LLPS-Dar-4110
bap1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ubiquitin carboxyl-terminal hydrolase BAP1; BRCA1-associated protein 1 |
| Gene Name: | bap1, si:dkey-42i9.9 |
| Ensembl Gene: | ENSDARG00000063051.8 |
| Ensembl Protein: | ENSDARP00000147485.1 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| PcG body | Predicted from orthologs | (View) |
▼ FUNCTION
| Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000184812.1 | ENSDARP00000147485.1 |
| Ensembl | ENSDART00000091777.6 | ENSDARP00000086210.5 |
| UniProt | A1L2G3, BAP1_DANRE, Q1LXB5 | |
| GeneBank | BC129506, BX465868 | AAI29507.1, CAK11034.1 |
| Entrez | 558885 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MYSLVVLISC ALSGLFTLLV EDFGVKGVQV EEIYDLQSKC QSPVYGFIFL FKWIEERRSR 60 61 RKVSTLVDET SVIDDDIVND MFFAHQLIPN SCATHALLSV LLNCSGVELG MTLSRMKAFT 120 121 KGFNPESKGY AIGNAPELAK AHNSHARPEP RHLPEKQNGI SAVRTMEAFH FVSYVPIKDR 180 181 LFELDGLKAY PIDHGPWGED EEWTDKARRV IMERIGLATA GEPYHDIRFN LMAVVPDRRI 240 241 KYESKLDILK RNRQIILEGL QQIREKKVIR MTQQESGQDR KQQDSSSSED TPPVVKKEEV 300 301 QETPIPSGAE QATPTETQEG AASLPSPAGK VRSMAKPALP AGGAPPPAPL PAPSTNTIVQ 360 361 RLPAFLDNHN YAKSPMQEEE DLAAGVGRSR PPQPPYSDDE DDYDDEEEEC STAGVTNSRV 420 421 RRKLGLRTRT MSRTAVGGVA AMEGQLALSV LAEKLKKEVQ RKDALATTGS TPLNVRTEGR 480 481 TGGISITSAC QPSPTPSNES TDTASEIGSA FNSPLRSPAR SQATTRPSSP VASHVGRVLF 540 541 GEEEGLPRLD ARHNRAVRDL GVLVSSTQLQ LQEDGVIFAL PPTEALEGLK KVGGVDKKKK 600 601 EEASGPGGEE EVKEGPSVEM KAEDVKESVD VKPEKENLPT TDVENSTKPP GEKYTPKELL 660 661 ALLKYVEADI ANYEVYLKEE VEKRKKYKID DQRRTHNYDE FICTFISMLA QEGMLASLVE 720 721 QNISVRRRQG VSIGRLHKQR KPDRRKRSRP YKAKRQ 756 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAACAAAG GTTGGCTGGA GTTAGAAAGT GACCCGGGGT TGTTCACACT CCTGGTGGAG 60 61 GACTTTGGCG TGAAAGGAGT TCAGGTGGAG GAGATTTATG ATCTTCAGAG CAAATGTCAA 120 121 AGTCCTGTAT ATGGCTTCAT CTTTCTTTTC AAATGGATCG AGGAGCGAAG ATCTCGGCGT 180 181 AAAGTCTCCA CACTGGTGGA TGAAACCTCT GTTATCGATG ACGACATTGT TAATGACATG 240 241 TTTTTCGCTC ATCAGTTGAT CCCGAACTCC TGTGCGACTC ATGCTCTTCT CAGCGTGCTC 300 301 CTGAACTGCA GCGGTGTGGA GCTGGGAATG ACTCTGAGCC GCATGAAGGC TTTCACCAAG 360 361 GGCTTCAATC CTGAGAGTAA AGGTTACGCC ATTGGAAACG CCCCAGAGCT GGCGAAAGCC 420 421 CACAACAGCC ATGCCAGGCC GGAGCCGCGG CATCTTCCGG AGAAACAGAA CGGCATTAGC 480 481 GCTGTGCGGA CGATGGAGGC GTTTCATTTT GTCAGTTACG TGCCAATCAA AGACAGACTG 540 541 TTTGAGCTAG ATGGGCTGAA GGCGTATCCC ATTGACCACG GACCATGGGG TGAGGATGAA 600 601 GAGTGGACAG ATAAAGCCAG ACGGGTCATA ATGGAGCGAA TAGGACTGGC CACTGCTGGA 660 661 GAGCCCTACC ATGACATCCG GTTTAATCTC ATGGCGGTGG TTCCAGATCG CAGGATAAAA 720 721 TACGAGTCCA AGTTGGACAT CCTGAAGCGG AACAGGCAGA TCATACTTGA AGGGCTCCAG 780 781 CAGATTAGAG AGAAAAAAGT TATTCGGATG ACTCAGCAAG AATCAGGCCA GGATCGTAAG 840 841 CAGCAAGACT CCTCTTCTTC AGAAGACACG CCCCCTGTTG TCAAAAAGGA GGAGGTGCAA 900 901 GAAACACCAA TACCTTCAGG TGCCGAGCAG GCCACACCCA CAGAAACTCA AGAAGGTGCT 960 961 GCCTCTTTAC CAAGTCCAGC TGGTAAAGTC AGATCCATGG CTAAACCCGC TTTGCCAGCA 1020 1021 GGGGGCGCTC CACCACCAGC CCCTCTACCT GCTCCAAGCA CCAACACCAT TGTGCAGCGT 1080 1081 CTACCAGCCT TCCTGGACAA TCACAACTAC GCCAAATCCC CCATGCAGGA AGAGGAGGAT 1140 1141 CTTGCTGCAG GTGTGGGACG CTCACGCCCC CCTCAGCCCC CTTATTCTGA TGATGAGGAT 1200 1201 GACTATGATG ATGAAGAGGA GGAGTGCAGC ACTGCTGGTG TCACAAACAG CAGGGTTCGA 1260 1261 AGAAAGTTGG GTCTGCGTAC CCGTACCATG AGCCGCACTG CAGTGGGCGG AGTCGCAGCA 1320 1321 ATGGAGGGTC AACTAGCACT CAGTGTTTTA GCAGAGAAGC TCAAGAAGGA GGTTCAGCGG 1380 1381 AAAGACGCCT TGGCCACAAC TGGATCCACA CCTCTGAACG TACGTACCGA GGGTCGGACA 1440 1441 GGTGGCATCA GCATCACCTC GGCTTGCCAG CCGTCGCCCA CCCCTAGTAA CGAAAGCACG 1500 1501 GACACAGCCT CCGAGATTGG TAGTGCATTC AACTCCCCAC TGCGGTCACC AGCTCGATCA 1560 1561 CAGGCGACTA CACGTCCCTC CAGCCCAGTG GCTTCCCATG TAGGCCGCGT GCTGTTTGGG 1620 1621 GAAGAGGAGG GGCTGCCTAG GTTAGATGCC CGACACAATC GGGCTGTCCG AGACTTGGGG 1680 1681 GTGCTCGTGA GCTCAACACA GCTCCAACTG CAAGAGGATG GAGTCATATT TGCCCTGCCA 1740 1741 CCTACAGAAG CATTGGAGGG GTTGAAGAAA GTGGGTGGTG TGGATAAGAA GAAGAAAGAA 1800 1801 GAGGCGAGTG GTCCAGGAGG GGAGGAGGAG GTGAAGGAGG GACCATCAGT GGAGATGAAA 1860 1861 GCAGAGGACG TCAAAGAGTC AGTTGACGTC AAACCTGAGA AGGAGAACCT GCCGACCACT 1920 1921 GATGTTGAGA ACAGCACCAA ACCTCCTGGG GAAAAATACA CTCCTAAGGA GTTGCTAGCT 1980 1981 TTGCTGAAGT ATGTGGAAGC AGATATCGCC AACTACGAAG TGTATTTGAA AGAAGAAGTG 2040 2041 GAAAAAAGGA AGAAGTACAA GATTGATGAC CAGAGGAGGA CTCATAACTA TGACGAGTTT 2100 2101 ATCTGCACCT TCATATCAAT GCTTGCACAA GAAGGTATGT TGGCGAGTCT GGTGGAGCAG 2160 2161 AACATCTCTG TGCGTCGGCG ACAAGGCGTA AGCATCGGTC GGCTTCACAA ACAACGCAAA 2220 2221 CCTGATCGGC GGAAACGTTC ACGGCCATAC AAAGCCAAAC GGCAATAG 2268 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Cellular Component | PR-DUB complex | |
Molecular Function | Chromatin binding | |
Molecular Function | Thiol-dependent ubiquitin-specific protease activity | |
Molecular Function | Thiol-dependent ubiquitinyl hydrolase activity | |
Biological Process | Cranial skeletal system development | |
Biological Process | Monoubiquitinated histone H2A deubiquitination | |
Biological Process | Notch signaling pathway | |
Biological Process | Protein deubiquitination | |
Biological Process | Protein K48-linked deubiquitination | |
Biological Process | Regulation of cell cycle | |
Biological Process | Regulation of cell growth | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Mum-3223 | Mus musculus | 93.4 | 2e-55 | 207 |
| LLPS-Mup-2456 | Mustela putorius furo | 81.03 | 1e-17 | 92.4 |
| LLPS-Meg-1656 | Meleagris gallopavo | 78.33 | 4e-173 | 507 |
| LLPS-Orn-3709 | Oreochromis niloticus | 75.57 | 0.0 | 1051 |
| LLPS-Ten-0956 | Tetraodon nigroviridis | 75.07 | 0.0 | 1034 |
| LLPS-Pof-0488 | Poecilia formosa | 75.0 | 0.0 | 1035 |
| LLPS-Xim-2916 | Xiphophorus maculatus | 74.33 | 0.0 | 1029 |
| LLPS-Gaa-3061 | Gasterosteus aculeatus | 74.26 | 0.0 | 1045 |
| LLPS-Tar-3815 | Takifugu rubripes | 74.14 | 0.0 | 1040 |
| LLPS-Asm-2874 | Astyanax mexicanus | 74.02 | 0.0 | 1037 |
| LLPS-Scm-3022 | Scophthalmus maximus | 73.61 | 0.0 | 1002 |
| LLPS-Icp-2787 | Ictalurus punctatus | 73.55 | 0.0 | 1032 |
| LLPS-Orl-1736 | Oryzias latipes | 72.92 | 0.0 | 1020 |
| LLPS-Mod-3448 | Monodelphis domestica | 66.32 | 0.0 | 907 |
| LLPS-Tag-1442 | Taeniopygia guttata | 66.01 | 0.0 | 896 |
| LLPS-Loa-3369 | Loxodonta africana | 66.0 | 0.0 | 885 |
| LLPS-Sah-3571 | Sarcophilus harrisii | 65.96 | 0.0 | 905 |
| LLPS-Scf-1532 | Scleropages formosus | 65.61 | 0.0 | 885 |
| LLPS-Chs-3800 | Chlorocebus sabaeus | 65.52 | 0.0 | 884 |
| LLPS-Otg-4002 | Otolemur garnettii | 65.42 | 0.0 | 889 |
| LLPS-Sus-4573 | Sus scrofa | 65.34 | 0.0 | 889 |
| LLPS-Bot-3535 | Bos taurus | 65.09 | 0.0 | 888 |
| LLPS-Dio-2668 | Dipodomys ordii | 65.08 | 0.0 | 880 |
| LLPS-Mam-1264 | Macaca mulatta | 65.05 | 0.0 | 865 |
| LLPS-Fud-2066 | Fukomys damarensis | 65.04 | 0.0 | 894 |
| LLPS-Myl-3355 | Myotis lucifugus | 64.95 | 0.0 | 883 |
| LLPS-Poa-1584 | Pongo abelii | 64.85 | 0.0 | 880 |
| LLPS-Aon-0559 | Aotus nancymaae | 64.75 | 0.0 | 887 |
| LLPS-Caj-0170 | Callithrix jacchus | 64.69 | 0.0 | 886 |
| LLPS-Ict-3708 | Ictidomys tridecemlineatus | 64.68 | 0.0 | 886 |
| LLPS-Gog-0617 | Gorilla gorilla | 64.56 | 0.0 | 884 |
| LLPS-Orc-4373 | Oryctolagus cuniculus | 64.48 | 0.0 | 883 |
| LLPS-Fec-1148 | Felis catus | 64.42 | 0.0 | 877 |
| LLPS-Mea-3437 | Mesocricetus auratus | 64.38 | 0.0 | 883 |
| LLPS-Hos-4544 | Homo sapiens | 64.35 | 0.0 | 879 |
| LLPS-Pap-3466 | Pan paniscus | 64.35 | 0.0 | 879 |
| LLPS-Pat-4919 | Pan troglodytes | 64.35 | 0.0 | 879 |
| LLPS-Ova-4487 | Ovis aries | 64.29 | 0.0 | 881 |
| LLPS-Cap-1175 | Cavia porcellus | 64.09 | 0.0 | 891 |
| LLPS-Anc-1336 | Anolis carolinensis | 63.77 | 0.0 | 893 |
| LLPS-Fia-3802 | Ficedula albicollis | 63.77 | 0.0 | 767 |
| LLPS-Gaga-3222 | Gallus gallus | 63.72 | 0.0 | 874 |
| LLPS-Cis-1914 | Ciona savignyi | 62.92 | 5e-97 | 313 |
| LLPS-Ran-2343 | Rattus norvegicus | 62.91 | 0.0 | 872 |
| LLPS-Caf-3821 | Canis familiaris | 62.8 | 0.0 | 835 |
| LLPS-Xet-2868 | Xenopus tropicalis | 61.98 | 0.0 | 832 |
| LLPS-Urm-0353 | Ursus maritimus | 61.48 | 0.0 | 814 |
| LLPS-Eqc-4090 | Equus caballus | 61.47 | 0.0 | 731 |
| LLPS-Mal-0267 | Mandrillus leucophaeus | 61.36 | 0.0 | 807 |
| LLPS-Cea-2042 | Cercocebus atys | 61.36 | 0.0 | 808 |
| LLPS-Maf-3409 | Macaca fascicularis | 61.36 | 0.0 | 808 |
| LLPS-Rhb-4426 | Rhinopithecus bieti | 61.27 | 0.0 | 813 |
| LLPS-Paa-2677 | Papio anubis | 60.97 | 0.0 | 807 |
| LLPS-Man-0739 | Macaca nemestrina | 60.85 | 0.0 | 788 |
| LLPS-Nol-4620 | Nomascus leucogenys | 60.68 | 0.0 | 798 |
| LLPS-Lac-3060 | Latimeria chalumnae | 59.95 | 0.0 | 788 |
| LLPS-Drm-0214 | Drosophila melanogaster | 55.29 | 5e-96 | 313 |