• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-4493
ATP2B3

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Calcium-transporting ATPase
Gene Name: ATP2B3
Ensembl Gene: ENSCAFG00000019230.3
Ensembl Protein: ENSCAFP00000028368.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: Others


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSCAFT00000030531.3ENSCAFP00000028368.3
UniProtE2R4W3, E2R4W3_CANLF
GeneBankAAEX03027078

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGDMANSSIE  FHPKPQQQRE  APHAGGFGCT  LAELRSLMEL  RGAEALQKVQ  EAYGDVSGLC  60
61    RRLKTSPTEG  LANNANDLEK  RRQIYGQNFI  PPKQPKTFLQ  LVWEALQDVT  LIILEVAAIV  120
121   SLGLSFYAPP  GEESEACGNV  SAGAEDEGEA  EAGWIEGAAI  LLSVTCVVLV  TAFNDWSKER  180
181   QFRGLQSRIE  QEQRFSVIRD  GQLLQVPVAA  LVVGDIAQVK  YGDLLPADGV  LIQGNDLKID  240
241   ESSLTGESDH  VRKSADKDPM  LLSGTHVMEG  SGRMVVTAVG  VNSQTGIIFT  LLGAGGEEEE  300
301   KKDKKGKQQD  GAMESSQTKA  KKQDGAVAME  MQPLKSAEGG  EMEEREKKKA  SVPKKEKSVL  360
361   QGKLTKLAVQ  IGKAGLVMSA  ITVIILVLYF  VIETFVVDGR  VWLAECTPVY  VQYFVKFFII  420
421   GVTVLVVAVP  EGLPLAVTIS  LAYSVKKMMR  DNNLVRHLDA  CETMGNATAI  CSDKTGTLTT  480
481   NRMTVVQSYL  GDTHYKEVPA  PSTLTPKILD  LLVHAISINS  AYTTKILPPE  KEGALPRQVG  540
541   NKTECALLGF  VLDLKRDFQP  VREQIPEDKL  YKVYTFNSVR  KSMSTVIRMP  DGGFRLFSKG  600
601   ASEILLKKCS  NILNSHGELR  GFRPRDRDDM  VKKIIEPMAC  DGLRTICIAY  RDFAAAQEPD  660
661   WDNENEVVGD  LTCIAVVGIE  DPVRPEVPEA  IRKCQRAGIT  VRMVTGDNIN  TARAIAAKCG  720
721   IIQPGEDFLC  LEGKEFNRRI  RNEKGEIEQE  RLDKVWPKLR  VLARSSPTDK  HTLVKGIIDS  780
781   NTGEQRQVVA  VTGDGTNDGP  ALKKADVGFA  MGIAGTDVAK  EASDIILTDD  NFTSIVKAVM  840
841   WGRNVYDSIS  KFLQFQLTVN  VVAVIVAFTG  ACITQDSPLK  AVQMLWVNLI  MDTFASLALA  900
901   TEPPTEALLL  RKPYGRDKPL  ISRTMMKNIL  GHAVYQLTII  FTLLFVGELF  FDIDSGRNAP  960
961   LHSPPSEHYT  IIFNTFVMMQ  LFNEINARKI  HGERNVFHGI  FSNPIFCTIV  LGTFAIQIVI  1020
1021  VQFGGKPFSC  SPLSTEQWLW  CLFVGVGELV  WGQVIATIPT  SQLKCLKEAG  HGPGKDEMTD  1080
1081  EELAEGEEEI  DHAERELRRG  QILWFRGLNR  IQTQMEVVST  FKRSASFQGA  VRRRSSVLSQ  1140
1141  LHDVTNLSTP  THIRVVKAFR  SSLYEGLEKP  ESKTSIHNFM  ATPEFLINDY  THNIPLIDDT  1200
1201  DVDENEERLR  APPPPSPNQN  NNAIDSGIYL  STHGTKSATS  SVLSSRPGSP  LHSVETSL  1258
Nucleotide CDS Sequence (FASTA)
1     ATGGGCGACA  TGGCCAACAG  TTCCATCGAG  TTCCACCCCA  AGCCCCAACA  GCAGCGGGAG  60
61    GCCCCCCATG  CCGGCGGCTT  CGGGTGCACA  CTGGCTGAGC  TGCGCTCCCT  CATGGAGCTC  120
121   CGAGGAGCCG  AAGCGCTGCA  GAAGGTCCAG  GAAGCCTACG  GCGACGTCAG  TGGGCTTTGC  180
181   AGGAGGCTGA  AGACCTCGCC  CACAGAGGGC  CTGGCCAACA  ATGCCAACGA  CCTGGAGAAG  240
241   CGCAGGCAGA  TCTACGGGCA  GAACTTCATC  CCCCCCAAGC  AGCCCAAGAC  CTTCCTGCAG  300
301   CTGGTGTGGG  AGGCCCTGCA  GGACGTGACC  CTCATCATCC  TCGAGGTGGC  CGCCATCGTG  360
361   TCCCTGGGCC  TGTCATTCTA  CGCGCCGCCC  GGAGAGGAGA  GCGAAGCGTG  CGGGAACGTG  420
421   TCAGCGGGGG  CAGAGGACGA  AGGGGAGGCC  GAGGCGGGCT  GGATCGAGGG  AGCCGCCATC  480
481   CTGCTGTCGG  TCACCTGCGT  GGTGCTGGTC  ACGGCCTTCA  ACGACTGGAG  CAAGGAGAGG  540
541   CAGTTCCGGG  GCCTGCAGAG  CCGCATCGAG  CAGGAGCAGA  GGTTCTCCGT  CATCCGGGAT  600
601   GGCCAGCTGC  TGCAGGTCCC  CGTGGCCGCG  CTGGTGGTGG  GAGACATCGC  CCAGGTCAAG  660
661   TACGGAGACC  TGCTGCCTGC  TGACGGCGTG  CTCATCCAAG  GCAACGACCT  CAAGATCGAC  720
721   GAGAGCTCCC  TGACAGGCGA  GTCAGACCAC  GTGCGCAAAT  CAGCTGACAA  GGACCCCATG  780
781   CTGCTCTCAG  GTACTCATGT  CATGGAAGGT  TCTGGAAGAA  TGGTGGTGAC  TGCCGTTGGT  840
841   GTGAACTCCC  AGACAGGCAT  CATCTTTACC  TTGCTCGGAG  CCGGTGGAGA  GGAGGAGGAG  900
901   AAGAAGGATA  AGAAAGGCAA  GCAGCAGGAC  GGGGCGATGG  AGAGTAGCCA  GACCAAAGCT  960
961   AAGAAGCAGG  ACGGGGCGGT  GGCCATGGAA  ATGCAGCCCC  TGAAGAGCGC  GGAGGGCGGG  1020
1021  GAGATGGAGG  AACGGGAGAA  GAAGAAAGCC  AGCGTGCCCA  AGAAGGAGAA  GTCGGTCCTG  1080
1081  CAGGGCAAGC  TCACCAAGCT  GGCGGTGCAG  ATCGGGAAAG  CAGGGCTGGT  GATGTCTGCC  1140
1141  ATCACTGTCA  TCATCCTGGT  CCTCTACTTT  GTGATCGAGA  CCTTCGTCGT  GGACGGCCGA  1200
1201  GTGTGGCTGG  CGGAGTGCAC  GCCCGTCTAC  GTGCAGTACT  TTGTGAAGTT  TTTCATCATC  1260
1261  GGTGTCACTG  TGCTGGTCGT  GGCCGTCCCG  GAGGGCCTGC  CTCTGGCTGT  CACCATCTCC  1320
1321  TTAGCCTACT  CGGTCAAGAA  AATGATGAGG  GACAACAACC  TGGTCCGCCA  CCTGGATGCC  1380
1381  TGCGAGACCA  TGGGCAACGC  CACAGCCATC  TGCTCGGACA  AGACCGGCAC  ACTCACCACC  1440
1441  AACCGTATGA  CCGTGGTCCA  GTCCTACCTC  GGGGACACCC  ACTACAAGGA  GGTTCCAGCC  1500
1501  CCCAGCACCC  TGACCCCCAA  GATCCTCGAC  CTCCTGGTCC  ACGCCATCTC  CATCAACAGT  1560
1561  GCCTACACCA  CGAAAATACT  ACCTCCAGAG  AAGGAAGGCG  CGCTCCCACG  CCAGGTGGGC  1620
1621  AACAAGACGG  AGTGTGCCCT  GCTGGGCTTT  GTCCTGGACC  TGAAGCGGGA  CTTCCAGCCT  1680
1681  GTGCGGGAGC  AGATTCCAGA  AGACAAGCTC  TACAAAGTGT  ACACCTTCAA  CTCCGTCCGC  1740
1741  AAGTCCATGA  GCACAGTCAT  CCGCATGCCT  GACGGCGGCT  TCCGCCTCTT  CAGCAAGGGC  1800
1801  GCCTCGGAGA  TCCTGCTGAA  AAAGTGCAGC  AACATCTTAA  ACAGCCACGG  TGAACTGCGT  1860
1861  GGCTTTCGCC  CCCGGGACCG  GGATGACATG  GTGAAGAAGA  TCATCGAGCC  CATGGCCTGC  1920
1921  GACGGCCTGC  GCACTATATG  TATTGCCTAC  CGGGACTTTG  CCGCGGCTCA  GGAGCCCGAC  1980
1981  TGGGACAACG  AGAACGAGGT  CGTGGGCGAC  CTCACCTGCA  TAGCCGTCGT  GGGCATCGAG  2040
2041  GACCCCGTGC  GGCCCGAGGT  CCCTGAGGCC  ATCCGCAAAT  GCCAGCGTGC  TGGCATCACG  2100
2101  GTCCGCATGG  TGACTGGAGA  CAACATCAAC  ACGGCCCGGG  CCATCGCGGC  CAAGTGCGGC  2160
2161  ATCATCCAGC  CTGGGGAGGA  CTTCCTGTGC  CTGGAGGGGA  AGGAGTTCAA  CCGGCGGATC  2220
2221  CGCAATGAGA  AAGGCGAGAT  AGAGCAGGAG  CGGCTGGACA  AGGTGTGGCC  CAAGCTGAGG  2280
2281  GTCCTCGCCC  GATCGTCTCC  CACCGACAAG  CACACCCTGG  TCAAAGGCAT  CATCGACAGC  2340
2341  AACACGGGCG  AGCAGCGGCA  GGTGGTGGCC  GTGACCGGGG  ACGGCACCAA  CGACGGGCCA  2400
2401  GCCCTCAAAA  AGGCAGATGT  GGGCTTCGCC  ATGGGCATCG  CAGGGACTGA  CGTGGCCAAG  2460
2461  GAGGCCTCGG  ACATCATCCT  GACCGATGAC  AACTTCACCA  GCATCGTCAA  GGCGGTCATG  2520
2521  TGGGGACGCA  ACGTGTACGA  CAGCATCTCC  AAGTTCCTGC  AGTTCCAGCT  GACGGTCAAC  2580
2581  GTGGTGGCCG  TGATCGTGGC  CTTCACCGGC  GCCTGCATCA  CTCAGGACTC  TCCCCTCAAA  2640
2641  GCCGTGCAGA  TGTTGTGGGT  GAACCTGATC  ATGGACACGT  TCGCCTCTCT  GGCCCTGGCC  2700
2701  ACGGAGCCAC  CGACCGAGGC  ACTGCTGCTG  CGGAAACCGT  ACGGCCGCGA  CAAGCCCCTG  2760
2761  ATCTCTCGCA  CCATGATGAA  GAACATTCTG  GGCCACGCAG  TGTACCAGCT  CACCATCATC  2820
2821  TTCACGCTGC  TGTTCGTCGG  GGAGCTCTTC  TTTGACATCG  ACAGCGGGAG  GAACGCACCC  2880
2881  CTGCACTCCC  CACCCTCCGA  GCACTACACC  ATCATCTTCA  ACACCTTCGT  CATGATGCAG  2940
2941  CTCTTCAACG  AGATCAATGC  CCGCAAGATC  CATGGTGAGC  GGAACGTCTT  CCATGGCATC  3000
3001  TTCAGCAACC  CCATCTTCTG  CACCATCGTC  CTGGGCACCT  TTGCAATTCA  GATTGTCATC  3060
3061  GTCCAGTTCG  GTGGAAAGCC  CTTCAGCTGC  TCCCCCCTGT  CCACGGAGCA  GTGGCTCTGG  3120
3121  TGCCTGTTCG  TTGGCGTTGG  GGAGCTGGTC  TGGGGACAGG  TCATCGCCAC  CATCCCCACC  3180
3181  AGCCAGCTCA  AGTGCCTGAA  GGAAGCAGGG  CACGGGCCCG  GGAAGGATGA  GATGACCGAC  3240
3241  GAGGAGCTGG  CCGAGGGGGA  GGAAGAGATC  GACCATGCCG  AGCGGGAGCT  CCGCCGCGGC  3300
3301  CAGATCCTCT  GGTTCCGGGG  CCTCAATCGG  ATTCAGACGC  AGATGGAGGT  AGTGAGTACC  3360
3361  TTCAAGAGAA  GCGCTTCATT  TCAGGGTGCC  GTGCGCCGGA  GGTCCTCGGT  CCTCAGCCAG  3420
3421  CTCCATGACG  TAACCAATCT  TTCTACCCCT  ACTCACATCC  GGGTGGTGAA  AGCATTCCGT  3480
3481  AGCTCGCTCT  ACGAAGGCCT  GGAGAAACCC  GAATCCAAGA  CGTCCATTCA  TAACTTCATG  3540
3541  GCGACGCCCG  AGTTTCTGAT  CAACGACTAC  ACCCACAACA  TCCCACTCAT  CGATGACACG  3600
3601  GACGTGGACG  AGAACGAGGA  GCGCCTGCGG  GCCCCCCCGC  CCCCGTCCCC  CAACCAGAAC  3660
3661  AACAACGCCA  TAGACAGCGG  CATCTACCTG  AGCACGCACG  GCACCAAGTC  AGCTACCTCG  3720
3721  TCAGTGCTTT  CTTCCAGACC  GGGGAGCCCC  CTCCACAGCG  TGGAGACGTC  CCTCTAG  3777

▼ KEYWORD

ID
Family
ATP-binding
Calcium
Calcium transport
Coiled coil
Complete proteome
Ion transport
Membrane
Nucleotide-binding
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
GABA-ergic synapse
Cellular Component
Glutamatergic synapse
Cellular Component
Golgi apparatus
Cellular Component
Integral component of plasma membrane
Cellular Component
Presynapse
Molecular Function
ATP binding
Molecular Function
Calcium-transporting ATPase activity
Molecular Function
Calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration
Molecular Function
PDZ domain binding
Biological Process
Calcium ion export across plasma membrane
Biological Process
Cellular calcium ion homeostasis
Biological Process
Regulation of cytosolic calcium ion concentration

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-3931Ailuropoda melanoleuca97.70.02326
LLPS-Myl-0465Myotis lucifugus97.540.02303
LLPS-Cas-3607Carlito syrichta97.30.02284
LLPS-Ran-0761Rattus norvegicus97.140.02293
LLPS-Chs-3120Chlorocebus sabaeus96.960.02107
LLPS-Otg-3661Otolemur garnettii96.660.02251
LLPS-Orc-0948Oryctolagus cuniculus96.560.01872
LLPS-Mea-3633Mesocricetus auratus96.550.02103
LLPS-Sus-2105Sus scrofa96.370.02200
LLPS-Nol-1203Nomascus leucogenys96.20.0 871
LLPS-Caj-1158Callithrix jacchus96.10.02241
LLPS-Fec-2088Felis catus96.030.02233
LLPS-Fud-3196Fukomys damarensis95.320.02228
LLPS-Mup-3286Mustela putorius furo95.230.02218
LLPS-Eqc-1617Equus caballus94.990.02197
LLPS-Bot-1171Bos taurus94.830.02215
LLPS-Mum-4049Mus musculus94.120.02196
LLPS-Cea-3115Cercocebus atys94.120.02174
LLPS-Pap-4074Pan paniscus93.960.02167
LLPS-Pat-3008Pan troglodytes93.960.02167
LLPS-Hos-1639Homo sapiens93.960.02167
LLPS-Ict-2190Ictidomys tridecemlineatus93.960.02191
LLPS-Gog-2296Gorilla gorilla93.960.02167
LLPS-Mal-1854Mandrillus leucophaeus93.880.02171
LLPS-Rhb-1635Rhinopithecus bieti93.80.02169
LLPS-Man-3519Macaca nemestrina93.640.02160
LLPS-Ora-0902Ornithorhynchus anatinus93.410.02025
LLPS-Maf-2469Macaca fascicularis93.320.02155
LLPS-Paa-3693Papio anubis93.240.02157
LLPS-Cap-4095Cavia porcellus93.120.02172
LLPS-Poa-0530Pongo abelii92.450.01966
LLPS-Mam-3047Macaca mulatta92.250.02131
LLPS-Aon-0404Aotus nancymaae92.080.02146
LLPS-Loa-0745Loxodonta africana91.760.02100
LLPS-Anc-4020Anolis carolinensis91.670.01988
LLPS-Sah-3559Sarcophilus harrisii90.30.02122
LLPS-Lac-3651Latimeria chalumnae88.220.02026
LLPS-Mod-0110Monodelphis domestica85.490.02006
LLPS-Urm-1927Ursus maritimus85.270.01983
LLPS-Leo-1517Lepisosteus oculatus83.770.02019
LLPS-Asm-2279Astyanax mexicanus80.910.01875
LLPS-Icp-3199Ictalurus punctatus80.650.01877
LLPS-Scm-1150Scophthalmus maximus79.950.01814
LLPS-Meg-0867Meleagris gallopavo79.760.01749
LLPS-Scf-4079Scleropages formosus79.210.01840
LLPS-Xim-1285Xiphophorus maculatus78.730.01698
LLPS-Pes-2257Pelodiscus sinensis78.180.01743
LLPS-Xet-0723Xenopus tropicalis77.950.01868
LLPS-Pof-1037Poecilia formosa77.830.01719
LLPS-Ova-3677Ovis aries77.530.01827
LLPS-Anp-3178Anas platyrhynchos77.380.01843
LLPS-Gaga-3767Gallus gallus76.880.01828
LLPS-Dio-3173Dipodomys ordii76.60.01051
LLPS-Dar-2802Danio rerio76.320.01823
LLPS-Tar-2285Takifugu rubripes75.690.01751
LLPS-Ten-2887Tetraodon nigroviridis73.80.01463
LLPS-Orn-0471Oreochromis niloticus73.240.01731
LLPS-Orl-0652Oryzias latipes69.560.01600
LLPS-Cae-1362Caenorhabditis elegans57.790.01216
LLPS-Glm-1831Glycine max47.085e-175 552
LLPS-Tra-2133Triticum aestivum46.846e-171 541
LLPS-Prp-2328Prunus persica46.783e-177 558
LLPS-Hov-2082Hordeum vulgare46.496e-173 547
LLPS-Via-0301Vigna angularis46.313e-172 545
LLPS-Nia-0923Nicotiana attenuata46.192e-168 535
LLPS-Met-0822Medicago truncatula45.942e-178 561
LLPS-Arl-1793Arabidopsis lyrata45.836e-180 566
LLPS-Zem-2525Zea mays45.725e-170 540
LLPS-Orb-1712Oryza barthii45.662e-167 532
LLPS-Thc-0051Theobroma cacao45.573e-173 548
LLPS-Vir-1376Vigna radiata45.434e-179 563
LLPS-Brd-2332Brachypodium distachyon45.37e-173 548
LLPS-Cus-0835Cucumis sativus45.223e-173 548
LLPS-Art-2143Arabidopsis thaliana45.182e-177 559
LLPS-Ors-0474Oryza sativa45.092e-167 532
LLPS-Bro-0717Brassica oleracea44.843e-177 557
LLPS-Orr-0922Oryza rufipogon44.822e-166 530
LLPS-Ori-2085Oryza indica44.828e-167 531
LLPS-Orni-2411Oryza nivara44.821e-166 530
LLPS-Orbr-2081Oryza brachyantha44.62e-166 530
LLPS-Brn-0676Brassica napus44.68e-176 555
LLPS-Phv-1661Phaseolus vulgaris44.552e-176 556
LLPS-Amt-1678Amborella trichopoda44.521e-177 560
LLPS-Dac-1456Daucus carota44.411e-174 551
LLPS-Org-0542Oryza glaberrima44.213e-174 551
LLPS-Brr-2183Brassica rapa44.194e-173 547
LLPS-Sem-2021Selaginella moellendorffii44.189e-172 545
LLPS-Pot-1751Populus trichocarpa44.041e-171 543
LLPS-Mae-1730Manihot esculenta43.674e-170 540
LLPS-Lep-2110Leersia perrieri43.561e-169 538
LLPS-Sei-2397Setaria italica43.541e-173 549
LLPS-Sol-2464Solanum lycopersicum43.461e-171 544
LLPS-Sot-1750Solanum tuberosum43.442e-171 544
LLPS-Gor-2334Gossypium raimondii43.425e-168 534
LLPS-Viv-1569Vitis vinifera43.419e-177 558
LLPS-Hea-0299Helianthus annuus43.334e-176 556
LLPS-Tru-0081Triticum urartu42.982e-168 534
LLPS-Orgl-1827Oryza glumaepatula42.926e-167 531
LLPS-Sob-1596Sorghum bicolor42.786e-174 550
LLPS-Cog-1352Colletotrichum gloeosporioides39.630.0 622
LLPS-Phn-1208Phaeosphaeria nodorum39.260.0 599
LLPS-Gag-1451Gaeumannomyces graminis38.990.0 594
LLPS-Nec-1402Neurospora crassa38.890.0 612
LLPS-Mao-0479Magnaporthe oryzae38.370.0 595
LLPS-Map-1402Magnaporthe poae38.260.0 587