCAACAG  CGGCACCCTG  CCCGTTTCGG  AGGCCTTCTC  CGTGGCCAAG  600
601   GCCGATGCCA  CCGAC  615

▼ KEYWORD

ID
Family
Complete proteome
Isomerase
Proteomics identification
Reference proteome
Rotamase
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Endomembrane system
Cellular Component
Extracellular region
Cellular Component
Extracellular space
Molecular Function
Cyclosporin A binding
Molecular Function
Peptidyl-prolyl cis-trans isomerase activity
Molecular Function
Unfolded protein binding
Biological Process
Multicellular organism reproduction
Biological Process
Protein refolding

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Scm-1098Scophthalmus maximus78.632e-57 185
LLPS-Dar-1076Danio rerio76.49e-83 251
LLPS-Orn-1516Oreochromis niloticus75.846e-82 249
LLPS-Icp-0124Ictalurus punctatus75.285e-82 250
LLPS-Cae-1813Caenorhabditis elegans75.288e-82 249
LLPS-Cii-0408Ciona intestinalis75.02e-75 233
LLPS-Caf-0901Canis familiaris74.674e-63 202
LLPS-Anp-0445Anas platyrhynchos74.241e-59 190
LLPS-Leo-0202Lepisosteus oculatus74.161e-80 246
LLPS-Orl-0307Oryzias latipes74.163e-81 248
LLPS-Eqc-0740Equus caballus73.813e-75 235
LLPS-Gaga-0223Gallus gallus73.61e-82 251
LLPS-Scf-1161Scleropages formosus73.65e-80 244
LLPS-Fec-1924Felis catus73.539e-77 237
LLPS-Gag-0423Gaeumannomyces graminis73.265e-74 229
LLPS-Mod-1772Monodelphis domestica73.036e-81 247
LLPS-Pof-1099Poecilia formosa73.032e-79 243
LLPS-Ten-0793Tetraodon nigroviridis73.037e-79 242
LLPS-Xet-0029Xenopus tropicalis73.036e-80 244
LLPS-Anc-0443Anolis carolinensis73.031e-82 251
LLPS-Mea-1016Mesocricetus auratus73.032e-82 251
LLPS-Tag-0076Taeniopygia guttata72.993e-79 243
LLPS-Map-0157Magnaporthe poae72.678e-73 226
LLPS-Loa-0074Loxodonta africana72.472e-80 246
LLPS-Otg-0284Otolemur garnettii72.478e-81 247
LLPS-Ran-0437Rattus norvegicus72.479e-82 249
LLPS-Tar-1918Takifugu rubripes72.418e-75 232
LLPS-Fia-0545Ficedula albicollis71.938e-77 236
LLPS-Urm-0027Ursus maritimus71.911e-79 244
LLPS-Mum-0639Mus musculus71.912e-80 246
LLPS-Sus-0088Sus scrofa71.912e-79 243
LLPS-Xim-0055Xiphophorus maculatus71.911e-77 239
LLPS-Bot-0109Bos taurus71.911e-79 244
LLPS-Aim-2390Ailuropoda melanoleuca71.911e-79 243
LLPS-Mup-0614Mustela putorius furo71.911e-79 244
LLPS-Myl-2435Myotis lucifugus71.916e-80 244
LLPS-Ova-1363Ovis aries71.911e-79 244
LLPS-Cis-0544Ciona savignyi71.431e-69 218
LLPS-Hos-1474Homo sapiens71.351e-79 243
LLPS-Pat-2286Pan troglodytes71.351e-79 243
LLPS-Pap-0853Pan paniscus71.351e-79 244
LLPS-Man-0745Macaca nemestrina71.351e-79 243
LLPS-Rhb-2617Rhinopithecus bieti71.351e-79 243
LLPS-Cap-0334Cavia porcellus71.351e-79 244
LLPS-Poa-0314Pongo abelii71.351e-79 243
LLPS-Mam-0097Macaca mulatta71.351e-79 243
LLPS-Ict-0460Ictidomys tridecemlineatus71.351e-79 244
LLPS-Maf-0916Macaca fascicularis71.351e-79 243
LLPS-Aon-1503Aotus nancymaae71.351e-79 244
LLPS-Cea-0842Cercocebus atys71.351e-79 243
LLPS-Sah-0750Sarcophilus harrisii71.351e-76 234
LLPS-Gog-2899Gorilla gorilla71.351e-79 243
LLPS-Caj-0187Callithrix jacchus71.351e-79 244
LLPS-Fud-2014Fukomys damarensis71.352e-79 243
LLPS-Dio-1234Dipodomys ordii71.353e-79 243
LLPS-Mal-0201Mandrillus leucophaeus71.351e-79 243
LLPS-Paa-0312Papio anubis71.351e-79 243
LLPS-Cogr-1295Colletotrichum graminicola71.182e-69 217
LLPS-Chs-0554Chlorocebus sabaeus70.791e-78 241
LLPS-Ora-0696Ornithorhynchus anatinus70.792e-78 241
LLPS-Dos-0440Dothistroma septosporum70.354e-69 217
LLPS-Cog-0486Colletotrichum gloeosporioides70.02e-68 216
LLPS-Osl-0446Ostreococcus lucimarinus70.07e-69 216
LLPS-Coo-0029Colletotrichum orbiculare70.05e-68 216
LLPS-Cas-0022Carlito syrichta69.946e-76 234
LLPS-Trr-0248Trichoderma reesei69.412e-65 207
LLPS-Ved-0524Verticillium dahliae69.416e-69 216
LLPS-Orc-2705Oryctolagus cuniculus69.272e-72 225
LLPS-Mao-0281Magnaporthe oryzae69.197e-70 218
LLPS-Pes-1004Pelodiscus sinensis69.012e-65 206
LLPS-Lac-2486Latimeria chalumnae68.391e-70 221
LLPS-Nec-0156Neurospora crassa68.243e-65 209
LLPS-Tut-0947Tursiops truncatus68.181e-69 218
LLPS-Abg-1657Absidia glauca68.022e-67 214
LLPS-Ere-0526Erinaceus europaeus68.024e-67 210
LLPS-Asm-0622Astyanax mexicanus68.09e-70 218
LLPS-Asni-0113Aspergillus niger67.868e-65 207
LLPS-Gaa-1762Gasterosteus aculeatus67.787e-78 239
LLPS-Pytr-0447Pyrenophora triticirepentis67.656e-64 203
LLPS-Fuv-0142Fusarium verticillioides67.659e-66 209
LLPS-Scs-0057Sclerotinia sclerotiorum67.446e-64 206
LLPS-Amt-0172Amborella trichopoda67.261e-63 204
LLPS-Orp-0356Oryza punctata67.075e-67 212
LLPS-Fuo-0689Fusarium oxysporum67.061e-65 209
LLPS-Tra-0980Triticum aestivum67.067e-65 207
LLPS-Asfu-0365Aspergillus fumigatus66.672e-63 202
LLPS-Nol-4125Nomascus leucogenys66.675e-72 224
LLPS-Pyt-0239Pyrenophora teres66.676e-65 209
LLPS-Met-1214Medicago truncatula66.673e-63 203
LLPS-Fus-0079Fusarium solani66.472e-62 200
LLPS-Tru-0418Triticum urartu66.475e-64 205
LLPS-Brn-1259Brassica napus66.478e-63 202
LLPS-Hov-1158Hordeum vulgare66.473e-63 204
LLPS-Sei-0622Setaria italica66.476e-64 205
LLPS-Trv-0867Trichoderma virens66.31e-66 212
LLPS-Cus-1360Cucumis sativus66.099e-62 197
LLPS-Brd-1141Brachypodium distachyon65.885e-63 202
LLPS-Brr-1309Brassica rapa65.872e-62 201
LLPS-Org-0654Oryza glaberrima65.871e-66 211
LLPS-Orb-0770Oryza barthii65.871e-66 211
LLPS-Orni-0057Oryza nivara65.871e-66 211
LLPS-Thc-0674Theobroma cacao65.872e-65 209
LLPS-Orgl-0913Oryza glumaepatula65.871e-66 211
LLPS-Lep-0378Leersia perrieri65.871e-66 212
LLPS-Zyt-0030Zymoseptoria tritici65.76e-64 203
LLPS-Viv-1232Vitis vinifera65.528e-62 197
LLPS-Mua-2093Musa acuminata65.523e-61 196
LLPS-Prp-0394Prunus persica65.54e-63 203
LLPS-Php-0588Physcomitrella patens65.453e-62 200
LLPS-Crn-0500Cryptococcus neoformans65.345e-63 205
LLPS-Art-2194Arabidopsis thaliana65.324e-65 208
LLPS-Bro-1086Brassica oleracea65.322e-65 209
LLPS-Beb-0820Beauveria bassiana65.297e-63 201
LLPS-Sob-1549Sorghum bicolor65.271e-66 211
LLPS-Orbr-1541Oryza brachyantha65.274e-65 209
LLPS-Orr-0600Oryza rufipogon65.276e-66 209
LLPS-Glm-2401Glycine max65.271e-63 204
LLPS-Ori-0463Oryza indica65.275e-66 209
LLPS-Dac-1320Daucus carota65.154e-1885.9
LLPS-Aso-0029Aspergillus oryzae65.01e-57 187
LLPS-Asc-0176Aspergillus clavatus64.881e-62 200
LLPS-Scp-0530Schizosaccharomyces pombe64.881e-62 200
LLPS-Mae-0912Manihot esculenta64.743e-63 203
LLPS-Coc-0576Corchorus capsularis64.745e-63 202
LLPS-Asn-1099Aspergillus nidulans64.718e-64 203
LLPS-Hea-0660Helianthus annuus64.713e-61 198
LLPS-Arl-0034Arabidopsis lyrata64.677e-61 196
LLPS-Sol-1875Solanum lycopersicum64.372e-60 196
LLPS-Vir-0720Vigna radiata64.331e-59 193
LLPS-Sem-1722Selaginella moellendorffii64.249e-63 201
LLPS-Zem-0760Zea mays64.125e-61 197
LLPS-Miv-0079Microbotryum violaceum64.092e-65 207
LLPS-Chr-1108Chlamydomonas reinhardtii64.023e-61 196
LLPS-Ors-0330Oryza sativa63.792e-60 195
LLPS-Orm-1763Oryza meridionalis63.792e-60 195
LLPS-Sot-1704Solanum tuberosum63.797e-61 195
LLPS-Nia-0534Nicotiana attenuata63.748e-61 197
LLPS-Pot-0912Populus trichocarpa63.582e-61 199
LLPS-Phv-1501Phaseolus vulgaris63.477e-60 194
LLPS-Gor-1345Gossypium raimondii63.013e-61 198
LLPS-Spr-0473Sporisorium reilianum62.724e-62 199
LLPS-Via-0309Vigna angularis62.579e-61 197
LLPS-Yal-0625Yarrowia lipolytica62.352e-60 195
LLPS-Scc-0600Schizosaccharomyces cryophilus62.216e-62 199
LLPS-Mel-0792Melampsora laricipopulina61.82e-58 189
LLPS-Kop-0620Komagataella pastoris61.541e-58 190
LLPS-Cym-0947Cyanidioschyzon merolae61.451e-52 176
LLPS-Usm-0289Ustilago maydis61.314e-60 194
LLPS-Chc-0255Chondrus crispus61.211e-56 184
LLPS-Blg-0822Blumeria graminis60.922e-54 179
LLPS-Scj-0218Schizosaccharomyces japonicus60.892e-61 197
LLPS-Nef-1294Neosartorya fischeri60.871e-52 172
LLPS-Gas-1091Galdieria sulphuraria60.871e-52 173
LLPS-Put-0804Puccinia triticina59.021e-54 181
LLPS-Ast-0926Aspergillus terreus58.581e-53 176
LLPS-Sac-1189Saccharomyces cerevisiae58.081e-53 177
LLPS-Pug-0073Puccinia graminis56.744e-53 177