• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caj-2170
SMAD3

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Mothers against decapentaplegic homolog
Gene Name: SMAD3
Ensembl Gene: ENSCJAG00000002088.3
Ensembl Protein: ENSCJAP00000062715.1
Organism: Callithrix jacchus
Taxa ID: 9483
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, PML nuclear bodyPredicted from orthologs(View)

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKHRLGAGGS  GSGSAAYAPG  RPSQRASERR  AGRRRAAGLR  GSRGGGICSS  KLARRAKFGR  60
61    GLDFPSRRRH  PNSYPVRKPK  LLLPLGVSRP  PPPPRVRGLP  DPAPLPSAHP  PGRRFPRRGS  120
121   SSGLRAARRT  PQAAAPRPGP  APRQLRRELG  EVWAAEAGPG  RAPLCAPGFP  PSTAPPGALL  180
181   AARAPSLAMS  SILPFTPPIV  KRLLGWKKGE  QNGQEEKWCE  KAVKSLVKKL  KKTGQLDELE  240
241   KAITTQNVNT  KCITIPRSLD  GRLQVSHRKG  LPHVIYCRLW  RWPDLHSHHE  LRAMELCEFA  300
301   FNMKKDEVCV  NPYHYQRVET  PVLPPVLVPR  HTEIPAEFPP  LDDYSHSIPE  NTNFPAGIEP  360
361   QSNIPETPPP  GYLSEDGETS  DHQMNHSMDA  GSPNLSPNPM  SPAHNNLDLQ  PVTYCEPAFW  420
421   CSISYYELNQ  RVGETFHASQ  PSMTVDGFTD  PSNSERFCLG  LLSNVNRNAA  VELTRRHIGR  480
481   GVRLYYIGGE  VFAECLSDSA  IFVQSPNCNQ  RYGWHPATVC  KIPPGCNLKI  FNNQEFAALL  540
541   AQSVNQGFEA  VYQLTRMCTI  RMSFVKGWGA  EYRRQTVTST  PCWIELHLNG  PLQWLDKVLT  600
601   QMGSPSIRCS  SVS  613
Nucleotide CDS Sequence (FASTA)
1     ATGTCTTGCT  GCTTTCTTGA  AGAATTTGAA  ACAAGCTTGC  AAACAAAGCA  AGCGCAACCC  60
61    ACATCTCCCT  CTCTTTCTGC  TCCTCCCCAT  CCCGGCAGGT  CCCTGGATGG  CCGGTTGCAG  120
121   GTGTCCCATC  GGAAAGGACT  CCCTCATGTC  ATCTACTGCC  GCCTGTGGCG  ATGGCCCGAC  180
181   CTGCACAGCC  ACCACGAGCT  GCGGGCCATG  GAGCTGTGTG  AGTTCGCCTT  CAATATGAAG  240
241   AAGGACGAGG  TCTGCGTGAA  TCCCTACCAC  TACCAGAGAG  TAGAGACACC  AGTTCTACCT  300
301   CCTGTGTTGG  TACCACGCCA  CACAGAGATC  CCGGCCGAGT  TCCCCCCACT  GGACGACTAC  360
361   AGCCATTCCA  TTCCCGAAAA  CACTAACTTC  CCCGCAGGCA  TCGAGCCCCA  GAGCAATATT  420
421   CCAGAGACCC  CGCCCCCTGG  CTACCTGAGT  GAAGATGGAG  AGACGAGTGA  CCACCAGATG  480
481   AACCACAGCA  TGGACGCAGG  TTCTCCAAAC  CTATCCCCGA  ATCCGATGTC  CCCAGCACAC  540
541   AATAACTTGG  ACCTGCAGCC  AGTCACCTAC  TGCGAGCCAG  CCTTCTGGTG  TTCCATCTCC  600
601   TACTACGAGC  TGAACCAGCG  CGTCGGGGAG  ACGTTCCATG  CCTCGCAGCC  ATCCATGACT  660
661   GTGGATGGCT  TCACCGACCC  CTCCAACTCG  GAGCGCTTCT  GCCTAGGGCT  GCTCTCTAAC  720
721   GTCAACAGGA  ACGCAGCAGT  GGAGCTGACG  AGGAGGCACA  TTGGAAGAGG  CGTGCGGCTC  780
781   TACTACATTG  GAGGGGAGGT  CTTCGCAGAG  TGCCTCAGTG  ACAGCGCTAT  CTTTGTCCAG  840
841   TCTCCCAACT  GTAACCAGCG  CTATGGGTGG  CACCCAGCCA  CCGTCTGCAA  GATCCCACCA  900
901   GGATGCAACC  TGAAGATCTT  CAACAACCAG  GAGTTCGCTG  CCCTCCTGGC  CCAATCCGTC  960
961   AACCAGGGCT  TCGAGGCTGT  CTACCAGTTG  ACCCGCATGT  GCACCATCCG  CATGAGCTTC  1020
1021  GTCAAAGGCT  GGGGAGCAGA  GTACAGGAGA  CAGACTGTGA  CCAGTACCCC  CTGCTGGATC  1080
1081  GAGCTGCACC  TGAATGGGCC  TTTGCAGTGG  CTTGACAAGG  TCCTCACCCA  GATGGGCTCC  1140
1141  CCAAGCATCC  GCTGTTCCAG  TGTGTCTTAA  1170

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ova-1326Ovis aries100.00.0 639
LLPS-Ran-2860Rattus norvegicus100.00.0 833
LLPS-Dio-0310Dipodomys ordii100.00.0 833
LLPS-Tut-2159Tursiops truncatus100.00.0 594
LLPS-Gog-1037Gorilla gorilla100.00.0 725
LLPS-Sus-2037Sus scrofa100.00.0 833
LLPS-Aon-0878Aotus nancymaae100.00.0 833
LLPS-Mum-2371Mus musculus100.00.0 833
LLPS-Ict-2003Ictidomys tridecemlineatus100.00.0 833
LLPS-Poa-1332Pongo abelii100.00.0 833
LLPS-Eqc-0562Equus caballus100.00.0 833
LLPS-Orc-4000Oryctolagus cuniculus100.03e-167 483
LLPS-Otg-3890Otolemur garnettii100.00.0 833
LLPS-Loa-2630Loxodonta africana100.00.0 593
LLPS-Hos-2559Homo sapiens100.00.0 833
LLPS-Pap-2899Pan paniscus100.00.0 833
LLPS-Fec-2896Felis catus100.00.0 833
LLPS-Mal-1848Mandrillus leucophaeus99.760.0 831
LLPS-Paa-0988Papio anubis99.760.0 831
LLPS-Bot-3478Bos taurus99.760.0 832
LLPS-Maf-2933Macaca fascicularis99.760.0 831
LLPS-Mea-3233Mesocricetus auratus99.760.0 832
LLPS-Chs-0411Chlorocebus sabaeus99.760.0 831
LLPS-Nol-0157Nomascus leucogenys99.760.0 831
LLPS-Caf-1951Canis familiaris99.760.0 828
LLPS-Man-0842Macaca nemestrina99.760.0 831
LLPS-Ora-2692Ornithorhynchus anatinus99.30.0 587
LLPS-Mod-0848Monodelphis domestica99.290.0 828
LLPS-Mup-1489Mustela putorius furo99.170.0 728
LLPS-Pes-2861Pelodiscus sinensis99.160.0 720
LLPS-Anp-1726Anas platyrhynchos98.880.0 716
LLPS-Gaga-1930Gallus gallus98.820.0 823
LLPS-Cas-1598Carlito syrichta98.820.0 824
LLPS-Cap-0571Cavia porcellus98.820.0 826
LLPS-Fia-0202Ficedula albicollis98.820.0 822
LLPS-Aim-0438Ailuropoda melanoleuca98.580.0 819
LLPS-Lac-0333Latimeria chalumnae97.490.0 709
LLPS-Scf-0891Scleropages formosus97.160.0 809
LLPS-Dar-2312Danio rerio97.160.0 808
LLPS-Asm-2680Astyanax mexicanus96.930.0 805
LLPS-Leo-0163Lepisosteus oculatus96.930.0 808
LLPS-Cea-0901Cercocebus atys96.480.0 819
LLPS-Tag-2370Taeniopygia guttata96.090.0 739
LLPS-Pof-1356Poecilia formosa95.980.0 801
LLPS-Scm-2550Scophthalmus maximus95.980.0 801
LLPS-Xim-0717Xiphophorus maculatus95.740.0 799
LLPS-Orl-1313Oryzias latipes95.740.0 798
LLPS-Fud-2028Fukomys damarensis95.310.0 795
LLPS-Meg-2242Meleagris gallopavo95.290.0 786
LLPS-Tar-1034Takifugu rubripes95.270.0 795
LLPS-Ten-3091Tetraodon nigroviridis95.270.0 791
LLPS-Gaa-0489Gasterosteus aculeatus93.850.0 781
LLPS-Icp-0481Ictalurus punctatus93.620.0 757
LLPS-Mam-2774Macaca mulatta92.470.0 776
LLPS-Pat-3536Pan troglodytes91.50.0 780
LLPS-Orn-2265Oreochromis niloticus89.670.0 788
LLPS-Sah-3809Sarcophilus harrisii86.960.0 626
LLPS-Xet-2008Xenopus tropicalis84.20.0 746
LLPS-Anc-0794Anolis carolinensis83.840.0 746
LLPS-Myl-2425Myotis lucifugus83.620.0 743
LLPS-Rhb-2240Rhinopithecus bieti83.620.0 743
LLPS-Ere-0447Erinaceus europaeus82.510.0 661
LLPS-Urm-2701Ursus maritimus81.860.0 718
LLPS-Cii-2194Ciona intestinalis73.540.0 610
LLPS-Cis-2031Ciona savignyi70.720.0 596