LLPS-Cea-1280
NAXE
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | NAD(P)H-hydrate epimerase; Apolipoprotein A-I-binding protein; AI-BP; NAD(P)HX epimerase |
| Gene Name: | NAXE, AIBP, APOA1BP |
| Ensembl Gene: | ENSCATG00000040211.1 |
| Ensembl Protein: | ENSCATP00000034631.1 |
| Organism: | Cercocebus atys |
| Taxa ID: | 9531 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Centrosome/Spindle pole body, P-body, Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCATT00000058911.1 | ENSCATP00000034631.1 |
| Ensembl | ENSCATT00000058909.1 | ENSCATP00000034629.1 |
| UniProt | A0A2K5NAY0, A0A2K5NAY0_CERAT |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSGVRTLLGL GLLVAGSRLL RIKSETIACR SGPTWWGPQR LNSGGRWDSE VMASTAVKYL 60 61 SQEEAQAVDQ ELFNEYQFSV DQLMELAGLS CATAIAKAYP PTSMSRSPPT VLVICGPGNN 120 121 GGDGLVCARH LKLFGYEPTI YYPKRPNKPL FTALVTQCQK MDIPFLGEMP SEPTMIDELY 180 181 ELVVDAIFGF SFKGDVREPF HSILSVLKGL TVPIASIDIP SGWDVEKGNS GGIQPDLLIS 240 241 LTAPKKSATQ FTGRYHYLGG RFVPPALEKK YQLNLPPYPD TACVYRLQ 288 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCAGGGG TGCGGACGCT GCTGGGCCTC GGGCTTCTGG TTGCGGGCTC GCGCCTGCTG 60 61 CGGATCAAAA GCGAGACCAT CGCCTGCCGC TCGGGACCCA CCTGGTGGGG ACCGCAGCGG 120 121 CTGAACTCGG GTGGCCGCTG GGACTCAGAG GTCATGGCGA GCACGGCGGT GAAGTACCTG 180 181 AGCCAGGAGG AGGCCCAGGC CGTGGACCAG GAGCTATTTA ACGAATACCA GTTCAGCGTG 240 241 GACCAACTTA TGGAGCTTGC CGGGCTGAGC TGTGCCACAG CCATCGCCAA GGCATATCCC 300 301 CCCACGTCCA TGTCCAGGAG CCCCCCTACT GTCCTGGTCA TCTGTGGCCC GGGGAATAAT 360 361 GGAGGAGATG GTCTGGTCTG TGCTCGACAC CTCAAACTCT TTGGCTATGA GCCAACCATC 420 421 TATTACCCCA AAAGGCCTAA CAAGCCCCTC TTCACCGCAT TGGTGACCCA GTGTCAGAAA 480 481 ATGGACATCC CTTTCCTTGG GGAAATGCCC TCAGAGCCCA CGATGATTGA TGAACTGTAT 540 541 GAGCTGGTGG TGGATGCCAT CTTTGGCTTC AGCTTCAAGG GTGATGTTCG GGAACCGTTC 600 601 CACAGCATCC TGAGTGTCCT GAAGGGACTC ACTGTGCCCA TTGCTAGCAT CGACATTCCC 660 661 TCAGGATGGG ACGTGGAGAA GGGAAACTCT GGAGGGATCC AGCCAGACTT GCTCATCTCC 720 721 CTCACAGCCC CCAAAAAATC TGCAACCCAG TTTACTGGTC GCTACCATTA CCTGGGGGGT 780 781 CGTTTTGTGC CACCTGCTCT GGAAAAGAAG TACCAGCTGA ATCTGCCACC CTACCCTGAC 840 841 ACCGCGTGTG TCTATCGTCT GCAGTGA 867 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell body | |
Cellular Component | Cilium | |
Cellular Component | Cytosol | |
Cellular Component | Extracellular space | |
Cellular Component | Mitochondrion | |
Cellular Component | Nucleoplasm | |
Molecular Function | Metal ion binding | |
Molecular Function | NADHX epimerase activity | |
Molecular Function | Nucleotide binding | |
Molecular Function | Protein homodimerization activity | |
Biological Process | Nicotinamide nucleotide metabolic process | |
Biological Process | Protein homotetramerization |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Maf-0488 | Macaca fascicularis | 100.0 | 0.0 | 555 |
| LLPS-Man-1031 | Macaca nemestrina | 100.0 | 0.0 | 555 |
| LLPS-Mam-0840 | Macaca mulatta | 100.0 | 0.0 | 555 |
| LLPS-Chs-0529 | Chlorocebus sabaeus | 99.63 | 0.0 | 553 |
| LLPS-Mal-3206 | Mandrillus leucophaeus | 99.63 | 0.0 | 552 |
| LLPS-Paa-1174 | Papio anubis | 99.25 | 0.0 | 551 |
| LLPS-Rhb-2019 | Rhinopithecus bieti | 98.88 | 0.0 | 549 |
| LLPS-Poa-0947 | Pongo abelii | 98.68 | 2e-164 | 464 |
| LLPS-Nol-3098 | Nomascus leucogenys | 98.5 | 0.0 | 547 |
| LLPS-Gog-4083 | Gorilla gorilla | 97.38 | 0.0 | 544 |
| LLPS-Hos-0812 | Homo sapiens | 97.38 | 0.0 | 543 |
| LLPS-Pap-2197 | Pan paniscus | 97.0 | 0.0 | 542 |
| LLPS-Pat-1387 | Pan troglodytes | 97.0 | 0.0 | 542 |
| LLPS-Ova-0555 | Ovis aries | 94.82 | 2e-174 | 491 |
| LLPS-Aon-3539 | Aotus nancymaae | 94.7 | 1e-100 | 302 |
| LLPS-Caj-0604 | Callithrix jacchus | 94.38 | 0.0 | 525 |
| LLPS-Fud-1501 | Fukomys damarensis | 92.97 | 1e-81 | 249 |
| LLPS-Cas-2809 | Carlito syrichta | 92.19 | 3e-180 | 506 |
| LLPS-Sus-1000 | Sus scrofa | 91.39 | 0.0 | 508 |
| LLPS-Bot-1582 | Bos taurus | 91.01 | 3e-179 | 506 |
| LLPS-Orc-2344 | Oryctolagus cuniculus | 91.01 | 2e-178 | 501 |
| LLPS-Mea-1706 | Mesocricetus auratus | 90.85 | 9e-89 | 269 |
| LLPS-Caf-3125 | Canis familiaris | 90.04 | 6e-171 | 484 |
| LLPS-Myl-1057 | Myotis lucifugus | 89.89 | 2e-177 | 499 |
| LLPS-Otg-1552 | Otolemur garnettii | 89.89 | 1e-177 | 499 |
| LLPS-Eqc-0749 | Equus caballus | 89.89 | 7e-180 | 505 |
| LLPS-Ict-2608 | Ictidomys tridecemlineatus | 89.51 | 2e-175 | 493 |
| LLPS-Ran-2655 | Rattus norvegicus | 88.39 | 1e-172 | 486 |
| LLPS-Mum-3553 | Mus musculus | 87.64 | 7e-171 | 482 |
| LLPS-Fec-4194 | Felis catus | 87.64 | 4e-173 | 488 |
| LLPS-Loa-2713 | Loxodonta africana | 87.64 | 9e-173 | 487 |
| LLPS-Dio-2048 | Dipodomys ordii | 86.89 | 2e-170 | 481 |
| LLPS-Cap-0071 | Cavia porcellus | 86.89 | 3e-168 | 475 |
| LLPS-Sah-1624 | Sarcophilus harrisii | 84.35 | 9e-139 | 398 |
| LLPS-Mod-1548 | Monodelphis domestica | 78.6 | 9e-144 | 413 |
| LLPS-Gaga-1630 | Gallus gallus | 78.26 | 7e-127 | 368 |
| LLPS-Xet-2539 | Xenopus tropicalis | 78.11 | 8e-131 | 380 |
| LLPS-Anc-1363 | Anolis carolinensis | 77.83 | 3e-126 | 369 |
| LLPS-Scf-2340 | Scleropages formosus | 77.78 | 3e-131 | 381 |
| LLPS-Tar-0736 | Takifugu rubripes | 76.62 | 3e-130 | 378 |
| LLPS-Orn-0799 | Oreochromis niloticus | 76.5 | 1e-129 | 377 |
| LLPS-Leo-2034 | Lepisosteus oculatus | 76.44 | 8e-103 | 305 |
| LLPS-Tag-3062 | Taeniopygia guttata | 76.29 | 1e-129 | 376 |
| LLPS-Pes-3440 | Pelodiscus sinensis | 76.08 | 6e-115 | 338 |
| LLPS-Anp-2629 | Anas platyrhynchos | 75.66 | 2e-123 | 358 |
| LLPS-Pof-2063 | Poecilia formosa | 75.43 | 3e-128 | 374 |
| LLPS-Gaa-1076 | Gasterosteus aculeatus | 75.31 | 4e-130 | 378 |
| LLPS-Xim-0020 | Xiphophorus maculatus | 75.0 | 1e-127 | 372 |
| LLPS-Fia-1994 | Ficedula albicollis | 74.79 | 3e-130 | 377 |
| LLPS-Orl-0445 | Oryzias latipes | 74.49 | 4e-131 | 380 |
| LLPS-Asm-0246 | Astyanax mexicanus | 72.34 | 5e-124 | 363 |
| LLPS-Scm-0338 | Scophthalmus maximus | 71.37 | 9e-128 | 372 |
| LLPS-Dar-0613 | Danio rerio | 68.91 | 3e-128 | 373 |
| LLPS-Cii-0829 | Ciona intestinalis | 63.29 | 4e-95 | 289 |
| LLPS-Icp-2943 | Ictalurus punctatus | 62.55 | 1e-97 | 293 |
| LLPS-Lac-0274 | Latimeria chalumnae | 60.7 | 1e-99 | 301 |
| LLPS-Drm-0288 | Drosophila melanogaster | 60.09 | 2e-91 | 277 |
| LLPS-Ora-0702 | Ornithorhynchus anatinus | 58.59 | 2e-84 | 259 |
| LLPS-Tru-0906 | Triticum urartu | 54.95 | 2e-72 | 233 |
| LLPS-Brn-2560 | Brassica napus | 53.78 | 2e-78 | 253 |
| LLPS-Brr-0391 | Brassica rapa | 53.78 | 9e-78 | 250 |
| LLPS-Bro-0974 | Brassica oleracea | 53.78 | 5e-78 | 252 |
| LLPS-Orbr-2023 | Oryza brachyantha | 53.6 | 3e-69 | 228 |
| LLPS-Meg-0309 | Meleagris gallopavo | 53.54 | 1e-71 | 226 |
| LLPS-Dac-0963 | Daucus carota | 53.09 | 3e-73 | 242 |
| LLPS-Hov-0386 | Hordeum vulgare | 53.09 | 1e-75 | 247 |
| LLPS-Tra-0504 | Triticum aestivum | 53.09 | 1e-76 | 248 |
| LLPS-Sol-0349 | Solanum lycopersicum | 52.67 | 2e-74 | 243 |
| LLPS-Brd-0779 | Brachypodium distachyon | 52.67 | 1e-74 | 244 |
| LLPS-Sem-1690 | Selaginella moellendorffii | 52.54 | 5e-75 | 243 |
| LLPS-Amt-1880 | Amborella trichopoda | 52.48 | 4e-75 | 245 |
| LLPS-Zem-1198 | Zea mays | 52.48 | 1e-71 | 241 |
| LLPS-Php-0988 | Physcomitrella patens | 52.46 | 1e-74 | 246 |
| LLPS-Pot-2622 | Populus trichocarpa | 51.85 | 6e-73 | 240 |
| LLPS-Sot-1286 | Solanum tuberosum | 51.78 | 3e-75 | 245 |
| LLPS-Ten-3194 | Tetraodon nigroviridis | 51.75 | 2e-80 | 249 |
| LLPS-Met-0982 | Medicago truncatula | 51.63 | 1e-71 | 236 |
| LLPS-Lep-0238 | Leersia perrieri | 51.6 | 4e-75 | 245 |
| LLPS-Abg-1374 | Absidia glauca | 51.57 | 1e-73 | 232 |
| LLPS-Hea-1090 | Helianthus annuus | 51.56 | 2e-73 | 241 |
| LLPS-Orb-1993 | Oryza barthii | 51.44 | 5e-74 | 242 |
| LLPS-Ori-0667 | Oryza indica | 51.44 | 2e-74 | 242 |
| LLPS-Orni-1927 | Oryza nivara | 51.44 | 5e-74 | 243 |
| LLPS-Orgl-1867 | Oryza glumaepatula | 51.44 | 5e-74 | 243 |
| LLPS-Viv-1371 | Vitis vinifera | 51.44 | 9e-72 | 236 |
| LLPS-Ors-2179 | Oryza sativa | 51.44 | 6e-74 | 243 |
| LLPS-Orp-2397 | Oryza punctata | 51.44 | 7e-74 | 242 |
| LLPS-Orr-1857 | Oryza rufipogon | 51.44 | 5e-74 | 243 |
| LLPS-Via-1334 | Vigna angularis | 51.42 | 3e-73 | 241 |
| LLPS-Coc-0180 | Corchorus capsularis | 51.41 | 1e-73 | 241 |
| LLPS-Map-0019 | Magnaporthe poae | 51.32 | 1e-71 | 227 |
| LLPS-Phv-2015 | Phaseolus vulgaris | 51.0 | 8e-74 | 242 |
| LLPS-Nia-1977 | Nicotiana attenuata | 50.83 | 4e-71 | 233 |
| LLPS-Gag-1479 | Gaeumannomyces graminis | 50.66 | 2e-70 | 224 |
| LLPS-Prp-0476 | Prunus persica | 50.62 | 9e-73 | 239 |
| LLPS-Mua-1164 | Musa acuminata | 50.61 | 2e-71 | 236 |
| LLPS-Org-1356 | Oryza glaberrima | 50.61 | 8e-69 | 229 |
| LLPS-Gor-2727 | Gossypium raimondii | 50.59 | 8e-75 | 244 |
| LLPS-Scj-0319 | Schizosaccharomyces japonicus | 50.48 | 2e-57 | 191 |
| LLPS-Art-2306 | Arabidopsis thaliana | 50.41 | 3e-72 | 238 |
| LLPS-Arl-0961 | Arabidopsis lyrata | 50.2 | 2e-72 | 238 |
| LLPS-Mao-0508 | Magnaporthe oryzae | 50.0 | 3e-70 | 224 |
| LLPS-Sei-1895 | Setaria italica | 50.0 | 8e-72 | 237 |
| LLPS-Mae-2287 | Manihot esculenta | 49.81 | 5e-74 | 243 |
| LLPS-Tum-0300 | Tuber melanosporum | 49.69 | 7e-42 | 150 |
| LLPS-Put-1115 | Puccinia triticina | 49.56 | 3e-68 | 218 |
| LLPS-Cus-0430 | Cucumis sativus | 49.43 | 5e-74 | 242 |
| LLPS-Nec-0367 | Neurospora crassa | 49.12 | 2e-68 | 219 |
| LLPS-Pytr-0803 | Pyrenophora triticirepentis | 49.12 | 6e-66 | 213 |
| LLPS-Trv-1479 | Trichoderma virens | 49.03 | 2e-62 | 203 |
| LLPS-Spr-0435 | Sporisorium reilianum | 48.97 | 1e-68 | 220 |
| LLPS-Blg-1216 | Blumeria graminis | 48.64 | 6e-61 | 199 |
| LLPS-Dos-1042 | Dothistroma septosporum | 48.5 | 2e-44 | 155 |
| LLPS-Usm-0479 | Ustilago maydis | 48.15 | 3e-66 | 214 |
| LLPS-Trr-1221 | Trichoderma reesei | 48.06 | 8e-61 | 199 |
| LLPS-Fus-1566 | Fusarium solani | 48.06 | 2e-60 | 197 |
| LLPS-Beb-0685 | Beauveria bassiana | 48.02 | 6e-65 | 210 |
| LLPS-Mel-0376 | Melampsora laricipopulina | 47.93 | 1e-63 | 207 |
| LLPS-Gas-0758 | Galdieria sulphuraria | 47.92 | 2e-57 | 192 |
| LLPS-Pug-0107 | Puccinia graminis | 47.88 | 2e-67 | 216 |
| LLPS-Scp-0315 | Schizosaccharomyces pombe | 47.83 | 6e-63 | 205 |
| LLPS-Glm-1188 | Glycine max | 47.5 | 3e-73 | 241 |
| LLPS-Chr-0300 | Chlamydomonas reinhardtii | 47.1 | 5e-62 | 210 |
| LLPS-Cogr-0935 | Colletotrichum graminicola | 47.09 | 1e-60 | 199 |
| LLPS-Scc-1287 | Schizosaccharomyces cryophilus | 46.98 | 7e-61 | 200 |
| LLPS-Phn-1008 | Phaeosphaeria nodorum | 46.98 | 2e-63 | 206 |
| LLPS-Aim-3229 | Ailuropoda melanoleuca | 46.75 | 4e-35 | 133 |
| LLPS-Crn-0356 | Cryptococcus neoformans | 46.59 | 3e-67 | 216 |
| LLPS-Asn-0410 | Aspergillus nidulans | 46.58 | 1e-37 | 137 |
| LLPS-Lem-1398 | Leptosphaeria maculans | 46.49 | 2e-61 | 201 |
| LLPS-Pyt-1183 | Pyrenophora teres | 46.49 | 1e-59 | 196 |
| LLPS-Yal-0089 | Yarrowia lipolytica | 46.46 | 7e-58 | 192 |
| LLPS-Coo-1362 | Colletotrichum orbiculare | 46.27 | 5e-52 | 176 |
| LLPS-Asfu-0421 | Aspergillus fumigatus | 45.97 | 3e-49 | 169 |
| LLPS-Tut-1352 | Tursiops truncatus | 45.56 | 1e-71 | 229 |
| LLPS-Ved-1001 | Verticillium dahliae | 45.5 | 2e-53 | 180 |
| LLPS-Asni-0704 | Aspergillus niger | 45.41 | 3e-62 | 203 |
| LLPS-Fuv-0819 | Fusarium verticillioides | 45.38 | 3e-65 | 211 |
| LLPS-Fuo-0868 | Fusarium oxysporum | 45.38 | 3e-65 | 211 |
| LLPS-Zyt-0577 | Zymoseptoria tritici | 45.37 | 2e-60 | 198 |
| LLPS-Asf-1223 | Aspergillus flavus | 44.83 | 1e-62 | 205 |
| LLPS-Kop-1243 | Komagataella pastoris | 44.58 | 9e-57 | 189 |
| LLPS-Mup-2377 | Mustela putorius furo | 44.57 | 3e-71 | 229 |
| LLPS-Aso-0008 | Aspergillus oryzae | 44.02 | 6e-60 | 197 |
| LLPS-Miv-0012 | Microbotryum violaceum | 44.02 | 2e-57 | 193 |
| LLPS-Asc-0840 | Aspergillus clavatus | 43.53 | 3e-56 | 188 |
| LLPS-Cae-0412 | Caenorhabditis elegans | 43.44 | 2e-56 | 191 |
| LLPS-Asg-0889 | Ashbya gossypii | 43.33 | 2e-53 | 181 |
| LLPS-Cog-0100 | Colletotrichum gloeosporioides | 42.63 | 4e-59 | 196 |
| LLPS-Nef-0559 | Neosartorya fischeri | 41.92 | 6e-53 | 179 |
| LLPS-Chc-0566 | Chondrus crispus | 41.1 | 7e-50 | 172 |
| LLPS-Sac-0141 | Saccharomyces cerevisiae | 40.41 | 3e-49 | 170 |
| LLPS-Ast-0503 | Aspergillus terreus | 39.3 | 9e-46 | 159 |
| LLPS-Osl-1216 | Ostreococcus lucimarinus | 38.19 | 2e-26 | 109 |
| LLPS-Cym-0175 | Cyanidioschyzon merolae | 38.08 | 1e-48 | 171 |