LLPS-Dar-a293
rasgrf2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ras-specific guanine nucleotide-releasing factor 2 |
| Gene Name: | rasgrf2, si:ch211-194b21.1, si:dkey-56d12.3 |
| Ensembl Gene: | ENSDARG00000002816.10 |
| Ensembl Protein: | ENSDARP00000077785.2 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Others |
▼ PROPERTY
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Functions as a calcium-regulated nucleotide exchange factor activating both Ras and rac1 through the exchange of bound GDP for GTP. May function in synaptic plasticity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000083350.4 | ENSDARP00000077785.2 |
| UniProt | A2CEA7, RGRF2_DANRE, B0S6A1 | |
| GeneBank | BX470070, CR388055, CR848716 | CAM16158.1, CAQ13408.1 |
| RefSeq | NM_001128233.1 | NP_001121705.1 |
| Entrez | 553520 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MQKSVRYNEG HALFLSVIAR KEGTKRGYLS KKTTENSKWH EKFFALYQNV LFYFDTDQSA 60 61 RPSGIYLLEG CTCERVPALK VSTVGKDALD KLQYFLVVFG HDGQKPLELR TEEESDCDEW 120 121 VEAIQQASYS DIIIEREVLM QKYIHLVQIV ETEKVAANQL RTQLEDQDTE IERLKAEIIA 180 181 LNKTKERMRP YHVFQEEEDP DIKKIKKVQS FMRGWLCRRK WKIIVQDYIC SPHAESMRKR 240 241 NQIVFNMVEA ETEYVHQLSI LVNCFLRPLR MAASSKKPPI SHDDVSSIFL NSETIMFLHE 300 301 IFHQGLKARI ANWPTLVLAD LFDILLPMLN IYQEFVRNHQ YSLQVLANCK QNRDFDKLLK 360 361 QYESNAACEG RMLETFLTYP MFQIPRYIIT LHELLAHTPH EHVERKSLEF AKSKLEELSR 420 421 VMHDEVSDTE NIRKNLAIER MIVEGCDILL DTSQTFVRQG SLIQLPSVER GKLSKVRLGS 480 481 LSLKKEGERQ CFLFTKHFLI CTRSSGGKLH LLKQGGVLSL IECTLIEEPD ANDEDAKNSG 540 541 QVFGHLDFKI VVEPSDAPAF TVVLLAPSRQ EKAAWTSDIS QCIDNIRCNG LMTSVFEENS 600 601 KVTVPHMIKS DARLHKDDVD ICFSKTLNSC KVPQIRYASV ERLLERLTDL RFLSIDFLNT 660 661 FLHTYRIFTT ATVVMEKLAD IYKKPFTSIP VRSLELFFAT NQNNRSGDHV NDKSPRLCRK 720 721 FSSPPPLSIS SRTSSPVRTR KLSLNSPIGS KVGILDLSTT SSSAASSPTS ANPTISPPPS 780 781 NNNNNSKPPL DLSRGQSPSS PEQSPGALDD NAEVPRIDAL CGKLRRSIRR AVLESVSLDK 840 841 FIPESPQASE PGEISPCRSP STPRHLRYRQ SGVQTAENSR CSVSPASAFA IATAAAGHSS 900 901 PPVFNNSERT CDKEFIIRRA ATNRVLNVLR HWVSKHSQDF EMNGELKMGV ICLLEEVLRD 960 961 PDLLPQERKA TANILSALSQ DDQDDAQLKI EDILQMAECP KAECFESLSA MEIAEQITLL 1020 1021 DHIVFRSIPY EEFLGQGWMK TDKTERTPYI MKTSQHFNDM SNLVASQIMS HTDVGSRAGS 1080 1081 IEKWVAVADI CRCLNNYNGV LEITSALNRS AIYRLKKTWA KVCKQTKALM DKLQKTVSSE 1140 1141 GRFKNLRETL KNCNPPCVPY LGMYLTDLAF IEEGTPNFTE EGLVNFSKMR MISHIIREIR 1200 1201 QFQQTPYRIE HQPKVTQYLL DKTLIMDEDT LYDLSLKIEP RLPA 1244 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCAGAAGA GTGTTCGGTA CAATGAGGGA CACGCTTTGT TTCTCTCCGT TATCGCGCGT 60 61 AAAGAGGGCA CCAAGCGAGG CTATCTCAGC AAGAAGACCA CGGAAAACAG CAAATGGCAC 120 121 GAGAAGTTTT TTGCACTTTA TCAGAATGTT TTGTTTTACT TCGACACCGA CCAAAGTGCT 180 181 CGACCATCAG GGATTTATCT TCTGGAGGGA TGCACATGTG AACGGGTCCC TGCGCTCAAG 240 241 GTGTCCACTG TTGGCAAAGA CGCACTTGAC AAGCTGCAAT ATTTCCTTGT GGTCTTCGGC 300 301 CATGATGGAC AGAAGCCTCT GGAGCTACGG ACGGAAGAAG AGTCTGACTG TGATGAATGG 360 361 GTTGAAGCCA TCCAGCAGGC CAGCTACTCT GATATCATCA TCGAGCGTGA GGTTCTCATG 420 421 CAGAAATACA TCCACCTGGT GCAAATCGTG GAGACGGAGA AAGTGGCAGC AAACCAGCTC 480 481 CGCACACAAC TGGAGGACCA AGACACTGAG ATTGAGAGGC TTAAAGCTGA GATTATAGCC 540 541 TTGAACAAAA CCAAGGAAAG AATGCGCCCC TACCATGTAT TTCAGGAAGA GGAAGATCCT 600 601 GATATTAAAA AAATTAAAAA GGTCCAGAGC TTCATGCGAG GGTGGCTGTG TAGAAGGAAG 660 661 TGGAAGATTA TTGTGCAGGA CTACATCTGT TCTCCTCATG CTGAGAGCAT GAGGAAGAGG 720 721 AATCAGATCG TCTTCAACAT GGTGGAGGCT GAGACCGAGT ACGTCCATCA GCTTTCCATT 780 781 TTAGTCAACT GCTTCCTGAG GCCACTCAGA ATGGCCGCCA GCTCCAAGAA ACCACCTATA 840 841 AGCCATGATG ATGTCAGTAG CATATTCCTT AACAGCGAGA CAATCATGTT TCTACATGAA 900 901 ATATTCCATC AGGGATTGAA GGCGAGGATA GCAAACTGGC CCACGCTGGT TCTAGCGGAC 960 961 CTCTTTGATA TCTTGCTGCC AATGCTGAAC ATCTATCAGG AGTTTGTGAG GAACCACCAG 1020 1021 TACAGTCTTC AGGTTCTGGC AAACTGCAAG CAGAATCGGG ACTTTGATAA ACTCCTGAAG 1080 1081 CAGTATGAAT CCAATGCTGC GTGTGAGGGG CGGATGCTGG AAACATTCCT CACATACCCC 1140 1141 ATGTTTCAGA TCCCTCGTTA CATCATCACT CTCCATGAGC TATTGGCTCA TACTCCTCAT 1200 1201 GAGCATGTGG AAAGGAAAAG TCTAGAATTT GCCAAGTCCA AACTGGAGGA GCTTTCCAGG 1260 1261 GTGATGCACG ATGAAGTAAG TGATACCGAA AACATCCGTA AGAACCTGGC TATTGAGCGC 1320 1321 ATGATCGTGG AGGGCTGCGA CATCCTCCTT GACACCAGCC AGACGTTTGT GAGACAAGGC 1380 1381 TCTTTGATCC AATTGCCCTC AGTGGAGCGA GGGAAGCTCA GTAAGGTGCG ACTCGGCTCT 1440 1441 CTCTCGCTCA AAAAGGAAGG AGAAAGACAG TGCTTCCTTT TTACCAAGCA CTTCCTTATC 1500 1501 TGCACACGCA GCTCAGGAGG CAAACTTCAC CTGCTCAAAC AAGGTGGTGT GCTGTCCCTG 1560 1561 ATTGAGTGCA CTCTCATCGA AGAGCCTGAT GCCAATGACG AGGATGCTAA GAATTCAGGG 1620 1621 CAGGTGTTCG GTCACCTTGA CTTTAAGATT GTGGTGGAGC CTTCAGATGC TCCGGCCTTC 1680 1681 ACTGTGGTGC TACTGGCACC ATCCCGTCAG GAGAAAGCAG CTTGGACCAG CGACATCAGC 1740 1741 CAGTGCATCG ATAACATCCG CTGCAATGGC CTGATGACCA GTGTGTTTGA GGAGAACTCA 1800 1801 AAAGTCACAG TACCTCATAT GATCAAATCT GATGCGCGTC TCCATAAAGA TGATGTTGAC 1860 1861 ATTTGCTTCA GTAAGACCCT CAACTCCTGC AAGGTTCCTC AGATCCGCTA CGCCAGCGTG 1920 1921 GAGAGACTGC TGGAGAGGTT GACCGACCTG CGCTTCCTCT CCATAGACTT CCTCAACACA 1980 1981 TTCCTGCACA CCTACCGCAT CTTCACTACT GCCACCGTGG TCATGGAGAA ACTGGCTGAC 2040 2041 ATCTACAAAA AGCCTTTTAC TTCCATACCA GTCAGATCCC TGGAGCTTTT CTTTGCCACC 2100 2101 AACCAGAACA ACCGCAGCGG GGACCACGTC AATGACAAAT CTCCAAGACT GTGCCGCAAG 2160 2161 TTCTCATCCC CTCCACCTCT CTCCATTTCC TCTCGTACTT CCTCTCCAGT TCGCACTAGA 2220 2221 AAACTCTCTC TTAATTCACC TATTGGCTCA AAAGTAGGCA TCCTTGATCT GTCCACCACT 2280 2281 TCATCATCTG CAGCAAGCAG TCCAACCTCC GCCAACCCCA CCATCTCACC TCCACCATCC 2340 2341 AACAACAATA ACAACAGCAA GCCACCTTTG GATCTTAGCC GTGGACAGAG TCCTTCCTCC 2400 2401 CCCGAGCAGA GTCCTGGAGC TCTGGACGAC AATGCTGAGG TGCCACGAAT CGATGCCCTT 2460 2461 TGTGGTAAAC TACGCCGCAG CATAAGGAGA GCTGTGCTGG AGTCAGTGTC TTTGGACAAA 2520 2521 TTTATTCCAG AGTCGCCCCA GGCCAGTGAA CCAGGAGAAA TCTCTCCGTG CCGCTCACCC 2580 2581 TCCACTCCAC GCCACCTCCG CTACAGACAG TCAGGAGTCC AGACGGCTGA GAACTCACGC 2640 2641 TGCTCTGTTT CTCCAGCCTC TGCGTTTGCC ATTGCCACTG CAGCAGCTGG ACACAGCAGC 2700 2701 CCTCCAGTTT TTAACAACTC TGAGAGGACT TGTGACAAGG AGTTCATTAT ACGTCGAGCG 2760 2761 GCTACTAACA GAGTCCTGAA TGTCTTGCGA CACTGGGTCT CCAAACACTC ACAGGACTTT 2820 2821 GAAATGAATG GAGAGTTGAA GATGGGTGTG ATCTGCCTGC TGGAAGAGGT GTTGAGAGAC 2880 2881 CCAGACCTTC TCCCTCAGGA GAGAAAAGCC ACAGCAAACA TACTAAGTGC CCTTTCTCAA 2940 2941 GATGACCAGG ATGATGCACA GCTGAAGATT GAAGACATTC TTCAGATGGC TGAGTGCCCA 3000 3001 AAGGCCGAGT GTTTTGAGTC TCTGTCTGCA ATGGAGATAG CAGAACAAAT CACTCTCCTT 3060 3061 GATCACATCG TGTTCAGGAG TATTCCCTAC GAGGAGTTCC TGGGCCAAGG ATGGATGAAG 3120 3121 ACAGATAAGA CAGAGAGAAC GCCATACATC ATGAAGACAA GTCAACACTT CAATGACATG 3180 3181 AGTAACCTGG TGGCCTCTCA GATCATGAGC CATACAGATG TGGGCTCCAG AGCGGGTTCT 3240 3241 ATTGAAAAAT GGGTCGCAGT GGCTGACATT TGCCGTTGTC TCAACAATTA TAACGGTGTC 3300 3301 TTGGAGATCA CATCTGCCCT GAACCGCAGC GCCATCTACA GGCTGAAGAA GACATGGGCT 3360 3361 AAAGTCTGCA AACAGACTAA AGCACTAATG GACAAACTTC AGAAGACCGT GTCATCTGAG 3420 3421 GGAAGATTTA AAAACTTGAG GGAAACTCTC AAAAACTGTA ATCCACCCTG TGTTCCATAT 3480 3481 CTGGGCATGT ACTTGACAGA CCTCGCGTTT ATCGAAGAGG GAACTCCAAA TTTCACAGAG 3540 3541 GAAGGTCTAG TTAACTTCTC AAAGATGAGA ATGATTTCTC ACATCATACG AGAGATCCGA 3600 3601 CAGTTCCAGC AAACTCCCTA CAGAATAGAG CACCAACCAA AGGTCACGCA GTATCTTCTG 3660 3661 GATAAGACCT TGATTATGGA TGAGGACACA CTTTATGATT TATCACTCAA GATTGAACCC 3720 3721 AGGCTTCCTG CATGA 3735 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum membrane | |
Cellular Component | Plasma membrane | |
Molecular Function | Calmodulin binding | |
Molecular Function | Rho guanyl-nucleotide exchange factor activity | |
Biological Process | Regulation of Rho protein signal transduction | |
Biological Process | Small GTPase mediated signal transduction |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a334 | Homo sapiens | 0.0 | 2127 | undefined |
| LLPS-Mum-a334 | Mus musculus | 0.0 | 1882 | undefined |