LLPS-Caf-4071
HOXA9
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Homeobox protein |
| Gene Name: | HOXA9 |
| Ensembl Gene: | ENSCAFG00000002961.2 |
| Ensembl Protein: | ENSCAFP00000004393.1 |
| Organism: | Canis familiaris |
| Taxa ID: | 9615 |
| LLPS Type: | Regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Insulator body | Predicted from orthologs | (View) |
▼ FUNCTION
| Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCAFT00000004746.1 | ENSCAFP00000004393.1 |
| UniProt | E2R520, E2R520_CANLF | |
| GeneBank | AAEX03009390 | |
| RefSeq | XM_539489.5 | XP_539489.2 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MATTGALGNY YVDSFLLGAD AADELGAGRY APGALGQPPR QATALAEHPD FSPCSFQSKA 60 61 AVFGASWNPV HAAGANAVPA AVYHHHHHHP YVHPQAPVAA AAPDGRYMRS WLEPTPGALS 120 121 FAGLPSSRPY GIKPEPLSAR RGDCPTLDTH TLSLTDYACG SPPVDREKQP SEGAFSENNA 180 181 ENESGGDKPP IDPSNPAANW LHARSTRKKR CPYTKHQTLE LEKEFLFNMY LTRDRRYEVA 240 241 RLLNLTERQV KIWFQNRRMK MKKINKDRAK DE 272 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCCACCA CCGGGGCCCT GGGCAACTAC TACGTGGACT CGTTCCTGCT GGGCGCCGAC 60 61 GCTGCGGACG AGCTGGGCGC GGGCCGCTAC GCGCCGGGGG CCCTGGGTCA GCCTCCCCGG 120 121 CAGGCCACCG CGCTGGCGGA ACACCCCGAC TTCAGCCCGT GCAGCTTCCA GTCCAAGGCG 180 181 GCGGTGTTCG GCGCCTCGTG GAACCCGGTG CACGCGGCGG GCGCCAACGC GGTGCCCGCT 240 241 GCCGTGTACC ACCACCATCA CCACCACCCC TACGTGCACC CCCAGGCGCC CGTGGCGGCG 300 301 GCGGCGCCGG ACGGCAGGTA CATGCGCTCC TGGCTGGAGC CCACGCCCGG CGCGCTCTCC 360 361 TTCGCGGGCT TGCCCTCCAG CCGGCCTTAC GGCATTAAAC CTGAACCACT GTCCGCCAGA 420 421 AGGGGTGACT GTCCCACGCT TGACACTCAC ACTTTGTCCC TGACTGACTA TGCTTGTGGT 480 481 TCTCCTCCAG TTGATAGAGA AAAACAGCCC AGCGAAGGCG CCTTCTCCGA AAACAATGCT 540 541 GAGAATGAGA GCGGCGGAGA CAAGCCCCCC ATCGATCCCA GCAACCCTGC TGCCAATTGG 600 601 CTCCATGCGC GCTCCACGAG AAAGAAGCGC TGCCCCTACA CCAAACACCA GACGCTGGAA 660 661 CTGGAGAAAG AGTTTCTGTT CAACATGTAC CTTACCAGGG ACCGCAGGTA CGAGGTGGCC 720 721 CGACTGCTCA ACCTCACCGA GAGGCAGGTG AAGATCTGGT TTCAGAACCG CAGGATGAAA 780 781 ATGAAGAAAA TCAACAAGGA CCGGGCAAAA GACGAGTGA 819 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Nucleus | |
Cellular Component | Transcription factor complex | |
Molecular Function | Enzyme binding | |
Molecular Function | RNA polymerase II proximal promoter sequence-specific DNA binding | |
Biological Process | Anterior/posterior pattern specification | |
Biological Process | Definitive hemopoiesis | |
Biological Process | Embryonic forelimb morphogenesis | |
Biological Process | Embryonic skeletal system development | |
Biological Process | Endothelial cell activation | |
Biological Process | Male gonad development | |
Biological Process | Mammary gland development | |
Biological Process | Negative regulation of myeloid cell differentiation | |
Biological Process | Positive regulation of transcription by RNA polymerase II | |
Biological Process | Proximal/distal pattern formation | |
Biological Process | Single fertilization | |
Biological Process | Spermatogenesis | |
Biological Process | Transcription, DNA-templated | |
Biological Process | Uterus development |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fec-2384 | Felis catus | 100.0 | 1e-157 | 447 |
| LLPS-Urm-0565 | Ursus maritimus | 99.63 | 5e-157 | 445 |
| LLPS-Sus-0630 | Sus scrofa | 99.26 | 5e-157 | 446 |
| LLPS-Aim-0963 | Ailuropoda melanoleuca | 99.26 | 4e-156 | 443 |
| LLPS-Ova-3746 | Ovis aries | 98.9 | 2e-156 | 444 |
| LLPS-Bot-1131 | Bos taurus | 98.9 | 3e-156 | 444 |
| LLPS-Eqc-3782 | Equus caballus | 98.9 | 7e-155 | 440 |
| LLPS-Poa-0483 | Pongo abelii | 98.17 | 6e-72 | 225 |
| LLPS-Cea-0128 | Cercocebus atys | 98.16 | 2e-155 | 441 |
| LLPS-Maf-2411 | Macaca fascicularis | 98.16 | 2e-155 | 441 |
| LLPS-Mal-3900 | Mandrillus leucophaeus | 98.16 | 2e-155 | 441 |
| LLPS-Man-3313 | Macaca nemestrina | 98.16 | 2e-155 | 441 |
| LLPS-Chs-1446 | Chlorocebus sabaeus | 97.79 | 3e-155 | 441 |
| LLPS-Rhb-1156 | Rhinopithecus bieti | 97.79 | 1e-154 | 439 |
| LLPS-Fud-0652 | Fukomys damarensis | 97.63 | 4e-118 | 345 |
| LLPS-Paa-0462 | Papio anubis | 97.43 | 5e-154 | 438 |
| LLPS-Hos-2149 | Homo sapiens | 97.43 | 1e-154 | 439 |
| LLPS-Nol-2623 | Nomascus leucogenys | 97.43 | 7e-153 | 435 |
| LLPS-Pap-2104 | Pan paniscus | 97.06 | 1e-154 | 439 |
| LLPS-Cap-0603 | Cavia porcellus | 97.06 | 3e-152 | 433 |
| LLPS-Gog-0842 | Gorilla gorilla | 96.69 | 9e-153 | 435 |
| LLPS-Otg-0134 | Otolemur garnettii | 96.69 | 3e-153 | 436 |
| LLPS-Pat-0037 | Pan troglodytes | 96.69 | 2e-154 | 439 |
| LLPS-Mup-1526 | Mustela putorius furo | 95.22 | 6e-156 | 443 |
| LLPS-Tut-1524 | Tursiops truncatus | 95.16 | 7e-34 | 129 |
| LLPS-Mum-3622 | Mus musculus | 94.49 | 4e-154 | 438 |
| LLPS-Ran-0281 | Rattus norvegicus | 94.49 | 1e-153 | 437 |
| LLPS-Sah-1097 | Sarcophilus harrisii | 94.03 | 5e-36 | 135 |
| LLPS-Ict-3341 | Ictidomys tridecemlineatus | 93.41 | 7e-154 | 437 |
| LLPS-Mea-3069 | Mesocricetus auratus | 93.38 | 2e-153 | 436 |
| LLPS-Caj-4344 | Callithrix jacchus | 92.65 | 2e-153 | 436 |
| LLPS-Aon-4175 | Aotus nancymaae | 92.65 | 7e-38 | 142 |
| LLPS-Ere-0467 | Erinaceus europaeus | 92.65 | 4e-38 | 142 |
| LLPS-Mod-2391 | Monodelphis domestica | 92.65 | 2e-35 | 135 |
| LLPS-Dio-3014 | Dipodomys ordii | 91.94 | 2e-150 | 429 |
| LLPS-Ora-2732 | Ornithorhynchus anatinus | 91.89 | 4e-41 | 150 |
| LLPS-Orc-2590 | Oryctolagus cuniculus | 90.94 | 1e-146 | 419 |
| LLPS-Meg-2757 | Meleagris gallopavo | 89.78 | 3e-87 | 263 |
| LLPS-Anp-0343 | Anas platyrhynchos | 88.17 | 6e-108 | 317 |
| LLPS-Anc-3091 | Anolis carolinensis | 78.87 | 4e-33 | 130 |
| LLPS-Mam-2560 | Macaca mulatta | 78.87 | 5e-33 | 129 |
| LLPS-Pes-1859 | Pelodiscus sinensis | 78.57 | 4e-89 | 269 |
| LLPS-Fia-1599 | Ficedula albicollis | 76.17 | 5e-115 | 337 |
| LLPS-Gaga-0429 | Gallus gallus | 72.06 | 2e-116 | 342 |
| LLPS-Tag-0975 | Taeniopygia guttata | 71.69 | 1e-115 | 340 |
| LLPS-Cis-0378 | Ciona savignyi | 70.49 | 1e-20 | 92.0 |
| LLPS-Orn-3613 | Oreochromis niloticus | 70.0 | 2e-20 | 92.4 |
| LLPS-Loa-1750 | Loxodonta africana | 68.55 | 1e-103 | 311 |
| LLPS-Lac-3342 | Latimeria chalumnae | 67.03 | 2e-115 | 339 |
| LLPS-Icp-0604 | Ictalurus punctatus | 66.67 | 3e-20 | 92.0 |
| LLPS-Myl-3266 | Myotis lucifugus | 66.67 | 2e-20 | 91.7 |
| LLPS-Xet-0362 | Xenopus tropicalis | 66.67 | 7e-112 | 330 |
| LLPS-Cas-3110 | Carlito syrichta | 66.67 | 2e-20 | 91.7 |
| LLPS-Ten-0722 | Tetraodon nigroviridis | 66.67 | 2e-20 | 91.3 |
| LLPS-Drm-0114 | Drosophila melanogaster | 63.51 | 1e-21 | 98.2 |
| LLPS-Cae-1525 | Caenorhabditis elegans | 62.32 | 4e-21 | 94.4 |
| LLPS-Xim-4097 | Xiphophorus maculatus | 61.33 | 1e-20 | 89.4 |
| LLPS-Scf-3751 | Scleropages formosus | 53.28 | 5e-77 | 242 |
| LLPS-Pof-2749 | Poecilia formosa | 51.65 | 2e-64 | 208 |
| LLPS-Orl-2950 | Oryzias latipes | 51.09 | 3e-66 | 214 |
| LLPS-Scm-2490 | Scophthalmus maximus | 51.09 | 1e-69 | 222 |
| LLPS-Tar-3386 | Takifugu rubripes | 50.0 | 8e-70 | 223 |
| LLPS-Leo-2545 | Lepisosteus oculatus | 49.27 | 2e-76 | 240 |
| LLPS-Asm-3686 | Astyanax mexicanus | 48.7 | 1e-72 | 230 |
| LLPS-Gaa-3353 | Gasterosteus aculeatus | 47.71 | 1e-58 | 194 |
| LLPS-Dar-3213 | Danio rerio | 47.43 | 2e-70 | 224 |