LLPS-Dar-1610
ccsap

▼ OVERVIEW

Status: Unreviewed
Protein Name: Centriole, cilia and spindle-associated protein
Gene Name: ccsap, si:dkey-162b3.6
Ensembl Gene: ENSDARG00000040085.5
Ensembl Protein: ENSDARP00000058627.4
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Plays a role in embryonic development, including proper left-right asymmetry formation. Also required for proper cilia beating (PubMed:22493317). Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MVTKRIRSEY  MKKFKDPKWD  TYAKCYEDLL  KYRLSRRLLE  QAHKPWFWGE  WGSETASSGK  60
61    STPLSRNKVE  PLKTLDEKPE  RSACVTPEPA  AEAETQAAEV  QDREHADTNL  VPCDAEVAHP  120
121   EGEEVRGKER  SPAVNPDSDT  QIQNMSKSKR  RSSHKYTRSK  VKPQAPKDPD  KENRHPFALY  180
181   GAGEKQTDMA  SKKTHNVGPA  ASTAEIHESA  LRAKTRREVE  KQIKRFDKQR  ARSADLEKSR  240
241   NKIIPDFNPW  MTEYMRCFSA  RSR  263
Nucleotide CDS Sequence (FASTA)
1     ATGGTGACCA  AGCGAATTAG  GTCGGAATAC  ATGAAGAAAT  TTAAAGACCC  GAAATGGGAT  60
61    ACTTACGCAA  AGTGTTATGA  GGATTTGCTG  AAGTACAGAC  TGTCAAGGCG  GCTGCTGGAG  120
121   CAGGCGCACA  AGCCGTGGTT  TTGGGGTGAA  TGGGGGAGCG  AGACTGCTTC  AAGTGGTAAA  180
181   TCTACTCCTC  TGAGTCGGAA  TAAAGTTGAA  CCTTTGAAGA  CTCTTGATGA  GAAACCTGAG  240
241   CGATCTGCTT  GTGTGACTCC  AGAACCAGCA  GCTGAAGCAG  AAACACAGGC  CGCAGAAGTG  300
301   CAGGACAGAG  AGCATGCAGA  CACCAATTTA  GTTCCCTGTG  ATGCTGAGGT  GGCTCATCCA  360
361   GAAGGAGAGG  AAGTAAGAGG  CAAAGAACGC  TCTCCTGCTG  TCAACCCAGA  CTCTGACACA  420
421   CAGATCCAGA  ACATGTCAAA  GAGCAAACGC  CGCTCTTCAC  ACAAGTACAC  AAGATCAAAG  480
481   GTCAAACCTC  AGGCCCCTAA  AGACCCCGAC  AAAGAGAACC  GTCACCCGTT  TGCCCTGTAT  540
541   GGAGCAGGAG  AGAAGCAGAC  TGACATGGCT  TCAAAGAAAA  CACATAATGT  GGGTCCTGCA  600
601   GCTTCAACCG  CAGAGATCCA  TGAGTCAGCG  CTGCGAGCAA  AAACCAGACG  GGAGGTGGAA  660
661   AAACAGATAA  AGAGATTTGA  CAAGCAGAGA  GCCAGATCTG  CTGACTTGGA  AAAGAGCAGA  720
721   AATAAAATCA  TCCCCGATTT  CAATCCCTGG  ATGACAGAGT  ACATGCGCTG  CTTTTCTGCT  780
781   CGCTCTCGGT  AG  792

▼ KEYWORD

ID
Family
Cell cycle
Cell division
Cell projection
Cilium
Complete proteome
Cytoplasm
Cytoskeleton
Developmental protein
Microtubule
Mitosis
Reference proteome
Repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Axon
Cellular Component
Axoneme
Cellular Component
Centriole
Cellular Component
Centrosome
Cellular Component
Ciliary basal body
Cellular Component
Ciliary transition zone
Cellular Component
Cilium
Cellular Component
Mitotic spindle
Cellular Component
Mitotic spindle astral microtubule
Cellular Component
Spindle
Molecular Function
Microtubule binding
Biological Process
Brain development
Biological Process
Cell cycle
Biological Process
Cell division
Biological Process
Cilium movement
Biological Process
Determination of heart left/right asymmetry
Biological Process
Heart development
Biological Process
Mitotic spindle microtubule depolymerization
Biological Process
Negative regulation of cell death
Biological Process
Negative regulation of mitotic cell cycle
Biological Process
Neuron development
Biological Process
Regulation of cilium beat frequency involved in ciliary motility
Biological Process
Regulation of embryonic development
Biological Process
Regulation of mitotic spindle assembly

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINMIST
Drug
CTD
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Loa-1318Loxodonta africana68.753e-1989.0
LLPS-Ova-0034Ovis aries65.593e-31 119
LLPS-Anc-0693Anolis carolinensis65.385e-0959.7
LLPS-Mup-0262Mustela putorius furo63.443e-30 116
LLPS-Tag-3268Taeniopygia guttata62.56e-31 118
LLPS-Gaga-2671Gallus gallus62.59e-0855.8
LLPS-Tut-0445Tursiops truncatus62.377e-29 112
LLPS-Nol-3015Nomascus leucogenys62.223e-26 109
LLPS-Asm-1275Astyanax mexicanus62.112e-104 311
LLPS-Caf-2926Canis familiaris61.72e-1682.0
LLPS-Orc-2319Oryctolagus cuniculus61.71e-1680.5
LLPS-Mam-4230Macaca mulatta61.394e-31 119
LLPS-Rhb-1042Rhinopithecus bieti61.395e-31 119
LLPS-Man-3201Macaca nemestrina61.391e-29 118
LLPS-Hos-0787Homo sapiens61.391e-29 118
LLPS-Pat-4396Pan troglodytes61.391e-29 117
LLPS-Mal-0979Mandrillus leucophaeus61.396e-31 118
LLPS-Paa-0523Papio anubis61.391e-29 117
LLPS-Caj-4483Callithrix jacchus61.392e-29 117
LLPS-Gog-1925Gorilla gorilla61.394e-30 118
LLPS-Cea-2659Cercocebus atys61.391e-29 117
LLPS-Chs-1786Chlorocebus sabaeus61.391e-29 118
LLPS-Maf-3863Macaca fascicularis61.391e-29 118
LLPS-Anp-0592Anas platyrhynchos61.068e-32 121
LLPS-Sah-0478Sarcophilus harrisii60.783e-28 113
LLPS-Aim-2452Ailuropoda melanoleuca59.262e-30 117
LLPS-Mod-2796Monodelphis domestica58.425e-26 108
LLPS-Meg-2604Meleagris gallopavo58.412e-31 119
LLPS-Fud-4112Fukomys damarensis58.13e-29 114
LLPS-Otg-4330Otolemur garnettii57.611e-25 107
LLPS-Cas-3243Carlito syrichta57.556e-31 118
LLPS-Icp-0550Ictalurus punctatus57.255e-92 279
LLPS-Ora-1145Ornithorhynchus anatinus56.526e-25 102
LLPS-Ict-4467Ictidomys tridecemlineatus53.983e-29 114
LLPS-Scf-3941Scleropages formosus50.353e-72 229
LLPS-Orn-2779Oreochromis niloticus49.454e-72 229
LLPS-Gaa-3099Gasterosteus aculeatus47.992e-71 227
LLPS-Xim-1694Xiphophorus maculatus47.73e-67 217
LLPS-Pof-2730Poecilia formosa47.169e-66 213
LLPS-Orl-1425Oryzias latipes46.716e-74 234
LLPS-Scm-3670Scophthalmus maximus46.216e-69 221
LLPS-Tar-3805Takifugu rubripes45.592e-66 214
LLPS-Ten-1050Tetraodon nigroviridis45.269e-61 199
LLPS-Ran-4767Rattus norvegicus45.113e-43 154
LLPS-Leo-3705Lepisosteus oculatus44.981e-66 215
LLPS-Mea-3736Mesocricetus auratus44.621e-41 149
LLPS-Eqc-3005Equus caballus44.321e-51 176
LLPS-Sus-4474Sus scrofa44.322e-50 172
LLPS-Mum-3634Mus musculus43.753e-44 156
LLPS-Bot-2095Bos taurus43.286e-48 167
LLPS-Fec-1985Felis catus42.966e-48 166
LLPS-Ere-0556Erinaceus europaeus42.039e-50 171
LLPS-Dio-0058Dipodomys ordii41.925e-42 150
LLPS-Aon-1172Aotus nancymaae40.983e-49 170
LLPS-Cap-3192Cavia porcellus38.877e-43 152
LLPS-Fia-2553Ficedula albicollis38.832e-42 151
LLPS-Lac-0712Latimeria chalumnae34.762e-25 105
LLPS-Cii-0311Ciona intestinalis27.723e-0651.2