LLPS-Dar-0489
celf1

▼ OVERVIEW

Status: Unreviewed
Protein Name: CUGBP Elav-like family member 1
Gene Name: celf1, brul, cugbp1
Ensembl Gene: ENSDARG00000005315.13
Ensembl Protein: ENSDARP00000115192.1
Organism: Danio rerio
Taxa ID: 7955
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, Perinucleolar compartment, P-body, Stress granulePredicted from orthologs(View)

▼ FUNCTION

RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation activation and stability (By similarity). Involved in the regulation of muscle-specific splicing of alpha actinin pre-mRNAs via the binding to the UR-repeat element (URE) at the branch point of the non-muscle (NM) exon.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MDSIEAEALY  LTTAQHGQPQ  CELSLPAVEV  PALGGSKKMN  GSLDHPDQPD  IDSIKMFVGQ  60
61    IPRTWSEDQL  RELFEPYGAV  YEINVLRDRS  QNPPQSKGCC  FVTYYTRKSA  LEAQNALHNM  120
121   KILPGMHHPI  QMKPADSEKN  NAVEDRKLFV  GMISKKCNEN  DIRLMFSPYG  QIEECRILRG  180
181   PDGLSRCAFV  TFTARQMAQS  AIKSMHQSQT  MEGCSSPIVV  KFADTQKDKE  QKRIAQQLQQ  240
241   QMQQLNAASM  WGNLTGLNSL  GPQYLALLQQ  SASSGNALNN  LHPMSGLNAM  QNLAALAAAA  300
301   SATQATPTGS  SALTTSSSPL  SVLTSSGTPS  GQPAQSAWDA  YKAGSSPTSS  TSSSVNPMAS  360
361   LGALQSLAAG  AGAGLNMSSL  ASMAALNGGL  GSGGLSNGSG  STMEALTQAA  YSGIQQYAAA  420
421   ALPSLYSQSL  LSQQNVSAAG  SQKEGPEGAN  LFIYHLPQEF  GDQDLLQMFM  PFGNVISAKV  480
481   FIDKQTNLSK  CFGFVSYDNP  VSSQAAIQSM  NGFQIGMKRL  KVQLKRSKND  SKPY  534
Nucleotide CDS Sequence (FASTA)
1     ATGGATAGTA  TCGAAGCTGA  AGCCCTGTAC  CTGACCACAG  CGCAGCACGG  GCAACCTCAA  60
61    TGCGAGCTTT  CTCTTCCTGC  TGTGGAAGTA  CCTGCCCTTG  GCGGAAGCAA  GAAGATGAAT  120
121   GGGTCTCTGG  ACCACCCAGA  CCAGCCCGAC  ATTGATTCTA  TAAAGATGTT  TGTGGGTCAG  180
181   ATCCCTCGGA  CGTGGTCAGA  GGATCAGCTG  CGTGAGCTGT  TTGAGCCCTA  TGGTGCAGTT  240
241   TATGAAATCA  ATGTTCTTCG  TGACAGGAGT  CAGAACCCCC  CACAGAGTAA  AGGTTGTTGT  300
301   TTTGTCACAT  ATTACACCCG  TAAGTCTGCA  TTAGAAGCAC  AAAATGCCCT  TCACAACATG  360
361   AAGATTCTTC  CAGGGATGCA  TCATCCCATA  CAAATGAAAC  CTGCAGACAG  TGAGAAAAAC  420
421   AATGCGGTAG  AAGATAGAAA  GCTGTTTGTT  GGAATGATTT  CAAAGAAGTG  CAATGAGAAC  480
481   GACATCAGAC  TCATGTTTTC  TCCATATGGT  CAAATCGAGG  AGTGCCGCAT  ATTGAGAGGT  540
541   CCAGACGGAC  TAAGCCGCTG  TGCCTTCGTC  ACATTCACAG  CGAGACAGAT  GGCCCAGTCT  600
601   GCCATCAAAT  CCATGCACCA  GTCACAGACT  ATGGAGGGCT  GTTCTTCTCC  CATCGTGGTG  660
661   AAGTTTGCAG  ACACACAGAA  GGATAAAGAA  CAGAAACGCA  TCGCCCAGCA  GCTGCAGCAA  720
721   CAGATGCAAC  AGCTCAATGC  TGCCTCCATG  TGGGGAAACC  TTACAGGGCT  GAACTCACTG  780
781   GGCCCACAGT  ACCTTGCACT  TCTACAGCAG  TCTGCTTCCT  CTGGAAATGC  GCTCAACAAT  840
841   CTCCATCCAA  TGTCAGGTCT  GAATGCCATG  CAAAATCTGG  CTGCATTAGC  AGCAGCAGCG  900
901   AGTGCTACAC  AGGCCACACC  TACAGGTAGC  AGTGCGCTGA  CCACCTCCAG  CTCCCCTCTC  960
961   AGCGTCCTCA  CCAGCTCAGG  TACGCCCTCC  GGACAGCCTG  CTCAATCTGC  CTGGGATGCC  1020
1021  TACAAGGCAG  GTTCCTCTCC  CACCTCCAGT  ACTAGTTCTT  CTGTGAACCC  CATGGCATCT  1080
1081  TTAGGTGCTC  TTCAGTCTCT  TGCTGCGGGC  GCTGGAGCAG  GTCTCAACAT  GAGTTCCCTA  1140
1141  GCAAGCATGG  CTGCTCTAAA  TGGTGGTCTG  GGCAGCGGAG  GTCTCTCCAA  CGGCTCTGGA  1200
1201  AGCACTATGG  AGGCTCTGAC  TCAGGCGGCC  TATTCTGGGA  TCCAGCAGTA  TGCAGCTGCC  1260
1261  GCTCTGCCAA  GCCTCTACAG  TCAGAGTTTA  CTGTCCCAGC  AGAACGTTAG  CGCTGCTGGC  1320
1321  AGCCAAAAAG  AAGGCCCTGA  AGGAGCAAAC  CTGTTCATCT  ACCATCTGCC  ACAGGAGTTT  1380
1381  GGTGATCAGG  ATTTGTTGCA  GATGTTTATG  CCTTTCGGCA  ACGTCATCTC  TGCCAAGGTC  1440
1441  TTTATTGACA  AACAGACCAA  CCTTAGCAAG  TGTTTTGGCT  TTGTAAGTTA  CGACAATCCA  1500
1501  GTTTCGTCCC  AGGCAGCCAT  TCAGTCAATG  AACGGTTTTC  AGATTGGAAT  GAAGCGGCTG  1560
1561  AAGGTGCAAC  TTAAACGATC  TAAAAATGAC  AGCAAGCCAT  ACTGA  1605

▼ KEYWORD

ID
Family
Activator
Alternative splicing
Complete proteome
Cytoplasm
mRNA processing
mRNA splicing
Nucleus
Reference proteome
Repeat
RNA-binding

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytoplasm
Cellular Component
Nucleus
Cellular Component
Pole plasm
Cellular Component
Ribonucleoprotein complex
Molecular Function
MRNA 3'-UTR binding
Molecular Function
MRNA binding
Molecular Function
RNA binding
Biological Process
Cell migration
Biological Process
Determination of left/right symmetry
Biological Process
Developmental cell growth
Biological Process
Digestive tract development
Biological Process
Embryonic liver development
Biological Process
Endodermal digestive tract morphogenesis
Biological Process
Liver development
Biological Process
MRNA splice site selection
Biological Process
Pancreas development
Biological Process
Pancreas morphogenesis
Biological Process
Positive regulation of mRNA catabolic process
Biological Process
Regulation of alternative mRNA splicing, via spliceosome

▼ KEGG


▼ ANNOTATION

Disorder
D2P2IUPred2A
Interaction
MIST
Physicochemical
AAindex

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Orn-2315Oreochromis niloticus94.744e-62 219
LLPS-Icp-0421Ictalurus punctatus94.160.0 692
LLPS-Xet-0939Xenopus tropicalis93.985e-61 215
LLPS-Asm-2201Astyanax mexicanus93.640.0 752
LLPS-Caj-2750Callithrix jacchus93.236e-59 210
LLPS-Fud-3234Fukomys damarensis93.235e-59 210
LLPS-Gog-1336Gorilla gorilla93.234e-59 210
LLPS-Cea-0955Cercocebus atys93.231e-58 209
LLPS-Aon-1168Aotus nancymaae93.235e-59 210
LLPS-Ora-1276Ornithorhynchus anatinus93.231e-61 217
LLPS-Chs-0396Chlorocebus sabaeus93.236e-59 210
LLPS-Mea-3475Mesocricetus auratus93.239e-60 210
LLPS-Mum-3168Mus musculus93.235e-59 210
LLPS-Maf-4718Macaca fascicularis93.231e-58 209
LLPS-Ova-2710Ovis aries93.231e-60 211
LLPS-Myl-2996Myotis lucifugus93.236e-59 209
LLPS-Mup-0959Mustela putorius furo93.235e-59 210
LLPS-Mal-2999Mandrillus leucophaeus93.237e-60 211
LLPS-Paa-2735Papio anubis93.231e-58 209
LLPS-Ran-4021Rattus norvegicus93.236e-59 209
LLPS-Bot-1480Bos taurus93.238e-59 209
LLPS-Dio-2405Dipodomys ordii93.236e-59 210
LLPS-Rhb-0700Rhinopithecus bieti93.232e-58 209
LLPS-Fia-2471Ficedula albicollis93.231e-58 209
LLPS-Orc-2972Oryctolagus cuniculus93.235e-59 210
LLPS-Pes-0297Pelodiscus sinensis93.235e-59 210
LLPS-Otg-3129Otolemur garnettii93.231e-60 211
LLPS-Loa-3177Loxodonta africana93.236e-59 210
LLPS-Anp-2616Anas platyrhynchos93.235e-59 210
LLPS-Man-1723Macaca nemestrina93.234e-59 210
LLPS-Mod-4341Monodelphis domestica93.232e-60 211
LLPS-Fec-1602Felis catus93.231e-58 209
LLPS-Urm-2610Ursus maritimus93.238e-59 209
LLPS-Pap-1839Pan paniscus93.235e-59 210
LLPS-Pat-3619Pan troglodytes93.231e-58 209
LLPS-Meg-1676Meleagris gallopavo93.235e-59 210
LLPS-Hos-2698Homo sapiens93.231e-58 209
LLPS-Tag-0026Taeniopygia guttata93.231e-61 217
LLPS-Ict-3320Ictidomys tridecemlineatus93.236e-59 210
LLPS-Nol-1640Nomascus leucogenys93.235e-59 210
LLPS-Anc-0338Anolis carolinensis93.239e-61 211
LLPS-Gaga-3046Gallus gallus93.235e-59 210
LLPS-Mam-1923Macaca mulatta93.231e-58 209
LLPS-Eqc-3011Equus caballus93.233e-58 209
LLPS-Cap-3750Cavia porcellus93.235e-59 210
LLPS-Caf-2969Canis familiaris93.233e-59 210
LLPS-Poa-0670Pongo abelii93.235e-59 210
LLPS-Scf-2730Scleropages formosus92.862e-60 214
LLPS-Sah-1598Sarcophilus harrisii92.488e-62 217
LLPS-Sus-2095Sus scrofa92.488e-58 207
LLPS-Aim-2132Ailuropoda melanoleuca92.481e-61 217
LLPS-Tut-0980Tursiops truncatus92.487e-62 217
LLPS-Xim-1971Xiphophorus maculatus92.482e-58 209
LLPS-Lac-2156Latimeria chalumnae92.488e-59 209
LLPS-Cas-3628Carlito syrichta92.481e-61 217
LLPS-Leo-2678Lepisosteus oculatus91.733e-58 208
LLPS-Orl-0786Oryzias latipes91.733e-58 208
LLPS-Tar-1738Takifugu rubripes91.734e-58 207
LLPS-Ten-3059Tetraodon nigroviridis91.732e-58 207
LLPS-Scm-1701Scophthalmus maximus88.064e-55 199
LLPS-Pof-2122Poecilia formosa87.417e-55 199
LLPS-Gaa-3616Gasterosteus aculeatus86.761e-54 198
LLPS-Drm-1468Drosophila melanogaster78.958e-42 165
LLPS-Cii-1650Ciona intestinalis76.02e-43 166
LLPS-Cae-1757Caenorhabditis elegans69.233e-33 137
LLPS-Cis-1057Ciona savignyi66.673e-41 160