LLPS-Cea-a561
SCN2A
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Sodium channel protein |
| Gene Name: | SCN2A |
| Ensembl Gene: | ENSCATG00000038517.1 |
| Ensembl Protein: | ENSCATP00000031444.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCATT00000055710.1 | ENSCATP00000031444.1 |
| Ensembl | ENSCATT00000055705.1 | ENSCATP00000031439.1 |
| Ensembl | ENSCATT00000055711.1 | ENSCATP00000031445.1 |
| Ensembl | ENSCATT00000055708.1 | ENSCATP00000031442.1 |
| Ensembl | ENSCATT00000055528.1 | ENSCATP00000031263.1 |
| Ensembl | ENSCATT00000055697.1 | ENSCATP00000031431.1 |
| UniProt | A0A2K5N1U5, A0A2K5N1U5_CERAT |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK 60 61 SLPFIYGDIP PEMVSVPLED LDPYYINKKT FIVLNKGKAI SRFSATPALY ILTPFNPIRK 120 121 LAIKILVHSY PFSNRIYTFE SLIKILARGF CLEDFTFLRD PWNWLDFTVI TFAYVTEFVD 180 181 LGNVSALRTF RVLRALKTIS VIPGLKTIVG ALIQSVKKLS DVMILTVFCL SVFALIGLQL 240 241 FMGNLRNKCL QWPPDNSSFE INITSFFNNS LDGNGTTFNR TVSMFNWDEY IEDKSHFYFL 300 301 EGQNDALLCG NSSDAGQCPE GYICVKAGRN PNYGYTSFDT FSWAFLSLFR LMTQDFWENL 360 361 YQLTLRAAGK TYMIFFVLVI FLGSFYLINL ILAVVAMAYE EQNQATLEEA EQKEAEFQQM 420 421 LEQLKKQQEE AQAAAAAASA ESRDFSGAGG IGVFSESSSV ASKLSSKSEK ELKNRRKKKK 480 481 QKEQSGEEEK NDRVRKSESE DSIRRKGFRF SLEGSRLTYE KRFSSPHQSL LSIRGSLFSP 540 541 RRNSRASLFS FRGRTKDIGS ENDFADDEHS TFEDNDSRRD SLFVPHRHGE RRHSNVSQAS 600 601 RASRVLPILP MNGKMHSAVD CNGVVSLVGG PSTLTSAGQL LPEGTTTETE IRKRRSSSYH 660 661 VSMDLLEDPT SRQRAMSIAS ILTNTMEELE ESRQKCPPCW YKFANMCLIW DCCKPWLKVK 720 721 HLVNLVVMDP FVDLAITICI VLNTLFMAME HYPMTEQFSS VLSVGNLVFT GIFTAEMFLK 780 781 IIAMDPYYYF QEGWNIFDGF IVSLSLMELG LANVEGLSVL RSFRLLRVFK LAKSWPTLNM 840 841 LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG MQLFGKSYKE CVCKISNDCE LPRWHMHDFF 900 901 HSFLIVFRVL CGEWIETMWD CMEVAGQTMC LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD 960 961 NLAATDDDNE MNNLQIAVGR MQKGIDFVKR KIREFIQKAF VRKQKALDEI KPLEDLNNKK 1020 1021 DSCISNHTTI EIGKDLNYLK DGNGTTSGIG SSVEKYVVDE SDYMSFINNP SLTVTVPIAV 1080 1081 GESDFENLNT EEFSSESDME ESKEKLNATS SSEGSTVDIG APAEGEQPEV EPEESLEPEA 1140 1141 CFTEDCVRKF KCCQISIEEG KGKLWWNLRK TCYKIVEHNW FETFIVFMIL LSSGALAFED 1200 1201 IYIEQRKTIK TMLEYADKVF TYIFILEMLL KWVAYGFQVY FTNAWCWLDF LIVDVSLVSL 1260 1261 TANALGYSEL GAIKSLRTLR ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL 1320 1321 IFSIMGVNLF AGKFYHCINY TTGEMFDVSV VNNYSECKAL IESNQTARWK NVKVNFDNVG 1380 1381 LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL QPKYEDNLYM YLYFVIFIIF GSFFTLNLFI 1440 1441 GVIIDNFNQQ KKKISQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPANKF QGMVFDFVTK 1500 1501 QVFDISIMIL ICLNMVTMMV ETDDQSQEMT NILYWINLVF IVLFTGECVL KLISLRYYYF 1560 1561 TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL 1620 1621 FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG IDDMFNFETF GNSMICLFQI 1680 1681 TTSAGWDGLL APILNSKPPD CDPNKVNPGS SVKGDCGNPS VGIFFFVSYI IISFLVVVNM 1740 1741 YIAVILENFS VATEESAEPL SEDDFEMFYE VWEKFDPDAT QFIEFAKLSD FADALDPPLL 1800 1801 IAKPNKVQLI AMDLPMVSGD RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK 1860 1861 VSYEPITTTL KRKQEEVSAI IIQRAYRRYL LKQKVKKVSS IYKKDKGKEC DGTPIKEDTL 1920 1921 IDKLNENSTP EKTDMTPSTT SPPSYDSVTK PEKEKFEKDK SEKEDKGKDI RESKK 1975 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Glutamatergic synapse | |
Cellular Component | Integral component of presynaptic membrane | |
Cellular Component | Intercalated disc | |
Cellular Component | Paranode region of axon | |
Cellular Component | T-tubule | |
Cellular Component | Voltage-gated sodium channel complex | |
Molecular Function | Voltage-gated ion channel activity | |
Molecular Function | Voltage-gated sodium channel activity | |
Biological Process | Intrinsic apoptotic signaling pathway in response to osmotic stress | |
Biological Process | Memory | |
Biological Process | Nervous system development | |
Biological Process | Neuron apoptotic process | |
Biological Process | Regulation of ion transmembrane transport |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a566 | Homo sapiens | 0.0 | 4020 | undefined |
| LLPS-Mum-a561 | Mus musculus | 0.0 | 3951 | undefined |