LLPS-Dar-2693
eral1
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | GTPase Era, mitochondrial; ERA-like protein 1 |
| Gene Name: | eral1, si:ch211-207c6.1 |
| Ensembl Gene: | ENSDARG00000059887.6 |
| Ensembl Protein: | ENSDARP00000078213.4 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Mitochondrial RNA granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000083778.5 | ENSDARP00000078213.4 |
| UniProt | B0S6U7, ERAL1_DANRE | |
| GeneBank | BC163480, BX548073, BC163468 | AAI63480.1, AAI63468.1, CAQ15626.1 |
| RefSeq | NM_001128747.1 | NP_001122219.1 |
| Entrez | 569087 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MTLRSCETFL RRSLRFSTAL NLTAFPEHEQ LYLRVSSGCS VFRPQTVRKC LFHWTPACTV 60 61 SQGVFLDRLQ KGAAVTDESL CNQPVSVSPD RAQQFSLLMK DPDQPENAKS LKVAIVGSPN 120 121 AGKSTLTNQL LGRKLFAVSS KVHTTRSRAV GVLTENDTQI VLLDTPGLTT QIKAKRHQLE 180 181 NSLLVDPFKS LKEADLVVVL VDVSDKWTRS KLSYEVLKCL ALNPDVPAVL VLNKVDLLKN 240 241 KALLLDITAQ LTEGMVNGKK IRIHGASKPV RKAAAGANSR LKEKKAAGSL EDEADHEDKL 300 301 KALKSHGGWP HFKDVFMLSS IDHEDVETLK RYLFVAAKPC QWQYHSEVLT DQSPEDVCFN 360 361 TIREKLLQNL PKEVPYTMTQ EIEVWKESED GVLDISIKLY VQKETHMKMV IGPGGQLITR 420 421 INQEAGNDLM KIFLCNVRLK ISVKLRK 447 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGACTTTGC GGAGCTGCGA GACGTTTTTA CGCAGATCTC TGCGATTCTC GACGGCCCTC 60 61 AACTTGACAG CATTCCCCGA GCACGAGCAG CTGTATCTGC GTGTGTCATC AGGTTGCTCA 120 121 GTATTTCGTC CACAGACAGT GAGGAAATGT CTCTTTCACT GGACCCCGGC CTGCACGGTG 180 181 TCCCAAGGTG TCTTTTTGGA CAGACTTCAG AAGGGAGCTG CTGTGACTGA CGAGAGTCTC 240 241 TGTAATCAGC CAGTGTCTGT TTCACCAGAC AGAGCCCAAC AGTTTTCCTT ATTAATGAAA 300 301 GATCCTGATC AACCTGAAAA TGCCAAATCT CTTAAAGTTG CAATAGTGGG TTCACCGAAT 360 361 GCAGGGAAGT CCACACTGAC GAATCAACTG CTGGGTCGAA AGTTGTTTGC TGTTTCATCA 420 421 AAAGTGCACA CCACAAGATC ACGTGCTGTT GGTGTCCTGA CAGAGAATGA CACTCAAATT 480 481 GTTTTGTTGG ATACCCCTGG TCTCACCACA CAGATAAAAG CTAAAAGACA CCAGCTGGAG 540 541 AACTCGCTCT TGGTGGATCC ATTTAAGTCA CTAAAGGAAG CTGATTTAGT GGTGGTGTTA 600 601 GTTGACGTGT CTGATAAATG GACCCGCAGT AAGCTGAGCT ATGAGGTGCT GAAGTGCCTG 660 661 GCCCTGAATC CAGATGTCCC TGCCGTCCTT GTCCTCAATA AGGTGGACTT ACTGAAGAAC 720 721 AAAGCGCTGT TGTTGGACAT CACGGCACAG CTGACAGAAG GCATGGTGAA TGGAAAGAAG 780 781 ATCAGAATCC ATGGCGCATC AAAACCAGTG CGGAAAGCAG CAGCCGGAGC CAACAGCAGA 840 841 CTTAAAGAAA AAAAAGCTGC TGGGAGCCTG GAGGACGAGG CGGATCATGA GGACAAGCTG 900 901 AAGGCCCTGA AGAGCCACGG GGGGTGGCCG CATTTCAAAG ACGTTTTCAT GCTCAGTTCT 960 961 ATTGACCATG AAGATGTGGA AACATTAAAG AGGTACTTGT TCGTAGCTGC AAAGCCTTGC 1020 1021 CAGTGGCAGT ACCACAGTGA GGTCCTGACA GATCAGAGTC CTGAGGACGT GTGCTTCAAT 1080 1081 ACCATCAGAG AGAAACTACT GCAGAATCTC CCTAAAGAGG TGCCGTACAC TATGACACAG 1140 1141 GAAATTGAAG TCTGGAAGGA GTCTGAGGAT GGGGTGCTCG ACATATCCAT CAAACTGTAT 1200 1201 GTGCAAAAGG AAACCCATAT GAAAATGGTT ATCGGTCCTG GAGGTCAGCT GATAACCAGA 1260 1261 ATAAACCAGG AAGCTGGAAA TGACCTGATG AAGATTTTCT TGTGTAATGT GCGCTTAAAA 1320 1321 ATCTCGGTGA AGTTGAGGAA GTGA 1344 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Mitochondrial inner membrane | |
Cellular Component | Mitochondrial matrix | |
Molecular Function | GTP binding | |
Molecular Function | Ribosomal small subunit binding | |
Molecular Function | RRNA binding | |
Biological Process | Ribosomal small subunit assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orn-3837 | Oreochromis niloticus | 64.0 | 4e-160 | 466 |
| LLPS-Gaa-3388 | Gasterosteus aculeatus | 62.08 | 2e-137 | 406 |
| LLPS-Scm-3324 | Scophthalmus maximus | 61.79 | 8e-150 | 441 |
| LLPS-Pof-1338 | Poecilia formosa | 60.55 | 8e-151 | 442 |
| LLPS-Phv-2523 | Phaseolus vulgaris | 60.32 | 5e-14 | 77.8 |
| LLPS-Met-0978 | Medicago truncatula | 60.32 | 1e-14 | 79.7 |
| LLPS-Orb-1804 | Oryza barthii | 59.32 | 2e-12 | 71.2 |
| LLPS-Scf-3179 | Scleropages formosus | 59.02 | 1e-128 | 385 |
| LLPS-Icp-2224 | Ictalurus punctatus | 58.75 | 4e-160 | 468 |
| LLPS-Orbr-1922 | Oryza brachyantha | 58.73 | 1e-13 | 75.9 |
| LLPS-Tra-2417 | Triticum aestivum | 58.73 | 1e-12 | 73.6 |
| LLPS-Asm-4007 | Astyanax mexicanus | 58.67 | 1e-159 | 466 |
| LLPS-Xim-3005 | Xiphophorus maculatus | 58.35 | 1e-150 | 443 |
| LLPS-Via-2028 | Vigna angularis | 58.21 | 3e-14 | 78.2 |
| LLPS-Anc-3690 | Anolis carolinensis | 57.89 | 6e-21 | 91.7 |
| LLPS-Dac-1571 | Daucus carota | 57.81 | 2e-14 | 79.3 |
| LLPS-Glm-2273 | Glycine max | 57.75 | 2e-14 | 79.3 |
| LLPS-Sob-0460 | Sorghum bicolor | 57.14 | 9e-13 | 73.9 |
| LLPS-Ors-1364 | Oryza sativa | 57.14 | 3e-12 | 72.0 |
| LLPS-Orp-2304 | Oryza punctata | 57.14 | 2e-12 | 73.2 |
| LLPS-Org-1428 | Oryza glaberrima | 57.14 | 2e-12 | 72.8 |
| LLPS-Zem-0921 | Zea mays | 57.14 | 8e-13 | 73.9 |
| LLPS-Orr-1824 | Oryza rufipogon | 57.14 | 3e-12 | 72.4 |
| LLPS-Orm-1430 | Oryza meridionalis | 57.14 | 3e-12 | 72.0 |
| LLPS-Thc-2382 | Theobroma cacao | 57.14 | 1e-13 | 76.3 |
| LLPS-Orni-1868 | Oryza nivara | 57.14 | 3e-12 | 72.0 |
| LLPS-Ori-1360 | Oryza indica | 57.14 | 3e-12 | 72.0 |
| LLPS-Brd-1067 | Brachypodium distachyon | 57.14 | 2e-12 | 72.8 |
| LLPS-Lep-0156 | Leersia perrieri | 57.14 | 2e-12 | 72.4 |
| LLPS-Xet-3312 | Xenopus tropicalis | 56.45 | 3e-122 | 368 |
| LLPS-Orl-2760 | Oryzias latipes | 56.42 | 2e-152 | 447 |
| LLPS-Sem-0192 | Selaginella moellendorffii | 56.06 | 9e-15 | 79.7 |
| LLPS-Hea-0399 | Helianthus annuus | 55.93 | 2e-11 | 69.7 |
| LLPS-Amt-2097 | Amborella trichopoda | 55.56 | 2e-12 | 73.2 |
| LLPS-Art-2657 | Arabidopsis thaliana | 55.56 | 5e-13 | 74.7 |
| LLPS-Brr-2637 | Brassica rapa | 55.56 | 5e-13 | 74.7 |
| LLPS-Bro-0036 | Brassica oleracea | 55.56 | 5e-13 | 74.7 |
| LLPS-Brn-2319 | Brassica napus | 55.56 | 7e-13 | 74.3 |
| LLPS-Arl-0984 | Arabidopsis lyrata | 55.56 | 5e-13 | 74.7 |
| LLPS-Gor-2209 | Gossypium raimondii | 54.93 | 1e-13 | 76.6 |
| LLPS-Tru-2063 | Triticum urartu | 54.55 | 4e-10 | 65.1 |
| LLPS-Ten-0862 | Tetraodon nigroviridis | 54.06 | 1e-96 | 302 |
| LLPS-Bot-1059 | Bos taurus | 53.7 | 3e-112 | 344 |
| LLPS-Php-2327 | Physcomitrella patens | 53.62 | 3e-16 | 84.3 |
| LLPS-Ova-2044 | Ovis aries | 53.46 | 2e-111 | 343 |
| LLPS-Tut-2367 | Tursiops truncatus | 52.91 | 2e-111 | 342 |
| LLPS-Ora-2642 | Ornithorhynchus anatinus | 52.86 | 4e-46 | 162 |
| LLPS-Fud-0354 | Fukomys damarensis | 52.77 | 2e-100 | 310 |
| LLPS-Sah-2832 | Sarcophilus harrisii | 52.76 | 9e-108 | 330 |
| LLPS-Orc-4377 | Oryctolagus cuniculus | 52.66 | 3e-109 | 337 |
| LLPS-Sus-4151 | Sus scrofa | 52.39 | 9e-110 | 338 |
| LLPS-Nia-0031 | Nicotiana attenuata | 52.31 | 4e-12 | 72.0 |
| LLPS-Fia-3759 | Ficedula albicollis | 52.31 | 1e-114 | 349 |
| LLPS-Viv-2355 | Vitis vinifera | 52.24 | 1e-13 | 76.6 |
| LLPS-Chs-0904 | Chlorocebus sabaeus | 52.21 | 4e-108 | 334 |
| LLPS-Rhb-4262 | Rhinopithecus bieti | 52.2 | 9e-110 | 338 |
| LLPS-Fec-0146 | Felis catus | 52.2 | 1e-114 | 350 |
| LLPS-Poa-4581 | Pongo abelii | 52.19 | 6e-110 | 338 |
| LLPS-Loa-2061 | Loxodonta africana | 52.13 | 5e-108 | 333 |
| LLPS-Urm-0584 | Ursus maritimus | 52.12 | 5e-111 | 341 |
| LLPS-Sot-1095 | Solanum tuberosum | 52.11 | 2e-12 | 72.8 |
| LLPS-Myl-2024 | Myotis lucifugus | 52.08 | 7e-110 | 338 |
| LLPS-Mup-1904 | Mustela putorius furo | 52.07 | 4e-113 | 347 |
| LLPS-Paa-1390 | Papio anubis | 52.06 | 1e-109 | 338 |
| LLPS-Mod-1691 | Monodelphis domestica | 51.94 | 3e-102 | 318 |
| LLPS-Pat-1806 | Pan troglodytes | 51.93 | 1e-109 | 338 |
| LLPS-Nol-0403 | Nomascus leucogenys | 51.93 | 5e-109 | 336 |
| LLPS-Maf-3685 | Macaca fascicularis | 51.93 | 4e-109 | 336 |
| LLPS-Caj-4072 | Callithrix jacchus | 51.86 | 1e-108 | 335 |
| LLPS-Aim-3853 | Ailuropoda melanoleuca | 51.86 | 1e-110 | 340 |
| LLPS-Lac-3180 | Latimeria chalumnae | 51.82 | 8e-122 | 370 |
| LLPS-Man-2453 | Macaca nemestrina | 51.8 | 2e-109 | 337 |
| LLPS-Mam-3470 | Macaca mulatta | 51.8 | 3e-108 | 337 |
| LLPS-Mea-3900 | Mesocricetus auratus | 51.7 | 1e-58 | 201 |
| LLPS-Hos-0021 | Homo sapiens | 51.67 | 2e-109 | 337 |
| LLPS-Cea-4797 | Cercocebus atys | 51.67 | 3e-109 | 337 |
| LLPS-Mal-1366 | Mandrillus leucophaeus | 51.67 | 9e-109 | 335 |
| LLPS-Eqc-3657 | Equus caballus | 51.43 | 2e-109 | 337 |
| LLPS-Ran-4511 | Rattus norvegicus | 51.3 | 2e-101 | 316 |
| LLPS-Caf-1261 | Canis familiaris | 51.29 | 9e-111 | 340 |
| LLPS-Leo-2756 | Lepisosteus oculatus | 51.24 | 9e-138 | 411 |
| LLPS-Gog-4532 | Gorilla gorilla | 51.19 | 8e-73 | 240 |
| LLPS-Otg-4519 | Otolemur garnettii | 51.16 | 8e-103 | 320 |
| LLPS-Dio-1400 | Dipodomys ordii | 51.15 | 8e-109 | 335 |
| LLPS-Anp-0000 | Anas platyrhynchos | 50.81 | 2e-99 | 309 |
| LLPS-Mum-4232 | Mus musculus | 50.79 | 2e-104 | 324 |
| LLPS-Cus-0486 | Cucumis sativus | 50.68 | 9e-14 | 77.0 |
| LLPS-Cap-3746 | Cavia porcellus | 50.64 | 1e-104 | 325 |
| LLPS-Cas-4096 | Carlito syrichta | 50.52 | 2e-108 | 335 |
| LLPS-Ict-3512 | Ictidomys tridecemlineatus | 50.39 | 3e-108 | 334 |
| LLPS-Aon-1382 | Aotus nancymaae | 50.27 | 5e-100 | 313 |
| LLPS-Pap-4069 | Pan paniscus | 50.2 | 3e-55 | 191 |
| LLPS-Meg-2798 | Meleagris gallopavo | 49.48 | 1e-106 | 328 |
| LLPS-Gaga-3118 | Gallus gallus | 49.25 | 5e-107 | 334 |
| LLPS-Osl-0537 | Ostreococcus lucimarinus | 49.15 | 7e-10 | 63.9 |
| LLPS-Pes-3221 | Pelodiscus sinensis | 48.84 | 1e-110 | 340 |
| LLPS-Cym-0635 | Cyanidioschyzon merolae | 48.28 | 2e-06 | 53.5 |
| LLPS-Chc-0375 | Chondrus crispus | 46.27 | 1e-10 | 67.0 |
| LLPS-Hov-1595 | Hordeum vulgare | 46.15 | 6e-13 | 74.7 |
| LLPS-Orgl-0416 | Oryza glumaepatula | 46.15 | 5e-13 | 74.7 |
| LLPS-Sol-1864 | Solanum lycopersicum | 45.83 | 9e-12 | 70.9 |
| LLPS-Abg-0413 | Absidia glauca | 44.79 | 7e-17 | 87.0 |
| LLPS-Tag-3214 | Taeniopygia guttata | 44.68 | 2e-77 | 253 |
| LLPS-Chr-0498 | Chlamydomonas reinhardtii | 44.23 | 3e-16 | 84.7 |
| LLPS-Mua-0491 | Musa acuminata | 43.59 | 9e-12 | 70.9 |
| LLPS-Vir-1339 | Vigna radiata | 40.48 | 1e-10 | 67.4 |
| LLPS-Gas-0536 | Galdieria sulphuraria | 40.24 | 1e-09 | 63.9 |
| LLPS-Sei-2256 | Setaria italica | 36.15 | 2e-13 | 75.9 |
| LLPS-Cii-1690 | Ciona intestinalis | 32.72 | 9e-38 | 146 |
| LLPS-Drm-2250 | Drosophila melanogaster | 32.64 | 2e-39 | 151 |
| LLPS-Prp-0534 | Prunus persica | 30.18 | 5e-30 | 125 |
| LLPS-Coc-2194 | Corchorus capsularis | 29.59 | 9e-32 | 130 |
| LLPS-Pot-0188 | Populus trichocarpa | 27.94 | 1e-28 | 120 |
| LLPS-Cae-1762 | Caenorhabditis elegans | 27.17 | 1e-24 | 108 |
| LLPS-Mae-1085 | Manihot esculenta | 26.77 | 1e-22 | 102 |