• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Cap-4044
PPIE

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Peptidyl-prolyl cis-trans isomerase E
Gene Name: PPIE
Ensembl Gene: ENSCPOG00000007365.4
Ensembl Protein: ENSCPOP00000006641.3
Organism: Cavia porcellus
Taxa ID: 10141
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear specklePredicted from orthologs(View)

▼ FUNCTION

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MATTKRVLYV  GGLAEEVDDK  VLHAAFIPFG  DITDIQIPLD  YETEKHRGFA  FVEFELAEDA  60
61    AAAIDNMNES  ELFGRTIRVN  LAKPMRIKEG  SSRPVWSDDD  WLKKFSGKTL  EENKEEEGTE  120
121   TPKAETQEGE  PPAKKARSNP  QVYMDIKIGN  KPAGRIQMLL  RSDVVPMTAE  NFRCLCTHEK  180
181   GYGFKGSSFH  RIIPQFMCQG  GDFTNHNGTG  GKSIYGKKFD  DENFILKHTG  PGLLSMANSG  240
241   PNTNGSQFFL  TCDKTDWLDG  KHVVFGEVTE  GLDVLRQIEA  QGSKDGKPKQ  KVIIADCGEY  300
301   M  301
Nucleotide CDS Sequence (FASTA)
1     ATGGCCACTA  CGAAGCGCGT  GCTGTACGTG  GGAGGGCTGG  CAGAAGAGGT  GGATGACAAA  60
61    GTTCTACATG  CTGCTTTTAT  TCCTTTTGGA  GACATCACAG  ATATTCAGAT  TCCTCTGGAT  120
121   TATGAAACAG  AAAAGCACCG  AGGATTTGCT  TTTGTTGAAT  TTGAGTTGGC  AGAGAATGAA  180
181   TCTGAGCTCT  TTGGACGGAC  AATTCGTGTC  AATTTGGCTA  AACCAATGAG  AATTAAAGAG  240
241   GGCTCTTCTA  GACCAGTTTG  GTCAGACGAT  GACTGGCTAA  AGAAGTTTTC  TGGGAAGACT  300
301   CTTGAAGAGA  ATAAAGAGGA  AGAAGGGACA  GAAACTCCCA  AAGCAGAAAC  CCAGGAGGGA  360
361   GAGCCCCCTG  CAAAAAAGGC  CCGGTCAAAT  CCTCAGGTGT  ACATGGACAT  CAAGATTGGG  420
421   AACAAGCCAG  CCGGCCGCAT  CCAGATGCTC  CTGCGTTCTG  ATGTTGTGCC  CATGACAGCG  480
481   GAGAATTTCC  GCTGCCTGTG  TACCCACGAA  AAGGGCTATG  GCTTCAAGGG  AAGCAGCTTC  540
541   CACCGCATCA  TCCCCCAGTT  CATGTGCCAG  GGTGGGGATT  TCACAAACCA  CAATGGCACC  600
601   GGGGGCAAGT  CCATCTACGG  GAAGAAGTTT  GATGATGAAA  ATTTTATCCT  CAAACACACA  660
661   GGACCAGGCC  TCCTCTCCAT  GGCCAACTCT  GGCCCAAATA  CCAACGGCTC  CCAGTTCTTC  720
721   CTGACCTGTG  ACAAGACGGA  CTGGCTGGAT  GGCAAGCACG  TGGTGTTTGG  AGAGGTCACC  780
781   GAAGGTCTGG  ATGTCTTGCG  GCAGATTGAA  GCCCAGGGCA  GCAAGGACGG  GAAACCAAAG  840
841   CAGAAGGTGA  TCATCGCCGA  CTGTGGGGAG  TACATGTGA  879

▼ KEYWORD

ID
Family
Complete proteome
Isomerase
Reference proteome
RNA-binding
Rotamase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Nuclear speck
Cellular Component
U2-type catalytic step 2 spliceosome
Molecular Function
Cyclosporin A binding
Molecular Function
MRNA binding
Molecular Function
Peptidyl-prolyl cis-trans isomerase activity
Molecular Function
Poly(A) binding
Biological Process
MRNA splicing, via spliceosome
Biological Process
Positive regulation of viral genome replication
Biological Process
Protein folding
Biological Process
Regulation of transcription, DNA-templated

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Dio-1630Dipodomys ordii98.670.0 584
LLPS-Rhb-0726Rhinopithecus bieti98.570.0 543
LLPS-Man-4716Macaca nemestrina98.340.0 582
LLPS-Mal-4395Mandrillus leucophaeus98.340.0 582
LLPS-Maf-4515Macaca fascicularis98.340.0 582
LLPS-Cea-0666Cercocebus atys98.340.0 582
LLPS-Nol-1902Nomascus leucogenys98.210.0 541
LLPS-Pap-4479Pan paniscus98.210.0 540
LLPS-Pat-4094Pan troglodytes98.210.0 540
LLPS-Ict-3909Ictidomys tridecemlineatus98.010.0 582
LLPS-Mum-2042Mus musculus98.010.0 578
LLPS-Fud-1913Fukomys damarensis97.950.0 566
LLPS-Caj-0987Callithrix jacchus97.860.0 540
LLPS-Cas-0114Carlito syrichta97.670.0 580
LLPS-Mea-1728Mesocricetus auratus97.631e-101 302
LLPS-Poa-1518Pongo abelii97.620.0 566
LLPS-Mam-4335Macaca mulatta97.620.0 566
LLPS-Caf-3236Canis familiaris97.520.0 536
LLPS-Aon-3817Aotus nancymaae97.50.0 540
LLPS-Urm-2519Ursus maritimus97.444e-156 448
LLPS-Chs-3929Chlorocebus sabaeus97.370.0 577
LLPS-Mup-4313Mustela putorius furo97.350.0 575
LLPS-Ran-3889Rattus norvegicus97.340.0 574
LLPS-Orc-1367Oryctolagus cuniculus97.330.0 574
LLPS-Paa-4782Papio anubis97.180.0 539
LLPS-Otg-3245Otolemur garnettii96.710.0 574
LLPS-Loa-2366Loxodonta africana96.680.0 584
LLPS-Bot-2886Bos taurus96.680.0 576
LLPS-Sus-4427Sus scrofa96.60.0 557
LLPS-Myl-1412Myotis lucifugus96.350.0 573
LLPS-Eqc-2197Equus caballus96.260.0 559
LLPS-Ova-3733Ovis aries95.580.0 556
LLPS-Fec-2675Felis catus94.640.0 511
LLPS-Hos-3046Homo sapiens93.330.0 540
LLPS-Aim-1710Ailuropoda melanoleuca93.121e-94 284
LLPS-Gog-4313Gorilla gorilla93.00.0 541
LLPS-Anp-0755Anas platyrhynchos92.862e-155 441
LLPS-Mod-3219Monodelphis domestica92.690.0 566
LLPS-Tut-0150Tursiops truncatus92.540.0 531
LLPS-Gaga-3198Gallus gallus92.120.0 540
LLPS-Ora-2434Ornithorhynchus anatinus91.690.0 565
LLPS-Sah-2630Sarcophilus harrisii91.690.0 562
LLPS-Anc-3791Anolis carolinensis90.370.0 561
LLPS-Fia-1529Ficedula albicollis89.630.0 546
LLPS-Leo-3822Lepisosteus oculatus89.552e-87 265
LLPS-Icp-3079Ictalurus punctatus88.70.0 548
LLPS-Xet-1099Xenopus tropicalis88.370.0 537
LLPS-Lac-0341Latimeria chalumnae87.750.0 548
LLPS-Scf-1696Scleropages formosus87.190.0 511
LLPS-Asm-4182Astyanax mexicanus86.050.0 535
LLPS-Tar-2253Takifugu rubripes86.00.0 534
LLPS-Ten-3363Tetraodon nigroviridis85.710.0 537
LLPS-Dar-2184Danio rerio85.430.0 535
LLPS-Xim-3913Xiphophorus maculatus85.380.0 538
LLPS-Orn-2193Oreochromis niloticus85.10.0 534
LLPS-Orl-3148Oryzias latipes84.861e-176 498
LLPS-Scm-2727Scophthalmus maximus84.770.0 530
LLPS-Tag-1019Taeniopygia guttata84.555e-128 372
LLPS-Pof-1266Poecilia formosa84.440.0 530
LLPS-Gaa-3658Gasterosteus aculeatus83.440.0 519
LLPS-Meg-0554Meleagris gallopavo72.543e-75 234
LLPS-Osl-0984Ostreococcus lucimarinus71.433e-82 252
LLPS-Drm-0238Drosophila melanogaster70.192e-78 243
LLPS-Chc-0337Chondrus crispus69.818e-76 236
LLPS-Beb-1264Beauveria bassiana69.757e-79 244
LLPS-Cii-1793Ciona intestinalis69.144e-78 241
LLPS-Nef-1294Neosartorya fischeri68.554e-74 231
LLPS-Ere-0294Erinaceus europaeus68.325e-80 248
LLPS-Gas-1091Galdieria sulphuraria67.95e-76 236
LLPS-Pytr-1437Pyrenophora triticirepentis67.465e-75 234
LLPS-Art-1372Arabidopsis thaliana67.467e-76 236
LLPS-Met-2225Medicago truncatula67.266e-77 239
LLPS-Brr-1441Brassica rapa67.076e-73 229
LLPS-Brn-1872Brassica napus67.073e-75 235
LLPS-Arl-2207Arabidopsis lyrata66.863e-76 237
LLPS-Asfu-0416Aspergillus fumigatus66.677e-72 226
LLPS-Bro-0964Brassica oleracea66.471e-73 231
LLPS-Cis-1775Ciona savignyi66.474e-78 243
LLPS-Prp-1223Prunus persica66.274e-76 237
LLPS-Mua-2093Musa acuminata66.275e-72 228
LLPS-Cae-1494Caenorhabditis elegans66.278e-74 231
LLPS-Phv-2295Phaseolus vulgaris66.071e-73 231
LLPS-Via-1475Vigna angularis66.076e-75 234
LLPS-Php-0782Physcomitrella patens66.071e-73 231
LLPS-Yal-1092Yarrowia lipolytica66.048e-73 229
LLPS-Mae-2373Manihot esculenta65.684e-76 237
LLPS-Pot-0306Populus trichocarpa65.682e-75 235
LLPS-Sem-1227Selaginella moellendorffii65.665e-73 230
LLPS-Hea-2446Helianthus annuus65.481e-74 233
LLPS-Dac-1455Daucus carota65.482e-76 238
LLPS-Gor-1041Gossypium raimondii65.092e-74 233
LLPS-Pyt-1006Pyrenophora teres65.091e-72 228
LLPS-Thc-1933Theobroma cacao65.091e-72 228
LLPS-Glm-0309Glycine max65.092e-74 233
LLPS-Brd-1516Brachypodium distachyon64.888e-73 228
LLPS-Coc-0046Corchorus capsularis64.292e-72 228
LLPS-Nia-0237Nicotiana attenuata63.913e-73 229
LLPS-Vir-0950Vigna radiata63.696e-72 226
LLPS-Viv-2474Vitis vinifera63.311e-72 228
LLPS-Hov-1671Hordeum vulgare63.311e-71 227
LLPS-Sot-0252Solanum tuberosum63.317e-74 231
LLPS-Sol-1544Solanum lycopersicum63.315e-74 231
LLPS-Lep-1114Leersia perrieri63.164e-73 229
LLPS-Zem-0978Zea mays62.136e-72 226
LLPS-Orbr-1585Oryza brachyantha62.071e-71 226