LLPS-Dar-3556
prpf18

▼ OVERVIEW

Status: Unreviewed
Protein Name: Pre-mRNA-splicing factor 18; PRP18 homolog
Gene Name: prpf18, si:ch211-220f12.3
Ensembl Gene: ENSDARG00000113879.1
Ensembl Protein: ENSDARP00000148817.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Participates in the second step of pre-mRNA splicing.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDILKAEIAR  KRKLIEEKEL  IDDSKKYFKR  AELARKEEED  YYRRCGYKVQ  ILDMDKPEEE  60
61    APQSTSANPV  LELELTEEKL  PMTLSRQEVI  RRLRERGEPI  RLFGESDYDA  FQRLRKIEIL  120
121   APEVNKGLRN  DLKAAMDKID  QQYLNEIVGG  AEGAELDTQH  DLKVHEENTT  IEELEALGAS  180
181   LGTGNDVRDM  DIINKVLRFL  LGVWAKDLNS  REDHIKRSVQ  GKLASATQKQ  TESYLEPLFR  240
241   KLRKKNLPAD  IKESITDIIK  FMLEREYVKA  NDAYLQMAIG  NAPWPIGVTM  VGIHARTGRE  300
301   KIFSKHVAHV  LNDETQRKYI  QGLKRLMTIC  QKHFPTDPSK  CVEYNAL  347
Nucleotide CDS Sequence (FASTA)
1     ATGGACATCC  TCAAAGCAGA  GATTGCGAGG  AAAAGAAAGC  TCATCGAGGA  GAAAGAGCTC  60
61    ATAGATGACT  CAAAGAAGTA  CTTTAAACGG  GCTGAACTCG  CGCGCAAAGA  AGAGGAGGAT  120
121   TATTACAGGA  GATGTGGATA  CAAGGTACAG  ATACTTGATA  TGGACAAACC  TGAGGAGGAG  180
181   GCGCCTCAGT  CTACATCAGC  CAATCCGGTG  TTAGAACTAG  AGCTCACAGA  GGAGAAGCTG  240
241   CCAATGACAC  TCTCTCGACA  GGAGGTGATC  AGACGTCTGC  GGGAACGTGG  CGAGCCCATC  300
301   CGTCTGTTCG  GAGAATCCGA  TTATGATGCT  TTCCAGAGAC  TCCGCAAGAT  TGAAATTCTG  360
361   GCACCTGAAG  TAAACAAGGG  TTTGAGGAAT  GATCTGAAGG  CTGCTATGGA  TAAGATTGAT  420
421   CAGCAGTATC  TGAATGAGAT  TGTGGGTGGA  GCGGAGGGTG  CAGAACTGGA  CACACAACAT  480
481   GATCTTAAAG  TACATGAGGA  AAATACCACT  ATTGAGGAGC  TGGAGGCTCT  GGGAGCATCT  540
541   CTTGGCACTG  GTAATGACGT  CAGAGACATG  GACATCATAA  ATAAAGTATT  GAGGTTCTTG  600
601   CTGGGTGTGT  GGGCTAAAGA  TCTGAACAGC  CGAGAAGACC  ACATAAAGCG  TAGTGTTCAG  660
661   GGCAAGCTCG  CCAGTGCCAC  CCAAAAGCAG  ACGGAATCAT  ATCTAGAACC  TCTTTTCAGA  720
721   AAACTGCGCA  AGAAGAATTT  ACCAGCAGAT  ATTAAGGAGT  CCATCACAGA  CATCATAAAG  780
781   TTCATGCTGG  AGAGGGAATA  TGTCAAGGCG  AATGATGCTT  ACCTGCAGAT  GGCTATAGGA  840
841   AACGCTCCAT  GGCCCATTGG  TGTGACCATG  GTGGGTATCC  ATGCTCGTAC  TGGACGTGAG  900
901   AAGATCTTCT  CCAAACACGT  CGCCCATGTG  CTCAACGACG  AGACCCAAAG  GAAGTACATT  960
961   CAGGGGCTGA  AAAGATTAAT  GACAATCTGT  CAGAAACATT  TCCCAACAGA  CCCCTCAAAG  1020
1021  TGTGTGGAGT  ACAACGCTCT  GTGA  1044

▼ KEYWORD

ID
Family
Complete proteome
mRNA processing
mRNA splicing
Nucleus
Reference proteome
Spliceosome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nuclear speck
Cellular Component
U2-type post-spliceosomal complex
Cellular Component
U4/U6 x U5 tri-snRNP complex
Cellular Component
U5 snRNP
Biological Process
Generation of catalytic spliceosome for second transesterification step
Biological Process
Nuclear retention of unspliced pre-mRNA at the site of transcription

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-2977Oreochromis niloticus88.240.0 576
LLPS-Leo-2456Lepisosteus oculatus87.750.0 605
LLPS-Xim-0949Xiphophorus maculatus86.610.0 602
LLPS-Ten-1750Tetraodon nigroviridis86.460.0 595
LLPS-Fud-1660Fukomys damarensis86.150.0 555
LLPS-Pof-2994Poecilia formosa86.040.0 599
LLPS-Scf-0036Scleropages formosus85.510.0 580
LLPS-Orl-3039Oryzias latipes85.450.0 549
LLPS-Gaa-3114Gasterosteus aculeatus85.30.0 610
LLPS-Scm-3712Scophthalmus maximus85.190.0 613
LLPS-Icp-3430Ictalurus punctatus84.810.0 597
LLPS-Tag-1011Taeniopygia guttata84.730.0 579
LLPS-Pes-3700Pelodiscus sinensis84.730.0 583
LLPS-Dio-3212Dipodomys ordii84.730.0 584
LLPS-Tar-0258Takifugu rubripes84.730.0 582
LLPS-Tut-0758Tursiops truncatus84.730.0 583
LLPS-Mum-3077Mus musculus84.730.0 583
LLPS-Loa-2015Loxodonta africana84.440.0 582
LLPS-Hos-1032Homo sapiens84.440.0 582
LLPS-Poa-2373Pongo abelii84.150.0 581
LLPS-Orc-2461Oryctolagus cuniculus84.150.0 581
LLPS-Myl-1099Myotis lucifugus84.150.0 581
LLPS-Sah-0406Sarcophilus harrisii84.150.0 581
LLPS-Meg-0166Meleagris gallopavo83.860.0 578
LLPS-Aim-1311Ailuropoda melanoleuca83.860.0 581
LLPS-Otg-3691Otolemur garnettii83.570.0 576
LLPS-Mup-4244Mustela putorius furo83.570.0 580
LLPS-Paa-4515Papio anubis83.190.0 578
LLPS-Anc-2493Anolis carolinensis83.150.0 579
LLPS-Asm-3881Astyanax mexicanus83.070.0 612
LLPS-Caf-4463Canis familiaris82.990.0 554
LLPS-Mam-3989Macaca mulatta82.910.0 575
LLPS-Cap-3571Cavia porcellus82.910.0 575
LLPS-Nol-2911Nomascus leucogenys82.910.0 575
LLPS-Cas-1430Carlito syrichta82.910.0 575
LLPS-Man-4333Macaca nemestrina82.910.0 575
LLPS-Pap-4325Pan paniscus82.910.0 575
LLPS-Pat-0665Pan troglodytes82.910.0 575
LLPS-Aon-3775Aotus nancymaae82.910.0 575
LLPS-Chs-4607Chlorocebus sabaeus82.910.0 575
LLPS-Maf-0885Macaca fascicularis82.910.0 575
LLPS-Caj-2770Callithrix jacchus82.910.0 575
LLPS-Anp-2392Anas platyrhynchos82.90.0 569
LLPS-Eqc-2681Equus caballus82.620.0 575
LLPS-Rhb-4427Rhinopithecus bieti82.620.0 573
LLPS-Ora-3483Ornithorhynchus anatinus82.490.0 573
LLPS-Fec-2721Felis catus82.340.0 574
LLPS-Sus-3870Sus scrofa82.340.0 574
LLPS-Lac-3162Latimeria chalumnae82.20.0 568
LLPS-Ict-1495Ictidomys tridecemlineatus82.050.0 573
LLPS-Bot-3660Bos taurus82.050.0 572
LLPS-Ova-0641Ovis aries82.050.0 572
LLPS-Gog-3413Gorilla gorilla81.540.0 516
LLPS-Gaga-0799Gallus gallus80.50.0 567
LLPS-Ran-1859Rattus norvegicus79.290.0 516
LLPS-Fia-1844Ficedula albicollis78.985e-179 507
LLPS-Urm-3984Ursus maritimus78.960.0 538
LLPS-Xet-0830Xenopus tropicalis78.10.0 553
LLPS-Mod-3100Monodelphis domestica75.50.0 539
LLPS-Cea-1379Cercocebus atys74.061e-172 490
LLPS-Mal-1195Mandrillus leucophaeus69.455e-155 444
LLPS-Chr-1185Chlamydomonas reinhardtii57.895e-0652.0
LLPS-Cii-0050Ciona intestinalis55.871e-127 377
LLPS-Cis-0983Ciona savignyi53.743e-120 357
LLPS-Tru-0068Triticum urartu51.535e-57 192
LLPS-Drm-1140Drosophila melanogaster51.453e-118 352
LLPS-Org-2254Oryza glaberrima50.963e-48 174
LLPS-Ors-1453Oryza sativa50.963e-48 174
LLPS-Orbr-1699Oryza brachyantha50.969e-50 174
LLPS-Gag-0497Gaeumannomyces graminis50.946e-30 117
LLPS-Map-0778Magnaporthe poae50.947e-30 117
LLPS-Scj-1279Schizosaccharomyces japonicus48.62e-27 114
LLPS-Orb-2141Oryza barthii48.432e-52 183
LLPS-Vir-1990Vigna radiata47.621e-0963.2
LLPS-Lem-1077Leptosphaeria maculans46.763e-34 134
LLPS-Cogr-1050Colletotrichum graminicola46.611e-29 121
LLPS-Coo-1601Colletotrichum orbiculare46.614e-29 119
LLPS-Sac-1520Saccharomyces cerevisiae45.95e-1063.2
LLPS-Beb-1073Beauveria bassiana45.611e-27 115
LLPS-Ast-1106Aspergillus terreus45.09e-32 127
LLPS-Ved-0828Verticillium dahliae44.129e-2297.8
LLPS-Asfu-0884Aspergillus fumigatus43.74e-30 123
LLPS-Nef-1267Neosartorya fischeri43.77e-30 122
LLPS-Mel-1391Melampsora laricipopulina43.667e-65 216
LLPS-Aso-1261Aspergillus oryzae43.576e-31 125
LLPS-Asf-1290Aspergillus flavus43.576e-31 125
LLPS-Asni-0945Aspergillus niger43.152e-30 124
LLPS-Miv-1323Microbotryum violaceum42.916e-58 199
LLPS-Gas-0641Galdieria sulphuraria42.539e-58 196
LLPS-Mao-1025Magnaporthe oryzae41.964e-30 122
LLPS-Tra-1289Triticum aestivum41.941e-62 211
LLPS-Asc-0266Aspergillus clavatus41.782e-30 123
LLPS-Art-2654Arabidopsis thaliana40.835e-59 202
LLPS-Zem-2026Zea mays40.798e-62 208
LLPS-Abg-0371Absidia glauca40.391e-51 181
LLPS-Brd-0979Brachypodium distachyon40.362e-59 202
LLPS-Cus-0402Cucumis sativus40.283e-56 195
LLPS-Cae-1068Caenorhabditis elegans40.232e-76 246
LLPS-Chc-1235Chondrus crispus40.04e-57 196
LLPS-Mua-1769Musa acuminata40.01e-54 190
LLPS-Sob-0782Sorghum bicolor39.652e-61 207
LLPS-Sot-1770Solanum tuberosum39.448e-56 194
LLPS-Thc-1023Theobroma cacao39.442e-53 187
LLPS-Ori-2030Oryza indica39.431e-59 203
LLPS-Brn-1815Brassica napus38.963e-59 202
LLPS-Put-0595Puccinia triticina38.612e-68 227
LLPS-Spr-1176Sporisorium reilianum38.547e-62 209
LLPS-Lep-0545Leersia perrieri38.468e-57 195
LLPS-Pug-1161Puccinia graminis38.31e-67 223
LLPS-Orni-1585Oryza nivara38.193e-56 195
LLPS-Orr-2058Oryza rufipogon38.163e-54 190
LLPS-Orgl-1271Oryza glumaepatula38.162e-54 191
LLPS-Hov-2018Hordeum vulgare38.064e-53 187
LLPS-Mae-2250Manihot esculenta38.03e-56 195
LLPS-Met-2603Medicago truncatula37.814e-53 186
LLPS-Orm-0444Oryza meridionalis37.724e-56 195
LLPS-Nia-2060Nicotiana attenuata37.635e-56 194
LLPS-Sem-0507Selaginella moellendorffii36.754e-58 199
LLPS-Pot-1289Populus trichocarpa36.617e-52 183
LLPS-Php-1002Physcomitrella patens36.414e-53 187
LLPS-Usm-1524Ustilago maydis36.272e-61 209
LLPS-Phv-1717Phaseolus vulgaris35.981e-56 196
LLPS-Crn-0934Cryptococcus neoformans35.848e-54 187
LLPS-Brr-1151Brassica rapa35.433e-62 210
LLPS-Sei-2152Setaria italica35.412e-61 207
LLPS-Amt-1013Amborella trichopoda35.382e-55 192
LLPS-Arl-2933Arabidopsis lyrata34.812e-60 206
LLPS-Hea-2566Helianthus annuus34.757e-62 210
LLPS-Gor-1053Gossypium raimondii34.635e-55 191
LLPS-Bro-0359Brassica oleracea34.472e-59 203
LLPS-Coc-1412Corchorus capsularis34.226e-57 196
LLPS-Prp-1745Prunus persica34.112e-58 201
LLPS-Sol-1861Solanum lycopersicum34.063e-38 145
LLPS-Glm-2927Glycine max34.011e-55 193
LLPS-Phn-0582Phaeosphaeria nodorum34.01e-29 121
LLPS-Nec-1037Neurospora crassa34.01e-29 121
LLPS-Via-0253Vigna angularis33.936e-58 199
LLPS-Dos-1532Dothistroma septosporum33.717e-30 122
LLPS-Zyt-0766Zymoseptoria tritici33.465e-33 130
LLPS-Osl-1305Ostreococcus lucimarinus33.453e-45 162
LLPS-Viv-1740Vitis vinifera33.422e-54 189
LLPS-Pytr-1201Pyrenophora triticirepentis33.335e-34 134
LLPS-Orp-1606Oryza punctata33.164e-55 191
LLPS-Asg-1014Ashbya gossypii32.353e-1268.2
LLPS-Blg-0606Blumeria graminis32.021e-29 121
LLPS-Fuo-1257Fusarium oxysporum31.732e-30 123
LLPS-Kop-0257Komagataella pastoris31.582e-0961.6
LLPS-Asn-1489Aspergillus nidulans31.375e-34 134
LLPS-Trv-0035Trichoderma virens31.051e-28 118
LLPS-Trr-1410Trichoderma reesei31.053e-32 128
LLPS-Fus-1162Fusarium solani30.925e-29 119
LLPS-Fuv-1356Fusarium verticillioides30.525e-30 122
LLPS-Scc-0462Schizosaccharomyces cryophilus29.877e-28 116
LLPS-Yal-1597Yarrowia lipolytica27.885e-1579.3
LLPS-Scp-1319Schizosaccharomyces pombe26.656e-26 110