LLPS-Cap-0353
ACTB
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Actin, cytoplasmic 1; Beta-actin |
| Gene Name: | ACTB |
| Ensembl Gene: | ENSCPOG00000013467.4 |
| Ensembl Protein: | ENSCPOP00000022236.1 |
| Organism: | Cavia porcellus |
| Taxa ID: | 10141 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCPOT00000044361.1 | ENSCPOP00000022236.1 |
| Ensembl | ENSCPOT00000027039.2 | ENSCPOP00000016826.2 |
| Ensembl | ENSCPOT00000012217.3 | ENSCPOP00000010883.3 |
| Ensembl | ENSCPOT00000013600.3 | ENSCPOP00000012125.2 |
| Ensembl | ENSCPOT00000046940.1 | ENSCPOP00000031903.1 |
| Ensembl | ENSCPOT00000027960.2 | ENSCPOP00000018600.2 |
| UniProt | Q71FK5, ACTB_CAVPO | |
| GeneBank | AF508792 | AAM34270.1 |
| RefSeq | NM_001172909.1, XM_005003653.2 | NP_001166380.1, XP_005003710.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 60 61 KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 120 121 QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 180 181 AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 240 241 ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 300 301 GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 360 361 EYDESGPSIV HRKCF 375 |
| Nucleotide CDS Sequence (FASTA) |
1 CCCCGCGCTG TCTTCCCCTC CATCGTGGGG CGCCCGAGGC ACCAGGGAGT CATGGTAGGC 60 61 ATGGGCCAGA AGGACTCCTA CGTGGGAGAC GAAGCCCAGA GCAAAAGAGG TATCCTGACC 120 121 CTGAAATACC CCATTGAGCA CGGCATCGTT ACCAACTGGG ACGACATGGA GAAGATCTGG 180 181 CACCACACCT TTTACAATGA ATTGCGTGTG GCCCCTGAGG AGCACCCTGT GCTGCTGACG 240 241 GAGGCTCCCC TGAACCCCAA GGCCAACCGT GAGAAGATGA CCCAGATCAT GTTCGAGACT 300 301 TTCAACACCC CAGCCATGTA CGTGGCCATC CAGGCTGTGC TGTCCCTGGC TACGCCCTCC 360 361 CCCATGCCAT CCTGCGTCTG GACCTGGCTG GCCGGGACCT GA 402 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Actin cytoskeleton | |
Cellular Component | Calyx of Held | |
Cellular Component | Cortical cytoskeleton | |
Cellular Component | Cytoplasmic ribonucleoprotein granule | |
Cellular Component | Cytoskeleton | |
Cellular Component | Cytosol | |
Cellular Component | Dense body | |
Cellular Component | Focal adhesion | |
Cellular Component | Glutamatergic synapse | |
Cellular Component | NuA4 histone acetyltransferase complex | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Cellular Component | Postsynaptic actin cytoskeleton | |
Cellular Component | Protein-containing complex | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | ATP binding | |
Molecular Function | Identical protein binding | |
Molecular Function | Kinesin binding | |
Molecular Function | Nitric-oxide synthase binding | |
Molecular Function | Protein kinase binding | |
Molecular Function | Structural constituent of postsynaptic actin cytoskeleton | |
Molecular Function | Tat protein binding | |
Biological Process | Cell motility | |
Biological Process | Cellular response to cytochalasin B | |
Biological Process | Negative regulation of protein binding | |
Biological Process | Regulation of norepinephrine uptake | |
Biological Process | Regulation of protein localization to plasma membrane | |
Biological Process | Regulation of transmembrane transporter activity | |
Biological Process | Synaptic vesicle endocytosis |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Caf-0256 | Canis familiaris | 100.0 | 0.0 | 785 |
| LLPS-Poa-1896 | Pongo abelii | 100.0 | 0.0 | 785 |
| LLPS-Mam-0542 | Macaca mulatta | 100.0 | 0.0 | 785 |
| LLPS-Gaga-3190 | Gallus gallus | 100.0 | 0.0 | 785 |
| LLPS-Ict-0962 | Ictidomys tridecemlineatus | 100.0 | 0.0 | 785 |
| LLPS-Pat-1241 | Pan troglodytes | 100.0 | 0.0 | 785 |
| LLPS-Meg-0217 | Meleagris gallopavo | 100.0 | 0.0 | 785 |
| LLPS-Hos-2228 | Homo sapiens | 100.0 | 0.0 | 785 |
| LLPS-Fec-0933 | Felis catus | 100.0 | 0.0 | 785 |
| LLPS-Man-0235 | Macaca nemestrina | 100.0 | 0.0 | 785 |
| LLPS-Anp-0124 | Anas platyrhynchos | 100.0 | 0.0 | 765 |
| LLPS-Fia-0835 | Ficedula albicollis | 100.0 | 0.0 | 785 |
| LLPS-Rhb-0734 | Rhinopithecus bieti | 100.0 | 0.0 | 785 |
| LLPS-Tut-0075 | Tursiops truncatus | 100.0 | 0.0 | 785 |
| LLPS-Dio-0854 | Dipodomys ordii | 100.0 | 0.0 | 785 |
| LLPS-Bot-0180 | Bos taurus | 100.0 | 0.0 | 785 |
| LLPS-Ran-1456 | Rattus norvegicus | 100.0 | 0.0 | 785 |
| LLPS-Mal-1626 | Mandrillus leucophaeus | 100.0 | 0.0 | 785 |
| LLPS-Paa-0618 | Papio anubis | 100.0 | 0.0 | 785 |
| LLPS-Mup-0602 | Mustela putorius furo | 100.0 | 0.0 | 785 |
| LLPS-Mea-0513 | Mesocricetus auratus | 100.0 | 0.0 | 785 |
| LLPS-Mum-2101 | Mus musculus | 100.0 | 0.0 | 785 |
| LLPS-Maf-1333 | Macaca fascicularis | 100.0 | 0.0 | 785 |
| LLPS-Ora-1274 | Ornithorhynchus anatinus | 100.0 | 0.0 | 785 |
| LLPS-Sah-0914 | Sarcophilus harrisii | 100.0 | 0.0 | 785 |
| LLPS-Aon-1131 | Aotus nancymaae | 100.0 | 0.0 | 785 |
| LLPS-Sus-0718 | Sus scrofa | 100.0 | 0.0 | 785 |
| LLPS-Gog-2073 | Gorilla gorilla | 100.0 | 0.0 | 785 |
| LLPS-Fud-0138 | Fukomys damarensis | 100.0 | 0.0 | 785 |
| LLPS-Xet-1147 | Xenopus tropicalis | 99.73 | 0.0 | 784 |
| LLPS-Mod-0535 | Monodelphis domestica | 99.73 | 0.0 | 782 |
| LLPS-Otg-1568 | Otolemur garnettii | 99.73 | 0.0 | 784 |
| LLPS-Aim-1959 | Ailuropoda melanoleuca | 99.73 | 0.0 | 783 |
| LLPS-Chs-1337 | Chlorocebus sabaeus | 99.73 | 0.0 | 783 |
| LLPS-Eqc-1702 | Equus caballus | 99.47 | 0.0 | 780 |
| LLPS-Lac-0118 | Latimeria chalumnae | 99.47 | 0.0 | 783 |
| LLPS-Scf-0836 | Scleropages formosus | 99.47 | 0.0 | 782 |
| LLPS-Nol-0366 | Nomascus leucogenys | 99.46 | 0.0 | 775 |
| LLPS-Cea-0793 | Cercocebus atys | 99.46 | 0.0 | 776 |
| LLPS-Ten-0140 | Tetraodon nigroviridis | 99.2 | 0.0 | 780 |
| LLPS-Dar-2232 | Danio rerio | 99.2 | 0.0 | 781 |
| LLPS-Pes-0671 | Pelodiscus sinensis | 99.2 | 0.0 | 779 |
| LLPS-Asm-0444 | Astyanax mexicanus | 99.2 | 0.0 | 781 |
| LLPS-Icp-0412 | Ictalurus punctatus | 99.2 | 0.0 | 781 |
| LLPS-Tag-1378 | Taeniopygia guttata | 98.93 | 0.0 | 778 |
| LLPS-Urm-2396 | Ursus maritimus | 98.93 | 0.0 | 780 |
| LLPS-Pof-0794 | Poecilia formosa | 98.93 | 0.0 | 778 |
| LLPS-Scm-2408 | Scophthalmus maximus | 98.93 | 0.0 | 778 |
| LLPS-Orn-2946 | Oreochromis niloticus | 98.93 | 0.0 | 778 |
| LLPS-Xim-3100 | Xiphophorus maculatus | 98.93 | 0.0 | 779 |
| LLPS-Tar-0209 | Takifugu rubripes | 98.93 | 0.0 | 779 |
| LLPS-Gaa-1427 | Gasterosteus aculeatus | 98.93 | 0.0 | 778 |
| LLPS-Ova-0921 | Ovis aries | 98.93 | 0.0 | 780 |
| LLPS-Leo-0381 | Lepisosteus oculatus | 98.93 | 0.0 | 780 |
| LLPS-Caj-0803 | Callithrix jacchus | 98.93 | 0.0 | 780 |
| LLPS-Loa-0665 | Loxodonta africana | 98.92 | 0.0 | 761 |
| LLPS-Anc-0209 | Anolis carolinensis | 98.67 | 0.0 | 773 |
| LLPS-Pap-0154 | Pan paniscus | 98.4 | 0.0 | 766 |
| LLPS-Orl-1272 | Oryzias latipes | 98.4 | 0.0 | 779 |
| LLPS-Drm-0201 | Drosophila melanogaster | 98.13 | 0.0 | 774 |
| LLPS-Cae-0498 | Caenorhabditis elegans | 98.13 | 0.0 | 774 |
| LLPS-Cii-0697 | Ciona intestinalis | 97.33 | 0.0 | 769 |
| LLPS-Cis-0982 | Ciona savignyi | 96.8 | 0.0 | 768 |
| LLPS-Orc-3179 | Oryctolagus cuniculus | 94.62 | 0.0 | 744 |
| LLPS-Cas-0785 | Carlito syrichta | 94.12 | 0.0 | 746 |
| LLPS-Myl-2181 | Myotis lucifugus | 94.12 | 0.0 | 746 |
| LLPS-Mel-0212 | Melampsora laricipopulina | 92.27 | 0.0 | 741 |
| LLPS-Abg-0899 | Absidia glauca | 92.0 | 0.0 | 743 |