LLPS-Dar-1614
tubb2b

▼ OVERVIEW

Status: Unreviewed
Protein Name: Tubulin beta chain
Gene Name: tubb2b, tubb4b
Ensembl Gene: ENSDARG00000098591.2
Ensembl Protein: ENSDARP00000137515.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSDART00000168241.2ENSDARP00000137515.1
UniProtA0A0R4IPH2, A0A0R4IPH2_DANRE
GeneBankCU984584
Entrez641421

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREIVHLQAG  QCGNQIGAKF  WEVISDEHGI  DPTGTYHGDS  DLQLDRINVY  YNEASGGKYV  60
61    PRAVLVDLEP  GTMDSVRSGP  FGQVFRPDNF  VFGQSGAGNN  WAKGHYTEGA  ELVDSVLDVV  120
121   RKEAESCDCL  QGFQLTHSLG  GGTGSGMGTL  LISKIREEYP  DRIMNTFSVV  PSPKVSDTVV  180
181   EPYNATLSVH  QLVENTDETY  CIDNEALYDI  CFRTLKLTTP  SYGDLNHLVS  ATMSGVTTCL  240
241   RFPGQLNADL  RKLAVNMVPF  PRLHFFMPGF  APLTSRGSQQ  YRSLTVPELT  QQMFDAKNMM  300
301   AACDPRHGRY  LTVAAIFRGR  MSMKEVDEQM  LNVQNKNSSY  FVEWIPNNVK  TAVCDIPPRG  360
361   LKMAATFIGN  STAIQELFKR  ISEQFTAMFR  RKAFLHWYTG  EGMDEMEFTE  AESNMNDLVS  420
421   EYQQYQDATA  EEEGEFEEEG  EEELA  445
Nucleotide CDS Sequence (FASTA)
1     ATGAGGGAAA  TCGTGCATCT  TCAAGCTGGA  CAATGCGGAA  ACCAGATTGG  AGCCAAGTTC  60
61    TGGGAGGTGA  TCAGTGACGA  GCATGGTATT  GATCCCACTG  GAACATATCA  TGGAGACAGC  120
121   GACCTTCAAC  TCGACAGAAT  CAATGTCTAT  TACAACGAGG  CATCAGGAGG  TAAATATGTG  180
181   CCCCGTGCTG  TGTTGGTGGA  TCTGGAGCCT  GGTACTATGG  ACTCTGTGAG  GTCCGGACCC  240
241   TTCGGTCAGG  TTTTCAGACC  AGATAACTTT  GTTTTTGGTC  AGAGTGGTGC  TGGAAACAAC  300
301   TGGGCTAAAG  GCCACTACAC  AGAGGGAGCA  GAGCTGGTGG  ACTCTGTCCT  GGATGTGGTT  360
361   CGCAAAGAGG  CAGAGAGCTG  CGATTGCCTG  CAGGGCTTCC  AGCTCACCCA  CTCCCTGGGT  420
421   GGAGGAACGG  GCTCTGGTAT  GGGCACCCTC  CTCATTAGCA  AGATCCGTGA  GGAGTATCCC  480
481   GACCGCATCA  TGAACACCTT  CAGCGTGGTG  CCCTCACCCA  AAGTGTCTGA  CACTGTGGTG  540
541   GAGCCCTACA  ACGCCACATT  GTCGGTTCAC  CAGCTGGTTG  AAAACACAGA  CGAGACCTAC  600
601   TGCATTGACA  ACGAGGCTCT  TTATGACATC  TGCTTCCGCA  CACTCAAACT  CACCACACCG  660
661   TCATACGGTG  ATCTCAACCA  TCTCGTATCT  GCCACCATGA  GTGGTGTGAC  CACCTGCCTC  720
721   AGGTTCCCCG  GCCAGCTCAA  TGCCGATCTC  CGCAAACTGG  CCGTCAACAT  GGTGCCCTTC  780
781   CCCCGTCTCC  ACTTCTTCAT  GCCCGGCTTC  GCTCCTCTGA  CCAGCAGGGG  GAGCCAGCAG  840
841   TACCGCTCTC  TAACCGTACC  CGAGCTCACA  CAGCAGATGT  TTGATGCTAA  AAACATGATG  900
901   GCTGCGTGCG  ACCCGCGTCA  CGGCCGCTAC  CTCACAGTCG  CCGCCATCTT  CCGTGGCCGC  960
961   ATGTCTATGA  AGGAGGTCGA  CGAGCAGATG  CTCAATGTTC  AAAACAAGAA  CAGCAGCTAC  1020
1021  TTTGTGGAAT  GGATCCCAAA  TAACGTCAAG  ACCGCCGTTT  GCGACATCCC  GCCTCGTGGT  1080
1081  CTGAAAATGG  CCGCCACCTT  CATCGGAAAC  AGCACTGCCA  TCCAGGAGCT  CTTCAAGCGC  1140
1141  ATCTCCGAGC  AGTTCACGGC  TATGTTCAGG  CGCAAGGCTT  TCCTGCATTG  GTACACAGGC  1200
1201  GAAGGTATGG  ATGAGATGGA  GTTCACCGAG  GCAGAGAGCA  ACATGAACGA  CCTGGTGTCT  1260
1261  GAGTACCAGC  AGTACCAGGA  CGCCACCGCC  GAGGAGGAGG  GCGAGTTTGA  GGAGGAGGGA  1320
1321  GAGGAAGAGC  TGGCTTAA  1338

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Microtubule
Nucleotide-binding
Proteomics identification
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Molecular Function
GTP binding
Molecular Function
GTPase activity
Molecular Function
Structural constituent of cytoskeleton
Biological Process
Microtubule-based process

▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaa-1344Gasterosteus aculeatus100.00.0 862
LLPS-Xim-1769Xiphophorus maculatus100.00.0 862
LLPS-Pof-0256Poecilia formosa100.00.0 862
LLPS-Orn-3235Oreochromis niloticus100.00.0 862
LLPS-Scf-0653Scleropages formosus99.530.0 858
LLPS-Icp-1398Ictalurus punctatus99.070.0 857
LLPS-Scm-0411Scophthalmus maximus99.070.0 847
LLPS-Leo-2361Lepisosteus oculatus98.60.0 855
LLPS-Asm-3759Astyanax mexicanus98.60.0 855
LLPS-Anc-1529Anolis carolinensis98.590.0 851
LLPS-Cis-0796Ciona savignyi98.370.0 854
LLPS-Cii-2095Ciona intestinalis98.370.0 854
LLPS-Fud-3138Fukomys damarensis98.370.0 853
LLPS-Xet-1448Xenopus tropicalis98.370.0 855
LLPS-Gaga-0553Gallus gallus98.370.0 853
LLPS-Bot-4278Bos taurus98.360.0 850
LLPS-Sah-3322Sarcophilus harrisii98.360.0 850
LLPS-Chs-0448Chlorocebus sabaeus98.360.0 850
LLPS-Mum-1755Mus musculus98.360.0 850
LLPS-Mea-3878Mesocricetus auratus98.360.0 850
LLPS-Caj-2185Callithrix jacchus98.360.0 850
LLPS-Mam-0567Macaca mulatta98.360.0 850
LLPS-Cap-3489Cavia porcellus98.360.0 850
LLPS-Caf-3592Canis familiaris98.360.0 850
LLPS-Ict-2948Ictidomys tridecemlineatus98.360.0 850
LLPS-Man-4381Macaca nemestrina98.360.0 850
LLPS-Fec-0114Felis catus98.360.0 850
LLPS-Mod-3852Monodelphis domestica98.360.0 850
LLPS-Lac-4047Latimeria chalumnae98.360.0 850
LLPS-Hos-2792Homo sapiens98.360.0 850
LLPS-Tar-2601Takifugu rubripes98.140.0 855
LLPS-Maf-3352Macaca fascicularis98.130.0 848
LLPS-Paa-2063Papio anubis97.80.0 810
LLPS-Dio-3081Dipodomys ordii97.670.0 849
LLPS-Ova-2492Ovis aries97.670.0 849
LLPS-Mal-0435Mandrillus leucophaeus97.670.0 849
LLPS-Ran-0387Rattus norvegicus97.670.0 849
LLPS-Aon-0745Aotus nancymaae97.670.0 849
LLPS-Cea-2760Cercocebus atys97.670.0 849
LLPS-Gog-0740Gorilla gorilla97.670.0 849
LLPS-Poa-2450Pongo abelii97.670.0 849
LLPS-Nol-3585Nomascus leucogenys97.670.0 849
LLPS-Cas-0144Carlito syrichta97.670.0 849
LLPS-Pat-3341Pan troglodytes97.670.0 849
LLPS-Urm-3705Ursus maritimus97.670.0 849
LLPS-Rhb-0035Rhinopithecus bieti97.670.0 849
LLPS-Eqc-3902Equus caballus97.440.0 840
LLPS-Myl-2541Myotis lucifugus97.420.0 843
LLPS-Sus-1819Sus scrofa97.420.0 842
LLPS-Orl-3812Oryzias latipes97.420.0 844
LLPS-Ten-2857Tetraodon nigroviridis97.420.0 844
LLPS-Pap-1145Pan paniscus97.420.0 843
LLPS-Orc-3339Oryctolagus cuniculus97.420.0 843
LLPS-Otg-1654Otolemur garnettii97.420.0 843
LLPS-Mup-3390Mustela putorius furo97.20.0 846
LLPS-Drm-0325Drosophila melanogaster97.070.0 802
LLPS-Tut-2274Tursiops truncatus96.980.0 847
LLPS-Aim-3912Ailuropoda melanoleuca96.980.0 847
LLPS-Fia-0318Ficedula albicollis96.980.0 847
LLPS-Pes-0306Pelodiscus sinensis96.980.0 847
LLPS-Ere-0293Erinaceus europaeus96.740.0 840
LLPS-Ora-3257Ornithorhynchus anatinus96.740.0 844
LLPS-Tag-2634Taeniopygia guttata96.740.0 846
LLPS-Cae-1271Caenorhabditis elegans96.050.0 836
LLPS-Anp-3174Anas platyrhynchos96.030.0 784
LLPS-Loa-2963Loxodonta africana94.650.0 823
LLPS-Php-1465Physcomitrella patens89.770.0 793
LLPS-Chr-0860Chlamydomonas reinhardtii89.070.0 794
LLPS-Sem-1389Selaginella moellendorffii88.840.0 792
LLPS-Orbr-1685Oryza brachyantha88.60.0 783
LLPS-Pot-1361Populus trichocarpa88.140.0 781
LLPS-Ors-0595Oryza sativa88.140.0 779
LLPS-Mae-1103Manihot esculenta87.440.0 779