LLPS-Dar-a145
fh
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Fumarate hydratase, mitochondrial |
| Gene Name: | fh, zgc:66253 |
| Ensembl Gene: | ENSDARG00000075132.4 |
| Ensembl Protein: | ENSDARP00000097494.2 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000108477.3 | ENSDARP00000097494.2 |
| UniProt | Q7SX99, FUMH_DANRE | |
| GeneBank | BC055566, BC066484 | AAH66484.1, AAH55566.1 |
| RefSeq | NM_200963.1 | NP_957257.1 |
| Entrez | 393938 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MYRSARSLHR FSASLSDLRA AQRSIKARNV CPAPGLRHQT VRMASSEAFR IERDTFGELK 60 61 VPSDKYYGAQ TVRSTMNFRI GGVTERMPIQ VIRAFGILKK AAAEVNKDYG LDPKIADAIM 120 121 KAADEVESGK LDDHFPLVVW QTGSGTQTNM NVNEVISNRA IEMLGGKLGS KDPVHPNDHV 180 181 NKSQSSNDTF PTAMHIAAAK EVHEVLLPGL QTLHDALAAK AEQFKDIIKI GRTHTQDAVP 240 241 LSLGQEFGGY VQQVKYSIAR VKASLPRVYE LAAGGTAVGT GLNTRIGFAE KVADKVSALT 300 301 GLPFVTAANK FEALAAHDAL VELSGALNTV AVSMMKIAND IRFLGSGPRS GLGELNLPEN 360 361 EPGSSIMPGK VNPTQCEAMT MVAAQVMGNH VAVTVGGSNG HFELNVFKPM IIKNVLNSAR 420 421 LLGDASVSFT NNCVVGIEAN TERINKLMSE SLMLVTALNP HIGYDKAAKI AKTAHKDGST 480 481 LKEAALKLGF LNEQQFEEWV RPHDMLGPK 509 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTACCGCT CCGCTCGCTC CCTGCATCGC TTCAGCGCGA GTTTGTCAGA TCTGCGGGCC 60 61 GCTCAGAGAT CCATCAAAGC TCGCAACGTC TGTCCAGCAC CCGGGCTCCG GCACCAGACC 120 121 GTCAGAATGG CCAGTTCAGA GGCATTTCGG ATTGAGAGGG ACACATTTGG AGAGCTTAAA 180 181 GTCCCCTCTG ATAAATACTA TGGAGCTCAG ACTGTCAGAT CCACCATGAA CTTCAGGATC 240 241 GGAGGAGTCA CGGAGAGGAT GCCGATTCAG GTGATCAGAG CTTTCGGTAT CCTGAAGAAA 300 301 GCTGCTGCAG AAGTCAATAA AGATTACGGT TTGGACCCAA AGATCGCAGA CGCCATCATG 360 361 AAAGCTGCTG ATGAGGTGGA GTCTGGGAAA CTGGATGATC ATTTCCCGCT GGTTGTTTGG 420 421 CAAACAGGAT CCGGAACTCA GACTAACATG AACGTCAATG AGGTGATCAG TAACAGAGCC 480 481 ATCGAGATGC TGGGAGGAAA ACTGGGCAGC AAAGACCCCG TTCATCCCAA TGACCACGTC 540 541 AACAAGAGCC AGAGCTCCAA TGACACGTTC CCCACAGCCA TGCACATCGC TGCTGCTAAA 600 601 GAGGTTCACG AGGTGCTCCT GCCGGGCCTT CAGACGCTTC ATGATGCTCT CGCTGCCAAA 660 661 GCTGAACAGT TCAAAGACAT CATAAAGATC GGCCGCACAC ACACACAGGA CGCCGTGCCG 720 721 CTCTCGCTCG GACAGGAGTT TGGCGGGTAC GTGCAGCAGG TGAAGTACAG TATTGCGCGC 780 781 GTGAAAGCGT CTCTGCCGCG TGTGTATGAG CTGGCAGCAG GAGGAACCGC AGTCGGCACT 840 841 GGACTCAACA CGCGCATCGG CTTTGCAGAG AAGGTGGCAG ATAAAGTGTC TGCACTTACA 900 901 GGTCTTCCGT TCGTGACCGC AGCCAATAAG TTCGAGGCTC TGGCGGCTCA TGATGCTCTG 960 961 GTGGAGCTGA GCGGCGCTCT AAACACTGTG GCCGTGAGCA TGATGAAGAT CGCCAATGAT 1020 1021 ATCCGCTTCC TCGGCTCTGG GCCTCGTTCA GGTCTCGGAG AACTCAACCT GCCAGAAAAC 1080 1081 GAACCCGGAT CCAGCATCAT GCCCGGTAAG GTGAACCCGA CGCAGTGTGA GGCCATGACT 1140 1141 ATGGTGGCCG CTCAGGTGAT GGGGAATCAT GTGGCCGTTA CTGTCGGGGG AAGCAATGGA 1200 1201 CACTTCGAGC TCAATGTGTT CAAGCCCATG ATCATTAAGA ACGTGCTGAA CTCGGCCAGG 1260 1261 CTGCTGGGCG ATGCTTCGGT CTCCTTCACT AATAACTGCG TGGTCGGCAT CGAGGCGAAC 1320 1321 ACCGAGAGGA TCAACAAGCT GATGAGCGAG TCTCTGATGC TGGTCACCGC CCTCAATCCA 1380 1381 CATATAGGTT ATGATAAAGC CGCAAAAATT GCGAAAACCG CTCATAAAGA CGGTTCGACT 1440 1441 CTGAAAGAGG CGGCGCTGAA GCTGGGATTC CTGAACGAGC AGCAGTTTGA GGAGTGGGTT 1500 1501 CGACCTCATG ACATGCTAGG CCCAAAGTAA 1530 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromosome | |
Cellular Component | Cytosol | |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleus | |
Cellular Component | Tricarboxylic acid cycle enzyme complex | |
Molecular Function | Fumarate hydratase activity | |
Biological Process | Cellular response to DNA damage stimulus | |
Biological Process | DNA repair | |
Biological Process | Fumarate metabolic process | |
Biological Process | Malate metabolic process | |
Biological Process | Negative regulation of histone H3-K36 methylation | |
Biological Process | Positive regulation of double-strand break repair via nonhomologous end joining | |
Biological Process | Regulation of arginine metabolic process | |
Biological Process | Tricarboxylic acid cycle | |
Biological Process | Urea cycle |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a167 | Homo sapiens | 0.0 | 862 | undefined |
| LLPS-Mum-a168 | Mus musculus | 0.0 | 860 | undefined |