LLPS-Caj-2005
NOP53
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Ribosome biogenesis protein NOP53 |
| Gene Name: | NOP53, GLTSCR2 |
| Ensembl Gene: | ENSCJAG00000011385.3 |
| Ensembl Protein: | ENSCJAP00000020955.2 |
| Organism: | Callithrix jacchus |
| Taxa ID: | 9483 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, P-body | Predicted from orthologs | (View) |
▼ FUNCTION
| May play a role in ribosome biogenesis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCJAT00000022157.2 | ENSCJAP00000020955.2 |
| UniProt | F7GVQ0, F7GVQ0_CALJA, U3CV56 | |
| GeneBank | GAMR01004104 | JAB29828.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MAVGGKGGSR KHSSKSDADS GFLGLRPTSV DPALRRRRRG PRNKKRGWRR LAQEPLGLEV 60 61 DQFLEDVRLQ ERTSGGLLSE APNEKLFFVD TGPKEKGLTK KRTKVQKKSL LLRKPLRVDL 120 121 ILENTSKVPA PKNVLAHQVP NAKKLRRKEQ LWEKLAKQGE LPREVRRAQA RLLNPPAVKA 180 181 KPSPQDTVER PFYDLWAPDN PLDRPLVGQD EFFLEQTKKK GVKRPPRLHT KPSRVPAVEV 240 241 VPAGASYNPS FEDHQTLLSA AHEVELQRQK EAEKLERQLA LPAAEQAATQ ESTFQELCEG 300 301 LLEESDGEGE PGQGQGQGKE PEAGDADVCP TPARLAATEK KTEQQRRREK AARRLRAQQA 360 361 VLRAARLRHQ ELFRLRGIKA QVALRLAELA RRRRQRQARR EAEADKPRRL GRLKYQAPDI 420 421 DVQLSSELTD SLRTLKPEGN ILRDRFKSFQ RRNMIEPRER AKFKRKYKVK LVEKRAFREI 480 481 QL 482 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGTGG GAGGCAAAGG TGGTAGTAGG AAGCACAGCT CGAAAAGCGA TGCCGATTCT 60 61 GGCTTCCTGG GGCTGCGGCC AACTTCAGTG GATCCAGCGC TGAGGCGGCG GCGGCGAGGC 120 121 CCAAGAAACA AGAAGCGGGG CTGGCGACGA CTCGCTCAGG AGCCGCTGGG GCTGGAGGTT 180 181 GACCAGTTCC TGGAAGACGT GCGGCTACAG GAGCGCACGA GCGGTGGCTT GTTGTCAGAG 240 241 GCCCCTAATG AAAAACTCTT CTTTGTGGAT ACTGGCCCCA AGGAAAAAGG GCTGACTAAG 300 301 AAGAGAACCA AAGTCCAGAA GAAGTCGCTG CTTCTCAGGA AACCCCTTCG GGTTGATCTC 360 361 ATCCTCGAGA ACACATCCAA AGTCCCTGCC CCCAAAAACG TCCTTGCCCA CCAGGTCCCC 420 421 AACGCCAAGA AGCTCAGGCG GAAGGAGCAG CTATGGGAGA AGCTGGCCAA GCAGGGCGAG 480 481 CTGCCTCGGG AGGTGCGCAG GGCCCAGGCC CGACTCCTCA ACCCTCCCGC AGTCAAGGCC 540 541 AAGCCCAGTC CCCAGGATAC TGTGGAGCGG CCCTTCTACG ACCTCTGGGC CCCAGACAAC 600 601 CCCTTGGACA GGCCGCTGGT TGGCCAGGAT GAGTTTTTCC TGGAGCAGAC CAAGAAGAAG 660 661 GGAGTGAAGC GGCCACCGCG CCTGCACACC AAGCCGTCCC GGGTCCCTGC TGTGGAGGTG 720 721 GTGCCTGCCG GAGCGTCCTA CAACCCGTCC TTTGAAGACC ACCAGACCCT GCTCTCAGCG 780 781 GCCCACGAGG TGGAGTTGCA GCGGCAGAAG GAGGCGGAGA AGCTGGAGCG GCAGCTGGCC 840 841 CTGCCCGCCG CGGAGCAGGC TGCCACCCAG GAGTCCACAT TCCAAGAGCT GTGTGAGGGG 900 901 CTGCTGGAGG AGTCGGATGG TGAGGGGGAG CCGGGCCAGG GCCAGGGCCA GGGCAAGGAG 960 961 CCGGAGGCTG GGGATGCTGA TGTGTGTCCC ACGCCCGCCC GCCTGGCTGC CACTGAGAAG 1020 1021 AAGACGGAGC AGCAGCGGCG GCGGGAGAAG GCCGCACGCA GGCTGCGGGC ACAGCAGGCG 1080 1081 GTGTTGCGGG CCGCCCGGCT GCGGCACCAG GAGCTGTTCC GGCTGCGCGG GATCAAGGCT 1140 1141 CAGGTGGCCC TGAGGCTGGC GGAGCTGGCG AGGCGGAGGA GGCAGCGGCA GGCACGGCGG 1200 1201 GAGGCTGAGG CTGACAAGCC CCGAAGGCTG GGGCGTCTCA AGTACCAGGC ACCCGACATT 1260 1261 GACGTGCAGC TCAGCTCGGA GCTGACCGAC TCGCTCAGGA CCTTGAAGCC CGAGGGCAAC 1320 1321 ATCCTTCGAG ACCGGTTCAA GAGCTTCCAG AGGAGAAATA TGATCGAGCC TCGAGAGAGA 1380 1381 GCCAAGTTCA AGCGAAAGTA CAAGGTGAAG CTGGTGGAGA AGCGGGCGTT CCGAGAGATC 1440 1441 CAGTTGTAG 1449 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Fibrillar center | |
Cellular Component | Nucleoplasm | |
Cellular Component | RDNA heterochromatin | |
Molecular Function | 5S rRNA binding | |
Molecular Function | Identical protein binding | |
Molecular Function | P53 binding | |
Biological Process | Cellular response to hypoxia | |
Biological Process | DNA repair | |
Biological Process | Mitotic G2 DNA damage checkpoint | |
Biological Process | Negative regulation of phosphatidylinositol 3-kinase signaling | |
Biological Process | Negative regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | Negative regulation of protein complex assembly | |
Biological Process | Negative regulation of protein kinase B signaling | |
Biological Process | Negative regulation of signal transduction by p53 class mediator | |
Biological Process | Negative regulation of transcription by RNA polymerase II | |
Biological Process | Negative regulation of transcription of nucleolar large rRNA by RNA polymerase I | |
Biological Process | Positive regulation of proteasomal ubiquitin-dependent protein catabolic process | |
Biological Process | Positive regulation of protein K63-linked deubiquitination | |
Biological Process | Protein localization to nucleolus | |
Biological Process | Protein localization to nucleoplasm | |
Biological Process | Protein stabilization | |
Biological Process | Regulation of aerobic respiration | |
Biological Process | Regulation of apoptotic process | |
Biological Process | Regulation of protein phosphorylation | |
Biological Process | Regulation of RIG-I signaling pathway | |
Biological Process | Ribosomal large subunit assembly |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Pap-1602 | Pan paniscus | 100.0 | 1e-40 | 156 |
| LLPS-Otg-0929 | Otolemur garnettii | 95.59 | 1e-32 | 134 |
| LLPS-Cas-0131 | Carlito syrichta | 94.12 | 1e-32 | 132 |
| LLPS-Man-0319 | Macaca nemestrina | 92.27 | 0.0 | 657 |
| LLPS-Nol-4027 | Nomascus leucogenys | 92.06 | 0.0 | 654 |
| LLPS-Mam-0054 | Macaca mulatta | 92.06 | 0.0 | 655 |
| LLPS-Maf-0118 | Macaca fascicularis | 92.06 | 0.0 | 655 |
| LLPS-Pat-0847 | Pan troglodytes | 91.85 | 0.0 | 655 |
| LLPS-Paa-0134 | Papio anubis | 91.85 | 0.0 | 656 |
| LLPS-Chs-1739 | Chlorocebus sabaeus | 91.63 | 0.0 | 655 |
| LLPS-Cea-2943 | Cercocebus atys | 91.49 | 0.0 | 656 |
| LLPS-Hos-0149 | Homo sapiens | 91.42 | 0.0 | 657 |
| LLPS-Rhb-0246 | Rhinopithecus bieti | 90.56 | 0.0 | 637 |
| LLPS-Fud-1221 | Fukomys damarensis | 88.89 | 5e-31 | 128 |
| LLPS-Gog-0726 | Gorilla gorilla | 87.96 | 0.0 | 602 |
| LLPS-Fec-2002 | Felis catus | 85.07 | 0.0 | 609 |
| LLPS-Aon-0140 | Aotus nancymaae | 84.23 | 0.0 | 554 |
| LLPS-Dio-2266 | Dipodomys ordii | 84.14 | 2e-150 | 438 |
| LLPS-Caf-4449 | Canis familiaris | 83.94 | 0.0 | 612 |
| LLPS-Poa-1375 | Pongo abelii | 83.91 | 0.0 | 622 |
| LLPS-Mup-0387 | Mustela putorius furo | 83.62 | 0.0 | 621 |
| LLPS-Sus-0057 | Sus scrofa | 83.48 | 0.0 | 575 |
| LLPS-Eqc-2866 | Equus caballus | 82.06 | 0.0 | 609 |
| LLPS-Mum-1963 | Mus musculus | 82.01 | 0.0 | 582 |
| LLPS-Ict-1647 | Ictidomys tridecemlineatus | 81.76 | 0.0 | 587 |
| LLPS-Aim-2115 | Ailuropoda melanoleuca | 81.55 | 0.0 | 593 |
| LLPS-Ran-1072 | Rattus norvegicus | 81.51 | 0.0 | 565 |
| LLPS-Bot-0670 | Bos taurus | 81.48 | 0.0 | 605 |
| LLPS-Cap-1492 | Cavia porcellus | 81.33 | 0.0 | 585 |
| LLPS-Mea-2119 | Mesocricetus auratus | 80.22 | 0.0 | 566 |
| LLPS-Tut-0228 | Tursiops truncatus | 79.38 | 0.0 | 592 |
| LLPS-Mal-2168 | Mandrillus leucophaeus | 77.46 | 0.0 | 550 |
| LLPS-Ten-0550 | Tetraodon nigroviridis | 73.53 | 3e-25 | 103 |
| LLPS-Myl-1236 | Myotis lucifugus | 69.46 | 9e-159 | 466 |
| LLPS-Sah-0191 | Sarcophilus harrisii | 67.89 | 2e-138 | 412 |
| LLPS-Xet-0525 | Xenopus tropicalis | 67.26 | 3e-28 | 122 |
| LLPS-Mod-2833 | Monodelphis domestica | 67.17 | 1e-158 | 466 |
| LLPS-Pof-0442 | Poecilia formosa | 65.18 | 5e-31 | 129 |
| LLPS-Cis-0079 | Ciona savignyi | 64.47 | 1e-17 | 88.6 |
| LLPS-Cii-1819 | Ciona intestinalis | 60.53 | 3e-16 | 84.7 |
| LLPS-Anc-1995 | Anolis carolinensis | 58.64 | 2e-71 | 235 |
| LLPS-Gaga-0408 | Gallus gallus | 52.33 | 6e-114 | 355 |
| LLPS-Dar-1455 | Danio rerio | 52.2 | 3e-105 | 328 |
| LLPS-Scf-0390 | Scleropages formosus | 51.99 | 3e-100 | 315 |
| LLPS-Lac-0792 | Latimeria chalumnae | 51.23 | 1e-98 | 309 |
| LLPS-Icp-2332 | Ictalurus punctatus | 50.83 | 2e-101 | 320 |
| LLPS-Php-0643 | Physcomitrella patens | 50.75 | 2e-06 | 54.3 |
| LLPS-Leo-1028 | Lepisosteus oculatus | 50.35 | 8e-103 | 322 |
| LLPS-Yal-0361 | Yarrowia lipolytica | 50.0 | 1e-14 | 80.1 |
| LLPS-Asm-0371 | Astyanax mexicanus | 48.82 | 1e-94 | 301 |
| LLPS-Brr-0901 | Brassica rapa | 48.08 | 4e-06 | 53.1 |
| LLPS-Bro-2237 | Brassica oleracea | 48.08 | 3e-06 | 53.5 |
| LLPS-Abg-0190 | Absidia glauca | 48.0 | 2e-12 | 73.9 |
| LLPS-Xim-0496 | Xiphophorus maculatus | 47.72 | 2e-96 | 306 |
| LLPS-Orn-0722 | Oreochromis niloticus | 47.56 | 3e-80 | 264 |
| LLPS-Tar-0002 | Takifugu rubripes | 47.36 | 1e-83 | 273 |
| LLPS-Scm-1737 | Scophthalmus maximus | 45.65 | 3e-89 | 287 |
| LLPS-Gaa-0323 | Gasterosteus aculeatus | 45.28 | 4e-91 | 291 |
| LLPS-Brn-1298 | Brassica napus | 44.78 | 1e-06 | 55.1 |
| LLPS-Chr-0107 | Chlamydomonas reinhardtii | 44.62 | 3e-06 | 53.9 |
| LLPS-Usm-0339 | Ustilago maydis | 44.44 | 4e-08 | 59.3 |
| LLPS-Tra-1374 | Triticum aestivum | 44.44 | 5e-06 | 52.8 |
| LLPS-Orl-0684 | Oryzias latipes | 44.35 | 2e-86 | 280 |
| LLPS-Tum-0104 | Tuber melanosporum | 43.84 | 1e-10 | 67.4 |
| LLPS-Osl-0108 | Ostreococcus lucimarinus | 43.75 | 5e-08 | 59.3 |
| LLPS-Kop-1148 | Komagataella pastoris | 43.55 | 9e-07 | 55.1 |
| LLPS-Scc-0233 | Schizosaccharomyces cryophilus | 42.86 | 1e-08 | 61.2 |
| LLPS-Scp-0687 | Schizosaccharomyces pombe | 42.86 | 2e-06 | 54.3 |
| LLPS-Trv-0288 | Trichoderma virens | 42.67 | 2e-08 | 60.5 |
| LLPS-Map-0201 | Magnaporthe poae | 42.67 | 1e-09 | 63.9 |
| LLPS-Gag-0524 | Gaeumannomyces graminis | 42.67 | 2e-09 | 63.9 |
| LLPS-Nec-0678 | Neurospora crassa | 42.67 | 5e-10 | 65.5 |
| LLPS-Blg-0773 | Blumeria graminis | 42.67 | 1e-08 | 61.2 |
| LLPS-Cae-0201 | Caenorhabditis elegans | 42.31 | 2e-07 | 57.8 |
| LLPS-Brd-1452 | Brachypodium distachyon | 41.67 | 3e-06 | 53.5 |
| LLPS-Trr-0119 | Trichoderma reesei | 41.33 | 1e-07 | 58.5 |
| LLPS-Ved-0198 | Verticillium dahliae | 41.33 | 5e-09 | 62.4 |
| LLPS-Coo-1026 | Colletotrichum orbiculare | 41.33 | 8e-10 | 65.1 |
| LLPS-Drm-0283 | Drosophila melanogaster | 41.1 | 6e-09 | 62.4 |
| LLPS-Pot-1605 | Populus trichocarpa | 40.58 | 2e-06 | 54.3 |
| LLPS-Cog-1154 | Colletotrichum gloeosporioides | 40.0 | 3e-09 | 60.8 |
| LLPS-Beb-1020 | Beauveria bassiana | 40.0 | 4e-07 | 56.6 |
| LLPS-Cogr-0564 | Colletotrichum graminicola | 40.0 | 8e-10 | 64.7 |
| LLPS-Crn-0595 | Cryptococcus neoformans | 39.44 | 3e-07 | 57.0 |
| LLPS-Spr-0590 | Sporisorium reilianum | 39.19 | 1e-06 | 54.7 |
| LLPS-Scj-1385 | Schizosaccharomyces japonicus | 39.19 | 7e-06 | 52.4 |
| LLPS-Phn-0319 | Phaeosphaeria nodorum | 38.96 | 7e-06 | 52.4 |
| LLPS-Fuo-0393 | Fusarium oxysporum | 38.67 | 2e-07 | 57.4 |
| LLPS-Fuv-1132 | Fusarium verticillioides | 38.67 | 2e-07 | 57.4 |
| LLPS-Scs-0371 | Sclerotinia sclerotiorum | 38.67 | 5e-07 | 56.2 |
| LLPS-Mao-0922 | Magnaporthe oryzae | 37.33 | 4e-08 | 59.3 |
| LLPS-Asg-0116 | Ashbya gossypii | 35.9 | 8e-06 | 52.4 |
| LLPS-Asfu-0184 | Aspergillus fumigatus | 32.13 | 8e-08 | 58.5 |
| LLPS-Lem-0764 | Leptosphaeria maculans | 31.43 | 2e-07 | 57.0 |
| LLPS-Prp-0301 | Prunus persica | 31.28 | 5e-07 | 55.8 |
| LLPS-Nef-1278 | Neosartorya fischeri | 31.25 | 5e-08 | 58.9 |
| LLPS-Asf-1476 | Aspergillus flavus | 31.0 | 2e-07 | 57.4 |
| LLPS-Aso-0184 | Aspergillus oryzae | 31.0 | 2e-07 | 57.4 |
| LLPS-Ast-0855 | Aspergillus terreus | 30.4 | 5e-07 | 56.2 |
| LLPS-Asni-0143 | Aspergillus niger | 30.22 | 2e-07 | 57.8 |
| LLPS-Mae-0147 | Manihot esculenta | 30.13 | 4e-10 | 65.5 |
| LLPS-Asn-0081 | Aspergillus nidulans | 29.09 | 5e-07 | 56.2 |
| LLPS-Arl-0832 | Arabidopsis lyrata | 28.44 | 7e-07 | 55.5 |
| LLPS-Amt-1818 | Amborella trichopoda | 27.57 | 1e-05 | 52.0 |
| LLPS-Viv-0105 | Vitis vinifera | 27.54 | 3e-09 | 62.8 |