• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cea-0750
PNP

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Purine nucleoside phosphorylase; Inosine-guanosine phosphorylase
Gene Name: PNP
Ensembl Gene: ENSCATG00000032993.1
Ensembl Protein: ENSCATP00000018291.1
Organism: Cercocebus atys
Taxa ID: 9531
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEKGYTYEDY  KNTAEWLLSH  TKHRPQVAII  CGSGLGGLTD  KLTEAQIFDY  SEIPNFPQST  60
61    VPGHVGRLVF  GFLNGRACVI  MQGRFHMYEG  YSLWKVTFPV  RVFHLLGVDT  LVVTNAAGGL  120
121   NPEFEVGDIM  LIRDHINLPG  FSGQNPLRGP  NDERFGVRFP  AMSDAYDRTM  RQRALSMWKQ  180
181   MGEQRELQEG  TYVMLAGPSF  ETVAESRLLQ  KLGADAVGMS  TVPEVIVARH  CGLRVFGFSL  240
241   ITNKVIMDYE  SLEKANHEEV  LAAGKQAAQK  LEQLVSILMA  SIPLPDKAS  289
Nucleotide CDS Sequence (FASTA)
1     ATGGAGAAAG  GATACACATA  TGAAGATTAT  AAGAACACTG  CAGAATGGCT  TCTGTCTCAC  60
61    ACTAAGCACC  GACCTCAAGT  TGCAATAATC  TGTGGTTCTG  GATTAGGAGG  TCTGACTGAT  120
121   AAATTAACTG  AGGCCCAGAT  CTTTGACTAC  AGTGAAATCC  CCAACTTTCC  CCAAAGTACA  180
181   GTGCCAGGTC  ATGTTGGCCG  ACTGGTGTTT  GGGTTCCTGA  ATGGCAGAGC  CTGTGTGATA  240
241   ATGCAGGGCA  GGTTCCATAT  GTATGAAGGG  TACTCGCTCT  GGAAGGTGAC  ATTCCCAGTG  300
301   AGGGTTTTCC  ACCTTCTGGG  TGTGGACACC  CTGGTGGTCA  CCAATGCAGC  AGGAGGGCTG  360
361   AACCCCGAGT  TTGAGGTTGG  AGATATCATG  CTGATCCGTG  ACCATATCAA  CCTACCTGGT  420
421   TTCAGTGGTC  AGAACCCTCT  CAGAGGGCCC  AATGATGAAA  GGTTTGGAGT  TCGTTTCCCT  480
481   GCCATGTCTG  ATGCCTACGA  CCGGACTATG  AGGCAGAGGG  CTCTCAGTAT  GTGGAAACAA  540
541   ATGGGGGAGC  AACGTGAGCT  ACAGGAAGGC  ACCTATGTGA  TGCTGGCAGG  CCCCAGCTTT  600
601   GAGACTGTGG  CAGAATCTCG  TCTGCTGCAG  AAGCTGGGAG  CAGATGCTGT  TGGCATGAGT  660
661   ACAGTACCAG  AAGTTATCGT  TGCACGGCAC  TGTGGACTTC  GAGTCTTCGG  CTTCTCACTC  720
721   ATCACCAACA  AGGTCATCAT  GGATTATGAA  AGCCTGGAGA  AGGCCAACCA  TGAAGAAGTA  780
781   TTAGCGGCTG  GCAAACAAGC  TGCACAGAAA  TTGGAACAGT  TGGTCTCCAT  TCTTATGGCC  840
841   AGCATTCCAC  TCCCTGACAA  AGCCAGTTGA  870

▼ KEYWORD

ID
Family
Coiled coil
Complete proteome
Glycosyltransferase
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Molecular Function
Drug binding
Molecular Function
Nucleoside binding
Molecular Function
Phosphate ion binding
Molecular Function
Purine nucleobase binding
Molecular Function
Purine-nucleoside phosphorylase activity
Biological Process
Immune response
Biological Process
Inosine catabolic process
Biological Process
Interleukin-2 secretion
Biological Process
NAD biosynthesis via nicotinamide riboside salvage pathway
Biological Process
Nicotinamide riboside catabolic process
Biological Process
Positive regulation of alpha-beta T cell differentiation
Biological Process
Positive regulation of T cell proliferation
Biological Process
Response to drug
Biological Process
Urate biosynthetic process

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Man-2394Macaca nemestrina99.310.0 600
LLPS-Maf-3862Macaca fascicularis99.310.0 600
LLPS-Mal-2647Mandrillus leucophaeus99.310.0 600
LLPS-Rhb-4697Rhinopithecus bieti98.620.0 597
LLPS-Mam-3565Macaca mulatta98.620.0 595
LLPS-Chs-2394Chlorocebus sabaeus98.270.0 595
LLPS-Paa-0532Papio anubis98.270.0 593
LLPS-Nol-1420Nomascus leucogenys95.850.0 583
LLPS-Poa-3319Pongo abelii95.850.0 583
LLPS-Hos-0991Homo sapiens95.160.0 578
LLPS-Pap-1157Pan paniscus95.160.0 579
LLPS-Pat-4374Pan troglodytes95.160.0 579
LLPS-Gog-0166Gorilla gorilla94.810.0 578
LLPS-Aon-1909Aotus nancymaae94.460.0 575
LLPS-Caj-1137Callithrix jacchus93.770.0 572
LLPS-Cas-0829Carlito syrichta92.040.0 562
LLPS-Orc-1887Oryctolagus cuniculus89.470.0 546
LLPS-Loa-4577Loxodonta africana88.170.0 525
LLPS-Tut-2156Tursiops truncatus87.540.0 534
LLPS-Sus-0799Sus scrofa87.150.0 529
LLPS-Dio-3480Dipodomys ordii87.110.0 531
LLPS-Myl-2417Myotis lucifugus86.710.0 532
LLPS-Bot-3782Bos taurus86.620.0 523
LLPS-Fud-1037Fukomys damarensis86.570.0 529
LLPS-Ict-0043Ictidomys tridecemlineatus86.455e-98 292
LLPS-Fec-2827Felis catus86.160.0 524
LLPS-Eqc-4407Equus caballus85.960.0 524
LLPS-Mum-4563Mus musculus85.470.0 521
LLPS-Mea-2874Mesocricetus auratus85.470.0 518
LLPS-Ova-2884Ovis aries85.144e-38 135
LLPS-Cap-0421Cavia porcellus85.070.0 528
LLPS-Mup-0635Mustela putorius furo84.780.0 523
LLPS-Ran-0829Rattus norvegicus84.780.0 518
LLPS-Aim-2918Ailuropoda melanoleuca84.561e-180 506
LLPS-Caf-3142Canis familiaris84.030.0 511
LLPS-Otg-2360Otolemur garnettii83.871e-178 502
LLPS-Urm-3827Ursus maritimus83.740.0 510
LLPS-Ere-0755Erinaceus europaeus83.11e-178 502
LLPS-Mod-2701Monodelphis domestica75.431e-165 469
LLPS-Sah-0422Sarcophilus harrisii72.821e-102 306
LLPS-Ora-1835Ornithorhynchus anatinus72.677e-82 251
LLPS-Anc-0453Anolis carolinensis71.532e-153 437
LLPS-Orl-0958Oryzias latipes67.991e-139 403
LLPS-Pof-2930Poecilia formosa66.913e-135 391
LLPS-Scm-1054Scophthalmus maximus66.911e-135 393
LLPS-Xim-2696Xiphophorus maculatus66.918e-136 393
LLPS-Scf-4159Scleropages formosus66.92e-138 399
LLPS-Gaa-3691Gasterosteus aculeatus66.557e-131 380
LLPS-Orn-3078Oreochromis niloticus66.544e-134 389
LLPS-Dar-3227Danio rerio66.187e-138 398
LLPS-Xet-3075Xenopus tropicalis65.47e-132 383
LLPS-Lac-2044Latimeria chalumnae65.343e-135 392
LLPS-Icp-3365Ictalurus punctatus65.234e-138 399
LLPS-Fia-0663Ficedula albicollis64.983e-129 377
LLPS-Ten-3266Tetraodon nigroviridis64.527e-138 398
LLPS-Leo-3534Lepisosteus oculatus63.641e-133 388
LLPS-Meg-3231Meleagris gallopavo62.459e-123 360
LLPS-Tag-2290Taeniopygia guttata62.328e-125 365
LLPS-Asm-2085Astyanax mexicanus61.812e-134 390
LLPS-Tar-2086Takifugu rubripes60.152e-120 354
LLPS-Gaga-0736Gallus gallus59.523e-122 358
LLPS-Anp-1451Anas platyrhynchos59.222e-115 341
LLPS-Asf-0993Aspergillus flavus53.794e-96 293
LLPS-Cis-1668Ciona savignyi53.417e-105 314
LLPS-Asc-0613Aspergillus clavatus52.726e-79 247
LLPS-Nef-0890Neosartorya fischeri52.466e-95 290
LLPS-Asfu-1384Aspergillus fumigatus51.894e-97 295
LLPS-Yal-0523Yarrowia lipolytica51.842e-94 288
LLPS-Asn-0958Aspergillus nidulans51.035e-97 295
LLPS-Drm-0414Drosophila melanogaster50.884e-100 306
LLPS-Miv-1012Microbotryum violaceum50.225e-71 229
LLPS-Ast-0453Aspergillus terreus49.441e-48 167
LLPS-Tum-1203Tuber melanosporum49.345e-96 293
LLPS-Cii-1149Ciona intestinalis49.287e-95 289
LLPS-Kop-0889Komagataella pastoris49.281e-84 263
LLPS-Scc-1425Schizosaccharomyces cryophilus49.082e-86 268
LLPS-Scp-1653Schizosaccharomyces pombe48.911e-86 268
LLPS-Sac-1591Saccharomyces cerevisiae48.441e-89 276
LLPS-Abg-1982Absidia glauca48.211e-78 248
LLPS-Zyt-1534Zymoseptoria tritici48.013e-95 290
LLPS-Dos-1294Dothistroma septosporum47.832e-88 274
LLPS-Pyt-0361Pyrenophora teres47.724e-88 272
LLPS-Asg-0471Ashbya gossypii47.454e-81 254
LLPS-Pytr-0784Pyrenophora triticirepentis47.378e-87 269
LLPS-Cae-1535Caenorhabditis elegans47.334e-79 249
LLPS-Phn-0818Phaeosphaeria nodorum47.069e-89 274
LLPS-Scj-1288Schizosaccharomyces japonicus46.264e-89 275
LLPS-Lem-0092Leptosphaeria maculans46.082e-88 273
LLPS-Spr-1246Sporisorium reilianum44.642e-74 238
LLPS-Blg-0528Blumeria graminis44.484e-72 233
LLPS-Usm-1050Ustilago maydis43.691e-71 230
LLPS-Pug-1224Puccinia graminis41.643e-71 229
LLPS-Mel-1518Melampsora laricipopulina41.36e-69 223
LLPS-Pes-2626Pelodiscus sinensis28.413e-1473.9