• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Caf-1291
MDH2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Malate dehydrogenase
Gene Name: MDH2
Ensembl Gene: ENSCAFG00000013515.3
Ensembl Protein: ENSCAFP00000019927.3
Organism: Canis familiaris
Taxa ID: 9615
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLSALARPAG  AALRRSFSTS  AQNNAKVAVL  GASGGIGQPL  ALLLKNSPLV  SRLTLYDIAH  60
61    TPGVAADLSH  IETRATVKGY  LGPEQLPDCL  KGCDVVVIPA  GVPRKPGMTR  DDLFNTNASI  120
121   VATLTAACAQ  HCPEAMICVI  SNPVNSTIPI  ATEVFKKHGA  YDPNKIFGVT  TLDIVRANTF  180
181   IAELKGLDPA  RVNVPVIGGH  AGKTIIPLIS  QCTPKVDLPQ  DQLTAVTGRI  QEAGTEVVKA  240
241   KAGAGSATLS  MAYAGARFVF  SLVDAMNGKE  GVVECSFVKS  QEADCAYFST  PLLLGKKGIE  300
301   KNLGIGKISP  FEEKMIAEAI  PELKASIKKG  EEFVKNMK  338
Nucleotide CDS Sequence (FASTA)
1     ATGCTCTCCG  CCCTCGCCCG  CCCTGCCGGC  GCCGCTCTCC  GCCGCAGCTT  CAGCACCTCG  60
61    GCCCAGAACA  ATGCTAAAGT  AGCTGTGCTT  GGGGCTTCCG  GAGGAATTGG  GCAGCCCCTT  120
121   GCGCTGCTTC  TCAAGAACAG  CCCCTTAGTG  AGCCGCCTGA  CCCTCTACGA  TATTGCTCAT  180
181   ACACCCGGAG  TGGCCGCAGA  TCTGAGCCAC  ATCGAGACCA  GAGCAACCGT  GAAAGGCTAC  240
241   CTCGGACCTG  AGCAGCTGCC  GGATTGCCTC  AAAGGCTGCG  ATGTTGTGGT  TATTCCAGCT  300
301   GGAGTCCCAA  GAAAACCAGG  CATGACACGG  GATGACCTGT  TCAACACCAA  TGCCTCAATT  360
361   GTGGCCACCC  TGACTGCTGC  CTGCGCCCAG  CATTGCCCCG  AGGCCATGAT  CTGCGTCATT  420
421   TCAAATCCGG  TCAACTCCAC  CATCCCAATT  GCAACGGAGG  TTTTCAAGAA  ACACGGAGCT  480
481   TACGACCCCA  ATAAAATCTT  CGGGGTGACG  ACCCTGGACA  TTGTCAGGGC  CAACACTTTC  540
541   ATTGCAGAAC  TAAAGGGTTT  GGATCCTGCG  CGAGTCAATG  TTCCTGTCAT  TGGCGGTCAT  600
601   GCTGGGAAGA  CCATCATCCC  CCTGATCTCT  CAGTGCACTC  CCAAGGTGGA  CCTTCCCCAG  660
661   GACCAGCTGA  CAGCCGTCAC  TGGGCGGATT  CAGGAGGCCG  GCACGGAGGT  GGTGAAAGCC  720
721   AAAGCTGGAG  CAGGCTCTGC  CACCCTGTCC  ATGGCATACG  CTGGAGCTCG  GTTTGTCTTC  780
781   TCCCTTGTGG  ATGCAATGAA  TGGGAAGGAA  GGAGTTGTCG  AATGTTCCTT  TGTTAAATCC  840
841   CAGGAAGCAG  ACTGTGCCTA  TTTCTCCACA  CCATTACTGC  TGGGGAAAAA  GGGCATCGAG  900
901   AAGAATCTAG  GCATTGGCAA  GATCTCCCCT  TTTGAAGAGA  AGATGATAGC  AGAAGCCATC  960
961   CCCGAGCTGA  AGGCCTCCAT  CAAAAAGGGA  GAGGAGTTTG  TGAAGAACAT  GAAATGA  1017

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Aim-2059Ailuropoda melanoleuca99.380.0 653
LLPS-Urm-0905Ursus maritimus98.760.0 652
LLPS-Mup-2269Mustela putorius furo98.730.0 634
LLPS-Fec-3518Felis catus96.590.0 640
LLPS-Bot-4698Bos taurus94.740.0 632
LLPS-Sus-2519Sus scrofa94.740.0 632
LLPS-Ova-3466Ovis aries94.430.0 625
LLPS-Ict-0605Ictidomys tridecemlineatus94.120.0 629
LLPS-Caj-3417Callithrix jacchus94.120.0 629
LLPS-Mea-0856Mesocricetus auratus93.810.0 629
LLPS-Orc-1455Oryctolagus cuniculus93.50.0 628
LLPS-Cas-0605Carlito syrichta93.480.0 626
LLPS-Hos-1861Homo sapiens93.190.0 624
LLPS-Ran-3330Rattus norvegicus93.190.0 627
LLPS-Dio-1882Dipodomys ordii93.170.0 622
LLPS-Pap-1116Pan paniscus92.880.0 624
LLPS-Pat-0527Pan troglodytes92.880.0 624
LLPS-Mum-3914Mus musculus92.880.0 625
LLPS-Gog-1616Gorilla gorilla92.880.0 623
LLPS-Eqc-1621Equus caballus92.570.0 620
LLPS-Myl-3573Myotis lucifugus92.570.0 622
LLPS-Mam-2378Macaca mulatta92.260.0 619
LLPS-Cap-2464Cavia porcellus92.260.0 616
LLPS-Man-4587Macaca nemestrina92.260.0 619
LLPS-Loa-1852Loxodonta africana92.260.0 620
LLPS-Cea-2471Cercocebus atys92.260.0 619
LLPS-Maf-0525Macaca fascicularis92.110.0 605
LLPS-Rhb-3148Rhinopithecus bieti91.950.0 617
LLPS-Paa-0473Papio anubis91.950.0 619
LLPS-Aon-2061Aotus nancymaae91.640.0 611
LLPS-Fud-0703Fukomys damarensis91.610.0 613
LLPS-Chs-2758Chlorocebus sabaeus91.330.0 614
LLPS-Mod-0140Monodelphis domestica90.40.0 611
LLPS-Mal-2078Mandrillus leucophaeus90.090.0 598
LLPS-Sah-0163Sarcophilus harrisii90.060.0 608
LLPS-Nol-1618Nomascus leucogenys89.780.0 586
LLPS-Anp-2634Anas platyrhynchos89.590.0 594
LLPS-Gaga-4056Gallus gallus89.130.0 600
LLPS-Meg-2179Meleagris gallopavo88.510.0 597
LLPS-Otg-1347Otolemur garnettii87.930.0 569
LLPS-Anc-2303Anolis carolinensis87.270.0 594
LLPS-Fia-2533Ficedula albicollis85.670.0 579
LLPS-Tag-2879Taeniopygia guttata85.190.0 576
LLPS-Poa-4106Pongo abelii84.830.0 554
LLPS-Leo-2131Lepisosteus oculatus84.470.0 571
LLPS-Dar-3317Danio rerio83.90.0 570
LLPS-Scf-2258Scleropages formosus83.90.0 569
LLPS-Xet-2472Xenopus tropicalis83.230.0 561
LLPS-Orl-2179Oryzias latipes83.230.0 565
LLPS-Orn-1375Oreochromis niloticus82.920.0 561
LLPS-Ten-1176Tetraodon nigroviridis82.660.0 565
LLPS-Pof-4156Poecilia formosa82.660.0 561
LLPS-Lac-2574Latimeria chalumnae82.660.0 565
LLPS-Xim-2821Xiphophorus maculatus82.660.0 563
LLPS-Tar-3341Takifugu rubripes82.660.0 567
LLPS-Icp-4228Ictalurus punctatus82.30.0 557
LLPS-Gaa-2898Gasterosteus aculeatus81.730.0 555
LLPS-Asm-2216Astyanax mexicanus80.750.0 552
LLPS-Ora-3271Ornithorhynchus anatinus75.243e-160 458
LLPS-Cis-1960Ciona savignyi70.133e-109 332
LLPS-Cii-1522Ciona intestinalis70.094e-167 477
LLPS-Glm-0254Glycine max61.693e-127 375
LLPS-Php-0658Physcomitrella patens61.515e-133 390
LLPS-Prp-1795Prunus persica61.322e-133 390
LLPS-Thc-1434Theobroma cacao61.27e-132 387
LLPS-Dac-0969Daucus carota61.012e-134 394
LLPS-Arl-2350Arabidopsis lyrata60.913e-124 370
LLPS-Gor-0384Gossypium raimondii60.881e-132 389
LLPS-Coc-0128Corchorus capsularis60.571e-130 384
LLPS-Phv-0732Phaseolus vulgaris60.393e-125 370
LLPS-Via-1327Vigna angularis60.392e-124 368
LLPS-Vir-1553Vigna radiata60.392e-124 368
LLPS-Art-1515Arabidopsis thaliana60.263e-122 365
LLPS-Pot-2264Populus trichocarpa60.252e-126 376
LLPS-Lep-1657Leersia perrieri60.192e-123 365
LLPS-Amt-2136Amborella trichopoda60.132e-124 370
LLPS-Abg-1944Absidia glauca60.064e-126 372
LLPS-Cus-1340Cucumis sativus60.063e-130 383
LLPS-Org-1897Oryza glaberrima60.09e-122 362
LLPS-Bro-2840Brassica oleracea60.06e-123 366
LLPS-Mae-0898Manihot esculenta59.948e-130 382
LLPS-Orgl-1759Oryza glumaepatula59.873e-123 365
LLPS-Orb-2155Oryza barthii59.873e-123 365
LLPS-Drm-0540Drosophila melanogaster59.753e-140 408
LLPS-Sei-1002Setaria italica59.754e-127 375
LLPS-Orr-2129Oryza rufipogon59.691e-125 373
LLPS-Osl-0651Ostreococcus lucimarinus59.682e-121 359
LLPS-Orp-1955Oryza punctata59.685e-121 360
LLPS-Brn-3220Brassica napus59.682e-122 365
LLPS-Zem-2446Zea mays59.55e-124 369
LLPS-Ors-0532Oryza sativa59.54e-125 372
LLPS-Ori-0309Oryza indica59.53e-125 372
LLPS-Brr-1173Brassica rapa59.433e-129 380
LLPS-Viv-1907Vitis vinifera59.381e-124 369
LLPS-Orni-1407Oryza nivara59.374e-122 367
LLPS-Mua-1447Musa acuminata59.325e-126 372
LLPS-Sot-1467Solanum tuberosum59.316e-129 379
LLPS-Hea-2428Helianthus annuus59.245e-124 369
LLPS-Orm-1256Oryza meridionalis59.191e-124 370
LLPS-Chr-0737Chlamydomonas reinhardtii58.977e-125 370
LLPS-Asc-0173Aspergillus clavatus58.923e-118 352
LLPS-Orbr-0141Oryza brachyantha58.97e-119 355
LLPS-Tra-1513Triticum aestivum58.846e-122 363
LLPS-Cae-1276Caenorhabditis elegans58.849e-128 377
LLPS-Sob-0057Sorghum bicolor58.811e-125 371
LLPS-Nef-1080Neosartorya fischeri58.799e-119 353
LLPS-Nia-0993Nicotiana attenuata58.683e-128 378
LLPS-Brd-1721Brachypodium distachyon58.684e-123 367
LLPS-Sem-1189Selaginella moellendorffii58.652e-120 358
LLPS-Sol-2434Solanum lycopersicum58.543e-121 366
LLPS-Asfu-0092Aspergillus fumigatus58.472e-118 352
LLPS-Tru-2018Triticum urartu58.397e-121 361
LLPS-Asn-1497Aspergillus nidulans58.235e-115 344
LLPS-Hov-2116Hordeum vulgare58.123e-118 355
LLPS-Pyt-0555Pyrenophora teres57.283e-120 357
LLPS-Ast-0577Aspergillus terreus57.14e-111 334
LLPS-Pytr-1208Pyrenophora triticirepentis56.971e-119 356
LLPS-Map-1111Magnaporthe poae56.973e-115 344
LLPS-Aso-0869Aspergillus oryzae56.969e-113 338
LLPS-Asf-0997Aspergillus flavus56.963e-111 337
LLPS-Lem-0848Leptosphaeria maculans56.791e-120 358
LLPS-Zyt-0764Zymoseptoria tritici56.793e-117 350
LLPS-Spr-1330Sporisorium reilianum56.72e-119 355
LLPS-Asni-1101Aspergillus niger56.691e-109 330
LLPS-Gag-0788Gaeumannomyces graminis56.664e-114 342
LLPS-Mao-0137Magnaporthe oryzae56.663e-115 345
LLPS-Trr-1355Trichoderma reesei56.173e-113 339
LLPS-Cog-0116Colletotrichum gloeosporioides56.042e-114 342
LLPS-Cogr-1627Colletotrichum graminicola55.867e-114 341
LLPS-Dos-1267Dothistroma septosporum55.861e-116 348
LLPS-Usm-0268Ustilago maydis55.765e-118 352
LLPS-Nec-1369Neurospora crassa55.732e-115 345
LLPS-Trv-1364Trichoderma virens55.692e-113 340
LLPS-Coo-1355Colletotrichum orbiculare55.593e-115 344
LLPS-Phn-0263Phaeosphaeria nodorum55.562e-120 358
LLPS-Tum-1247Tuber melanosporum55.562e-116 348
LLPS-Met-2172Medicago truncatula55.481e-122 364
LLPS-Kop-0888Komagataella pastoris55.084e-112 336
LLPS-Fus-0519Fusarium solani54.81e-110 332
LLPS-Crn-0385Cryptococcus neoformans54.664e-120 357
LLPS-Put-0898Puccinia triticina54.496e-111 334
LLPS-Mel-0505Melampsora laricipopulina54.291e-108 328
LLPS-Blg-1217Blumeria graminis54.014e-111 334
LLPS-Pug-0298Puccinia graminis53.685e-111 334
LLPS-Scs-0776Sclerotinia sclerotiorum53.251e-107 325