LLPS-Drm-0031
polo

▼ OVERVIEW

Status: Reviewed
Protein Name: Serine/threonine-protein kinase polo
Gene Name: polo, CG12306
Ensembl Gene: FBgn0003124
Ensembl Protein: FBpp0099722
Organism: Drosophila melanogaster
Taxa ID: 7227
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Centrosome/Spindle pole body
"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."
N/A9730982, 10629938; 14570580; 15640838

▼ FUNCTION

May play a role in regulating both nuclear and cytoplasmic aspects of the mitotic cycle (PubMed:1660828). Regulates localization of the augmin complex during mitosis by ensuring its location on mitotic spindles (PubMed:24829288). Also regulates augmin complex localization during male meiosis by promoting its placement at kinetochores while preventing its association with spindle microtubules (PubMed:24829288).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAAKPEDKST  DIPDRLVDIN  QRKTYKRMRF  FGKGGFAKCY  EIIDVETDDV  FAGKIVSKKL  60
61    MIKHNQKEKT  AQEITIHRSL  NHPNIVKFHN  YFEDSQNIYI  VLELCKKRSM  MELHKRRKSI  120
121   TEFECRYYIY  QIIQGVKYLH  DNRIIHRDLK  LGNLFLNDLL  HVKIGDFGLA  TRIEYEGERK  180
181   KTLCGTPNYI  APEILTKKGH  SFEVDIWSIG  CVMYTLLVGQ  PPFETKTLKD  TYSKIKKCEY  240
241   RVPSYLRKPA  ADMVIAMLQP  NPESRPAIGQ  LLNFEFLKGS  KVPMFLPSSC  LTMAPRIGSN  300
301   DTIEDSMHRK  PLMEMNGIRP  DDTRLESTFL  KANLHDAITA  SAQVCRHSED  YRSDIESLYQ  360
361   QLTNLINGKP  RILQGNLGDE  NTDPAAQPLF  WISKWVDYSD  KYGFGYQLCD  EGIGVMFNDT  420
421   TKLILLPNQI  NVHFIDKDGK  ETYMTTTDYC  KSLDKKMKLL  SYFKRYMIEH  LVKAGANNVN  480
481   IESDQISRMP  HLHSWFRTTC  AVVMHLTNGS  VQLNFSDHMK  LILCPRMSAI  TYMDQEKNFR  540
541   TYRFSTIVEN  GVSKDLYQKI  RYAQEKLRKM  LEKMFT  576
Nucleotide CDS Sequence (FASTA)
1     ATGGCCGCGA  AGCCCGAGGA  TAAGAGCACG  GATATTCCGG  ATCGCCTCGT  CGACATCAAC  60
61    CAGCGGAAAA  CCTACAAGCG  CATGCGGTTC  TTCGGCAAGG  GCGGGTTTGC  AAAATGTTAC  120
121   GAGATCATCG  ATGTGGAAAC  CGACGACGTC  TTCGCCGGCA  AGATCGTATC  CAAGAAGCTG  180
181   ATGATCAAAC  ACAATCAGAA  GGAGAAGACC  GCCCAGGAGA  TAACTATTCA  CCGCAGCCTT  240
241   AACCATCCGA  ACATTGTCAA  GTTTCACAAC  TACTTTGAAG  ATTCGCAGAA  TATCTACATT  300
301   GTGCTGGAGC  TGTGCAAGAA  AAGATCCATG  ATGGAGCTGC  ACAAACGTAG  GAAAAGCATT  360
361   ACGGAGTTCG  AATGCCGCTA  CTACATTTAC  CAGATAATCC  AGGGCGTTAA  GTACTTGCAC  420
421   GATAACCGCA  TTATCCATCG  AGATCTGAAG  CTGGGCAATC  TCTTCCTCAA  CGATTTGTTG  480
481   CACGTGAAGA  TCGGGGATTT  CGGGTTGGCC  ACGCGCATTG  AGTATGAGGG  CGAGCGAAAA  540
541   AAGACCTTAT  GCGGAACGCC  CAACTATATA  GCCCCGGAGA  TCCTCACCAA  GAAGGGCCAC  600
601   TCCTTCGAGG  TGGACATCTG  GTCGATTGGC  TGCGTCATGT  ACACACTGCT  TGTGGGCCAG  660
661   CCGCCGTTCG  AAACCAAGAC  TCTGAAGGAT  ACGTACTCGA  AAATCAAGAA  GTGCGAGTAC  720
721   CGCGTGCCCA  GCTACTTAAG  GAAACCGGCG  GCGGATATGG  TCATCGCCAT  GCTGCAGCCA  780
781   AATCCGGAGA  GCCGCCCGGC  AATTGGTCAG  CTGCTGAACT  TTGAGTTCCT  CAAGGGCTCA  840
841   AAGGTGCCCA  TGTTCTTGCC  CAGCTCTTGT  CTGACAATGG  CGCCGCGTAT  CGGCAGCAAC  900
901   GACACCATCG  AGGATTCGAT  GCACCGCAAG  CCACTGATGG  AGATGAACGG  CATCAGGCCC  960
961   GACGACACTC  GTCTGGAGTC  GACCTTCCTC  AAGGCCAATC  TGCACGACGC  CATTACCGCG  1020
1021  TCAGCGCAGG  TGTGCCGCCA  CAGCGAGGAC  TATCGCAGCG  ATATCGAGAG  CCTGTACCAG  1080
1081  CAGCTCACTA  ATCTTATCAA  CGGAAAGCCG  CGAATTCTGC  AAGGCAATCT  GGGCGACGAG  1140
1141  AACACAGATC  CTGCAGCGCA  GCCGCTCTTC  TGGATATCCA  AGTGGGTTGA  CTACAGCGAC  1200
1201  AAGTACGGAT  TTGGTTACCA  GCTGTGCGAT  GAGGGCATCG  GCGTGATGTT  CAACGACACC  1260
1261  ACAAAGCTGA  TCCTGCTGCC  GAATCAGATC  AACGTACACT  TCATCGACAA  GGATGGCAAG  1320
1321  GAGACGTACA  TGACCACCAC  GGATTACTGC  AAGTCGCTTG  ACAAGAAGAT  GAAGCTGCTG  1380
1381  TCGTACTTTA  AGCGCTACAT  GATCGAGCAC  CTGGTGAAGG  CAGGTGCCAA  CAATGTGAAC  1440
1441  ATTGAGAGCG  ATCAAATCTC  GCGTATGCCC  CATTTACACT  CCTGGTTCCG  TACAACATGT  1500
1501  GCCGTAGTTA  TGCATTTGAC  CAACGGTTCT  GTGCAGCTAA  ACTTCTCAGA  TCACATGAAG  1560
1561  CTCATCCTCT  GCCCGCGCAT  GAGTGCTATA  ACCTATATGG  ACCAGGAGAA  GAACTTCCGC  1620
1621  ACCTACCGAT  TTTCGACCAT  TGTGGAGAAC  GGCGTGTCTA  AAGACTTGTA  CCAGAAGATC  1680
1681  CGATATGCCC  AGGAGAAACT  TAGGAAAATG  CTGGAGAAGA  TGTTCACA  1728

▼ KEYWORD

ID
Family
ATP-binding
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Reference proteome
Repeat
Serine/threonine-protein kinase
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centriole
Cellular Component
Centrosome
Cellular Component
Condensed chromosome outer kinetochore
Cellular Component
Cytoplasm
Cellular Component
Kinetochore
Cellular Component
Kinetochore microtubule
Cellular Component
Microtubule
Cellular Component
Midbody
Cellular Component
Mitotic spindle midzone
Cellular Component
Nuclear envelope
Cellular Component
Spindle
Cellular Component
Spindle pole
Molecular Function
ATP binding
Molecular Function
Protein kinase activity
Molecular Function
Protein serine/threonine kinase activity
Biological Process
Actomyosin contractile ring assembly
Biological Process
Astral microtubule nucleation
Biological Process
Attachment of mitotic spindle microtubules to kinetochore
Biological Process
Cellular protein localization
Biological Process
Centrosome cycle
Biological Process
Embryonic heart tube development
Biological Process
Female meiosis II
Biological Process
Female meiotic nuclear division
Biological Process
Male germline ring canal formation
Biological Process
Male meiosis cytokinesis
Biological Process
Male meiotic nuclear division
Biological Process
Meiotic spindle midzone assembly
Biological Process
Mitotic cell cycle
Biological Process
Negative regulation of neuroblast proliferation
Biological Process
Oocyte fate commitment
Biological Process
Pronuclear fusion
Biological Process
Pronuclear migration
Biological Process
Protein localization
Biological Process
Protein phosphorylation
Biological Process
Sperm aster formation
Biological Process
Spindle assembly involved in female meiosis II

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Cym-0181Cyanidioschyzon merolae54.512e-89 301
LLPS-Mea-1798Mesocricetus auratus54.050.0 611
LLPS-Chs-1501Chlorocebus sabaeus53.760.0 577
LLPS-Ran-2070Rattus norvegicus53.710.0 607
LLPS-Dio-2192Dipodomys ordii53.630.0 598
LLPS-Fec-0200Felis catus53.530.0 596
LLPS-Sus-2279Sus scrofa53.520.0 591
LLPS-Mum-1016Mus musculus53.520.0 607
LLPS-Paa-0496Papio anubis53.460.0 593
LLPS-Caf-1605Canis familiaris53.380.0 594
LLPS-Otg-0798Otolemur garnettii53.260.0 592
LLPS-Cas-1457Carlito syrichta53.260.0 591
LLPS-Mup-1053Mustela putorius furo53.240.0 530
LLPS-Poa-2511Pongo abelii53.20.0 592
LLPS-Orc-1114Oryctolagus cuniculus53.180.0 592
LLPS-Ict-3133Ictidomys tridecemlineatus53.180.0 594
LLPS-Aon-1415Aotus nancymaae53.180.0 593
LLPS-Aim-0012Ailuropoda melanoleuca53.180.0 593
LLPS-Man-1097Macaca nemestrina53.090.0 593
LLPS-Mam-0649Macaca mulatta53.090.0 593
LLPS-Cea-2830Cercocebus atys53.090.0 593
LLPS-Maf-0815Macaca fascicularis53.090.0 593
LLPS-Mal-1185Mandrillus leucophaeus53.090.0 593
LLPS-Cap-2477Cavia porcellus53.00.0 601
LLPS-Eqc-2353Equus caballus53.00.0 592
LLPS-Tut-0801Tursiops truncatus53.00.0 584
LLPS-Scf-1064Scleropages formosus52.950.0 610
LLPS-Hos-2315Homo sapiens52.910.0 590
LLPS-Pap-2013Pan paniscus52.910.0 590
LLPS-Loa-1163Loxodonta africana52.870.0 595
LLPS-Bot-0806Bos taurus52.70.0 597
LLPS-Mod-3815Monodelphis domestica52.670.0 592
LLPS-Pof-0716Poecilia formosa52.660.0 605
LLPS-Nol-1760Nomascus leucogenys52.550.0 589
LLPS-Myl-1078Myotis lucifugus52.470.0 585
LLPS-Ova-0638Ovis aries52.460.0 594
LLPS-Ora-1428Ornithorhynchus anatinus52.374e-163 481
LLPS-Fud-3188Fukomys damarensis52.370.0 590
LLPS-Caj-0051Callithrix jacchus52.350.0 589
LLPS-Xim-1142Xiphophorus maculatus52.30.0 609
LLPS-Tar-0811Takifugu rubripes52.130.0 594
LLPS-Xet-1145Xenopus tropicalis52.040.0 578
LLPS-Lac-1339Latimeria chalumnae51.770.0 584
LLPS-Orn-0394Oreochromis niloticus51.770.0 602
LLPS-Ten-0139Tetraodon nigroviridis51.590.0 589
LLPS-Urm-0006Ursus maritimus51.570.0 572
LLPS-Dar-0277Danio rerio51.410.0 585
LLPS-Sah-3021Sarcophilus harrisii51.371e-165 488
LLPS-Gaga-0349Gallus gallus51.320.0 595
LLPS-Scm-0823Scophthalmus maximus51.240.0 585
LLPS-Icp-0772Ictalurus punctatus51.230.0 593
LLPS-Orl-0090Oryzias latipes51.150.0 590
LLPS-Asm-1558Astyanax mexicanus51.140.0 582
LLPS-Fia-0038Ficedula albicollis51.077e-179 522
LLPS-Gaa-0157Gasterosteus aculeatus51.070.0 587
LLPS-Cis-1412Ciona savignyi51.020.0 581
LLPS-Anp-0284Anas platyrhynchos50.991e-153 456
LLPS-Tag-1999Taeniopygia guttata50.872e-152 453
LLPS-Cii-0177Ciona intestinalis50.853e-155 461
LLPS-Rhb-0182Rhinopithecus bieti50.090.0 536
LLPS-Pes-1956Pelodiscus sinensis49.768e-143 427
LLPS-Meg-0901Meleagris gallopavo49.262e-141 423
LLPS-Gog-1141Gorilla gorilla48.731e-179 529
LLPS-Anc-3065Anolis carolinensis48.324e-86 288
LLPS-Pat-2572Pan troglodytes47.224e-164 489
LLPS-Scp-0032Schizosaccharomyces pombe46.918e-71 247
LLPS-Scj-0236Schizosaccharomyces japonicus46.918e-72 250
LLPS-Leo-3195Lepisosteus oculatus46.223e-153 459
LLPS-Usm-0705Ustilago maydis45.552e-68 244
LLPS-Cae-0318Caenorhabditis elegans45.344e-172 510
LLPS-Crn-1212Cryptococcus neoformans45.35e-71 250
LLPS-Put-0102Puccinia triticina45.193e-63 229
LLPS-Miv-0734Microbotryum violaceum45.053e-65 232
LLPS-Spr-0015Sporisorium reilianum44.843e-66 237
LLPS-Yal-0838Yarrowia lipolytica43.872e-63 227
LLPS-Pug-0706Puccinia graminis42.011e-61 224
LLPS-Asg-0043Ashbya gossypii41.947e-67 236
LLPS-Sac-0053Saccharomyces cerevisiae39.833e-70 246
LLPS-Mel-0993Melampsora laricipopulina37.762e-61 224
LLPS-Kop-0445Komagataella pastoris33.496e-95 311
LLPS-Gas-0734Galdieria sulphuraria32.881e-97 320
LLPS-Scc-0087Schizosaccharomyces cryophilus32.771e-104 338
LLPS-Tum-0411Tuber melanosporum32.295e-74 254
LLPS-Abg-1366Absidia glauca31.757e-64 226