• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Chs-2014
ME2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Malic enzyme
Gene Name: ME2
Ensembl Gene: ENSCSAG00000018086.1
Ensembl Protein: ENSCSAP00000014104.1
Organism: Chlorocebus sabaeus
Taxa ID: 60711
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Mitochondrial RNA granulePredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLSRLRVVST  TCTLACRRLH  IKEKGKPLML  NPRTNKGMAF  TLQERQMLGL  QGLLPPKIET  60
61    QDIQALRFHR  NLKKMTSPLE  KYIYIMGIQE  RNEKLFYRIL  QDDIESLMPI  VYTPTVGLAC  120
121   SQYGHIFRRP  KGLFISISDR  GHVRSIVDNW  PENHVKAVVV  TDGERILGLG  DLGVYGMGIP  180
181   VGKLCLYTAC  AGIQPDRCLP  VCIDVGTDNI  ALLKDPFYMG  LYQKRDRTQQ  YDDLIDEFMK  240
241   AITDRYGRNT  LIQFEDFGNH  NAFRFLRKYR  EKYCTFNDDI  QGTAAVALAG  LLAAQKVISK  300
301   PISEHKILFL  GAGEAALGIA  NLIVMSMVEN  GLSEQEAQQK  IWMFDKYGLL  VKGRKAKIDS  360
361   YQEPFTHPVP  ESIPDTFEDA  VNILKPSTII  GVAGAGRLFT  PDVIRAMASI  NERPVIFALS  420
421   NPTAQAECTA  EEAYALTEGR  CLFASGSPFG  PVKLTDGRVF  TPGQGNNVYI  FPGVALAVIL  480
481   CNTRHISDSV  FLEAAKALTS  QLTDEELAQG  RLYPPLANIQ  EVSINIAIKV  TEYLYANKMA  540
541   FRYPEPEDKA  KYVKERIWRS  EYDSLLPDVY  EWPESASSPP  VITE  584
Nucleotide CDS Sequence (FASTA)
1     ATGTTGTCCC  GGTTAAGAGT  AGTTTCTACC  ACTTGTACTT  TGGCATGTCG  ACGTTTGCAC  60
61    ATAAAAGAAA  AAGGCAAGCC  ACTTATGCTG  AACCCGAGAA  CCAACAAGGG  AATGGCATTT  120
121   ACTTTACAAG  AACGACAAAT  GCTTGGTCTT  CAAGGACTTC  TACCTCCCAA  AATAGAGACA  180
181   CAAGATATTC  AAGCCTTACG  ATTCCATAGA  AACTTAAAGA  AAATGACTAG  CCCTTTGGAA  240
241   AAATATATCT  ACATAATGGG  AATACAAGAA  AGAAATGAGA  AATTGTTTTA  TAGAATACTG  300
301   CAAGATGACA  TTGAGAGTTT  AATGCCAATT  GTATATACAC  CAACGGTTGG  TCTTGCCTGC  360
361   TCCCAGTATG  GACACATCTT  TAGAAGACCT  AAGGGATTAT  TTATTTCGAT  CTCAGACAGA  420
421   GGTCATGTTA  GATCAATTGT  GGATAACTGG  CCAGAAAATC  ATGTTAAGGC  TGTTGTAGTG  480
481   ACTGATGGAG  AGAGAATTTT  GGGTCTTGGA  GATCTGGGTG  TCTATGGAAT  GGGAATTCCA  540
541   GTAGGAAAAC  TTTGTTTGTA  TACAGCTTGT  GCAGGAATAC  AGCCTGATAG  ATGCCTGCCA  600
601   GTGTGTATTG  ATGTGGGAAC  TGATAATATC  GCACTCTTAA  AAGACCCATT  TTACATGGGC  660
661   TTGTACCAGA  AACGAGATCG  CACACAACAG  TATGATGACC  TGATTGATGA  GTTTATGAAA  720
721   GCTATTACTG  ACAGATATGG  TCGGAACACA  CTCATTCAGT  TCGAAGACTT  TGGAAATCAT  780
781   AATGCGTTCA  GATTTTTGAG  AAAGTACCGA  GAAAAATATT  GTACTTTCAA  TGATGATATT  840
841   CAAGGGACAG  CTGCAGTAGC  TCTAGCAGGT  CTTCTTGCAG  CACAAAAAGT  AATTAGTAAA  900
901   CCAATCTCCG  AACACAAAAT  CTTATTCCTT  GGAGCAGGAG  AGGCTGCTCT  TGGAATTGCA  960
961   AATCTTATAG  TTATGTCTAT  GGTAGAAAAT  GGCCTGTCAG  AACAAGAGGC  ACAACAGAAA  1020
1021  ATCTGGATGT  TTGACAAGTA  TGGTTTATTA  GTTAAGGGGC  GGAAAGCAAA  AATAGATAGT  1080
1081  TATCAGGAAC  CATTTACTCA  CCCAGTCCCA  GAGAGCATAC  CTGATACTTT  TGAAGATGCA  1140
1141  GTGAATATAC  TGAAGCCTTC  AACTATAATC  GGAGTTGCAG  GTGCTGGCCG  TCTTTTCACT  1200
1201  CCTGATGTAA  TCAGAGCCAT  GGCCTCTATC  AATGAAAGGC  CTGTAATATT  TGCATTAAGT  1260
1261  AATCCTACGG  CACAGGCAGA  GTGCACGGCT  GAAGAAGCAT  ATGCACTTAC  AGAGGGCAGG  1320
1321  TGTTTGTTTG  CCAGTGGCAG  TCCATTTGGG  CCAGTGAAAC  TCACAGATGG  GCGAGTCTTT  1380
1381  ACACCAGGTC  AAGGAAACAA  TGTATATATT  TTTCCAGGTG  TGGCTTTAGC  TGTTATTCTC  1440
1441  TGTAACACCC  GGCATATTAG  TGACAGTGTT  TTCCTAGAAG  CTGCAAAGGC  ACTGACAAGC  1500
1501  CAATTGACAG  ATGAAGAGCT  AGCCCAAGGG  AGACTTTACC  CACCACTTGC  TAATATTCAG  1560
1561  GAAGTTTCTA  TTAACATTGC  TATTAAAGTT  ACAGAATACC  TATATGCTAA  TAAAATGGCT  1620
1621  TTCCGATACC  CAGAACCTGA  AGACAAGGCC  AAATATGTTA  AAGAAAGAAT  ATGGCGGAGT  1680
1681  GAATATGATT  CCCTGCTGCC  AGATGTGTAT  GAATGGCCGG  AATCTGCATC  AAGCCCTCCT  1740
1741  GTGATAACAG  AATAG  1755

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mam-1621Macaca mulatta99.660.01183
LLPS-Paa-3153Papio anubis99.490.01183
LLPS-Maf-4693Macaca fascicularis99.490.01181
LLPS-Cea-1165Cercocebus atys99.490.01181
LLPS-Man-4568Macaca nemestrina99.320.01180
LLPS-Nol-1124Nomascus leucogenys99.140.01177
LLPS-Pap-4017Pan paniscus98.970.01176
LLPS-Gog-4445Gorilla gorilla98.970.01176
LLPS-Hos-2462Homo sapiens98.80.01174
LLPS-Caj-4519Callithrix jacchus98.120.01168
LLPS-Mal-3561Mandrillus leucophaeus96.230.01122
LLPS-Pat-3817Pan troglodytes96.060.01129
LLPS-Aon-0378Aotus nancymaae94.920.01132
LLPS-Cas-2508Carlito syrichta93.490.01123
LLPS-Cap-0406Cavia porcellus92.980.01116
LLPS-Otg-3035Otolemur garnettii92.980.01115
LLPS-Fud-2889Fukomys damarensis92.980.01117
LLPS-Rhb-1222Rhinopithecus bieti92.910.01093
LLPS-Poa-4642Pongo abelii92.640.01112
LLPS-Dio-2619Dipodomys ordii92.640.01110
LLPS-Ict-1378Ictidomys tridecemlineatus92.560.01104
LLPS-Sus-1605Sus scrofa92.120.01108
LLPS-Fec-3140Felis catus91.780.01099
LLPS-Eqc-1145Equus caballus91.440.01103
LLPS-Mup-3205Mustela putorius furo91.440.01097
LLPS-Bot-2416Bos taurus91.10.01099
LLPS-Caf-1979Canis familiaris90.750.01088
LLPS-Urm-2428Ursus maritimus90.580.01088
LLPS-Orc-3822Oryctolagus cuniculus90.410.01068
LLPS-Ova-3603Ovis aries90.410.01096
LLPS-Aim-3899Ailuropoda melanoleuca90.410.01083
LLPS-Myl-0691Myotis lucifugus89.210.01079
LLPS-Mum-4744Mus musculus89.210.01077
LLPS-Loa-4476Loxodonta africana88.870.01069
LLPS-Ran-3051Rattus norvegicus88.870.01070
LLPS-Ora-1892Ornithorhynchus anatinus85.690.01038
LLPS-Sah-1516Sarcophilus harrisii84.930.01035
LLPS-Mod-2487Monodelphis domestica82.190.01013
LLPS-Tag-1058Taeniopygia guttata81.270.0 978
LLPS-Anc-3782Anolis carolinensis80.620.0 973
LLPS-Leo-3091Lepisosteus oculatus78.390.0 964
LLPS-Xet-0860Xenopus tropicalis77.440.0 941
LLPS-Scf-0910Scleropages formosus76.50.0 933
LLPS-Orl-1079Oryzias latipes75.90.0 928
LLPS-Fia-3289Ficedula albicollis75.650.0 893
LLPS-Orn-0698Oreochromis niloticus75.650.0 919
LLPS-Tar-2676Takifugu rubripes75.390.0 919
LLPS-Dar-2827Danio rerio75.220.0 934
LLPS-Scm-0176Scophthalmus maximus75.040.0 924
LLPS-Pof-0766Poecilia formosa74.310.0 904
LLPS-Ten-2551Tetraodon nigroviridis74.140.0 914
LLPS-Gaa-3371Gasterosteus aculeatus73.790.0 894
LLPS-Xim-0077Xiphophorus maculatus73.460.0 895
LLPS-Asm-2469Astyanax mexicanus70.910.0 846
LLPS-Icp-4048Ictalurus punctatus65.980.0 771
LLPS-Lac-1024Latimeria chalumnae58.430.0 679
LLPS-Pes-1982Pelodiscus sinensis58.170.0 663
LLPS-Anp-1315Anas platyrhynchos57.550.0 676
LLPS-Gaga-1619Gallus gallus57.520.0 673
LLPS-Meg-0012Meleagris gallopavo56.680.0 654
LLPS-Drm-2204Drosophila melanogaster53.80.0 605
LLPS-Thc-0091Theobroma cacao52.030.0 578
LLPS-Coc-1926Corchorus capsularis51.950.0 578
LLPS-Zem-0606Zea mays51.20.0 566
LLPS-Sob-1172Sorghum bicolor51.110.0 563
LLPS-Brr-2530Brassica rapa50.830.0 545
LLPS-Nia-1152Nicotiana attenuata50.740.0 568
LLPS-Art-0841Arabidopsis thaliana50.550.0 548
LLPS-Bro-2262Brassica oleracea50.460.0 550
LLPS-Prp-1283Prunus persica50.460.0 563
LLPS-Amt-0317Amborella trichopoda50.460.0 555
LLPS-Brn-0913Brassica napus50.460.0 549
LLPS-Org-1342Oryza glaberrima50.280.0 558
LLPS-Orm-1217Oryza meridionalis50.280.0 558
LLPS-Orr-2325Oryza rufipogon50.280.0 558
LLPS-Ors-2221Oryza sativa50.280.0 558
LLPS-Orp-2288Oryza punctata50.280.0 554
LLPS-Orb-0328Oryza barthii50.280.0 558
LLPS-Cus-2224Cucumis sativus50.180.0 560
LLPS-Cae-1694Caenorhabditis elegans50.170.0 558
LLPS-Lep-1639Leersia perrieri50.090.0 555
LLPS-Orni-1754Oryza nivara50.090.0 556
LLPS-Mae-1088Manihot esculenta50.00.0 548
LLPS-Gor-2624Gossypium raimondii50.00.0 541
LLPS-Arl-1944Arabidopsis lyrata50.00.0 543
LLPS-Pot-2392Populus trichocarpa49.910.0 538
LLPS-Sol-1417Solanum lycopersicum49.820.0 559
LLPS-Hov-0083Hordeum vulgare49.810.0 545
LLPS-Orbr-1769Oryza brachyantha49.630.0 548
LLPS-Sot-1606Solanum tuberosum49.630.0 558
LLPS-Hea-0388Helianthus annuus49.630.0 557
LLPS-Mua-2258Musa acuminata49.630.0 546
LLPS-Tru-1881Triticum urartu49.611e-179 527
LLPS-Via-1147Vigna angularis49.540.0 545
LLPS-Met-1289Medicago truncatula49.450.0 536
LLPS-Brd-1466Brachypodium distachyon49.450.0 546
LLPS-Dac-1666Daucus carota49.440.0 535
LLPS-Glm-1833Glycine max49.440.0 543
LLPS-Sem-1967Selaginella moellendorffii49.359e-178 523
LLPS-Tra-0267Triticum aestivum49.260.0 544
LLPS-Vir-0386Vigna radiata49.269e-180 530
LLPS-Sei-2079Setaria italica49.170.0 550
LLPS-Orgl-1507Oryza glumaepatula49.080.0 552
LLPS-Phv-2007Phaseolus vulgaris49.070.0 545
LLPS-Php-1330Physcomitrella patens48.791e-176 520
LLPS-Viv-2336Vitis vinifera48.610.0 548
LLPS-Cym-1077Cyanidioschyzon merolae48.481e-177 523
LLPS-Lem-0462Leptosphaeria maculans44.72e-143 434
LLPS-Chc-0928Chondrus crispus44.228e-157 468
LLPS-Gas-1332Galdieria sulphuraria43.327e-148 447
LLPS-Osl-0457Ostreococcus lucimarinus43.053e-136 416
LLPS-Blg-0896Blumeria graminis42.522e-130 403
LLPS-Spr-1168Sporisorium reilianum42.447e-147 444
LLPS-Usm-0647Ustilago maydis42.265e-146 442
LLPS-Pug-1105Puccinia graminis41.233e-127 394
LLPS-Ori-1302Oryza indica40.979e-125 386
LLPS-Mel-1393Melampsora laricipopulina40.184e-125 387
LLPS-Map-1054Magnaporthe poae39.639e-129 403
LLPS-Cog-0336Colletotrichum gloeosporioides38.567e-108 343
LLPS-Dos-0866Dothistroma septosporum38.362e-114 360
LLPS-Miv-0944Microbotryum violaceum38.328e-115 362
LLPS-Coo-1342Colletotrichum orbiculare38.151e-110 350
LLPS-Nec-1485Neurospora crassa38.144e-104 335
LLPS-Sac-0134Saccharomyces cerevisiae38.112e-102 331
LLPS-Pytr-0825Pyrenophora triticirepentis37.822e-110 350
LLPS-Ast-0283Aspergillus terreus37.743e-85 280
LLPS-Mao-0666Magnaporthe oryzae37.742e-115 363
LLPS-Asc-1559Aspergillus clavatus37.733e-110 348
LLPS-Fuv-1440Fusarium verticillioides37.637e-92 298
LLPS-Pyt-1425Pyrenophora teres37.271e-108 345
LLPS-Scs-1115Sclerotinia sclerotiorum37.272e-108 345
LLPS-Scj-0761Schizosaccharomyces japonicus37.192e-102 328
LLPS-Scp-1610Schizosaccharomyces pombe37.142e-102 328
LLPS-Asg-0603Ashbya gossypii36.883e-95 311
LLPS-Scc-0037Schizosaccharomyces cryophilus36.554e-103 330
LLPS-Kop-0860Komagataella pastoris36.451e-101 327
LLPS-Cogr-1170Colletotrichum graminicola36.436e-108 343
LLPS-Asfu-1561Aspergillus fumigatus36.367e-99 319
LLPS-Nef-1404Neosartorya fischeri36.365e-101 325
LLPS-Asf-1593Aspergillus flavus36.34e-108 343
LLPS-Aso-1388Aspergillus oryzae36.34e-108 343
LLPS-Asni-1554Aspergillus niger36.37e-108 343
LLPS-Ved-0958Verticillium dahliae36.284e-73 248
LLPS-Tum-1629Tuber melanosporum36.172e-111 352
LLPS-Yal-0723Yarrowia lipolytica35.981e-100 325
LLPS-Zyt-1099Zymoseptoria tritici35.758e-109 345
LLPS-Crn-1238Cryptococcus neoformans35.688e-111 352
LLPS-Trr-1590Trichoderma reesei35.51e-101 327
LLPS-Beb-1528Beauveria bassiana35.455e-102 327
LLPS-Asn-1306Aspergillus nidulans35.372e-98 318
LLPS-Fus-1356Fusarium solani35.352e-105 337
LLPS-Abg-1724Absidia glauca35.01e-102 328
LLPS-Phn-1588Phaeosphaeria nodorum34.952e-94 308
LLPS-Gag-0969Gaeumannomyces graminis34.937e-103 330
LLPS-Trv-1547Trichoderma virens34.723e-96 313
LLPS-Fuo-0756Fusarium oxysporum33.633e-91 299