LLPS-Dar-1555
klc1a

▼ OVERVIEW

Status: Unreviewed
Protein Name: Kinesin light chain 1a
Gene Name: klc1a
Ensembl Gene: ENSDARG00000009796.11
Ensembl Protein: ENSDARP00000011544.9
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: LLPS regulator


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
P-body, Stress granule, Postsynaptic densityPredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MREDMSSVLC  VKETEGQGDL  GEKLSQDELL  CRTREVMQGL  EALRAEHQAI  LEGLMGTLRC  60
61    LKQSQEGRAV  EEKTAMIQRS  MEMLELGLSE  AQVMMALSGH  LSAVEAEKQK  LRAQVRRLCQ  120
121   ENQWLRDELA  GTQQRLQKSE  QSVAQLEEEK  KHLEFMNQLK  KYDQDLSPSD  DKDSDSSRET  180
181   LDDLFPDEQD  EPGPGIQPPH  SSAVAAAQQG  GYEIPARLRT  LHNLVIQYAS  QGRYEVAVPL  240
241   CKQALEDLEK  TSGHDHPDVA  TMLNILALVY  RDQNKYKEAA  NLLNDALAIR  EKTLGRDHPA  300
301   VAATLNNLAV  LYGKRGKYKE  AEPLCKRALE  IREKVLGKDH  PDVAKQLNNL  ALLCQNQGKY  360
361   EEVEYYYQRA  LEIYQTKLGP  DDPNVAKTKN  NLASCYLKQG  KFKQAETLYK  EILTRAHERE  420
421   FGSVDDENKP  IWMHAEEREE  QSKIKQKDGT  PFGEYGGWYK  ACKVDSPTVT  TTLKNLGALY  480
481   RRQGKFEAAE  TLEEAALRSR  KQGLDTAHKQ  RVAEVLGDPE  VREKQRSRES  LTSDTVKYES  540
541   GPDGGEEVSM  SVEWNGDGSG  SLKRSGSFSK  LRASIRRSSE  KLVRKLKGGG  VRENEPKNPG  600
601   NEIIV  605
Nucleotide CDS Sequence (FASTA)
1     ATGCGTGAGG  ATATGTCGAG  CGTGCTGTGT  GTGAAGGAGA  CGGAGGGCCA  GGGGGACCTC  60
61    GGTGAAAAGC  TATCCCAGGA  TGAGCTGCTA  TGTCGGACGC  GCGAGGTCAT  GCAGGGGCTG  120
121   GAGGCGCTCC  GTGCTGAACA  TCAGGCCATT  TTGGAGGGGC  TGATGGGGAC  CTTGCGCTGC  180
181   CTCAAACAGA  GCCAGGAGGG  GCGTGCTGTT  GAGGAGAAGA  CTGCAATGAT  CCAACGCTCA  240
241   ATGGAGATGC  TGGAGCTGGG  CCTCAGTGAA  GCACAGGTGA  TGATGGCTCT  GTCAGGGCAT  300
301   CTGAGTGCAG  TGGAGGCAGA  GAAACAGAAG  CTTCGAGCAC  AGGTACGGAG  GCTGTGTCAG  360
361   GAGAACCAGT  GGCTGCGGGA  CGAGCTGGCA  GGAACCCAGC  AGCGGCTGCA  GAAGAGCGAG  420
421   CAAAGTGTGG  CTCAGTTGGA  GGAGGAGAAG  AAACACTTGG  AGTTCATGAA  CCAGCTCAAG  480
481   AAATATGATC  AAGATCTTAG  CCCATCAGAT  GATAAGGACT  CTGATTCCAG  CAGGGAGACA  540
541   CTGGATGATC  TTTTCCCAGA  TGAGCAGGAT  GAGCCTGGAC  CTGGCATCCA  GCCTCCTCAC  600
601   AGCAGTGCAG  TGGCAGCAGC  TCAGCAGGGT  GGTTATGAGA  TCCCTGCTCG  TCTTCGAACC  660
661   CTTCACAACC  TGGTGATCCA  GTATGCCTCA  CAAGGCAGGT  ATGAGGTGGC  CGTTCCTCTC  720
721   TGCAAACAGG  CTCTTGAAGA  TCTGGAGAAA  ACATCTGGAC  ACGATCATCC  CGATGTAGCC  780
781   ACCATGCTTA  ACATTCTCGC  TCTCGTCTAC  AGGGACCAGA  ATAAATATAA  AGAGGCAGCA  840
841   AACCTTCTTA  ATGATGCACT  GGCAATCAGA  GAGAAGACTT  TGGGCAGAGA  CCACCCTGCG  900
901   GTGGCTGCCA  CACTGAACAA  TTTGGCTGTT  CTTTATGGCA  AACGAGGGAA  GTACAAGGAA  960
961   GCAGAGCCTC  TGTGTAAAAG  AGCCTTGGAA  ATCAGAGAGA  AGGTGCTGGG  GAAGGACCAC  1020
1021  CCTGATGTTG  CCAAACAGCT  AAATAATCTG  GCCTTACTGT  GTCAGAACCA  AGGCAAGTAT  1080
1081  GAAGAAGTGG  AGTACTACTA  CCAGAGGGCC  CTGGAGATCT  ATCAGACCAA  ACTGGGCCCC  1140
1141  GATGACCCCA  ATGTGGCCAA  GACCAAAAAC  AACCTGGCTT  CATGCTATCT  GAAACAGGGA  1200
1201  AAATTTAAGC  AGGCAGAGAC  TCTATATAAA  GAGATCCTCA  CCCGAGCCCA  TGAGAGAGAA  1260
1261  TTTGGTTCTG  TTGATGATGA  AAATAAACCC  ATCTGGATGC  ATGCTGAAGA  AAGAGAAGAA  1320
1321  CAGAGCAAGA  TCAAGCAGAA  GGATGGGACT  CCATTTGGAG  AATATGGTGG  ATGGTACAAG  1380
1381  GCCTGTAAAG  TAGACAGCCC  AACCGTGACA  ACGACACTGA  AGAATCTTGG  AGCTCTTTAC  1440
1441  AGGAGACAGG  GCAAGTTTGA  GGCTGCTGAG  ACTCTGGAGG  AGGCGGCTTT  GCGCTCCAGA  1500
1501  AAACAGGGTC  TGGACACAGC  TCATAAGCAG  CGTGTTGCAG  AGGTGCTGGG  AGACCCTGAA  1560
1561  GTACGAGAGA  AACAGAGGAG  TCGTGAGAGC  CTGACCTCTG  ACACGGTGAA  GTACGAGAGT  1620
1621  GGCCCTGACG  GTGGAGAGGA  AGTGAGTATG  AGCGTGGAGT  GGAATGGGGA  CGGTTCAGGC  1680
1681  TCCTTGAAGC  GAAGCGGTTC  TTTTAGCAAA  CTACGGGCCT  CTATCCGGCG  CAGCAGCGAG  1740
1741  AAACTAGTCC  GCAAACTCAA  AGGAGGAGGT  GTACGAGAAA  ACGAACCCAA  AAATCCAGGG  1800
1801  AACGAAATAA  TCGTCTAA  1818

▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
MIST
Drug
CTD
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Asm-3307Astyanax mexicanus97.50.01090
LLPS-Icp-1291Ictalurus punctatus94.830.01058
LLPS-Tar-2445Takifugu rubripes90.030.0 970
LLPS-Orn-3322Oreochromis niloticus89.80.0 953
LLPS-Scm-0585Scophthalmus maximus89.790.0 981
LLPS-Ten-2369Tetraodon nigroviridis89.280.0 977
LLPS-Xim-2487Xiphophorus maculatus88.70.0 947
LLPS-Scf-0021Scleropages formosus88.170.0 970
LLPS-Orl-0896Oryzias latipes87.870.0 934
LLPS-Fud-0672Fukomys damarensis86.50.0 940
LLPS-Lac-0770Latimeria chalumnae86.430.0 908
LLPS-Sah-2186Sarcophilus harrisii86.410.0 931
LLPS-Myl-1678Myotis lucifugus86.410.0 902
LLPS-Caj-2154Callithrix jacchus86.330.0 928
LLPS-Pat-3038Pan troglodytes86.170.0 932
LLPS-Pap-0331Pan paniscus86.170.0 932
LLPS-Urm-2048Ursus maritimus86.170.0 905
LLPS-Hos-1200Homo sapiens86.170.0 932
LLPS-Fec-2552Felis catus86.170.0 935
LLPS-Man-0160Macaca nemestrina86.170.0 932
LLPS-Rhb-2293Rhinopithecus bieti86.170.0 932
LLPS-Eqc-0843Equus caballus86.170.0 901
LLPS-Cap-2245Cavia porcellus86.170.0 936
LLPS-Ict-2313Ictidomys tridecemlineatus86.170.0 936
LLPS-Maf-1154Macaca fascicularis86.170.0 932
LLPS-Aon-0067Aotus nancymaae86.170.0 931
LLPS-Cea-0945Cercocebus atys86.170.0 932
LLPS-Gog-0468Gorilla gorilla86.170.0 932
LLPS-Paa-2591Papio anubis86.170.0 931
LLPS-Ran-4062Rattus norvegicus86.150.0 854
LLPS-Loa-2025Loxodonta africana86.00.0 937
LLPS-Otg-0216Otolemur garnettii86.00.0 934
LLPS-Cas-1380Carlito syrichta86.00.0 926
LLPS-Mum-0537Mus musculus86.00.0 931
LLPS-Mup-3288Mustela putorius furo86.00.0 906
LLPS-Caf-0797Canis familiaris85.930.0 896
LLPS-Anp-0019Anas platyrhynchos85.910.0 912
LLPS-Ora-1597Ornithorhynchus anatinus85.880.0 917
LLPS-Mod-3083Monodelphis domestica85.830.0 926
LLPS-Bot-0554Bos taurus85.830.0 905
LLPS-Mam-1972Macaca mulatta85.790.0 851
LLPS-Meg-2311Meleagris gallopavo85.740.0 922
LLPS-Gaga-1936Gallus gallus85.670.0 916
LLPS-Sus-1451Sus scrofa85.670.0 899
LLPS-Poa-3240Pongo abelii85.40.0 835
LLPS-Anc-0509Anolis carolinensis85.40.0 830
LLPS-Orc-4209Oryctolagus cuniculus85.330.0 915
LLPS-Xet-3641Xenopus tropicalis85.150.0 808
LLPS-Fia-3108Ficedula albicollis85.040.0 817
LLPS-Aim-0821Ailuropoda melanoleuca84.930.0 824
LLPS-Tag-2793Taeniopygia guttata84.880.0 813
LLPS-Nol-2405Nomascus leucogenys84.820.0 889
LLPS-Pes-1992Pelodiscus sinensis84.230.0 880
LLPS-Chs-1955Chlorocebus sabaeus78.170.0 842
LLPS-Pof-0059Poecilia formosa76.380.0 825
LLPS-Leo-2286Lepisosteus oculatus76.370.0 808
LLPS-Gaa-1511Gasterosteus aculeatus76.320.0 793
LLPS-Mal-3271Mandrillus leucophaeus72.170.0 725
LLPS-Drm-1215Drosophila melanogaster69.160.0 630
LLPS-Cii-1943Ciona intestinalis65.350.0 665
LLPS-Cis-0183Ciona savignyi63.870.0 664
LLPS-Cae-0482Caenorhabditis elegans62.150.0 545
LLPS-Chr-0618Chlamydomonas reinhardtii49.072e-1068.6
LLPS-Map-1345Magnaporthe poae44.121e-1068.6
LLPS-Osl-1478Ostreococcus lucimarinus43.967e-1272.8
LLPS-Fuv-0043Fusarium verticillioides38.274e-23 108
LLPS-Aso-0229Aspergillus oryzae35.869e-24 109
LLPS-Fus-1049Fusarium solani35.714e-1476.3
LLPS-Cog-1033Colletotrichum gloeosporioides34.681e-0965.9
LLPS-Asf-1390Aspergillus flavus33.333e-0861.2
LLPS-Trv-0576Trichoderma virens31.586e-30 130
LLPS-Asc-1677Aspergillus clavatus30.732e-1378.2
LLPS-Orbr-1306Oryza brachyantha30.044e-0757.4
LLPS-Mua-1386Musa acuminata29.896e-0653.9
LLPS-Ors-0547Oryza sativa29.61e-0655.8
LLPS-Org-1224Oryza glaberrima29.61e-0655.8
LLPS-Ori-0208Oryza indica29.61e-0655.8
LLPS-Hov-1151Hordeum vulgare29.61e-0656.2
LLPS-Tra-1482Triticum aestivum29.61e-0655.8
LLPS-Blg-0374Blumeria graminis29.077e-0653.5
LLPS-Abg-0805Absidia glauca28.981e-0862.8
LLPS-Cogr-0565Colletotrichum graminicola28.975e-0653.9
LLPS-Asfu-0984Aspergillus fumigatus26.895e-0756.6