LLPS-Dar-a967
vps16
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Vacuolar protein sorting-associated protein 16 homolog |
| Gene Name: | vps16 |
| Ensembl Gene: | ENSDARG00000109363.1 |
| Ensembl Protein: | ENSDARP00000150270.1 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000187064.1 | ENSDARP00000150270.1 |
| UniProt | A0A2R8QEF2, A0A2R8QEF2_DANRE | |
| GeneBank | BX890550 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAFVTANWNP LGEAFYRKIE LYEMAWNLKD GLKDCLFAAA PYGGPIALLK WHNRRSPSAR 60 61 PQLEIYSSSG LPLASFPWKS GVVKQLGWTV SDDLLCVQED GTVLVYDLLG GFKRHFSMGN 120 121 EVSQSQVLET KIFHSPYGTG VAILTGALRF TLATNIDDIK LRRLPEVPGI QAAPSCWAVL 180 181 TQDRQSKVLV ASGAHLFILD NTACTPVTPP GLSPQASSIL HMCVSFSYKY LALLTDSGHV 240 241 WMGTSNLKEK LSEVETKIKT PPRQMAWCRR PKSQEPSAVV MWDGLLLVVG ECKETIQYQL 300 301 DDDSILVPEL DGVRIISGTH HELLQEVPGA CEEIFKIASM APGALLLEAH KEYEKESQKA 360 361 DEYLREIKEQ SLLSEAVQQC VEAAGHEHEP ETQKTLLRAA SFGKCFLSNF PPEQFVSMCR 420 421 DLRVLNAVRD YTIGIPLTHT QFKQMTVQVL IDRLVYRKLY PLAIEVCRYL KTPEYQGVSR 480 481 VLKHWACFKV QQKEESDEVI AKAVSVKLAD AAGISYSEIA TKAYESGRTE LAIKLLEFEP 540 541 RSGEQVPLLL KMKKSPLALS KAIESGDTDL VYTVVMYLKN ELNRGDFFMM LRNQPVALSL 600 601 YRQFCKHQEQ DTLKDLFNQD DDHEELGNFY VKASYKEQRL EARIALLQSA VDEYYKAKNE 660 661 FSAKSTEDEM RLLRFQRKLE EEKGEPLVGF SLHDTMTTLL SVGLHKHAEQ LYKDFRVPDK 720 721 RFWWLKLKAL AEKEDWDELE KFAKSKKSPI GYLPFVDVCI KHHNKYEARK YVSKVTPEQK 780 781 VKAHLAVGDM EGAAEAAIER RNDTEISTVL SRCSSTTDHA LVERLNRARA TATKK 835 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | CORVET complex | |
Cellular Component | Endosome | |
Cellular Component | HOPS complex | |
Cellular Component | Late endosome membrane | |
Cellular Component | Lysosomal membrane | |
Molecular Function | Actin binding | |
Biological Process | Endosomal transport | |
Biological Process | Intracellular protein transport | |
Biological Process | Regulation of SNARE complex assembly | |
Biological Process | Regulation of vacuole fusion, non-autophagic | |
Biological Process | Vacuole organization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a1150 | Homo sapiens | 0.0 | 1214 | undefined |
| LLPS-Mum-a1130 | Mus musculus | 0.0 | 1211 | undefined |