LLPS-Caj-a117
CAPZB
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | F-actin-capping protein subunit beta |
| Gene Name: | CAPZB |
| Ensembl Gene: | ENSCJAG00000006715.3 |
| Ensembl Protein: | ENSCJAP00000059185.1 |
| Organism: | Callithrix jacchus |
| Taxa ID: | 9483 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCJAT00000067521.1 | ENSCJAP00000059185.1 |
| Ensembl | ENSCJAT00000052315.2 | ENSCJAP00000048157.2 |
| Ensembl | ENSCJAT00000013189.3 | ENSCJAP00000012512.3 |
| Ensembl | ENSCJAT00000013213.3 | ENSCJAP00000012536.2 |
| Ensembl | ENSCJAT00000013196.3 | ENSCJAP00000012519.3 |
| UniProt | A0A2R8N3V0, A0A2R8N3V0_CALJA | |
| Entrez | 100391719 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MHPSRRSLPF PLNCQLVRVG TADYGSPSDQ SDQQLDCALD LMRRLPPQQI EKNLSDLIDL 60 61 VPSLCEDLLS SVDQPLKIAR DKVVGKDYLL CDYNRDGDSY RSPWSNKYDP PLEDGAMPSA 120 121 RLRKLEVEAN NAFDQYRDLY FEGGVSSVYL WDLDHGFAGV ILIKKAGDGS KKIKGCWDSI 180 181 HVVEVQEKSS GRTAHYKLTS TVMLWLQTNK SGSGTMNLGG SLTRQMEKDE TVSDCSPHIA 240 241 NIGRLVEDME NKIRSTLNEI YFGKTKDIVN GLRSVQTFAD KSKQEALKND LVEALKRKQQ 300 301 C 301 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGAGGCGCC TGCCTCCACA GCAAATCGAG AAAAACCTCA GCGACCTGAT TGACCTGGTC 60 61 CCCAGTCTAT GTGAGGATCT CCTGTCTTCT GTTGACCAGC CACTGAAAAT TGCCAGAGAC 120 121 AAGGTGGTGG GAAAGGATTA CCTTTTGTGT GACTACAACA GAGATGGGGA CTCCTATAGG 180 181 TCACCATGGA GTAACAAGTA TGACCCTCCC TTGGAAGATG GGGCCATGCC GTCAGCTCGG 240 241 CTGCGAAAGC TGGAGGTGGA AGCCAACAAT GCCTTTGACC AGTACCGAGA CCTGTATTTT 300 301 GAAGGCGGCG TCTCATCTGT CTACCTCTGG GATCTGGATC ATGGCTTTGC TGGAGTGATC 360 361 CTCATAAAGA AGGCTGGAGA TGGATCAAAG AAGATCAAAG GCTGCTGGGA TTCCATCCAC 420 421 GTGGTGGAAG TGCAGGAGAA ATCCAGCGGC CGCACCGCCC ATTACAAGTT GACCTCCACG 480 481 GTGATGCTGT GGCTGCAGAC CAACAAATCC GGCTCTGGCA CCATGAACCT CGGAGGCAGC 540 541 CTCACCAGAC AGATGGAGAA AGATGAGACT GTGAGCGACT GCTCCCCACA CATAGCCAAC 600 601 ATCGGGCGCC TGGTAGAGGA CATGGAAAAT AAAATCAGAA GTACACTGAA CGAGATCTAC 660 661 TTTGGAAAAA CAAAGGATAT TGTCAACGGT CTGAGATCTG TTGATGCTAT CCCTGACAAC 720 721 CAAAAGTTTA AGCAGTTGCA GAGGGAGCTC TCTCAAGTGC TGACCCAGCG CCAGATCTAC 780 781 ATCCAGCCTG ATAATTAG 798 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Brush border | |
Cellular Component | Cortical cytoskeleton | |
Cellular Component | F-actin capping protein complex | |
Cellular Component | Hippocampal mossy fiber to CA3 synapse | |
Cellular Component | Lamellipodium | |
Cellular Component | Membrane | |
Cellular Component | Postsynaptic density | |
Cellular Component | Schaffer collateral - CA1 synapse | |
Molecular Function | Actin binding | |
Biological Process | Actin cytoskeleton organization | |
Biological Process | Barbed-end actin filament capping | |
Biological Process | Lamellipodium assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a119 | Homo sapiens | 0.0 | 622 | undefined |
| LLPS-Mum-a121 | Mus musculus | 0.0 | 617 | undefined |