• Disorder
  • Domain
  • PTM
  • Variation
  • Mutation
  • Interaction
  • Disease
  • Drug
  • Physicochemical
  • Function
  • Proteomics
  • Structure
  • Localization
  • Expression
  • Element
  • Methylation

LLPS-Caf-2703
BCCIP

Integrated Annotations

▼ OVERVIEW


Status: Unreviewed
Protein Name: BRCA2 and CDKN1A-interacting protein
Gene Name: BCCIP
Ensembl Gene: ENSCAFG00000012873.3
Ensembl Protein: ENSCAFP00000018957.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: Others


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION


May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MASRPKRRAV  GSAAPQPPGG  LAVRAEEEEE  DGVEDEDEDE  EDSDEDEDED  DESVDEEVNV  60
61    EFEAYSISDK  DHDGIKKLLQ  QLFLKAPVNT  AELTDLLIQQ  NHIGSVIKQT  DVSEDSDDDV  120
121   DEDEIFGFIS  LLNLTERKGT  QCVEQIKELI  LSSCEKNCGK  SLVEQLDTLL  NDNSKPVGFL  180
181   LSERFINVPP  QIALPMHQQL  QKELAEAHKT  NKPCGKCYFY  LLISKTFVEA  GKNSKKKGSN  240
241   QEEKEELMFA  NAEEEFFYEK  AILKFSYSVQ  EESDTRLGGR  WSFDDVPMKP  LRTVMLIPGD  300
301   RMDEIMDRLK  EHLSV  315
Nucleotide CDS Sequence (FASTA)
1     ATGGCGTCCA  GGCCCAAGCG  GCGCGCGGTG  GGCAGCGCGG  CTCCGCAGCC  CCCGGGCGGC  60
61    CTGGCAGTGC  GCGCCGAGGA  GGAAGAGGAA  GACGGAGTGG  AAGATGAGGA  CGAAGACGAG  120
121   GAAGACAGCG  ACGAAGACGA  GGATGAAGAC  GACGAGAGCG  TCGACGAGGA  AGTGAATGTT  180
181   GAATTTGAAG  CTTATTCCAT  CTCTGACAAG  GATCATGACG  GAATTAAGAA  GTTATTGCAA  240
241   CAGCTTTTCC  TAAAGGCTCC  TGTGAACACT  GCAGAACTAA  CTGATCTCTT  AATTCAACAA  300
301   AACCATATTG  GGAGTGTGAT  AAAGCAGACG  GATGTTTCAG  AAGACAGCGA  TGACGATGTG  360
361   GATGAAGATG  AGATTTTTGG  GTTCATAAGT  CTTTTAAATT  TAACTGAAAG  AAAGGGAACC  420
421   CAGTGTGTTG  AACAAATTAA  AGAGCTGATC  CTGAGCTCCT  GTGAGAAGAA  CTGTGGAAAG  480
481   AGTTTGGTGG  AACAGCTGGA  TACACTTTTA  AACGACAACT  CCAAGCCTGT  GGGCTTTCTC  540
541   CTCAGCGAGA  GGTTCATTAA  CGTCCCTCCT  CAGATTGCGC  TGCCCATGCA  CCAGCAGCTC  600
601   CAGAAAGAAC  TAGCAGAGGC  ACACAAAACT  AACAAGCCGT  GTGGGAAGTG  TTACTTCTAC  660
661   CTTCTGATTA  GCAAGACGTT  TGTGGAAGCT  GGAAAAAATT  CCAAAAAGAA  AGGGAGCAAC  720
721   CAAGAAGAAA  AAGAGGAGTT  AATGTTTGCA  AATGCAGAGG  AAGAATTTTT  CTATGAGAAG  780
781   GCCATCCTGA  AGTTCAGCTA  CTCGGTGCAG  GAAGAGAGCG  ACACTCGTCT  GGGAGGCAGG  840
841   TGGTCCTTTG  ATGACGTCCC  CATGAAGCCC  TTGCGAACCG  TGATGTTGAT  TCCAGGTGAC  900
901   CGGATGGACG  AAATCATGGA  CAGACTGAAA  GAGCACCTCT  CCGTGTGA  948

▼ KEYWORD


ID
Family
Cell cycle
Complete proteome
DNA damage
DNA repair
Nucleus
Reference proteome

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Centriole
Cellular Component
Centrosome
Cellular Component
Cytosol
Cellular Component
Mitotic spindle pole
Cellular Component
Nuclear cyclin-dependent protein kinase holoenzyme complex
Cellular Component
Nucleoplasm
Molecular Function
Kinase regulator activity
Molecular Function
Tubulin binding
Biological Process
Cellular response to DNA damage stimulus
Biological Process
DNA repair
Biological Process
Establishment of mitotic spindle orientation
Biological Process
Microtubule anchoring
Biological Process
Mitotic spindle assembly
Biological Process
Mitotic spindle organization
Biological Process
Neuroendocrine cell differentiation
Biological Process
Regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process
Ribosomal large subunit export from nucleus

▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Fec-3514Felis catus89.31e-142 417
LLPS-Mup-0731Mustela putorius furo87.623e-161 460
LLPS-Aon-1472Aotus nancymaae86.154e-114 340
LLPS-Aim-1512Ailuropoda melanoleuca86.032e-161 460
LLPS-Urm-2786Ursus maritimus85.713e-167 475
LLPS-Poa-4064Pongo abelii85.321e-140 408
LLPS-Cas-0841Carlito syrichta85.136e-155 444
LLPS-Cap-3761Cavia porcellus84.811e-151 436
LLPS-Fud-2829Fukomys damarensis84.767e-148 426
LLPS-Hos-1396Homo sapiens84.263e-100 305
LLPS-Mea-0708Mesocricetus auratus84.182e-102 309
LLPS-Pap-1155Pan paniscus83.768e-100 303
LLPS-Pat-1308Pan troglodytes83.768e-100 303
LLPS-Otg-2134Otolemur garnettii83.172e-145 419
LLPS-Eqc-0196Equus caballus82.863e-154 442
LLPS-Bot-0697Bos taurus82.282e-148 427
LLPS-Ova-1130Ovis aries82.082e-144 417
LLPS-Ict-1631Ictidomys tridecemlineatus81.77e-149 428
LLPS-Nol-2717Nomascus leucogenys81.471e-102 311
LLPS-Myl-1688Myotis lucifugus80.324e-141 409
LLPS-Tut-0966Tursiops truncatus79.921e-103 313
LLPS-Pes-2639Pelodiscus sinensis79.842e-141 407
LLPS-Rhb-0179Rhinopithecus bieti79.763e-132 385
LLPS-Mam-4025Macaca mulatta79.373e-131 382
LLPS-Gog-3353Gorilla gorilla78.856e-102 310
LLPS-Anp-1471Anas platyrhynchos78.749e-134 388
LLPS-Dio-2270Dipodomys ordii78.731e-152 437
LLPS-Anc-0870Anolis carolinensis78.354e-137 399
LLPS-Sah-0645Sarcophilus harrisii77.872e-128 374
LLPS-Sus-0695Sus scrofa77.788e-122 358
LLPS-Gaga-1952Gallus gallus77.478e-134 389
LLPS-Meg-1090Meleagris gallopavo77.175e-133 387
LLPS-Ran-2908Rattus norvegicus76.836e-139 405
LLPS-Orc-0655Oryctolagus cuniculus76.512e-145 420
LLPS-Mal-0185Mandrillus leucophaeus75.871e-135 394
LLPS-Caj-0586Callithrix jacchus75.862e-110 330
LLPS-Maf-4472Macaca fascicularis75.567e-134 390
LLPS-Lac-1183Latimeria chalumnae75.494e-130 380
LLPS-Fia-2777Ficedula albicollis75.24e-129 378
LLPS-Tag-1166Taeniopygia guttata75.26e-129 375
LLPS-Paa-4690Papio anubis74.922e-133 389
LLPS-Man-0457Macaca nemestrina74.64e-99 301
LLPS-Cea-0809Cercocebus atys74.63e-99 302
LLPS-Mod-2477Monodelphis domestica74.312e-117 346
LLPS-Xet-1936Xenopus tropicalis74.246e-86 265
LLPS-Chs-3797Chlorocebus sabaeus73.811e-99 303
LLPS-Mum-3630Mus musculus73.733e-140 406
LLPS-Loa-0046Loxodonta africana73.355e-138 401
LLPS-Orn-3280Oreochromis niloticus67.068e-112 333
LLPS-Orl-3453Oryzias latipes67.065e-105 316
LLPS-Leo-2559Lepisosteus oculatus67.062e-101 308
LLPS-Tar-0824Takifugu rubripes67.068e-115 341
LLPS-Ten-1643Tetraodon nigroviridis66.672e-112 335
LLPS-Ora-2193Ornithorhynchus anatinus65.773e-109 326
LLPS-Scf-2169Scleropages formosus65.619e-107 321
LLPS-Gaa-0442Gasterosteus aculeatus65.087e-110 327
LLPS-Scm-2757Scophthalmus maximus64.683e-106 319
LLPS-Asm-0058Astyanax mexicanus64.291e-106 320
LLPS-Xim-1228Xiphophorus maculatus63.895e-99 301
LLPS-Pof-1171Poecilia formosa62.31e-104 315
LLPS-Icp-3034Ictalurus punctatus60.321e-97 297
LLPS-Dar-0961Danio rerio59.526e-97 295
LLPS-Cis-2072Ciona savignyi34.441e-1579.0
LLPS-Drm-0435Drosophila melanogaster34.264e-38 142
LLPS-Asni-0135Aspergillus niger31.94e-1166.6
LLPS-Zyt-0181Zymoseptoria tritici30.81e-2196.3
LLPS-Mel-0202Melampsora laricipopulina29.936e-0651.2
LLPS-Abg-0308Absidia glauca29.661e-0962.4
LLPS-Sot-0131Solanum tuberosum29.281e-1373.9
LLPS-Scj-0814Schizosaccharomyces japonicus29.172e-0755.8
LLPS-Scp-0581Schizosaccharomyces pombe29.022e-1578.6
LLPS-Cii-1262Ciona intestinalis28.914e-1885.9
LLPS-Nec-0216Neurospora crassa28.333e-1578.2
LLPS-Viv-2042Vitis vinifera28.31e-1168.6
LLPS-Hea-1399Helianthus annuus28.299e-1578.2
LLPS-Dos-0063Dothistroma septosporum28.082e-1372.8
LLPS-Bro-0218Brassica oleracea28.026e-1166.2
LLPS-Blg-1338Blumeria graminis27.943e-1578.2
LLPS-Ast-0098Aspergillus terreus27.862e-1578.2
LLPS-Osl-1045Ostreococcus lucimarinus27.839e-0959.7
LLPS-Orbr-1281Oryza brachyantha27.63e-1476.3
LLPS-Thc-1139Theobroma cacao27.545e-1887.0
LLPS-Asfu-0376Aspergillus fumigatus27.243e-1783.6
LLPS-Tum-0702Tuber melanosporum27.24e-1475.1
LLPS-Phn-0163Phaeosphaeria nodorum27.176e-1372.0
LLPS-Scs-0096Sclerotinia sclerotiorum27.118e-0856.6
LLPS-Prp-1092Prunus persica27.054e-1886.7
LLPS-Coc-0619Corchorus capsularis27.056e-1886.3
LLPS-Nia-0101Nicotiana attenuata26.912e-1579.3
LLPS-Scc-0295Schizosaccharomyces cryophilus26.912e-1475.9
LLPS-Asc-0024Aspergillus clavatus26.889e-1782.4
LLPS-Nef-0533Neosartorya fischeri26.852e-1681.3
LLPS-Trv-0097Trichoderma virens26.82e-1784.3
LLPS-Kop-0877Komagataella pastoris26.756e-1268.9
LLPS-Mua-0122Musa acuminata26.673e-1784.7
LLPS-Tru-0135Triticum urartu26.62e-0962.4
LLPS-Mae-1667Manihot esculenta26.543e-1167.4
LLPS-Cus-0198Cucumis sativus26.512e-1270.9
LLPS-Glm-1091Glycine max26.441e-1065.9
LLPS-Arl-0398Arabidopsis lyrata26.442e-1065.5
LLPS-Ved-0210Verticillium dahliae26.42e-1784.3
LLPS-Trr-0635Trichoderma reesei26.298e-1782.4
LLPS-Lem-0274Leptosphaeria maculans26.191e-1373.9
LLPS-Asn-0218Aspergillus nidulans26.172e-1475.9
LLPS-Pot-1196Populus trichocarpa26.022e-1373.9
LLPS-Pyt-1021Pyrenophora teres25.972e-1373.2
LLPS-Tra-2035Triticum aestivum25.931e-1477.8
LLPS-Orgl-1294Oryza glumaepatula25.933e-1270.5
LLPS-Fuo-0944Fusarium oxysporum25.91e-1167.8
LLPS-Sol-1029Solanum lycopersicum25.771e-0756.6
LLPS-Art-0301Arabidopsis thaliana25.66e-1166.6
LLPS-Gor-2595Gossypium raimondii25.68e-1371.6
LLPS-Miv-0397Microbotryum violaceum25.432e-0756.2
LLPS-Fuv-1187Fusarium verticillioides25.42e-1270.5
LLPS-Map-0195Magnaporthe poae25.392e-1475.9
LLPS-Usm-0094Ustilago maydis25.32e-0756.2
LLPS-Mao-1086Magnaporthe oryzae25.33e-1167.0
LLPS-Gag-0404Gaeumannomyces graminis25.27e-1474.3
LLPS-Dac-0161Daucus carota25.122e-0962.0
LLPS-Met-0169Medicago truncatula25.123e-1579.3
LLPS-Zem-0847Zea mays25.112e-1476.6
LLPS-Beb-0890Beauveria bassiana25.17e-1371.6
LLPS-Fus-0163Fusarium solani25.04e-1166.6
LLPS-Orp-0944Oryza punctata25.09e-1577.8
LLPS-Brd-0784Brachypodium distachyon24.884e-1270.5
LLPS-Orni-1094Oryza nivara24.777e-1577.4
LLPS-Pytr-0292Pyrenophora triticirepentis24.613e-1167.0
LLPS-Ors-0419Oryza sativa24.552e-1477.0
LLPS-Org-0272Oryza glaberrima24.553e-1476.6
LLPS-Orr-0355Oryza rufipogon24.553e-1476.6
LLPS-Orb-1093Oryza barthii24.552e-1476.6
LLPS-Ori-0686Oryza indica24.552e-1477.0
LLPS-Amt-0615Amborella trichopoda24.512e-1579.0
LLPS-Yal-1096Yarrowia lipolytica24.422e-0858.5
LLPS-Sob-0297Sorghum bicolor24.311e-1271.6
LLPS-Hov-1017Hordeum vulgare24.193e-1373.6
LLPS-Phv-0344Phaseolus vulgaris24.151e-0859.3
LLPS-Via-0972Vigna angularis24.155e-1063.5
LLPS-Lep-0682Leersia perrieri24.119e-1475.1
LLPS-Cogr-0038Colletotrichum graminicola24.12e-1167.8
LLPS-Sem-0335Selaginella moellendorffii23.922e-0961.6
LLPS-Cog-0600Colletotrichum gloeosporioides23.691e-0962.0
LLPS-Sei-0990Setaria italica23.535e-1475.1
LLPS-Asf-0430Aspergillus flavus23.235e-1166.2
LLPS-Aso-0487Aspergillus oryzae23.235e-1166.2
LLPS-Php-0009Physcomitrella patens23.222e-0859.3
LLPS-Vir-0234Vigna radiata23.193e-0961.6
LLPS-Coo-0592Colletotrichum orbiculare22.622e-0755.5