LLPS-Dar-2116
snap25a
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Synaptosomal-associated protein 25-A |
| Gene Name: | snap25a, Snap, snap25.1, si:dkeyp-8f4.6 |
| Ensembl Gene: | ENSDARG00000020609.12 |
| Ensembl Protein: | ENSDARP00000019054.5 |
| Organism: | Danio rerio |
| Taxa ID: | 7955 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density, Receptor cluster | Predicted from orthologs | (View) |
▼ FUNCTION
| May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSDART00000007584.8 | ENSDARP00000019054.5 |
| Ensembl | ENSDART00000153064.3 | ENSDARP00000127339.1 |
| Ensembl | ENSDART00000062738.7 | ENSDARP00000062737.6 |
| UniProt | Q5TZ66, SN25A_DANRE, O93578, Q5TZ65, Q6P3L7 | |
| GeneBank | AF091593, BC063942, BX465184, BX470246 | AAH63942.1, CAI21359.1, CAI21360.1, CAH69031.1, AAC64289.1, CAH69032.1 |
| RefSeq | NM_131435.1, XM_005160623.3 | NP_571510.1, XP_005160680.1 |
| Entrez | 30712 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAEDSDMRNE LADMQQRADQ LADESLESTR RMLQLVEESK DAGIRTLVML DEQGEQLDRV 60 61 EDGMNHINQD MKEAEKNLKD LGKCCGLFIC PCNKMKSGAS KAWGNNQDGV VASQPARVVD 120 121 EREQMAISGG FIRRVTDDAR ENEMDENLEQ VGGIIGNLRH MALDMGNEID TQNRQIDRIM 180 181 EKADSNKTRI DEANQRATKM LGSG 204 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCAGAGG ATTCGGATAT GCGCAATGAG CTCGCTGACA TGCAGCAACG TGCAGACCAG 60 61 CTGGCCGATG AGTCACTGGA GAGCACCCGT CGTATGCTGC AGCTTGTGGA AGAGAGTAAA 120 121 GATGCTGGTA TCAGGACTTT GGTTATGCTG GATGAGCAGG GAGAGCAACT GGAACGCATC 180 181 GAGGAGGGAA TGGACCAAAT CAATAAGGAC ATGAAGGATG CAGAAAAGAA TTTGAACGAT 240 241 CTAGGAAAAT TCTGTGGTCT TTGTTCCTGT CCATGTAACA AAATGAAGAG TGGCGCCAGC 300 301 AAGGCTTGGG GAAACAACCA GGATGGAGTG GTTGCCAGCC AGCCTGCCCG CGTTGTGGAT 360 361 GAGCGTGAAC AGATGGCCAT CAGCGGAGGC TTCATCCGCA GGGTAACAGA CGACGCCAGG 420 421 GAAAATGAGA TGGATGAGAA CTTAGAGCAG GTGGGAGGCA TCATTGGTAA CTTGCGCCAC 480 481 ATGGCCCTTG ATATGGGCAA CGAGATCGAT ACCCAGAACC GCCAGATCGA CAGGATCATG 540 541 GAGAAGGCTG ATTCCAACAA GACCAGGATT GATGAAGCCA ACCAGAGGGC CACAAAGATG 600 601 CTGGGCAGTG GCTAA 615 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell junction | |
Cellular Component | Cytoplasm | |
Cellular Component | Membrane | |
Cellular Component | Neuron projection | |
Cellular Component | Plasma membrane | |
Cellular Component | Presynapse | |
Cellular Component | SNARE complex | |
Molecular Function | SNAP receptor activity | |
Molecular Function | Syntaxin binding | |
Molecular Function | Syntaxin-1 binding | |
Molecular Function | Voltage-gated potassium channel activity | |
Biological Process | Exocytosis | |
Biological Process | Locomotory behavior | |
Biological Process | Mitotic cytokinesis | |
Biological Process | Synaptic vesicle fusion to presynaptic active zone membrane | |
Biological Process | Synaptic vesicle priming | |
Biological Process | Vesicle fusion |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ten-1535 | Tetraodon nigroviridis | 98.53 | 5e-144 | 407 |
| LLPS-Orn-1713 | Oreochromis niloticus | 98.04 | 2e-143 | 405 |
| LLPS-Gaa-0846 | Gasterosteus aculeatus | 97.55 | 9e-143 | 404 |
| LLPS-Dio-4198 | Dipodomys ordii | 93.69 | 1e-136 | 388 |
| LLPS-Bot-1411 | Bos taurus | 93.69 | 1e-136 | 388 |
| LLPS-Paa-4463 | Papio anubis | 93.69 | 1e-136 | 388 |
| LLPS-Mal-3281 | Mandrillus leucophaeus | 93.69 | 1e-136 | 388 |
| LLPS-Mea-0629 | Mesocricetus auratus | 93.69 | 1e-136 | 388 |
| LLPS-Maf-1866 | Macaca fascicularis | 93.69 | 1e-136 | 388 |
| LLPS-Cea-4421 | Cercocebus atys | 93.69 | 1e-136 | 388 |
| LLPS-Gog-0454 | Gorilla gorilla | 93.69 | 1e-136 | 388 |
| LLPS-Caj-4230 | Callithrix jacchus | 93.69 | 1e-136 | 388 |
| LLPS-Caf-1296 | Canis familiaris | 93.69 | 1e-136 | 388 |
| LLPS-Eqc-3076 | Equus caballus | 93.69 | 1e-136 | 388 |
| LLPS-Mam-4300 | Macaca mulatta | 93.69 | 1e-136 | 388 |
| LLPS-Gaga-3155 | Gallus gallus | 93.69 | 1e-136 | 388 |
| LLPS-Ict-3466 | Ictidomys tridecemlineatus | 93.69 | 1e-136 | 388 |
| LLPS-Nol-2389 | Nomascus leucogenys | 93.69 | 1e-136 | 388 |
| LLPS-Pap-4252 | Pan paniscus | 93.69 | 1e-136 | 388 |
| LLPS-Man-2426 | Macaca nemestrina | 93.69 | 1e-136 | 388 |
| LLPS-Rhb-1542 | Rhinopithecus bieti | 93.69 | 1e-136 | 388 |
| LLPS-Cap-2105 | Cavia porcellus | 93.63 | 4e-135 | 384 |
| LLPS-Orl-2617 | Oryzias latipes | 93.14 | 2e-134 | 382 |
| LLPS-Xim-3882 | Xiphophorus maculatus | 92.65 | 8e-134 | 381 |
| LLPS-Pof-2876 | Poecilia formosa | 92.65 | 9e-134 | 381 |
| LLPS-Leo-2881 | Lepisosteus oculatus | 91.26 | 7e-132 | 376 |
| LLPS-Asm-2114 | Astyanax mexicanus | 91.18 | 2e-131 | 375 |
| LLPS-Icp-2737 | Ictalurus punctatus | 91.18 | 3e-131 | 374 |
| LLPS-Scf-0885 | Scleropages formosus | 90.69 | 8e-131 | 374 |
| LLPS-Tut-1609 | Tursiops truncatus | 89.32 | 6e-129 | 369 |
| LLPS-Ere-0748 | Erinaceus europaeus | 89.32 | 6e-129 | 369 |
| LLPS-Mup-2209 | Mustela putorius furo | 89.32 | 6e-129 | 369 |
| LLPS-Aim-2272 | Ailuropoda melanoleuca | 89.32 | 6e-129 | 369 |
| LLPS-Myl-2599 | Myotis lucifugus | 89.32 | 6e-129 | 369 |
| LLPS-Ova-3857 | Ovis aries | 89.32 | 6e-129 | 369 |
| LLPS-Mum-1893 | Mus musculus | 89.32 | 6e-129 | 369 |
| LLPS-Chs-3570 | Chlorocebus sabaeus | 89.32 | 6e-129 | 369 |
| LLPS-Ora-1490 | Ornithorhynchus anatinus | 89.32 | 6e-129 | 369 |
| LLPS-Sah-1868 | Sarcophilus harrisii | 89.32 | 6e-129 | 369 |
| LLPS-Sus-4565 | Sus scrofa | 89.32 | 6e-129 | 369 |
| LLPS-Fud-2881 | Fukomys damarensis | 89.32 | 6e-129 | 369 |
| LLPS-Poa-1974 | Pongo abelii | 89.32 | 6e-129 | 369 |
| LLPS-Cas-0566 | Carlito syrichta | 89.32 | 6e-129 | 369 |
| LLPS-Tag-2194 | Taeniopygia guttata | 89.32 | 6e-129 | 369 |
| LLPS-Pat-2695 | Pan troglodytes | 89.32 | 6e-129 | 369 |
| LLPS-Hos-3819 | Homo sapiens | 89.32 | 6e-129 | 369 |
| LLPS-Mod-2163 | Monodelphis domestica | 89.32 | 6e-129 | 369 |
| LLPS-Anp-3180 | Anas platyrhynchos | 89.32 | 6e-129 | 369 |
| LLPS-Loa-0694 | Loxodonta africana | 89.32 | 6e-129 | 369 |
| LLPS-Fia-3525 | Ficedula albicollis | 89.32 | 6e-129 | 369 |
| LLPS-Orc-0920 | Oryctolagus cuniculus | 89.32 | 6e-129 | 369 |
| LLPS-Aon-4202 | Aotus nancymaae | 89.0 | 1e-123 | 357 |
| LLPS-Lac-1888 | Latimeria chalumnae | 88.83 | 6e-128 | 366 |
| LLPS-Meg-3099 | Meleagris gallopavo | 88.04 | 5e-112 | 327 |
| LLPS-Anc-3147 | Anolis carolinensis | 87.86 | 1e-125 | 360 |
| LLPS-Pes-3053 | Pelodiscus sinensis | 87.86 | 2e-125 | 360 |
| LLPS-Tar-0089 | Takifugu rubripes | 86.76 | 4e-120 | 346 |
| LLPS-Xet-2424 | Xenopus tropicalis | 85.44 | 3e-123 | 354 |
| LLPS-Otg-0634 | Otolemur garnettii | 82.52 | 7e-119 | 343 |
| LLPS-Scm-2532 | Scophthalmus maximus | 81.69 | 2e-117 | 340 |
| LLPS-Urm-2467 | Ursus maritimus | 80.1 | 4e-111 | 323 |
| LLPS-Ran-0314 | Rattus norvegicus | 79.71 | 1e-109 | 320 |
| LLPS-Fec-2250 | Felis catus | 77.78 | 1e-121 | 351 |
| LLPS-Cis-1227 | Ciona savignyi | 64.22 | 6e-88 | 265 |
| LLPS-Cii-0880 | Ciona intestinalis | 61.94 | 2e-61 | 196 |
| LLPS-Drm-2083 | Drosophila melanogaster | 55.5 | 2e-72 | 225 |
| LLPS-Cae-1384 | Caenorhabditis elegans | 52.24 | 5e-64 | 204 |
| LLPS-Arl-0486 | Arabidopsis lyrata | 29.95 | 1e-16 | 80.1 |
| LLPS-Gor-0647 | Gossypium raimondii | 29.9 | 9e-16 | 77.4 |
| LLPS-Sob-2554 | Sorghum bicolor | 28.86 | 3e-15 | 75.9 |
| LLPS-Tra-3064 | Triticum aestivum | 28.64 | 1e-13 | 70.9 |
| LLPS-Nia-1138 | Nicotiana attenuata | 28.64 | 1e-13 | 71.2 |
| LLPS-Brn-3152 | Brassica napus | 28.5 | 9e-16 | 77.8 |
| LLPS-Bro-2359 | Brassica oleracea | 28.5 | 9e-16 | 77.8 |
| LLPS-Brr-1943 | Brassica rapa | 28.5 | 2e-15 | 76.6 |
| LLPS-Art-2545 | Arabidopsis thaliana | 28.37 | 3e-15 | 75.5 |
| LLPS-Sei-2311 | Setaria italica | 28.0 | 4e-14 | 72.4 |
| LLPS-Mua-0417 | Musa acuminata | 27.86 | 7e-16 | 77.8 |
| LLPS-Vir-1372 | Vigna radiata | 27.78 | 6e-14 | 72.0 |
| LLPS-Glm-0629 | Glycine max | 27.67 | 7e-15 | 74.7 |
| LLPS-Phn-1279 | Phaeosphaeria nodorum | 27.65 | 8e-09 | 58.2 |
| LLPS-Via-2413 | Vigna angularis | 27.62 | 3e-15 | 75.9 |
| LLPS-Pot-1593 | Populus trichocarpa | 27.4 | 3e-16 | 78.6 |
| LLPS-Brd-0823 | Brachypodium distachyon | 27.36 | 2e-15 | 76.3 |
| LLPS-Coc-2180 | Corchorus capsularis | 27.36 | 3e-13 | 70.1 |
| LLPS-Sem-2222 | Selaginella moellendorffii | 27.23 | 6e-11 | 62.8 |
| LLPS-Orgl-2069 | Oryza glumaepatula | 27.0 | 5e-15 | 75.1 |
| LLPS-Orb-2133 | Oryza barthii | 27.0 | 6e-15 | 74.7 |
| LLPS-Ori-0515 | Oryza indica | 27.0 | 5e-15 | 75.1 |
| LLPS-Orni-1162 | Oryza nivara | 27.0 | 5e-15 | 75.1 |
| LLPS-Orr-1520 | Oryza rufipogon | 27.0 | 5e-15 | 75.1 |
| LLPS-Org-1025 | Oryza glaberrima | 27.0 | 6e-15 | 74.7 |
| LLPS-Ors-2306 | Oryza sativa | 27.0 | 5e-15 | 75.1 |
| LLPS-Cus-2341 | Cucumis sativus | 26.96 | 8e-15 | 75.1 |
| LLPS-Orm-1157 | Oryza meridionalis | 26.85 | 7e-12 | 65.9 |
| LLPS-Prp-2060 | Prunus persica | 26.76 | 2e-12 | 68.2 |
| LLPS-Orbr-1318 | Oryza brachyantha | 26.67 | 5e-09 | 59.3 |
| LLPS-Lem-0575 | Leptosphaeria maculans | 26.64 | 2e-07 | 54.3 |
| LLPS-Hea-0815 | Helianthus annuus | 26.61 | 5e-14 | 72.8 |
| LLPS-Tru-1282 | Triticum urartu | 26.5 | 2e-11 | 66.2 |
| LLPS-Orp-2145 | Oryza punctata | 26.5 | 2e-14 | 73.2 |
| LLPS-Lep-2149 | Leersia perrieri | 26.44 | 1e-12 | 67.8 |
| LLPS-Amt-1404 | Amborella trichopoda | 26.34 | 6e-11 | 64.7 |
| LLPS-Phv-2404 | Phaseolus vulgaris | 26.19 | 1e-12 | 68.6 |
| LLPS-Met-1205 | Medicago truncatula | 25.98 | 9e-12 | 65.9 |
| LLPS-Zem-2401 | Zea mays | 25.94 | 1e-11 | 65.5 |
| LLPS-Sol-1876 | Solanum lycopersicum | 25.93 | 7e-14 | 72.8 |
| LLPS-Viv-1055 | Vitis vinifera | 25.7 | 2e-12 | 67.8 |
| LLPS-Dac-1111 | Daucus carota | 25.37 | 1e-12 | 69.7 |
| LLPS-Thc-0358 | Theobroma cacao | 24.88 | 2e-11 | 65.1 |
| LLPS-Sot-1894 | Solanum tuberosum | 24.77 | 1e-12 | 69.3 |
| LLPS-Hov-0322 | Hordeum vulgare | 24.75 | 3e-10 | 61.6 |
| LLPS-Mae-1952 | Manihot esculenta | 23.96 | 2e-10 | 62.8 |