LLPS-Cap-a565
ATAT1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Alpha-tubulin N-acetyltransferase 1 |
| Gene Name: | ATAT1, MEC17 |
| Ensembl Gene: | ENSCPOG00000015407.4 |
| Ensembl Protein: | ENSCPOP00000013890.2 |
| Organism: | Cavia porcellus |
| Taxa ID: | 10141 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCPOT00000015557.3 | ENSCPOP00000013890.2 |
| Ensembl | ENSCPOT00000035685.1 | ENSCPOP00000022606.1 |
| UniProt | H0VTA3, H0VTA3_CAVPO | |
| GeneBank | AAKN02057232 | |
| RefSeq | XM_004999306.2 | XP_004999363.1 |
| Entrez | 100719818 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MEFPFDVDAL LPERITVLDQ HLRPPARRPG TTTPARVDLQ QQIMTIVDEL GKASAKAQHL 60 61 PAPITSASRM QSNRHVIYVL KDTSARPAGK GAIVGFLKVG YKKLFVLDDR EAHNEVEPLC 120 121 ILDFYIHESL QRHGHGRELF QYMLQKERVE PHQLAIDRPS QKLLKFLNKH YNLETTVPQV 180 181 NNFVIFEGFF AHQHRPPAPS LRASRLSRTT AAEPTPTAPA RKLPPKRAEG DIKPYSSSDR 240 241 EFLKVAVEPP WPLNRAPRRA TPTAHPPPRS SSLGSSPERG PLRPFVPEQE LLRSLRLCPP 300 301 HPTARLLLAT DPGGSPAQRR RTRGTPPGLL AQSRCYSRHR GPSPSAPGAN EHRPSSPTTG 360 361 SSRPRDVAVS EDQQESGQGK RETESGCARG EPTSAPPAQR CTARGDALDA RFVRSLQERR 420 421 STRPW 425 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAGTTCC CTTTCGATGT GGACGCGCTG CTCCCGGAGC GGATCACGGT GCTGGACCAG 60 61 CACCTTCGGC CTCCGGCCCG CCGACCCGGA ACCACAACGC CAGCCCGCGT TGATCTGCAG 120 121 CAGCAAATTA TGACCATTGT TGATGAACTG GGCAAGGCTT CTGCTAAGGC CCAGCATCTT 180 181 CCTGCTCCAA TCACCAGTGC ATCCAGGATG CAGAGTAACC GCCATGTGAT CTATGTGCTC 240 241 AAAGACACTT CCGCCCGACC GGCTGGGAAA GGCGCTATTG TTGGTTTCCT CAAAGTTGGA 300 301 TACAAGAAAC TCTTTGTACT GGATGACCGT GAGGCTCACA ATGAGGTAGA ACCGCTGTGT 360 361 ATCCTGGACT TCTACATACA CGAGTCGCTG CAGCGCCATG GCCATGGGCG AGAACTCTTC 420 421 CAGTACATGC TGCAGAAGGA ACGGGTTGAA CCACACCAGC TGGCCATTGA CCGGCCCTCA 480 481 CAGAAGCTGC TGAAGTTCTT GAATAAGCAC TACAACCTGG AGACCACAGT CCCACAGGTG 540 541 AACAACTTTG TGATCTTTGA AGGCTTCTTC GCGCATCAGC ACCGGCCCCC TGCTCCCTCC 600 601 CTGAGGGCCT CACGACTCTC CCGCACCACC GCCGCGGAGC CCACACCCAC TGCGCCAGCA 660 661 CGGAAGCTGC CACCCAAGAG GGCCGAGGGC GACATCAAGC CATACTCCTC CAGTGACCGA 720 721 GAATTTCTGA AGGTGGCTGT GGAGCCCCCA TGGCCCCTAA ACAGGGCCCC ACGCCGCGCC 780 781 ACCCCCACAG CGCACCCACC ACCACGCTCC AGCAGCCTAG GGAGCTCGCC AGAGCGGGGC 840 841 CCGCTGCGCC CCTTTGTGCC CGAGCAGGAG CTATTGCGCT CTCTGCGCCT CTGCCCCCCA 900 901 CACCCGACTG CCCGCCTGCT GCTGGCCACC GACCCCGGGG GCAGCCCCGC ACAACGCCGC 960 961 AGGACCAGGG GGACGCCCCC AGGGCTGCTG GCTCAAAGCC GCTGCTACAG CCGCCACAGG 1020 1021 GGTCCGAGCC CCTCTGCCCC CGGCGCGAAT GAGCACCGCC CCTCCTCGCC CACCACGGGC 1080 1081 TCCAGCCGCC CACGCGATGT CGCGGTCTCC GAAGACCAAC AGGAATCGGG TCAGGGAAAG 1140 1141 CGAGAAACCG AGAGCGGGTG CGCCCGCGGG GAGCCGACGT CAGCTCCCCC GGCCCAGCGC 1200 1201 TGCACGGCGC GGGGGGACGC GCTCGACGCA AGGTTTGTCC GGAGCTTGCA GGAGCGCCGC 1260 1261 AGCACCAGGC CTTGGTGA 1278 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Axon | |
Cellular Component | Clathrin-coated pit | |
Cellular Component | Cytosol | |
Cellular Component | Focal adhesion | |
Cellular Component | Golgi apparatus | |
Cellular Component | Microtubule | |
Cellular Component | Microtubule bundle | |
Cellular Component | Mitotic spindle | |
Molecular Function | Coenzyme binding | |
Molecular Function | Lysine N-acetyltransferase activity, acting on acetyl phosphate as donor | |
Molecular Function | Tubulin N-acetyltransferase activity | |
Biological Process | Alpha-tubulin acetylation | |
Biological Process | Dentate gyrus development | |
Biological Process | Neuron development | |
Biological Process | Positive regulation of NLRP3 inflammasome complex assembly | |
Biological Process | Regulation of fat cell differentiation | |
Biological Process | Regulation of microtubule cytoskeleton organization | |
Biological Process | Spermatogenesis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a577 | Homo sapiens | 0.0 | 702 | undefined |
| LLPS-Mum-a572 | Mus musculus | 0.0 | 685 | undefined |