LLPS-Caf-a924
PC
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Pyruvate carboxylase |
| Gene Name: | PC |
| Ensembl Gene: | ENSCAFG00000012081.3 |
| Ensembl Protein: | ENSCAFP00000017923.3 |
| Organism: | Canis familiaris |
| Taxa ID: | 9615 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCAFT00000019325.3 | ENSCAFP00000017923.3 |
| UniProt | F1P6G9, F1P6G9_CANLF | |
| GeneBank | AAEX03011621, AAEX03011622 | |
| RefSeq | XM_005631416.2, XM_540825.5 | XP_005631473.1, XP_540825.2 |
| Entrez | 483704 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MLKFQTVRGG LRLLGIHRSS TAPAASPNVR RLEYKPIKKV MVANRGEIAI RVFRACTELG 60 61 IRTVAVYSEQ DTGQMHRQKA DEAYLIGRGL APVQAYLHIP DIIKVAKENN VDAVHPGYGF 120 121 LSERADFAQA CQDAGVRFIG PSPEVVRKMG DKVEARAIAI AAGVPVVPGT DAPITSLHEA 180 181 HEFSNTYGFP IIFKAAYGGG GRGMRVVHSY EELEESYNRA YSEALAAFGN GALFVEKFIE 240 241 KPRHIEVQIL GDQYGNILHL YERDCSIQRR HQKVVEIAPA AHLDPQLRTR LTSDSVKLAK 300 301 QVGYENAGTV EFLVDRHGRH YFIEVNSRLQ VEHTVTEEIT DVDLVHAQIH VAEGRSLPDL 360 361 GLRQENIRIN GCAIQCRVTT EDPARSFQPD TGRIEVFRSG EGMGIRLDNA SAFQGAVISP 420 421 HYDSLLVKVI AHGKDHPTAA TKMSRALAEF RVRGVKTNIP FLQNVLNNQQ FLAGTVDTQF 480 481 IDENPELFQL RPAQNRAQKL LHYLGHVMVN GPTTPIPVKA SPSPTDPVVP AVPIGPPPAG 540 541 FRDILLREGP EGFARAVRNH QGLLLMDTTF RDAHQSLLAT RVRTHDLKKI APYVAHNFSK 600 601 LFSIENWGGA TFDVAMRFLY ECPWRRLQEL RELIPNIPFQ MLLRGANAVG YTNYPDNVVF 660 661 KFCEVAKENG MDVFRVFDSL NYMPNLLLGM EAAGNAGGVV EAAISYTGDV ADPNRTKYSL 720 721 QYYMGLAEEL VRAGTHILCI KDMAGLLKPT ACTMLVSSLR DRFPDLPLHI HTHDTSGAGV 780 781 AAMLACAQAG ADVVDVASDS MSGMTSQPSM GALVACTRGT PLDTGVPLER VFDYSEYWEG 840 841 ARGLYAAFDC TATMKSGNSD VYENEIPGGQ YTNLHFQAHS MGLGSKFKEV KKAYVEANQM 900 901 LGDLIKVTPS SKIVGDLAQF MVQNGLSRAE AEAQAEELSF PRSVVEFLQG YIGIPHGGFP 960 961 EPLRSKVLKD LPRVEGRPGA SLPPLDLQLL EKELTERHGE EVTPEDVLSA AIYPDVFAHF 1020 1021 KDFTATFGPL DSLNTRLFLQ GPKIAEEFEV ELERGKTLHI KALAISDLNR AGQRQVFFEL 1080 1081 NGQLRSILVK DTQAMKEMHF HPKALKDVKG QIGAPMPGKV IDIKVAAGAK VAKGQPLCVL 1140 1141 SAMKMETVVT SPMEGTVRKV HVTTDMTLEG DDLILEIE 1178 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGCTGAAGT TCCAAACCGT CCGTGGGGGC CTGAGGCTCC TGGGTATCCA CCGAAGCTCC 60 61 ACTGCCCCTG CTGCCTCCCC AAATGTCCGG CGCCTGGAGT ACAAGCCCAT CAAGAAAGTT 120 121 ATGGTGGCCA ACAGAGGTGA GATTGCTATC CGTGTGTTCC GGGCCTGCAC AGAGCTGGGC 180 181 ATCCGCACTG TAGCTGTCTA CTCGGAGCAG GACACAGGCC AGATGCACCG GCAGAAAGCA 240 241 GATGAAGCCT ACCTCATCGG CCGCGGCCTT GCCCCAGTGC AGGCCTATCT GCACATCCCA 300 301 GACATCATCA AGGTGGCCAA GGAAAACAAT GTGGATGCAG TGCACCCTGG CTACGGGTTC 360 361 CTGTCAGAGC GAGCAGACTT TGCCCAAGCC TGCCAGGATG CAGGGGTTCG GTTTATTGGG 420 421 CCGAGCCCTG AGGTGGTCCG CAAGATGGGC GATAAGGTGG AGGCCCGGGC CATCGCCATT 480 481 GCTGCAGGTG TCCCTGTGGT CCCTGGCACA GATGCCCCCA TCACTTCCTT GCACGAGGCC 540 541 CATGAATTCT CTAACACCTA TGGCTTCCCC ATTATCTTCA AGGCCGCCTA TGGAGGTGGG 600 601 GGACGTGGCA TGAGGGTCGT GCACAGTTAT GAGGAGCTGG AGGAAAGCTA TAACCGGGCC 660 661 TACTCGGAGG CCCTGGCCGC CTTTGGGAAT GGGGCGCTGT TTGTGGAGAA GTTCATTGAG 720 721 AAGCCACGCC ACATCGAGGT GCAGATCCTG GGAGACCAGT ACGGGAATAT TCTGCACCTC 780 781 TATGAGCGAG ACTGTTCCAT CCAACGGCGG CACCAGAAAG TGGTTGAGAT TGCTCCTGCA 840 841 GCCCACCTGG ATCCCCAGCT TCGGACACGG CTCACCAGTG ACTCTGTCAA ACTTGCTAAG 900 901 CAGGTGGGCT ACGAGAACGC AGGCACGGTG GAGTTCCTGG TGGACCGGCA TGGCAGGCAC 960 961 TACTTCATCG AGGTCAACTC ACGCCTGCAG GTGGAGCACA CAGTCACCGA GGAGATCACA 1020 1021 GATGTGGATC TGGTTCACGC CCAGATCCAT GTGGCCGAGG GCCGGAGCCT GCCTGACCTG 1080 1081 GGCCTGCGGC AGGAGAATAT CCGTATCAAC GGTTGTGCCA TTCAGTGCCG GGTCACCACC 1140 1141 GAGGACCCTG CACGCAGCTT CCAGCCAGAC ACTGGCCGAA TCGAGGTGTT CCGGAGCGGA 1200 1201 GAGGGCATGG GCATCCGCCT GGATAATGCA TCTGCCTTCC AAGGAGCTGT CATCTCCCCG 1260 1261 CACTATGACT CCCTGCTCGT CAAAGTCATT GCTCATGGCA AAGACCACCC CACGGCCGCC 1320 1321 ACCAAGATGA GCAGAGCCCT TGCGGAGTTC CGAGTCCGAG GTGTAAAGAC CAACATCCCC 1380 1381 TTCCTGCAGA ATGTGCTCAA CAACCAGCAG TTCCTGGCAG GCACCGTGGA CACCCAGTTC 1440 1441 ATCGATGAGA ACCCGGAGCT TTTCCAGCTG CGGCCTGCGC AGAACCGGGC TCAGAAGCTG 1500 1501 CTGCACTACC TCGGTCATGT CATGGTGAAC GGACCAACCA CCCCAATCCC TGTCAAGGCC 1560 1561 AGCCCCAGCC CCACGGACCC TGTTGTCCCT GCGGTGCCCA TAGGCCCACC CCCAGCTGGT 1620 1621 TTCAGAGACA TCCTGCTGCG GGAGGGGCCT GAGGGCTTTG CTCGAGCTGT GAGGAACCAC 1680 1681 CAGGGGCTGC TGCTCATGGA CACAACCTTC AGGGATGCCC ACCAGTCGCT GCTGGCCACT 1740 1741 CGTGTGCGAA CCCATGATCT CAAAAAGATT GCCCCCTACG TTGCCCACAA CTTCAGCAAG 1800 1801 CTCTTCAGCA TAGAGAACTG GGGAGGAGCC ACGTTTGATG TTGCCATGCG CTTTCTGTAC 1860 1861 GAGTGCCCCT GGCGGCGGCT GCAGGAGCTC CGGGAGCTCA TCCCCAACAT CCCGTTTCAG 1920 1921 ATGCTGCTGC GGGGGGCCAA TGCTGTGGGC TACACCAACT ACCCTGACAA TGTGGTGTTC 1980 1981 AAGTTCTGTG AGGTAGCCAA GGAGAATGGC ATGGACGTCT TCCGGGTTTT TGACTCCCTC 2040 2041 AACTACATGC CAAATCTGCT ACTGGGCATG GAGGCTGCAG GCAATGCTGG TGGCGTGGTG 2100 2101 GAGGCTGCCA TCTCCTACAC TGGTGACGTG GCCGACCCCA ACCGCACCAA ATACTCACTG 2160 2161 CAGTACTACA TGGGCTTGGC GGAAGAGCTG GTGCGAGCTG GCACCCATAT CCTGTGTATC 2220 2221 AAGGACATGG CAGGGCTGCT AAAGCCTACA GCCTGCACCA TGCTGGTCAG CTCCCTCAGG 2280 2281 GACCGGTTCC CCGACCTTCC ACTGCACATC CACACCCATG ACACATCAGG GGCAGGTGTG 2340 2341 GCAGCTATGT TGGCCTGTGC CCAGGCTGGG GCTGATGTGG TAGATGTGGC ATCTGACTCC 2400 2401 ATGTCCGGGA TGACTTCACA GCCCAGCATG GGGGCCCTGG TGGCCTGCAC CCGAGGGACT 2460 2461 CCCCTGGACA CAGGGGTGCC CCTGGAACGT GTGTTTGACT ACAGTGAGTA CTGGGAGGGG 2520 2521 GCCCGGGGAT TGTATGCGGC CTTTGACTGC ACGGCCACCA TGAAGTCTGG CAATTCGGAC 2580 2581 GTGTATGAGA ACGAGATCCC AGGCGGCCAG TACACCAATC TGCACTTCCA GGCACACAGC 2640 2641 ATGGGGCTTG GCTCCAAGTT CAAGGAAGTC AAGAAGGCCT ATGTGGAGGC CAACCAGATG 2700 2701 CTGGGCGATC TCATCAAGGT GACCCCGTCC TCCAAGATCG TGGGCGACCT GGCCCAGTTC 2760 2761 ATGGTACAGA ATGGGCTGAG CCGGGCAGAG GCTGAAGCCC AGGCAGAAGA ATTGTCCTTC 2820 2821 CCCCGTTCCG TGGTGGAGTT CCTGCAGGGC TACATTGGCA TTCCCCACGG GGGCTTCCCT 2880 2881 GAGCCCCTTC GCTCTAAGGT GCTAAAGGAC CTGCCAAGGG TAGAAGGGCG GCCAGGAGCC 2940 2941 TCCCTCCCCC CACTGGATCT GCAGCTGCTG GAGAAGGAGC TGACTGAACG GCATGGGGAG 3000 3001 GAGGTGACCC CAGAAGATGT GCTCTCAGCA GCCATATATC CAGACGTCTT TGCCCACTTC 3060 3061 AAGGACTTCA CAGCTACCTT TGGCCCCCTG GATAGCCTCA ATACCCGCCT CTTCCTGCAG 3120 3121 GGACCCAAAA TTGCAGAGGA GTTTGAGGTG GAGCTGGAGC GGGGCAAGAC ACTGCACATC 3180 3181 AAGGCTCTGG CCATAAGTGA CCTGAACCGG GCTGGCCAGA GGCAGGTCTT CTTTGAGCTC 3240 3241 AATGGACAGC TGCGGTCCAT TCTGGTCAAG GACACTCAGG CCATGAAGGA AATGCACTTC 3300 3301 CACCCCAAGG CCCTGAAGGA TGTGAAGGGC CAGATTGGGG CACCCATGCC TGGGAAGGTG 3360 3361 ATAGACATCA AGGTGGCAGC TGGGGCCAAG GTGGCCAAGG GCCAGCCCCT CTGTGTGCTC 3420 3421 AGTGCCATGA AGATGGAGAC TGTGGTGACT TCACCCATGG AGGGCACTGT CCGCAAGGTC 3480 3481 CACGTAACCA CAGACATGAC ACTGGAGGGC GATGACCTCA TCCTGGAGAT TGAGTGA 3537 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Mitochondrion | |
Molecular Function | ATP binding | |
Molecular Function | Biotin binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Pyruvate carboxylase activity | |
Biological Process | Gluconeogenesis | |
Biological Process | Pyruvate metabolic process |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a962 | Homo sapiens | 0.0 | 2389 | undefined |
| LLPS-Mum-a947 | Mus musculus | 0.0 | 2361 | undefined |