LLPS-Caf-2170
DNAJC10
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | DnaJ homolog subfamily C member 10 |
| Gene Name: | DNAJC10 |
| Ensembl Gene: | ENSCAFG00000014289.3 |
| Ensembl Protein: | ENSCAFP00000021105.3 |
| Organism: | Canis familiaris |
| Taxa ID: | 9615 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSCAFT00000022723.3 | ENSCAFP00000021105.3 |
| UniProt | E2RCY4, E2RCY4_CANLF | |
| GeneBank | AAEX03017837 | |
| RefSeq | XM_005640379.2, XM_005640380.2, XM_845828.4 | XP_005640436.1, XP_005640437.1, XP_850921.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGVWLNKNDY VRDLKRVILC FLIVYMAILV GTDQDFYSLL GVSKTASSRE IRQAFKKLAL 60 61 KLHPDKNPNN PNAHSDFLKI NRAYEVLKDE DLRKKYDKYG EKGLADNQEG GQYESWNYYR 120 121 YDFGIYDDDP EIITLDRREF DAAVNSGELW FVNFYSPGCS HCHDLAPTWR DFAKEVDGLL 180 181 RIGAVNCGDD RMLCRMKGVN SYPSLFIFRS GMAAVKYHGD RSKESLVSFA MQHVRRTVTE 240 241 LWTGNFVNSI QTAFAAGVGW LITFCSKGGD CLTSQTRLRL SGMLDGLVNV GWMDCATQDN 300 301 LCKSLDITTS TTAYFPPGAT LNNKEKSSVL FLNSLDAKEI YLEIMHNLPD FELLSANTLE 360 361 DRLAHHRWLL FFNFGKHENS NDPELKKLKT LLKNEHIQVG RFDCSSAPDV CSNLYVFQPC 420 421 LAVFKGQGTK EYEIHHGKKI LYDILAFAKE SVNSHVTTLG PQNFPANDKE PWLVDFFAPW 480 481 CPPCRALLPE LRKASKHLYG QLKFGTLDCT IHEGLCNMYN IQAYPTTVVF NQSNVHEYEG 540 541 HHSAEQILEF IEDLMNPSVI SLTPTTFNEL VKQRKHDEVW MVDFYSPWCH PCQVLMPEWK 600 601 RMARTLTGLI NVGSIDCQQY HSFCAQENVR RYPEIRFYPQ KSNKAYQYHS YNGWNRDAYS 660 661 LRIWGLGFLP QASIDLTPQT FNEKVLQGKN HWVVDFYAPW CGPCQNFAPE FELLARMIKG 720 721 KVKAGKVDCQ AYGQTCQKAG IRAYPTVKFY PYERAKRNIW GEQIDARDAK EIATLIHEKL 780 781 KNLQNHGKRD KDEL 794 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGGAGTCT GGTTAAATAA AAATGACTAT GTCAGAGACT TGAAAAGGGT CATTCTCTGT 60 61 TTTCTAATAG TGTATATGGC CATTTTAGTG GGCACAGATC AGGATTTTTA CAGTTTGCTT 120 121 GGAGTATCCA AAACTGCAAG CAGTAGAGAA ATAAGACAAG CTTTCAAGAA ATTGGCATTG 180 181 AAGCTACATC CTGATAAAAA CCCGAATAAC CCAAACGCAC ATAGTGATTT TTTAAAAATA 240 241 AACAGAGCAT ATGAAGTACT CAAAGATGAA GATCTGCGGA AAAAGTATGA CAAATATGGA 300 301 GAAAAGGGAC TTGCAGATAA TCAAGAAGGA GGCCAGTATG AAAGCTGGAA TTATTATCGT 360 361 TATGATTTTG GTATTTATGA TGATGATCCT GAAATCATAA CATTGGATAG AAGAGAATTT 420 421 GATGCTGCTG TTAATTCTGG AGAACTGTGG TTTGTGAACT TTTACTCCCC GGGATGTTCA 480 481 CACTGCCATG ATTTAGCTCC CACGTGGAGA GACTTTGCTA AAGAAGTGGA TGGATTACTT 540 541 CGAATTGGTG CCGTTAACTG TGGTGATGAT AGAATGCTTT GCCGAATGAA AGGAGTCAAC 600 601 AGTTATCCCA GCCTCTTCAT TTTTAGGTCT GGAATGGCCG CAGTGAAATA TCATGGTGAC 660 661 AGATCCAAGG AAAGTTTAGT GAGTTTCGCC ATGCAGCATG TTAGACGCAC AGTGACAGAA 720 721 TTATGGACAG GAAATTTTGT TAACTCCATA CAAACTGCTT TTGCTGCTGG TGTCGGCTGG 780 781 TTGATCACTT TTTGTTCCAA AGGCGGAGAC TGTTTGACTT CACAGACACG ACTCAGGCTG 840 841 AGTGGCATGT TGGACGGTCT TGTTAATGTA GGATGGATGG ACTGTGCCAC CCAGGACAAC 900 901 CTTTGTAAAA GTTTGGATAT TACAACAAGT ACTACTGCCT ATTTTCCTCC TGGAGCCACT 960 961 TTAAATAACA AAGAGAAAAG CAGTGTTTTG TTCCTTAACT CATTGGATGC TAAAGAAATA 1020 1021 TATTTGGAAA TAATGCATAA TCTTCCAGAC TTTGAACTAC TTTCGGCAAA CACACTAGAG 1080 1081 GATCGGTTGG CTCATCATCG GTGGCTCTTA TTTTTTAATT TTGGAAAACA TGAAAATTCA 1140 1141 AATGATCCTG AGCTGAAGAA ACTAAAAACT CTACTTAAAA ATGAACATAT TCAAGTTGGC 1200 1201 AGGTTTGACT GTTCCTCTGC ACCAGATGTC TGCAGTAATC TGTATGTATT TCAGCCATGT 1260 1261 CTAGCAGTAT TTAAAGGACA AGGGACCAAA GAATATGAAA TTCATCATGG AAAGAAGATT 1320 1321 CTATATGATA TACTTGCCTT TGCCAAAGAA AGTGTTAATT CTCATGTTAC CACACTTGGA 1380 1381 CCTCAAAATT TTCCTGCCAA TGACAAGGAA CCGTGGCTTG TTGATTTCTT TGCCCCATGG 1440 1441 TGTCCACCGT GTCGAGCTTT ATTGCCAGAG TTACGAAAAG CATCAAAGCA TCTTTATGGT 1500 1501 CAGCTTAAAT TTGGTACACT AGATTGTACA ATTCATGAGG GACTCTGTAA CATGTATAAC 1560 1561 ATTCAGGCTT ATCCAACAAC AGTGGTGTTC AACCAGTCCA ACGTTCATGA ATACGAAGGC 1620 1621 CATCACTCTG CTGAACAGAT CTTGGAATTC ATAGAGGACC TTATGAATCC TTCAGTGATC 1680 1681 TCCCTGACAC CCACCACTTT CAATGAACTG GTTAAACAGA GAAAACATGA CGAAGTCTGG 1740 1741 ATGGTTGATT TCTATTCTCC ATGGTGTCAT CCATGTCAAG TCCTAATGCC AGAATGGAAA 1800 1801 AGAATGGCCC GGACATTAAC TGGACTGATC AATGTGGGCA GCATAGACTG CCAACAGTAT 1860 1861 CATTCTTTTT GTGCCCAAGA AAATGTTCGG AGATACCCTG AGATAAGATT TTACCCCCAA 1920 1921 AAATCAAATA AAGCTTATCA GTATCATAGT TACAACGGTT GGAATAGAGA TGCTTATTCC 1980 1981 CTGAGAATTT GGGGTCTAGG ATTTTTACCT CAAGCATCCA TAGACTTAAC TCCTCAGACT 2040 2041 TTCAATGAAA AAGTTCTACA AGGGAAAAAT CACTGGGTGG TTGATTTCTA TGCTCCTTGG 2100 2101 TGTGGACCTT GCCAAAATTT TGCTCCAGAG TTTGAGCTCT TGGCTAGAAT GATTAAAGGA 2160 2161 AAAGTGAAAG CTGGAAAAGT AGATTGTCAG GCTTATGGTC AAACATGCCA GAAAGCTGGT 2220 2221 ATCAGAGCCT ATCCAACTGT TAAATTTTAT CCCTATGAAA GAGCAAAGAG AAATATTTGG 2280 2281 GGAGAGCAGA TAGATGCCAG AGATGCAAAA GAAATTGCTA CCTTAATACA TGAAAAATTG 2340 2341 AAAAATCTCC AAAATCATGG AAAGAGAGAT AAGGATGAAC TTTAA 2385 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Endoplasmic reticulum chaperone complex | |
Cellular Component | Endoplasmic reticulum lumen | |
Cellular Component | Integral component of membrane | |
Molecular Function | ATPase activator activity | |
Molecular Function | ATPase binding | |
Molecular Function | Chaperone binding | |
Molecular Function | Disulfide oxidoreductase activity | |
Molecular Function | Hsp70 protein binding | |
Molecular Function | Misfolded protein binding | |
Molecular Function | Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor | |
Molecular Function | Protein disulfide oxidoreductase activity | |
Biological Process | Cell redox homeostasis | |
Biological Process | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | |
Biological Process | Negative regulation of protein phosphorylation | |
Biological Process | Positive regulation of ATPase activity | |
Biological Process | Protein folding in endoplasmic reticulum | |
Biological Process | Response to endoplasmic reticulum stress | |
Biological Process | Ubiquitin-dependent ERAD pathway |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Fec-0852 | Felis catus | 97.66 | 0.0 | 1573 |
| LLPS-Urm-2441 | Ursus maritimus | 97.36 | 0.0 | 1618 |
| LLPS-Aim-2818 | Ailuropoda melanoleuca | 97.24 | 0.0 | 1614 |
| LLPS-Mup-3983 | Mustela putorius furo | 96.98 | 0.0 | 1617 |
| LLPS-Aon-3240 | Aotus nancymaae | 94.84 | 0.0 | 1504 |
| LLPS-Sus-1894 | Sus scrofa | 94.46 | 0.0 | 1578 |
| LLPS-Orc-4339 | Oryctolagus cuniculus | 94.36 | 1e-179 | 523 |
| LLPS-Bot-3965 | Bos taurus | 94.33 | 0.0 | 1576 |
| LLPS-Ova-3775 | Ovis aries | 94.33 | 0.0 | 1570 |
| LLPS-Myl-3968 | Myotis lucifugus | 94.21 | 0.0 | 1571 |
| LLPS-Hos-4556 | Homo sapiens | 93.7 | 0.0 | 1556 |
| LLPS-Pap-1465 | Pan paniscus | 93.7 | 0.0 | 1556 |
| LLPS-Man-4288 | Macaca nemestrina | 93.7 | 0.0 | 1556 |
| LLPS-Mam-4704 | Macaca mulatta | 93.7 | 0.0 | 1556 |
| LLPS-Gog-3066 | Gorilla gorilla | 93.68 | 0.0 | 1550 |
| LLPS-Pat-3859 | Pan troglodytes | 93.68 | 0.0 | 1550 |
| LLPS-Maf-4435 | Macaca fascicularis | 93.58 | 0.0 | 1553 |
| LLPS-Paa-2501 | Papio anubis | 93.58 | 0.0 | 1554 |
| LLPS-Mal-1479 | Mandrillus leucophaeus | 93.58 | 0.0 | 1555 |
| LLPS-Chs-4765 | Chlorocebus sabaeus | 93.45 | 0.0 | 1550 |
| LLPS-Poa-2462 | Pongo abelii | 93.32 | 0.0 | 1550 |
| LLPS-Cas-3937 | Carlito syrichta | 93.2 | 0.0 | 1558 |
| LLPS-Caj-0627 | Callithrix jacchus | 93.07 | 0.0 | 1551 |
| LLPS-Loa-3862 | Loxodonta africana | 92.95 | 0.0 | 1563 |
| LLPS-Ict-3886 | Ictidomys tridecemlineatus | 91.31 | 0.0 | 1526 |
| LLPS-Dio-4326 | Dipodomys ordii | 91.06 | 0.0 | 1515 |
| LLPS-Mea-4465 | Mesocricetus auratus | 91.04 | 7e-177 | 516 |
| LLPS-Otg-2454 | Otolemur garnettii | 91.04 | 0.0 | 1504 |
| LLPS-Nol-4057 | Nomascus leucogenys | 90.52 | 0.0 | 1486 |
| LLPS-Cea-2590 | Cercocebus atys | 90.12 | 0.0 | 1529 |
| LLPS-Mum-3109 | Mus musculus | 90.05 | 0.0 | 1499 |
| LLPS-Fud-3125 | Fukomys damarensis | 89.8 | 0.0 | 1502 |
| LLPS-Ran-1031 | Rattus norvegicus | 89.8 | 0.0 | 1478 |
| LLPS-Cap-1406 | Cavia porcellus | 89.04 | 0.0 | 1479 |
| LLPS-Rhb-1206 | Rhinopithecus bieti | 85.46 | 0.0 | 1394 |
| LLPS-Sah-1972 | Sarcophilus harrisii | 80.0 | 0.0 | 1345 |
| LLPS-Mod-2152 | Monodelphis domestica | 79.97 | 0.0 | 1350 |
| LLPS-Tag-0019 | Taeniopygia guttata | 78.82 | 0.0 | 1302 |
| LLPS-Pes-0650 | Pelodiscus sinensis | 77.93 | 0.0 | 1306 |
| LLPS-Fia-2547 | Ficedula albicollis | 77.32 | 0.0 | 1310 |
| LLPS-Meg-3034 | Meleagris gallopavo | 76.86 | 0.0 | 1297 |
| LLPS-Gaga-0332 | Gallus gallus | 76.44 | 0.0 | 1298 |
| LLPS-Anp-0813 | Anas platyrhynchos | 75.78 | 0.0 | 1300 |
| LLPS-Ora-2401 | Ornithorhynchus anatinus | 73.6 | 1e-53 | 187 |
| LLPS-Leo-2130 | Lepisosteus oculatus | 69.07 | 0.0 | 1177 |
| LLPS-Icp-0735 | Ictalurus punctatus | 63.79 | 0.0 | 1090 |
| LLPS-Xet-3065 | Xenopus tropicalis | 63.55 | 0.0 | 1040 |
| LLPS-Orn-2879 | Oreochromis niloticus | 63.12 | 0.0 | 1068 |
| LLPS-Scm-1322 | Scophthalmus maximus | 63.11 | 3e-157 | 490 |
| LLPS-Tar-3393 | Takifugu rubripes | 63.08 | 0.0 | 1062 |
| LLPS-Orl-3828 | Oryzias latipes | 61.71 | 0.0 | 976 |
| LLPS-Ten-2519 | Tetraodon nigroviridis | 53.02 | 7e-92 | 297 |
| LLPS-Xim-3268 | Xiphophorus maculatus | 50.0 | 2e-22 | 103 |
| LLPS-Pof-0366 | Poecilia formosa | 50.0 | 2e-22 | 103 |
| LLPS-Asm-2212 | Astyanax mexicanus | 49.46 | 2e-22 | 103 |
| LLPS-Dar-0389 | Danio rerio | 47.47 | 7e-24 | 108 |
| LLPS-Lac-1240 | Latimeria chalumnae | 43.0 | 8e-22 | 101 |
| LLPS-Eqc-4360 | Equus caballus | 43.0 | 4e-21 | 100 |
| LLPS-Anc-0719 | Anolis carolinensis | 42.17 | 4e-15 | 83.2 |
| LLPS-Orbr-0939 | Oryza brachyantha | 39.29 | 9e-13 | 75.9 |
| LLPS-Tru-1358 | Triticum urartu | 39.29 | 5e-13 | 75.5 |
| LLPS-Orni-1283 | Oryza nivara | 39.22 | 3e-14 | 79.7 |
| LLPS-Via-0655 | Vigna angularis | 38.71 | 2e-13 | 77.4 |
| LLPS-Gaa-3072 | Gasterosteus aculeatus | 38.55 | 3e-14 | 79.7 |
| LLPS-Orb-1690 | Oryza barthii | 38.24 | 1e-13 | 78.2 |
| LLPS-Orgl-1628 | Oryza glumaepatula | 38.24 | 1e-13 | 78.2 |
| LLPS-Ors-0865 | Oryza sativa | 38.24 | 1e-13 | 78.2 |
| LLPS-Orp-0524 | Oryza punctata | 38.24 | 1e-13 | 77.8 |
| LLPS-Orm-1405 | Oryza meridionalis | 38.24 | 1e-13 | 78.2 |
| LLPS-Orr-1004 | Oryza rufipogon | 38.24 | 1e-13 | 78.2 |
| LLPS-Org-1295 | Oryza glaberrima | 38.24 | 1e-13 | 78.2 |
| LLPS-Vir-0257 | Vigna radiata | 37.89 | 2e-13 | 77.8 |
| LLPS-Cis-1514 | Ciona savignyi | 37.5 | 3e-11 | 70.5 |
| LLPS-Cus-1889 | Cucumis sativus | 37.5 | 5e-15 | 82.4 |
| LLPS-Brr-2566 | Brassica rapa | 37.38 | 6e-14 | 79.0 |
| LLPS-Php-0031 | Physcomitrella patens | 37.37 | 3e-13 | 77.0 |
| LLPS-Scf-1506 | Scleropages formosus | 36.46 | 2e-14 | 80.9 |
| LLPS-Lep-0476 | Leersia perrieri | 36.27 | 5e-13 | 76.3 |
| LLPS-Sem-0352 | Selaginella moellendorffii | 36.07 | 4e-13 | 76.6 |
| LLPS-Mae-0723 | Manihot esculenta | 35.85 | 1e-08 | 61.6 |
| LLPS-Sol-1214 | Solanum lycopersicum | 35.59 | 4e-13 | 76.3 |
| LLPS-Sot-1157 | Solanum tuberosum | 35.59 | 1e-12 | 75.1 |
| LLPS-Chr-0920 | Chlamydomonas reinhardtii | 35.29 | 7e-12 | 72.8 |
| LLPS-Art-0704 | Arabidopsis thaliana | 35.25 | 6e-14 | 79.3 |
| LLPS-Hov-1159 | Hordeum vulgare | 35.19 | 4e-13 | 77.0 |
| LLPS-Tra-0253 | Triticum aestivum | 35.19 | 3e-13 | 77.0 |
| LLPS-Brd-1339 | Brachypodium distachyon | 35.19 | 2e-13 | 77.0 |
| LLPS-Fuv-0102 | Fusarium verticillioides | 35.14 | 2e-10 | 67.4 |
| LLPS-Fuo-1444 | Fusarium oxysporum | 35.14 | 8e-11 | 68.9 |
| LLPS-Gor-2335 | Gossypium raimondii | 34.91 | 3e-08 | 60.8 |
| LLPS-Drm-0474 | Drosophila melanogaster | 34.55 | 6e-11 | 69.3 |
| LLPS-Arl-2114 | Arabidopsis lyrata | 34.55 | 2e-13 | 77.0 |
| LLPS-Prp-0512 | Prunus persica | 34.55 | 2e-12 | 73.9 |
| LLPS-Glm-0873 | Glycine max | 34.38 | 3e-14 | 80.1 |
| LLPS-Mua-1137 | Musa acuminata | 34.29 | 7e-10 | 65.9 |
| LLPS-Sei-1416 | Setaria italica | 34.29 | 6e-13 | 76.3 |
| LLPS-Amt-1668 | Amborella trichopoda | 34.29 | 9e-08 | 59.3 |
| LLPS-Sob-1460 | Sorghum bicolor | 34.15 | 3e-13 | 76.6 |
| LLPS-Phv-2138 | Phaseolus vulgaris | 33.98 | 4e-09 | 63.5 |
| LLPS-Gag-1212 | Gaeumannomyces graminis | 33.94 | 6e-11 | 69.3 |
| LLPS-Hea-1539 | Helianthus annuus | 33.94 | 5e-15 | 82.4 |
| LLPS-Nia-0569 | Nicotiana attenuata | 33.9 | 1e-12 | 75.1 |
| LLPS-Brn-3309 | Brassica napus | 33.83 | 4e-14 | 79.3 |
| LLPS-Bro-2927 | Brassica oleracea | 33.83 | 4e-14 | 79.7 |
| LLPS-Dac-0945 | Daucus carota | 33.64 | 1e-11 | 72.8 |
| LLPS-Viv-0329 | Vitis vinifera | 33.64 | 8e-12 | 72.4 |
| LLPS-Ori-0615 | Oryza indica | 33.62 | 1e-10 | 68.9 |
| LLPS-Met-1450 | Medicago truncatula | 33.59 | 4e-13 | 76.6 |
| LLPS-Pot-2206 | Populus trichocarpa | 33.56 | 2e-14 | 80.5 |
| LLPS-Tut-1627 | Tursiops truncatus | 33.33 | 1e-12 | 75.1 |
| LLPS-Pyt-1008 | Pyrenophora teres | 33.03 | 2e-10 | 67.4 |
| LLPS-Pytr-1102 | Pyrenophora triticirepentis | 33.03 | 2e-10 | 67.4 |
| LLPS-Thc-1526 | Theobroma cacao | 33.02 | 3e-13 | 76.6 |
| LLPS-Zem-1751 | Zea mays | 32.47 | 3e-13 | 76.6 |
| LLPS-Coc-2000 | Corchorus capsularis | 32.41 | 3e-13 | 77.0 |
| LLPS-Cae-1899 | Caenorhabditis elegans | 31.48 | 3e-11 | 70.9 |
| LLPS-Beb-1656 | Beauveria bassiana | 30.47 | 2e-21 | 101 |
| LLPS-Map-0951 | Magnaporthe poae | 30.33 | 9e-07 | 56.2 |