LLPS-Dar-a1083
gja1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Gap junction alpha-1 protein; Connexin-43; Cx43; Short fin protein |
| Gene Name: | gja1, cx43, shf, sof |
| Ensembl Gene: | ENSDARG00000041799.7 |
| Ensembl Protein: | ENSDARP00000127342.1 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000153151.2 | ENSDARP00000127342.1 |
| Ensembl | ENSDART00000181663.1 | ENSDARP00000150086.1 |
| Ensembl | ENSDART00000061261.4 | ENSDARP00000061260.3 |
| Ensembl | ENSDART00000138569.2 | ENSDARP00000114698.1 |
| UniProt | O57474, CXA1_DANRE, Q5TYN6, Q7ZTS1 | |
| GeneBank | AY340236, BC049297, AY313942, CR352322, AF035481 | AAQ17183.1, AAC04759.1, AAQ62128.1, AAH49297.1, CAH69066.1, CAH69065.1 |
| RefSeq | NM_131038.1 | NP_571113.1 |
| Entrez | 30236 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGDWSALGRL LDKVQAYSTA GGKVWLSVLF IFRILVLGTA VESAWGDEQS AFKCNTQQPG 60 61 CENVCYDKSF PISHVRFWVL QIIFVSTPTL LYLAHVFYLM RKEEKLNRKE EELKAVQNDG 120 121 GDVELHLKKI ELKKFKHGLE EHGKVKMKGS LLRTYIFSII FKSICEVVFL VIQWYLYGFS 180 181 LSAVYTCERT PCPHRVDCFL SRPTEKTIFI IFMLVVSLFS LLLNIIELFY VLFKRIKDRV 240 241 KSRQNTQFPT GTLSPTPKEL STTKYAYYNG CSSPTAPLSP MSPPGYKLAT GERTNSCRNY 300 301 NKQANEQNWA NYSTEQNRLG QNGSTISNSH AQAFDYPDDT HEHKKLTPGH ELQPLALIDA 360 361 RPCSRASSRM SSRARPDDLD V 381 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGTGACT GGAGTGCGTT GGGAAGGCTT CTTGACAAGG TGCAGGCCTA CTCCACGGCC 60 61 GGAGGGAAGG TCTGGCTCTC TGTGCTCTTC ATCTTCCGGA TCCTTGTTCT GGGAACAGCA 120 121 GTGGAATCGG CCTGGGGTGA CGAGCAGTCA GCTTTCAAGT GCAATACCCA GCAGCCTGGT 180 181 TGCGAGAATG TCTGCTATGA CAAATCGTTC CCCATCTCGC ACGTGCGCTT CTGGGTGCTT 240 241 CAGATCATCT TCGTGTCCAC GCCGACGCTC CTGTACCTGG CGCATGTCTT CTACCTGATG 300 301 CGAAAGGAGG AGAAACTCAA CCGTAAAGAA GAGGAGCTGA AGGCCGTGCA GAACGACGGC 360 361 GGCGACGTTG AGCTCCATCT CAAGAAAATC GAGCTCAAGA AGTTTAAGCA TGGCCTAGAG 420 421 GAGCACGGCA AGGTGAAGAT GAAGGGTAGC CTGCTGCGCA CCTACATCTT CAGCATCATT 480 481 TTCAAGTCCA TCTGTGAGGT GGTCTTCCTG GTCATCCAAT GGTACCTCTA CGGCTTCAGC 540 541 CTCTCTGCCG TGTACACATG CGAACGCACG CCTTGCCCTC ATAGGGTGGA CTGTTTCCTT 600 601 TCTCGGCCCA CCGAGAAGAC CATCTTCATC ATCTTCATGC TAGTGGTTTC GCTCTTCTCG 660 661 CTTTTGCTCA ACATCATCGA GCTCTTCTAC GTGCTCTTCA AACGAATCAA GGACCGCGTC 720 721 AAAAGCCGAC AAAACACACA GTTTCCCACT GGCACTTTGA GCCCCACGCC GAAGGAACTG 780 781 TCTACGACCA AATACGCGTA CTACAATGGT TGCTCCTCAC CAACTGCACC GCTCTCACCA 840 841 ATGTCACCTC CAGGCTACAA ACTGGCCACC GGCGAAAGGA CCAACTCTTG CCGCAATTAC 900 901 AACAAGCAGG CTAATGAGCA GAATTGGGCC AACTACAGCA CAGAACAGAA TCGCTTGGGC 960 961 CAGAATGGCA GCACCATCTC CAATTCACAT GCACAAGCCT TCGACTACCC TGATGATACA 1020 1021 CATGAGCACA AGAAACTGAC GCCAGGGCAT GAGTTGCAGC CATTGGCGTT GATAGATGCA 1080 1081 CGGCCGTGCA GCCGTGCCAG CAGCCGCATG AGCAGTCGAG CGAGGCCTGA TGACCTGGAC 1140 1141 GTCTAG 1146 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Apical plasma membrane | |
Cellular Component | Connexin complex | |
Cellular Component | Gap junction | |
Cellular Component | Integral component of membrane | |
Cellular Component | Intercalated disc | |
Cellular Component | Mitochondrion | |
Cellular Component | Plasma membrane | |
Molecular Function | Gap junction channel activity | |
Molecular Function | Gap junction hemi-channel activity | |
Molecular Function | Voltage-gated channel activity | |
Biological Process | Bone growth | |
Biological Process | Bone morphogenesis | |
Biological Process | Caudal fin morphogenesis | |
Biological Process | Cell communication | |
Biological Process | Cell differentiation | |
Biological Process | Cell population proliferation | |
Biological Process | Cell-cell signaling | |
Biological Process | Embryonic heart tube development | |
Biological Process | Embryonic hemopoiesis | |
Biological Process | Embryonic skeletal joint morphogenesis | |
Biological Process | Fin development | |
Biological Process | Fin morphogenesis | |
Biological Process | Fin regeneration | |
Biological Process | Kupffer's vesicle development | |
Biological Process | Medial fin development | |
Biological Process | Microtubule-based transport |