LLPS-Chs-2551
GNG12
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Guanine nucleotide-binding protein subunit gamma |
| Gene Name: | GNG12 |
| Ensembl Gene: | ENSCSAG00000001367.1 |
| Ensembl Protein: | ENSCSAP00000016650.1 |
| Organism: | Chlorocebus sabaeus |
| Taxa ID: | 60711 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCSAT00000017166.1 | ENSCSAP00000016650.1 |
| UniProt | A0A0D9S711, A0A0D9S711_CHLSB | |
| GeneBank | AQIB01085429 | |
| RefSeq | XM_007978345.1, XM_007978346.1, XM_007978347.1, XM_007978349.1, XM_007978350.1 | XP_007976536.1, XP_007976537.1, XP_007976538.1, XP_007976540.1, XP_007976541.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSSKTASTNN IAQARRTVQQ LRLEASIERI KVSKASADLM SYCEEHARSD PLLIGIPTSE 60 61 NPFKDKKTCI IL 72 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCCAGCA AAACAGCAAG TACCAACAAT ATAGCCCAGG CAAGGAGAAC TGTGCAGCAG 60 61 TTAAGATTAG AAGCCTCCAT TGAAAGAATA AAGGTTTCGA AGGCATCAGC GGACCTCATG 120 121 TCCTACTGTG AGGAACATGC CAGGAGTGAC CCTTTGCTGA TAGGAATACC AACTTCAGAA 180 181 AACCCTTTCA AGGATAAAAA AACTTGCATC ATCTTA 216 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Heterotrimeric G-protein complex | |
Molecular Function | GTPase activity | |
Molecular Function | PDZ domain binding | |
Biological Process | G protein-coupled receptor signaling pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Rhb-1882 | Rhinopithecus bieti | 100.0 | 3e-46 | 148 |
| LLPS-Orc-2598 | Oryctolagus cuniculus | 100.0 | 3e-46 | 148 |
| LLPS-Hos-2183 | Homo sapiens | 100.0 | 3e-46 | 148 |
| LLPS-Pat-0301 | Pan troglodytes | 100.0 | 3e-46 | 148 |
| LLPS-Pap-2398 | Pan paniscus | 100.0 | 3e-46 | 148 |
| LLPS-Man-3101 | Macaca nemestrina | 100.0 | 3e-46 | 148 |
| LLPS-Poa-4612 | Pongo abelii | 100.0 | 3e-46 | 148 |
| LLPS-Gog-2786 | Gorilla gorilla | 100.0 | 3e-46 | 148 |
| LLPS-Caj-2792 | Callithrix jacchus | 100.0 | 3e-46 | 148 |
| LLPS-Maf-3957 | Macaca fascicularis | 100.0 | 3e-46 | 148 |
| LLPS-Cea-3167 | Cercocebus atys | 100.0 | 3e-46 | 148 |
| LLPS-Aon-4808 | Aotus nancymaae | 100.0 | 3e-46 | 148 |
| LLPS-Mal-4485 | Mandrillus leucophaeus | 100.0 | 3e-46 | 148 |
| LLPS-Paa-2123 | Papio anubis | 100.0 | 3e-46 | 148 |
| LLPS-Fec-3266 | Felis catus | 98.61 | 7e-46 | 147 |
| LLPS-Cas-4032 | Carlito syrichta | 98.61 | 8e-46 | 147 |
| LLPS-Ict-3281 | Ictidomys tridecemlineatus | 98.61 | 2e-45 | 146 |
| LLPS-Caf-3561 | Canis familiaris | 98.61 | 7e-46 | 147 |
| LLPS-Ere-0434 | Erinaceus europaeus | 98.61 | 5e-46 | 147 |
| LLPS-Dio-2855 | Dipodomys ordii | 98.61 | 2e-45 | 146 |
| LLPS-Loa-4369 | Loxodonta africana | 97.22 | 3e-45 | 145 |
| LLPS-Nol-0377 | Nomascus leucogenys | 97.22 | 3e-45 | 145 |
| LLPS-Cap-1550 | Cavia porcellus | 97.22 | 4e-45 | 145 |
| LLPS-Myl-1858 | Myotis lucifugus | 96.97 | 2e-40 | 133 |
| LLPS-Otg-4535 | Otolemur garnettii | 95.83 | 7e-44 | 142 |
| LLPS-Sus-0864 | Sus scrofa | 95.83 | 6e-45 | 145 |
| LLPS-Ran-4818 | Rattus norvegicus | 95.83 | 3e-44 | 143 |
| LLPS-Aim-3538 | Ailuropoda melanoleuca | 95.83 | 5e-44 | 142 |
| LLPS-Ova-2307 | Ovis aries | 94.44 | 3e-44 | 143 |
| LLPS-Bot-4491 | Bos taurus | 94.44 | 3e-44 | 143 |
| LLPS-Mod-1716 | Monodelphis domestica | 91.67 | 6e-43 | 140 |
| LLPS-Sah-2512 | Sarcophilus harrisii | 91.67 | 7e-43 | 139 |
| LLPS-Pes-3453 | Pelodiscus sinensis | 90.0 | 7e-34 | 117 |
| LLPS-Lac-3761 | Latimeria chalumnae | 88.06 | 9e-38 | 126 |
| LLPS-Urm-0875 | Ursus maritimus | 87.34 | 2e-41 | 136 |
| LLPS-Eqc-3375 | Equus caballus | 86.59 | 1e-42 | 139 |
| LLPS-Meg-3152 | Meleagris gallopavo | 86.3 | 8e-39 | 129 |
| LLPS-Anp-1723 | Anas platyrhynchos | 86.3 | 2e-39 | 131 |
| LLPS-Gaga-4048 | Gallus gallus | 86.3 | 2e-39 | 131 |
| LLPS-Tag-3232 | Taeniopygia guttata | 86.3 | 3e-39 | 130 |
| LLPS-Fia-0338 | Ficedula albicollis | 84.93 | 2e-38 | 128 |
| LLPS-Mum-4234 | Mus musculus | 84.34 | 1e-41 | 137 |
| LLPS-Asm-1938 | Astyanax mexicanus | 81.94 | 3e-37 | 125 |
| LLPS-Scm-0302 | Scophthalmus maximus | 80.56 | 2e-36 | 123 |
| LLPS-Icp-2658 | Ictalurus punctatus | 80.56 | 3e-36 | 123 |
| LLPS-Tar-1818 | Takifugu rubripes | 80.56 | 1e-36 | 124 |
| LLPS-Gaa-0142 | Gasterosteus aculeatus | 80.56 | 7e-37 | 124 |
| LLPS-Orn-3204 | Oreochromis niloticus | 75.0 | 1e-32 | 113 |
| LLPS-Orl-2714 | Oryzias latipes | 72.22 | 1e-31 | 111 |
| LLPS-Mup-4176 | Mustela putorius furo | 62.5 | 1e-28 | 103 |