LLPS-Cap-0111
TP63
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Tumor protein 63 (p63) |
| Gene Name: | TP63 |
| Ensembl Gene: | ENSCPOG00000014770.4 |
| Ensembl Protein: | ENSCPOP00000027113.1 |
| Organism: | Cavia porcellus |
| Taxa ID: | 10141 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nuclear speckle, PML nuclear body | Predicted from orthologs | (View) |
▼ FUNCTION
| Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCPOT00000034562.1 | ENSCPOP00000027113.1 |
| Ensembl | ENSCPOT00000038222.1 | ENSCPOP00000022433.1 |
| Ensembl | ENSCPOT00000041837.1 | ENSCPOP00000032350.1 |
| Ensembl | ENSCPOT00000014915.3 | ENSCPOP00000013308.3 |
| UniProt | A0A286XNY6, A0A286XNY6_CAVPO | |
| GeneBank | AAKN02012370, AAKN02012372, AAKN02012371 | |
| RefSeq | XM_003477086.2 | XP_003477134.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MNFETPRCAT LQYCPDPYIQ RFVETPGHFS WKESYYRSTM SQSTQTSEFL SPEVFQHIWD 60 61 FLEQPICSVQ PIDLNFMDES SENGATNKIE ISMDCIRMQD SDLRDPMWPQ YTNLGLLNSM 120 121 DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180 181 FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240 241 VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300 301 TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360 361 KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420 421 LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ 480 481 LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQTLPPPLS MPSTSHCTPP 540 541 PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600 601 ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660 661 FNFDMDARRN KQQRIKEEGE 680 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAACTTTG AAACGCCCCG GTGTGCCACC CTGCAGTACT GTCCTGACCC TTACATCCAG 60 61 CGCTTCGTAG AAACCCCAGG TCATTTCTCT TGGAAAGAAA GTTATTACCG GTCTACCATG 120 121 TCCCAGAGTA CACAGACGAG TGAATTCCTC AGTCCAGAGG TTTTCCAGCA TATCTGGGAT 180 181 TTTCTAGAAC AGCCTATATG TTCAGTTCAG CCCATTGACT TGAACTTCAT GGACGAATCA 240 241 TCAGAAAATG GTGCAACTAA CAAAATTGAG ATCAGCATGG ACTGTATTCG CATGCAAGAC 300 301 TCAGACCTGA GGGACCCCAT GTGGCCACAG TACACAAACC TGGGGCTCCT GAACAGCATG 360 361 GACCAGCAGA TCCAAAACGG CTCCTCGTCC ACCAGCCCCT ACAACACTGA CCACGCACAG 420 421 AACAGCGTCA CTGCGCCCTC GCCCTATGCG CAGCCCAGCT CCACCTTCGA CGCCCTGTCG 480 481 CCGTCGCCCG CTATCCCCTC CAACACTGAC TATCCGGGCC CGCACAGCTT CGACGTGTCC 540 541 TTCCAGCAGT CCAGCACCGC CAAGTCGGCC ACCTGGACGT ATTCCACAGA ACTGAAGAAG 600 601 CTGTACTGCC AAATCGCGAA GACATGCCCC ATTCAGATCA AGGTGATGAC GCCACCCCCT 660 661 CAGGGAGCTG TCATCCGCGC CATGCCCGTC TACAAGAAAG CCGAGCACGT CACCGAGGTG 720 721 GTGAAGCGGT GCCCCAACCA TGAGCTGAGC CGTGAATTCA ATGAGGGACA GATTGCCCCG 780 781 CCTAGTCATT TGATTCGAGT AGAAGGGAAC AGCCATGCCC AATATGTAGA AGATCCCATC 840 841 ACAGGAAGAC AGAGTGTGCT GGTGCCTTAC GAACCACCCC AGGTCGGCAC TGAATTCACG 900 901 ACAGTCTTGT ACAATTTCAT GTGCAACAGC AGTTGTGTCG GAGGGATGAA CCGCCGTCCA 960 961 ATTTTAATCA TCGTTACTCT GGAAACCAGA GATGGGCAAG TCCTGGGCCG ACGGTGCTTT 1020 1021 GAGGCCAGGA TTTGTGCCTG CCCAGGGAGA GACAGGAAGG CAGATGAAGA CAGCATCAGA 1080 1081 AAGCAACAAG TTTCGGACAG TACAAAGAAC GGTGATGGTA CGAAGCGCCC TTTTCGGCAG 1140 1141 AATACACATG GCATCCAGAT GACATCCATC AAGAAGCGAA GATCCCCAGA TGATGAGCTG 1200 1201 CTGTACTTGC CAGTGAGGGG TCGTGAGACT TATGAAATGC TGTTAAAGAT CAAAGAGTCC 1260 1261 CTGGAGCTCA TGCAGTACCT TCCGCAGCAC ACGATCGAAA CATACAGGCA GCAGCAGCAG 1320 1321 CAGCAGCACC AGCACTTACT TCAAAAACAG ACCTCAATGC AGTCTCAGTC TTCATACGGT 1380 1381 AATAGCTCCC CGCCTCTGAA CAAAATGAAC AGTATGAACA AGCTGCCTTC GGTGAGCCAG 1440 1441 CTCATCAACC CCCAGCAGCG CAACGCCCTC ACCCCCACCA CCATACCCGA CGGCATGGGA 1500 1501 GCCAACATTC CTATGATGGG CACCCACATG CCAATGGCTG GAGACATGAA TGGACTCAGC 1560 1561 CCCACCCAGA CCCTCCCTCC CCCACTCTCC ATGCCATCCA CCTCCCACTG CACCCCCCCA 1620 1621 CCTCCGTACC CCACAGATTG CAGCATTGTC AGGATTTGGC AAGTCTAA 1668 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Golgi apparatus | |
Cellular Component | Nuclear chromatin | |
Cellular Component | Nucleoplasm | |
Molecular Function | Chromatin binding | |
Molecular Function | Damaged DNA binding | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | Identical protein binding | |
Molecular Function | MDM2/MDM4 family protein binding | |
Molecular Function | Metal ion binding | |
Molecular Function | P53 binding | |
Molecular Function | Sequence-specific DNA binding | |
Molecular Function | Transcription regulatory region DNA binding | |
Molecular Function | WW domain binding | |
Biological Process | Cell aging | |
Biological Process | Cell population proliferation | |
Biological Process | Chromatin remodeling | |
Biological Process | Cloacal septation | |
Biological Process | Cranial skeletal system development | |
Biological Process | Ectoderm and mesoderm interaction | |
Biological Process | Embryonic forelimb morphogenesis | |
Biological Process | Embryonic hindlimb morphogenesis | |
Biological Process | Epidermal cell division | |
Biological Process | Epithelial cell development | |
Biological Process | Establishment of planar polarity | |
Biological Process | Establishment of skin barrier | |
Biological Process | Female genitalia morphogenesis | |
Biological Process | Hair follicle morphogenesis | |
Biological Process | Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | |
Biological Process | Keratinocyte differentiation | |
Biological Process | Multicellular organism aging | |
Biological Process | Negative regulation of intracellular estrogen receptor signaling pathway | |
Biological Process | Negative regulation of keratinocyte differentiation | |
Biological Process | Negative regulation of mesoderm development | |
Biological Process | Negative regulation of transcription by RNA polymerase II | |
Biological Process | Neuron apoptotic process | |
Biological Process | Odontogenesis of dentin-containing tooth | |
Biological Process | Polarized epithelial cell differentiation | |
Biological Process | Positive regulation of apoptotic signaling pathway | |
Biological Process | Positive regulation of fibroblast apoptotic process | |
Biological Process | Positive regulation of keratinocyte proliferation | |
Biological Process | Positive regulation of Notch signaling pathway | |
Biological Process | Positive regulation of osteoblast differentiation | |
Biological Process | Positive regulation of somatic stem cell population maintenance | |
Biological Process | Post-anal tail morphogenesis | |
Biological Process | Prostatic bud formation | |
Biological Process | Protein homotetramerization | |
Biological Process | Proximal/distal pattern formation | |
Biological Process | Regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
Biological Process | Regulation of epidermal cell division | |
Biological Process | Skeletal system development | |
Biological Process | Skin morphogenesis | |
Biological Process | Squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | |
Biological Process | Sympathetic nervous system development |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orc-0164 | Oryctolagus cuniculus | 99.83 | 0.0 | 1092 |
| LLPS-Mup-4279 | Mustela putorius furo | 99.3 | 0.0 | 1089 |
| LLPS-Cas-0282 | Carlito syrichta | 99.09 | 0.0 | 1264 |
| LLPS-Bot-3698 | Bos taurus | 98.97 | 0.0 | 1309 |
| LLPS-Sus-2620 | Sus scrofa | 98.97 | 0.0 | 1310 |
| LLPS-Ict-1222 | Ictidomys tridecemlineatus | 98.97 | 0.0 | 1309 |
| LLPS-Eqc-0898 | Equus caballus | 98.97 | 0.0 | 1310 |
| LLPS-Otg-0872 | Otolemur garnettii | 98.95 | 0.0 | 1072 |
| LLPS-Loa-1908 | Loxodonta africana | 98.82 | 0.0 | 1308 |
| LLPS-Myl-1480 | Myotis lucifugus | 98.79 | 0.0 | 1264 |
| LLPS-Ova-0664 | Ovis aries | 98.64 | 0.0 | 1267 |
| LLPS-Tut-1687 | Tursiops truncatus | 98.53 | 0.0 | 1304 |
| LLPS-Aim-2920 | Ailuropoda melanoleuca | 98.38 | 0.0 | 1302 |
| LLPS-Dio-3130 | Dipodomys ordii | 98.38 | 0.0 | 1303 |
| LLPS-Fud-3471 | Fukomys damarensis | 98.38 | 0.0 | 1305 |
| LLPS-Fec-1203 | Felis catus | 98.38 | 0.0 | 1301 |
| LLPS-Chs-1829 | Chlorocebus sabaeus | 98.36 | 0.0 | 907 |
| LLPS-Paa-1743 | Papio anubis | 98.33 | 0.0 | 1256 |
| LLPS-Maf-1446 | Macaca fascicularis | 98.33 | 0.0 | 1256 |
| LLPS-Mam-3924 | Macaca mulatta | 98.33 | 0.0 | 1256 |
| LLPS-Man-0265 | Macaca nemestrina | 98.33 | 0.0 | 1256 |
| LLPS-Nol-2408 | Nomascus leucogenys | 98.24 | 0.0 | 1301 |
| LLPS-Poa-1124 | Pongo abelii | 98.24 | 0.0 | 1301 |
| LLPS-Rhb-0893 | Rhinopithecus bieti | 98.24 | 0.0 | 1301 |
| LLPS-Urm-0390 | Ursus maritimus | 98.24 | 0.0 | 1300 |
| LLPS-Ran-1285 | Rattus norvegicus | 98.09 | 0.0 | 1301 |
| LLPS-Mum-1888 | Mus musculus | 98.09 | 0.0 | 1302 |
| LLPS-Caf-1199 | Canis familiaris | 98.09 | 0.0 | 1296 |
| LLPS-Pap-3067 | Pan paniscus | 98.09 | 0.0 | 1300 |
| LLPS-Pat-0338 | Pan troglodytes | 98.09 | 0.0 | 1300 |
| LLPS-Hos-2210 | Homo sapiens | 98.09 | 0.0 | 1300 |
| LLPS-Gog-1097 | Gorilla gorilla | 97.94 | 0.0 | 1297 |
| LLPS-Aon-2010 | Aotus nancymaae | 97.94 | 0.0 | 1298 |
| LLPS-Caj-1567 | Callithrix jacchus | 97.79 | 0.0 | 1296 |
| LLPS-Mea-2047 | Mesocricetus auratus | 97.79 | 0.0 | 1295 |
| LLPS-Cea-3865 | Cercocebus atys | 96.59 | 0.0 | 1258 |
| LLPS-Mal-1740 | Mandrillus leucophaeus | 96.44 | 0.0 | 912 |
| LLPS-Meg-0131 | Meleagris gallopavo | 95.76 | 0.0 | 1232 |
| LLPS-Anp-2081 | Anas platyrhynchos | 95.76 | 0.0 | 1231 |
| LLPS-Mod-1247 | Monodelphis domestica | 95.15 | 0.0 | 1217 |
| LLPS-Gaga-2471 | Gallus gallus | 94.85 | 0.0 | 1255 |
| LLPS-Tag-0775 | Taeniopygia guttata | 94.26 | 0.0 | 1243 |
| LLPS-Fia-0453 | Ficedula albicollis | 93.82 | 0.0 | 1234 |
| LLPS-Ora-0488 | Ornithorhynchus anatinus | 93.39 | 0.0 | 1228 |
| LLPS-Pes-1889 | Pelodiscus sinensis | 90.38 | 0.0 | 813 |
| LLPS-Gaa-0220 | Gasterosteus aculeatus | 87.8 | 0.0 | 603 |
| LLPS-Xet-2156 | Xenopus tropicalis | 81.12 | 0.0 | 913 |
| LLPS-Lac-1479 | Latimeria chalumnae | 80.8 | 0.0 | 1014 |
| LLPS-Scf-2160 | Scleropages formosus | 80.77 | 0.0 | 879 |
| LLPS-Tar-1766 | Takifugu rubripes | 79.02 | 0.0 | 889 |
| LLPS-Icp-0939 | Ictalurus punctatus | 77.23 | 0.0 | 833 |
| LLPS-Orn-1211 | Oreochromis niloticus | 74.81 | 0.0 | 983 |
| LLPS-Leo-0755 | Lepisosteus oculatus | 74.64 | 0.0 | 962 |
| LLPS-Scm-1886 | Scophthalmus maximus | 74.33 | 0.0 | 967 |
| LLPS-Pof-1860 | Poecilia formosa | 73.7 | 0.0 | 966 |
| LLPS-Ten-1025 | Tetraodon nigroviridis | 73.57 | 0.0 | 958 |
| LLPS-Xim-0802 | Xiphophorus maculatus | 72.81 | 0.0 | 948 |
| LLPS-Dar-1699 | Danio rerio | 72.8 | 0.0 | 898 |
| LLPS-Orl-0340 | Oryzias latipes | 72.36 | 0.0 | 929 |
| LLPS-Asm-2943 | Astyanax mexicanus | 69.7 | 0.0 | 918 |
| LLPS-Anc-1449 | Anolis carolinensis | 48.09 | 3e-28 | 116 |
| LLPS-Cii-1707 | Ciona intestinalis | 45.23 | 1e-72 | 249 |
| LLPS-Cis-0319 | Ciona savignyi | 43.65 | 8e-71 | 244 |
| LLPS-Drm-1424 | Drosophila melanogaster | 26.78 | 2e-10 | 67.8 |