LLPS-Dar-a561
pomgnt2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 |
| Gene Name: | pomgnt2, ago61, gtdc2, im:7153239, zgc:112079 |
| Ensembl Gene: | ENSDARG00000010941.10 |
| Ensembl Protein: | ENSDARP00000151467.1 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000193303.1 | ENSDARP00000151467.1 |
| Ensembl | ENSDART00000139432.2 | ENSDARP00000115932.1 |
| UniProt | Q5NDE5, PMGT2_DANRE, Q502K0 | |
| GeneBank | AJ868539, BC095667 | CAI30873.1, AAH95667.1 |
| Entrez | 497644 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MRAIGCRMNL PAVLNGLLVS VVAALLWKYV RLVEHTSQLE EELQLTRQSQ EFSQVRIDYH 60 61 GALLALQEHG TRMVCTGKMH TDRICRFDYL CYCTEAEEFV FFHSNASVML PNLGSRRFQP 120 121 ALLDLSSVED HNTQYFNFLE LPAAALKFMP KPVFVPDVTL ILNRFNPDNL MHIFHDDLLP 180 181 VYYTMQQYSD LDDEARLVFM EGWGEGAHFD LYRLLSSKQP LLKDQLKTFG KLMCFTKSYV 240 241 GLSKMTTWYQ YGFVQPQGPK ANILISGNEI RQFASFLMER LNITREEEEE DDDYIVVFKR 300 301 TTNRLILNEA ELLLALAQEF QMRTVTVSLE EQSFDNIIQI ISRAAMLVSM HGAQMITSMF 360 361 LPRGAAVVEL FPYGVNPEQY TPYKTLASLP GMDLQYVAWR NTMEENTVTF PDRPWDQGGI 420 421 VHLEKEEQER ILASKEVPRH LCCRNPEWLF RIYQDTTVDL ASFLDVLRDG LKKLNLKKAK 480 481 VASTVHPGRV REPKCQTSVQ ATNEAKLSVS WQIPWNLKYL KVKEVKYEVW IQEQGENTYM 540 541 PYILPHQNYT FSENIKPFTT YLVWVRCIFN KNLLGPFADV LICKT 585 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCGTGCTA TCGGGTGTAG GATGAACCTG CCGGCAGTGC TGAATGGCCT GCTGGTGTCA 60 61 GTGGTGGCAG CCTTGCTTTG GAAATACGTT CGTCTGGTTG AACACACATC ACAGCTGGAA 120 121 GAGGAGCTAC AGCTTACACG CCAGTCACAA GAATTTTCAC AGGTGCGTAT CGATTACCAT 180 181 GGTGCCTTGT TGGCACTCCA AGAGCATGGG ACCAGAATGG TCTGCACCGG CAAGATGCAC 240 241 ACTGATCGCA TCTGCCGTTT TGACTACCTC TGCTACTGCA CAGAAGCTGA GGAGTTTGTA 300 301 TTCTTCCACA GTAATGCCTC TGTGATGTTG CCCAACCTTG GCTCTCGCCG TTTCCAACCA 360 361 GCCCTGCTGG ACCTCTCATC TGTAGAAGAT CACAACACGC AATATTTTAA CTTTCTCGAG 420 421 CTTCCAGCGG CGGCTCTGAA ATTTATGCCA AAACCTGTGT TTGTGCCAGA CGTCACTCTT 480 481 ATTCTGAATC GATTTAATCC AGACAACCTC ATGCACATTT TCCACGATGA TCTTTTGCCG 540 541 GTCTACTACA CCATGCAGCA GTATTCAGAC TTGGACGATG AAGCCAGACT CGTCTTCATG 600 601 GAGGGTTGGG GTGAAGGGGC TCACTTCGAC CTCTATCGCT TGCTAAGCAG CAAGCAACCA 660 661 CTTCTCAAGG ACCAGTTGAA GACCTTCGGC AAGCTCATGT GCTTCACCAA GTCCTACGTA 720 721 GGACTGTCAA AGATGACCAC ATGGTACCAG TATGGCTTTG TGCAACCCCA AGGACCCAAA 780 781 GCCAACATTC TGATATCAGG TAACGAGATC CGTCAGTTTG CTTCATTTCT GATGGAGAGG 840 841 CTGAACATCA CAAGAGAGGA GGAGGAGGAG GATGATGACT ACATTGTAGT TTTTAAACGT 900 901 ACCACGAACA GGCTCATCCT GAACGAGGCC GAGCTGCTTC TGGCTTTAGC TCAAGAGTTT 960 961 CAGATGAGGA CGGTCACTGT GTCTTTGGAG GAGCAGTCGT TTGATAACAT CATCCAAATT 1020 1021 ATTAGCAGAG CAGCCATGCT GGTCAGCATG CACGGAGCCC AGATGATCAC CTCCATGTTT 1080 1081 TTGCCCCGTG GTGCAGCTGT GGTCGAACTC TTCCCTTATG GTGTGAACCC GGAACAGTAC 1140 1141 ACTCCCTACA AAACCTTGGC CTCCTTACCT GGCATGGACT TACAGTATGT TGCCTGGAGA 1200 1201 AATACCATGG AAGAGAACAC TGTCACTTTC CCTGACCGCC CTTGGGATCA GGGTGGCATC 1260 1261 GTTCATTTGG AGAAGGAGGA GCAAGAACGT ATCCTTGCCA GCAAGGAGGT GCCAAGACAT 1320 1321 CTTTGTTGTC GTAATCCAGA ATGGCTTTTT CGCATTTACC AGGACACCAC TGTAGATCTT 1380 1381 GCCTCTTTCC TGGACGTACT CAGAGATGGT CTGAAAAAGC TTAACCTCAA AAAGGCTAAG 1440 1441 GTGGCTAGCA CTGTACATCC CGGTCGAGTC CGAGAGCCCA AGTGCCAGAC TTCAGTGCAG 1500 1501 GCCACCAATG AAGCAAAGCT CTCGGTTTCA TGGCAGATCC CTTGGAACCT GAAGTACCTG 1560 1561 AAGGTCAAAG AGGTGAAATA TGAGGTGTGG ATCCAGGAAC AGGGAGAGAA CACGTATATG 1620 1621 CCTTACATTC TGCCCCACCA GAACTACACC TTTTCAGAGA ACATCAAACC ATTCACCACG 1680 1681 TATTTAGTGT GGGTGCGCTG CATCTTTAAC AAGAACCTCT TGGGCCCATT TGCAGATGTT 1740 1741 CTTATATGTA AAACTTGA 1758 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum | |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Integral component of membrane | |
Molecular Function | Acetylglucosaminyltransferase activity | |
Biological Process | Brain development | |
Biological Process | Muscle fiber development | |
Biological Process | Neuron migration | |
Biological Process | Protein O-linked glycosylation | |
Biological Process | Protein O-linked mannosylation | |
Biological Process | Retina development in camera-type eye |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a650 | Homo sapiens | 0.0 | 869 | undefined |
| LLPS-Mum-a644 | Mus musculus | 0.0 | 863 | undefined |