LLPS-Dar-0867
riox1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ribosomal oxygenase 1; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
Gene Name: riox1, no66, zgc:162967
Ensembl Gene: ENSDARG00000067838.6
Ensembl Protein: ENSDARP00000150721.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region (By similarity).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MERKHMSALS  IYQSLSGGKT  PQAQDKAPPA  KKVKRKENGV  RPSKKATKKK  RTKPLKSSVR  60
61    SSSSEKEKHE  GESDCREMNG  KRFDNVALDI  LLTDLAKVNN  SRDRANRLFQ  WLIHPVQDKS  120
121   FFRDNWEKKP  ILIQRQNADY  YKGLFSTAEF  DRILRNDDVQ  YGVNLDVTSY  TNGKRETHNP  180
181   PGRALPYTVW  DFYESGCSIR  MLNPQAFSST  VWQVLSVLQE  KFGSMAGANV  YLTPPGTQGF  240
241   APHFDDIEAF  VVQLEGRKHW  RVYNPRCEDE  VLSLVSSPNF  SQDEIGEPVM  DVVLEAGDLL  300
301   YFPRGFVHQG  DCLPDAHSLH  ITISSYQRNS  WGDLMLKLMP  AALEVAMEED  VEFRKGLPLD  360
361   YLQYMGVQNS  EKEDPRRDRF  MAHIQGLMKK  LVSFAPVDAA  VDQKAKDFLH  DCLPPLLTAE  420
421   EKAGSVYGAP  ARWGDSEALD  VAVELKSQTR  IKLVRAGAAR  LCSDGDTVHL  YYTTENSRVY  480
481   HKEASKSFEM  KTEHIDAMEF  LIHSYPKFVS  VASLPCETAE  AKMSLAELLF  EKGLIFTAEP  540
541   LTAQ  544
Nucleotide CDS Sequence (FASTA)
1     ATGGAAAGAA  AACACATGTC  CGCATTGTCC  ATATATCAGT  CACTCTCAGG  AGGAAAAACA  60
61    CCACAAGCTC  AGGATAAAGC  ACCACCGGCA  AAGAAAGTCA  AAAGGAAGGA  GAACGGTGTC  120
121   AGACCAAGCA  AGAAAGCAAC  TAAAAAGAAA  AGGACGAAAC  CTCTTAAATC  CAGCGTGAGA  180
181   TCCAGCAGCA  GTGAAAAGGA  GAAACATGAA  GGAGAGAGCG  ACTGTAGGGA  GATGAATGGT  240
241   AAAAGGTTTG  ATAATGTAGC  TCTCGATATT  CTCCTGACGG  ATCTGGCGAA  GGTCAACAAC  300
301   AGCAGAGATC  GAGCCAACAG  ACTCTTCCAG  TGGCTCATTC  ACCCAGTGCA  GGACAAAAGC  360
361   TTCTTCAGAG  ATAACTGGGA  GAAGAAGCCA  ATTTTGATCC  AACGACAGAA  TGCAGATTAT  420
421   TATAAAGGAC  TCTTTTCGAC  TGCTGAATTT  GACCGGATAT  TAAGAAACGA  TGATGTTCAG  480
481   TATGGAGTGA  ATCTGGATGT  GACCAGCTAC  ACTAATGGGA  AAAGAGAGAC  ACACAATCCT  540
541   CCAGGACGAG  CGTTACCGTA  CACCGTATGG  GATTTTTATG  AGAGTGGTTG  CTCTATCAGA  600
601   ATGCTCAATC  CTCAAGCGTT  TTCCTCCACG  GTTTGGCAGG  TGCTCTCTGT  TCTTCAGGAG  660
661   AAGTTTGGCA  GCATGGCAGG  AGCAAACGTG  TATCTGACGC  CACCAGGGAC  GCAGGGCTTT  720
721   GCCCCTCATT  TTGATGATAT  AGAGGCGTTT  GTTGTGCAAC  TAGAGGGCAG  AAAGCACTGG  780
781   AGAGTTTACA  ACCCACGTTG  TGAAGACGAA  GTGCTGTCGC  TGGTGTCCAG  TCCTAATTTC  840
841   AGTCAGGATG  AGATCGGGGA  GCCCGTCATG  GATGTGGTTC  TGGAGGCTGG  AGATCTGCTG  900
901   TATTTTCCTC  GTGGTTTTGT  TCATCAGGGC  GACTGTCTGC  CTGACGCTCA  TTCCCTGCAC  960
961   ATCACCATCT  CATCCTATCA  GAGGAACAGC  TGGGGAGACC  TGATGCTCAA  ATTGATGCCA  1020
1021  GCCGCTCTGG  AGGTTGCGAT  GGAGGAGGAT  GTGGAGTTCA  GGAAGGGTCT  GCCGCTCGAT  1080
1081  TACCTGCAGT  ATATGGGCGT  TCAGAACTCT  GAGAAGGAGG  ATCCGCGGCG  AGACCGATTC  1140
1141  ATGGCACACA  TTCAGGGCCT  CATGAAGAAG  CTGGTCAGTT  TTGCTCCAGT  CGATGCTGCT  1200
1201  GTGGATCAGA  AAGCCAAAGA  CTTCCTGCAC  GACTGCCTTC  CACCTCTGCT  GACCGCTGAA  1260
1261  GAGAAGGCCG  GCAGTGTGTA  CGGTGCTCCT  GCTCGATGGG  GAGACTCTGA  GGCTCTGGAT  1320
1321  GTGGCTGTAG  AACTGAAGAG  TCAAACAAGA  ATCAAATTGG  TGCGAGCCGG  AGCTGCCAGG  1380
1381  TTGTGCAGTG  ATGGAGACAC  TGTACATCTT  TATTACACCA  CTGAAAACTC  CAGAGTCTAC  1440
1441  CATAAAGAAG  CATCCAAGAG  CTTTGAGATG  AAAACAGAGC  ACATCGACGC  CATGGAGTTT  1500
1501  CTGATTCACT  CATATCCCAA  GTTTGTGTCT  GTGGCTAGTT  TACCATGCGA  GACGGCGGAG  1560
1561  GCTAAGATGT  CTCTGGCCGA  GCTGCTCTTC  GAGAAGGGAT  TGATCTTCAC  CGCTGAACCG  1620
1621  CTAACAGCTC  AATAA  1635

▼ KEYWORD

ID
Family
Chromatin regulator
Complete proteome
Dioxygenase
Iron
Metal-binding
Nucleus
Oxidoreductase
Reference proteome
Repressor
Transcription
Transcription regulation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleolus
Cellular Component
Nucleoplasm
Cellular Component
Nucleus
Molecular Function
2-oxoglutarate-dependent dioxygenase activity
Molecular Function
Histone demethylase activity (H3-K36 specific)
Molecular Function
Histone demethylase activity (H3-K4 specific)
Molecular Function
Iron ion binding
Biological Process
Histone H3-K36 demethylation
Biological Process
Histone H3-K4 demethylation
Biological Process
Negative regulation of osteoblast differentiation
Biological Process
Negative regulation of transcription, DNA-templated

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
RAINMIST
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Icp-2818Ictalurus punctatus79.450.0 761
LLPS-Asm-1070Astyanax mexicanus79.30.0 800
LLPS-Scm-2909Scophthalmus maximus75.770.0 763
LLPS-Ten-1068Tetraodon nigroviridis72.770.0 711
LLPS-Leo-1330Lepisosteus oculatus71.050.0 714
LLPS-Scf-2310Scleropages formosus69.060.0 755
LLPS-Lac-1767Latimeria chalumnae66.810.0 670
LLPS-Orn-0963Oreochromis niloticus66.360.0 759
LLPS-Orl-1696Oryzias latipes65.970.0 720
LLPS-Pof-0693Poecilia formosa65.580.0 754
LLPS-Fia-0997Ficedula albicollis63.70.0 612
LLPS-Xim-3190Xiphophorus maculatus63.650.0 740
LLPS-Xet-2147Xenopus tropicalis63.580.0 645
LLPS-Tar-1231Takifugu rubripes63.520.0 719
LLPS-Gaga-1960Gallus gallus62.420.0 615
LLPS-Mod-2023Monodelphis domestica58.590.0 568
LLPS-Otg-0736Otolemur garnettii57.720.0 546
LLPS-Bot-1553Bos taurus57.140.0 583
LLPS-Mam-1179Macaca mulatta56.980.0 577
LLPS-Maf-1876Macaca fascicularis56.980.0 577
LLPS-Loa-2633Loxodonta africana56.920.0 580
LLPS-Fec-2655Felis catus56.920.0 579
LLPS-Caf-1071Canis familiaris56.920.0 580
LLPS-Man-0846Macaca nemestrina56.760.0 575
LLPS-Mea-1566Mesocricetus auratus56.760.0 569
LLPS-Fud-1717Fukomys damarensis56.70.0 579
LLPS-Caj-0344Callithrix jacchus56.70.0 578
LLPS-Nol-0895Nomascus leucogenys56.640.0 576
LLPS-Ict-0895Ictidomys tridecemlineatus56.480.0 580
LLPS-Myl-0280Myotis lucifugus56.420.0 575
LLPS-Sus-2178Sus scrofa56.340.0 585
LLPS-Paa-2434Papio anubis56.030.0 580
LLPS-Dio-2553Dipodomys ordii56.010.0 580
LLPS-Cap-3231Cavia porcellus55.90.0 566
LLPS-Mum-2707Mus musculus55.60.0 568
LLPS-Rhb-0411Rhinopithecus bieti55.510.0 579
LLPS-Hos-2005Homo sapiens55.410.0 578
LLPS-Pap-1582Pan paniscus55.410.0 578
LLPS-Cea-2103Cercocebus atys55.410.0 579
LLPS-Aon-3235Aotus nancymaae55.410.0 579
LLPS-Ran-1255Rattus norvegicus55.160.0 562
LLPS-Orc-4104Oryctolagus cuniculus53.12e-175 516
LLPS-Cis-1475Ciona savignyi50.933e-155 459
LLPS-Cii-0523Ciona intestinalis50.118e-162 476
LLPS-Php-1430Physcomitrella patens44.711e-1274.7
LLPS-Drm-2294Drosophila melanogaster41.573e-119 373
LLPS-Phv-1432Phaseolus vulgaris38.646e-1375.9
LLPS-Vir-0769Vigna radiata38.645e-1479.3
LLPS-Via-1272Vigna angularis38.179e-1478.2
LLPS-Tag-1944Taeniopygia guttata37.317e-60 211
LLPS-Mae-0626Manihot esculenta36.725e-1066.6
LLPS-Osl-1326Ostreococcus lucimarinus36.674e-54 197
LLPS-Anc-3457Anolis carolinensis36.592e-57 201
LLPS-Cus-0148Cucumis sativus36.231e-1378.2
LLPS-Poa-0972Pongo abelii35.041e-64 224
LLPS-Mua-2249Musa acuminata34.934e-1376.3
LLPS-Urm-3088Ursus maritimus34.762e-66 229
LLPS-Mup-2566Mustela putorius furo34.768e-66 227
LLPS-Aim-0371Ailuropoda melanoleuca34.764e-66 228
LLPS-Orbr-0306Oryza brachyantha34.597e-1375.5
LLPS-Pot-2216Populus trichocarpa34.519e-1168.9
LLPS-Coc-0567Corchorus capsularis34.462e-1377.8
LLPS-Zem-1760Zea mays34.467e-1169.3
LLPS-Eqc-1156Equus caballus34.238e-65 225
LLPS-Brd-0130Brachypodium distachyon34.154e-1170.1
LLPS-Sob-2311Sorghum bicolor34.014e-0963.5
LLPS-Hov-0721Hordeum vulgare34.019e-1065.5
LLPS-Lep-0769Leersia perrieri33.954e-1170.1
LLPS-Cae-1547Caenorhabditis elegans33.932e-83 281
LLPS-Prp-0871Prunus persica33.794e-1273.2
LLPS-Met-2451Medicago truncatula33.799e-1065.5
LLPS-Ora-2067Ornithorhynchus anatinus33.635e-67 230
LLPS-Gog-2059Gorilla gorilla33.567e-66 227
LLPS-Viv-1855Vitis vinifera33.556e-1168.9
LLPS-Cas-2426Carlito syrichta33.482e-66 229
LLPS-Pat-2375Pan troglodytes33.333e-65 225
LLPS-Amt-0955Amborella trichopoda33.335e-1169.7
LLPS-Mal-2613Mandrillus leucophaeus33.114e-65 225
LLPS-Tut-1380Tursiops truncatus32.968e-64 222
LLPS-Chs-0494Chlorocebus sabaeus32.892e-64 223
LLPS-Ova-1672Ovis aries32.892e-63 221
LLPS-Orp-0063Oryza punctata32.76e-1272.4
LLPS-Sei-1337Setaria italica32.655e-0963.2
LLPS-Anp-3371Anas platyrhynchos32.615e-63 220
LLPS-Pes-0770Pelodiscus sinensis32.466e-68 234
LLPS-Ori-2449Oryza indica32.266e-1066.2
LLPS-Meg-2745Meleagris gallopavo32.098e-64 222
LLPS-Sem-1914Selaginella moellendorffii32.031e-1067.8
LLPS-Sah-2959Sarcophilus harrisii31.871e-63 221
LLPS-Gaa-0893Gasterosteus aculeatus31.853e-58 207
LLPS-Gor-0948Gossypium raimondii31.753e-1067.0
LLPS-Glm-1474Glycine max31.512e-1170.9
LLPS-Dac-2175Daucus carota31.515e-1168.9
LLPS-Orr-1792Oryza rufipogon31.451e-1068.2
LLPS-Org-0774Oryza glaberrima31.452e-1067.8
LLPS-Orb-2183Oryza barthii31.451e-1068.2
LLPS-Orni-1963Oryza nivara31.451e-1068.2
LLPS-Orgl-0289Oryza glumaepatula31.451e-1068.6
LLPS-Tra-0081Triticum aestivum31.221e-1068.2
LLPS-Orm-0416Oryza meridionalis30.821e-0965.5
LLPS-Chc-1204Chondrus crispus30.624e-70 239
LLPS-Chr-1494Chlamydomonas reinhardtii30.14e-36 147
LLPS-Hea-2297Helianthus annuus26.495e-1272.8